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description Publicationkeyboard_double_arrow_right Article , Other literature type 2022 CanadaFrontiers Media SA NIH | ARTFL LEFFTDS Longitudina..., CIHRNIH| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) ,CIHRAuthors: Spyros Papapetropoulos; Spyros Papapetropoulos; Angela Pontius; Elizabeth Finger; +16 AuthorsSpyros Papapetropoulos; Spyros Papapetropoulos; Angela Pontius; Elizabeth Finger; Virginija Karrenbauer; Virginija Karrenbauer; David S. Lynch; Matthew Brennan; Samantha Zappia; Wolfgang Koehler; Ludger Schoels; Ludger Schoels; Stefanie N. Hayer; Stefanie N. Hayer; Takuya Konno; Takeshi Ikeuchi; Troy Lund; Jennifer Orthmann-Murphy; Florian Eichler; Zbigniew K. Wszolek;A comprehensive review of published literature was conducted to elucidate the genetics, neuropathology, imaging findings, prevalence, clinical course, diagnosis/clinical evaluation, potential biomarkers, and current and proposed treatments for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare, debilitating, and life-threatening neurodegenerative disorder for which disease-modifying therapies are not currently available. Details on potential efficacy endpoints for future interventional clinical trials in patients with ALSP and data related to the burden of the disease on patients and caregivers were also reviewed. The information in this position paper lays a foundation to establish an effective clinical rationale and address the clinical gaps for creation of a robust strategy to develop therapeutic agents for ALSP, as well as design future clinical trials, that have clinically meaningful and convergent endpoints.
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For further information contact us at helpdesk@openaire.eu22 citations 22 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 CanadaResearch Square Platform LLC Susan Hunter; Alison Divine; Humberto Omana; Edward Madou; Jeffrey Holmes;Abstract Background Balance and gait problems are common and progressive in dementia. Use of a mobility aid provides physical support and confidence. Yet, mobility aid use in people with dementia increases falls three-fold. An assessment tool of mobility aid safety in people with dementia does not currently exist. The objectives of this study were: 1) to develop a tool for the evaluation of physical function and safe use of a 4-wheeled walker in people with dementia, and 2) to evaluate its construct and criterion validity, inter-rater and test-retest reliability and minimal detectable change. Methods Healthcare professionals (HCP) experienced in rehabilitation of people with dementia participated in focus groups for item generation of the new tool, The Safe Use of Mobility Aid Checklist (SUMAC). The SUMAC evaluates physical function (PF) and safe use of the equipment (EQ) on nine tasks of daily life. Reliability was evaluated by HCP (n = 5) scored participant videos of people with dementia (n = 10) using a 4-wheeled walker performing the SUMAC. Inter-rater and test-retest reliability was assessed using intra-class correlation coefficients (ICC). Construct validity evaluated scores of the HCPs to a consensus HCP panel using Spearman’s rank-order correlations. Criterion validity evaluated SUMAC-PF to the Performance-Oriented Mobility Assessment (POMA) gait subscale using Spearman’s rank-order correlations. Results Three focus groups (n = 17) generated a tool comprised of nine tasks and the components within each task for physical function and safe use. Inter-rater reliability was statistically significant for SUMAC-PF (ICC = 0.92, 95%CI (0.81, 0.98), p < 0.001) and SUMAC-EQ. (ICC = 0.82, 95%CI (0.54, 0.95), p < 0.001). Test-retest reliability was statistically significant for SUMAC-PF (ICC = 0.89, 95%CI (0.81, 0.94), p < 0.001) and SUMAC-EQ. (ICC = 0.88, 95%CI (0.79, 0.93), p < 0.001). As hypothesized, the POMA gait subscale correlated strongly with the SUMAC-PF (rs = 0.84), but not EQ (rs = 0.39). Conclusions The focus groups and research team developed a tool of nine tasks with evaluation on physical function and safe use of a 4-wheeled walker for people with dementia. The SUMAC tool has demonstrated content validity for the whole scale and good construct and criterion validity for the SUMAC-PF and SUMAC-EQ. The subscores of the SUMAC demonstrated excellent to good inter-rater and test-retest reliability.
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For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Average influence Average impulse Average Powered by BIP!visibility 2visibility views 2 download downloads 12 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaElsevier BV Aras Kayvanrad; Stephen R. Arnott; Nathan W. Churchill; Stefanie Hassel; Aditi Chemparathy; Fan Dong; Mojdeh Zamyadi; Tom Gee; Robert Bartha; Sandra E. Black; Jane M. Lawrence-Dewar; Christopher J.M. Scott; Sean P. Symons; Andrew D. Davis; Geoffrey B. Hall; Jacqueline K. Harris; Nancy J. Lobaugh; Glenda MacQueen; Cindy Woo; Stephen C. Strother;pmid: 34029737
Quality assurance (QA) is crucial in longitudinal and/or multi-site studies, which involve the collection of data from a group of subjects over time and/or at different locations. It is important to regularly monitor the performance of the scanners over time and at different locations to detect and control for intrinsic differences (e.g., due to manufacturers) and changes in scanner performance (e.g., due to gradual component aging, software and/or hardware upgrades, etc.). As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners. QA parameters were calculated for each scan using the functional Biomarker Imaging Research Network's (fBIRN) QA phantom and pipeline to capture between- and within-scanner variability. We also describe a QA protocol to measure the full-width-at-half-maximum (FWHM) of slice-wise point spread functions (PSF), used in conjunction with the fBIRN QA parameters. Variations in image resolution measured by the FWHM are a primary source of variance over time for many sites, as well as between sites and between manufacturers. We also identify an unexpected range of instabilities affecting individual slices in a number of scanners, which may amount to a substantial contribution of unexplained signal variance to their data. Finally, we identify a preliminary preprocessing approach to reduce this variance and/or alleviate the slice anomalies, and in a small human data set show that this change in preprocessing can have a significant impact on seed-based connectivity measurements for some individual subjects. We expect that other fMRI centres will find this approach to identifying and controlling scanner instabilities useful in similar studies.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 Netherlands, BelgiumImpact Journals, LLC NIH | Genes, Hormones &Environm..., NIH | UCLA Clinical and Transla..., NIH | Mayo Clinic SPORE in Ovar... +45 projectsNIH| Genes, Hormones &Environment in an Ovarian Cancer Model ,NIH| UCLA Clinical and Translational Science Institute ,NIH| Mayo Clinic SPORE in Ovarian Cancer ,NIH| OVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERS ,NIH| USC CANCER CENTER EPIDEMIOLOGY &BIOSTATISTICS UNIT ,NIH| Regulatory T Cell Function in Ovarian Cancer ,NIH| Haplotype-Based Genome Screen for Ovarian Cancer Loci ,NIH| GENETIC EPIDEMIOLOGY OF OVARIAN CANCER ,NIH| HEREDITARY BREAST CANCER--GENETIC AND MOLECULAR STUDIES ,NIH| MOUSE GENETICS ,NIH| Epidemiology of Ovarian Cancer:New Hypotheses ,NIH| MHC-Restricted and MHC-Non-Restricted Targeting of Ovarian Cancer by alphaDC1 ,NIH| ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER ,NIH| Moffitt Cancer Center Support Grant ,NHMRC| Risk and prognostic factors for breast cancer of different immunohistochemical subtypes ,NHMRC| Towards cancer control: Population and molecular strategies ,NIH| SURVEILLANCE EPIDEMIOLOGY AND END RESULTS (SEER) ,NIH| PRE SURGICAL O6 BENZYLGUANINE TREATMENT OF PTS W/ MALIGNANT GLIOMA ,NIH| Inflammation and Ovarian Cancer ,NIH| The Progesterone Receptor Gene and Ovarian Cancer Risk ,NIH| Ovarian Cancer and Gonadotropin Signaling ,NIH| Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) ,NIH| Steroid Hormone Genes and Ovarian Cancer Risk ,NIH| Obesity in ovarian cancer prognosis ,NIH| Phytoestrogens, alcohol, and endometrial cancer risk ,NIH| Core--Tissue Banking and Pathology ,NIH| USC COMPREHENSIVE CANCER CENTER (CORE) SUPPORT ,NIH| ROSWELL PARK MEMORIAL INSTITUTE CENTER CORE GRANT ,NIH| SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM ,NIH| COLLABORATIVE STUDY OF OVARIAN CANCER IN TWO RISK GROUPS ,NIH| Mitochondrial DNA and Ovarian Cancer Risk and Survival ,NIH| SURVEILLANCE EPIDEMIOLOGY AND END RESULTS ,NIH| RISK FACTORS AND PROGNOSTIC FACTORS FOR OVARIAN CANCER ,NIH| The Mitochondrial Genome and Ovarian Cancer Risk ,NIH| Premenopausal Hormone Levels and Risk of Breast Cancer ,NHMRC| Epidemiology of Chronic Disease, Health Interventions and DNA Studies ,NIH| CANCER CENTER SUPPORT GRANT ,NIH| Life Course Cancer Epidemiology Cohort in Women ,NIH| SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS PROGRAM ,NIH| CASE-CONTROL STUDY OF OVARIAN CANCER IN LOS ANGELES ,NHMRC| Molecular Epidemiology of Ovarian Cancer: The Australian Ovarian Cancer Study National Clinical Follow-Up Core ,NIH| Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology ,CIHR ,NIH| Genetic Epidemiology of Ovarian and Prostate Cancer ,NIH| MOFFITT CANCER CENTER SUPPORT GRANT ,NIH| Mayo Comprehensive Cancer Center Grant ,NIH| PREVENTION OF HEREDITARY BREAST AND OVARIAN CANCER ,NIH| NORTHERN CALIFORNIA COOPERATIVE FAMILY REGISTRYJennifer B. Permuth; Brett M. Reid; Madalene Earp; Y. Ann Chen; Alvaro N.A. Monteiro; Zhihua Chen; Georgia Chenevix-Trench; Peter A. Fasching; Matthias W. Beckmann; Diether Lambrechts; Adriaan Vanderstichele; Els Van Niewenhuyse; Ignace Vergote; Mary Anne Rossing; Jennifer A. Doherty; Jenny Chang-Claude; Kirsten B. Moysich; Kunle Odunsi; Marc T. Goodman; Yurii B. Shvetsov; Lynne R. Wilkens; Pamela J. Thompson; Thilo Dörk; Natalia Bogdanova; Ralf Bützow; Heli Nevanlinna; Liisa M. Pelttari; Arto Leminen; Francesmary Modugno; Robert P. Edwards; Roberta B. Ness; Joseph L. Kelley; Florian Heitz; Beth Y. Karlan; Jenny Lester; Susanne K. Kjaer; Allan Jensen; Graham G. Giles; Michelle A.T. Hildebrandt; Dong Liang; Karen H. Lu; Xifeng Wu; Douglas A. Levine; Maria Bisogna; Andrew Berchuck; Daniel W. Cramer; Kathryn L. Terry; Shelley S. Tworoger; Elizabeth M. Poole; Elisa V. Bandera; Brooke L. Fridley; Julie M. Cunningham; Stacey J. Winham; Sara H. Olson; Irene Orlow; Line Bjørge; Lambertus A. Kiemeney; Leon F.A.G. Massuger; Tanja Pejovic; Melissa Moffitt; Nhu D. Le; Linda S. Cook; Angela Brooks-Wilson; Linda E. Kelemen; Jacek Gronwald; Jan Lubinski; Nicolas Wentzensen; Louise A. Brinton; Jolanta Lissowska; Hanna Yang; Estrid Høgdall; Claus Høgdall; Lene Lundvall; Paul D.P. Pharoah; Honglin Song; Ian G. Campbell; Diana Eccles; Iain A. McNeish; Alice S. Whittemore; Valerie McGuire; Weiva Sieh; Joseph H. Rothstein; Catherine M. Phelan; Harvey A. Risch; Steven A. Narod; John McLaughlin; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A. Gayther; Susan J. Ramus; Aleksandra Gentry-Maharaj; Celeste Leigh Pearce; Anna H. Wu; Jolanta Kupryjanczyk; Agnieszka Dansonka-Mieszkowska; Joellen M. Schildkraut; Jin Q. Cheng; Ellen L. Goode; Thomas A. Sellers;pmc: PMC5340123
pmid: 27911851
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene expression. Using directly genotyped and imputed data from 10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI), with adjustment for European ancestry. We conducted gene-level analyses using the Admixture Maximum Likelihood (AML) test and the Sequence-Kernel Association test for common and rare variants (SKAT-CR). Association analysis revealed top risk-associated SNP rs77027562 (OR (95% CI)= 1.39 (1.17-1.64), P=1.0x10-4) in ADAR3 and rs185455523 in SND1 (OR (95% CI)= 0.68 (0.56-0.83), P=2.0x10-4). When restricting to serous histology (n=6,500), the magnitude of association strengthened for rs185455523 (OR=0.60, P=1.0x10-4). Gene-level analyses revealed that variation in ADAR was associated (P<0.05) with EOC susceptibility, with PAML=0.022 and PSKAT-CR=0.020. Expression quantitative trait locus analysis in EOC tissue revealed significant associations (P<0.05) with ADAR expression for several SNPs in ADAR, including rs1127313 (G/A), a SNP in the 3' untranslated region. In summary, germline variation involving RNA editing genes may influence EOC susceptibility, warranting further investigation of inherited and acquired alterations affecting RNA editing. Contains fulltext : 172820.pdf (Publisher’s version ) (Open Access)
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For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 1visibility views 1 download downloads 0 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Netherlands, CanadaSpringer Science and Business Media LLC Palma, David A.; Olson, Robert; Harrow, Stephen; Correa, Rohann J.M.; Schneiders, Famke; Haasbeek, Cornelis J.A.; Rodrigues, George B.; Lock, Michael; Yaremko, Brian P.; Bauman, Glenn S.; Ahmad, Belal; Schellenberg, Devin; Liu, Mitchell; Gaede, Stewart; Laba, Joanna; Mulroy, Liam; Senthi, Sashendra; Louie, Alexander V.; Swaminath, Anand; Chalmers, Anthony; Warner, Andrew; Slotman, Ben J.; de Gruijl, Tanja D.; Allan, Alison; Senan, Suresh;Background Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evaluated SABR in a group of patients with a small burden of oligometastatic disease (mostly with 1–3 metastatic lesions), and found that SABR was associated with benefits in progression-free survival and overall survival. The goal of this phase III trial is to assess the impact of SABR in patients with 4–10 metastatic cancer lesions. Methods One hundred and fifty-nine patients will be randomized in a 1:2 ratio between the control arm (consisting of standard of care palliative-intent treatments), and the SABR arm (consisting of standard of care treatment + SABR to all sites of known disease). Randomization will be stratified by two factors: histology (Group 1: prostate, breast, or renal; Group 2: all others), and type of pre-specified systemic therapy (Group 1: immunotherapy/targeted; Group 2: cytotoxic; Group 3: observation). SABR is to be completed within 2 weeks, allowing for rapid initiation of systemic therapy. Recommended SABR doses are 20 Gy in 1 fraction, 30 Gy in 3 fractions, or 35 Gy in 5 fractions, chosen to minimize risks of toxicity. The primary endpoint is overall survival, and secondary endpoints include progression-free survival, time to development of new metastatic lesions, quality of life, and toxicity. Translational endpoints include assessment of circulating tumor cells, cell-free DNA, and tumor tissue as prognostic and predictive markers, including assessment of immunological predictors of response and long-term survival. Discussion This study will provide an assessment of the impact of SABR on clinical outcomes and quality of life, to determine if long-term survival can be achieved for selected patients with 4–10 oligometastatic lesions. Trial registration Clinicaltrials.gov identifier: NCT03721341. Date of registration: October 26, 2018. Electronic supplementary material The online version of this article (10.1186/s12885-019-5977-6) contains supplementary material, which is available to authorized users.
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For further information contact us at helpdesk@openaire.eu169 citations 169 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 0visibility views 0 download downloads 6 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Review 2020 CanadaInforma UK Limited Carrie Anne Marshall; Leonie Boland; Lee Ann Westover; Roxanne Isard; Sharon A. Gutman;Background: Although systematic and scoping reviews have identified a range of interventions for persons experiencing homelessness, no known reviews have captured the range and quality of intervention studies aimed at supporting a transition from homelessness. Objectives: To capture the range and quality of occupational therapy intervention studies aimed at supporting a transition to housing following homelessness. Method: Using Joanna Briggs Institute (JBI) guidelines, we conducted a systematic review including a critical appraisal and narrative synthesis of experimental studies. Results: Eleven studies were included. Critical appraisal scores ranged from 33.3 to 88.9 of a possible score of 100 (Mdn = 62.5; IQR = 33.4). The majority of studies evaluated interventions for the development of life skills (n = 9; 81.8%), and all were conducted in the USA. Several of the included studies were exploratory evaluation and feasibility studies, and all were quasi-experimental in design. Only three studies (27.2%) incorporated a control group. Intervention strategies included (1) integrated group and individual life skills interventions (n = 6); (2) group-based life skills interventions (n = 3); and (3) psychosocial and consultative interventions (n = 2). Conclusions: Research evaluating occupational therapy interventions aimed at supporting homeless individuals as they transition to housing is in an early stage of development. Significance: Implications for research and practice are discussed.
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For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2006 NetherlandsSpringer Science and Business Media LLC Rhydderch, S.M.; Edwards, A.; Marshall, M.; Elwyn, G.; Grol, R.P.T.M.;pmc: PMC1526440
pmid: 16784540
BACKGROUND: The relationship between effective organisation of general practices and health improvement is widely accepted. The Maturity Matrix is an instrument designed to assess organisational development in general practice settings and to stimulate quality improvement. It is undertaken by a practice team with the aid of a facilitator. There is a tradition in the primary care systems in many countries of using practice visitors to educate practice teams about how to improve. However the role of practice visitors as facilitators who enable teams to plan practice-led organisational development using quality improvement instruments is less well understood. The objectives of the study were to develop and explore a facilitation model to support practice teams in stimulating organisational development using a quality improvement instrument called the Maturity Matrix. A qualitative study based on transcript analysis was adopted. METHOD: A model of facilitation was constructed based on a review of relevant literature. Audio tapes of Maturity Matrix assessment sessions with general practices were transcribed and facilitator skills were compared to the model. The sample consisted of two facilitators working with twelve general practices based in UK primary care. RESULTS: The facilitation model suggested that four areas describing eighteen skills were important. The four areas are structuring the session, obtaining consensus, handling group dynamics and enabling team learning. Facilitators effectively employed skills associated with the first three areas, but less able to consistently stimulate team learning. CONCLUSION: This study suggests that facilitators need careful preparation for their role and practices need protected time in order to make best use of practice-led quality improvement instruments. The role of practice visitor as a facilitator is becoming important as the need to engender ownership of the quality improvement process by practices increases. Contains fulltext : 50032.pdf ( ) (Open Access)
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For further information contact us at helpdesk@openaire.eu24 citations 24 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 1 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, Italy, Italy, Germany, Italy, Italy, Netherlands, Italy, Belgium, Italy, ItalyAmerican Medical Association (AMA) Bellani, Giacomo; Laffey, John G.; Pham, Tài; Fan, Eddy; Brochard, Laurent; Esteban, Andres; Gattinoni, Luciano; van Haren, Frank; Larsson, Anders; McAuley, Daniel F.; Ranieri, Marco; Rubenfeld, Gordon; Thompson, B. Taylor; Wrigge, Hermann; Slutsky, Arthur S.; Pesenti, Antonio; LUNG SAFE Investigators; ESICM Trials Group; Wittebole, Xavier; Berghe, Caroline; Bulpa, Pierre; Dive, Alain-Michel;pmid: 30023112
pmc: PMC6036017
handle: 2078.1/172166 , 2434/381160 , 2066/172480 , 2318/1588268 , 10807/88347 , 11573/859307 , 10807/88635
pmid: 30023112
pmc: PMC6036017
handle: 2078.1/172166 , 2434/381160 , 2066/172480 , 2318/1588268 , 10807/88347 , 11573/859307 , 10807/88635
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Berlin Definition. DESIGN, SETTING, AND PARTICIPANTS: The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents. EXPOSURES: Acute respiratory distress syndrome. MAIN OUTCOMES AND MEASURES: The primary outcome was ICU incidence of ARDS. Secondary outcomes included assessment of clinician recognition of ARDS, the application of ventilatory management, the use of adjunctive interventions in routine clinical practice, and clinical outcomes from ARDS. RESULTS: Of 29,144 patients admitted to participating ICUs, 3022 (10.4%) fulfilled ARDS criteria. Of these, 2377 patients developed ARDS in the first 48 hours and whose respiratory failure was managed with invasive mechanical ventilation. The period prevalence of mild ARDS was 30.0% (95% CI, 28.2%-31.9%); of moderate ARDS, 46.6% (95% CI, 44.5%-48.6%); and of severe ARDS, 23.4% (95% CI, 21.7%-25.2%). ARDS represented 0.42 cases per ICU bed over 4 weeks and represented 10.4% (95% CI, 10.0%-10.7%) of ICU admissions and 23.4% of patients requiring mechanical ventilation. Clinical recognition of ARDS ranged from 51.3% (95% CI, 47.5%-55.0%) in mild to 78.5% (95% CI, 74.8%-81.8%) in severe ARDS. Less than two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight. Plateau pressure was measured in 40.1% (95% CI, 38.2-42.1), whereas 82.6% (95% CI, 81.0%-84.1%) received a positive end-expository pressure (PEEP) of less than 12 cm H2O. Prone positioning was used in 16.3% (95% CI, 13.7%-19.2%) of patients with severe ARDS. Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning. Hospital mortality was 34.9% (95% CI, 31.4%-38.5%) for those with mild, 40.3% (95% CI, 37.4%-43.3%) for those with moderate, and 46.1% (95% CI, 41.9%-50.4%) for those with severe ARDS. CONCLUSIONS AND RELEVANCE: Among ICUs in 50 countries, the period prevalence of ARDS was 10.4% of ICU admissions. This syndrome appeared to be underrecognized and undertreated and associated with a high mortality rate. These findings indicate the potential for improvement in the management of patients with ARDS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT02010073. Contains fulltext : 172480.pdf (Publisher’s version ) (Closed access)
Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu3K citations 3,278 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!more_vert Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2016 United Kingdom, Australia, United Kingdom, United Kingdom, United Kingdom, NetherlandsBMJ Trisha Greenhalgh; Ellen Annandale; Richard Ashcroft; James Barlow; Nick Black; Alan Bleakley; Ruth Boaden; Jeffrey Braithwaite; Nicky Britten; Franco A. Carnevale; Katherine Checkland; Julianne Cheek; Alexander M. Clark; Simon Cohn; Jack Coulehan; Benjamin F. Crabtree; Steven Cummins; Frank Davidoff; Huw Davies; Robert Dingwall; Mary Dixon-Woods; Glyn Elwyn; Eivind Engebretsen; Ewan Ferlie; Naomi Fulop; John Gabbay; Marie-Pierre Gagnon; Dariusz Galasiński; Ruth Garside; Lucy Gilson; Peter Griffiths; Penny Hawe; Jan-Kees Helderman; Brian Hodges; David J. Hunter; Margaret H. Kearney; Celia Kitzinger; Jenny Kitzinger; Ayelet Kuper; Saville Kushner; Andrée le May; Lorelei Lingard; Louise Locock; Jill Maben; Mary Ellen Macdonald; Frances S. Mair; Russell Mannion; Martin Marshall; Carl May; Nicholas Mays; Lorna McKee; Marissa Miraldo; David G. Morgan; Janice M. Morse; Sarah Nettleton; Sandy Oliver; Warrren Pearce; Pierre Pluye; Catherine Pope; Glenn Robert; Celia Roberts; Stefania Rodella; Jo Rycroft-Malone; Margarete Sandelowski; Paul G. Shekelle; Fiona Stevenson; Sharon E. Straus; Deborah Swinglehurst; Sally Thorne; Göran Tomson; Gerd Westert; Sue Wilkinson; Brian Williams; Terry Young; Sue Ziebland;doi: 10.1136/bmj.i563
pmid: 26980743
Seventy six senior academics from 11 countries invite The BMJ ’s editors to reconsider their policy of rejecting qualitative research on the grounds of low priority. They challenge the journal to develop a proactive, scholarly, and pluralist approach to research that aligns with its stated mission
NARCIS; Radboud Repo... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu287 citations 287 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 43visibility views 43 download downloads 1,033 Powered bymore_vert NARCIS; Radboud Repo... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmj.i563&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Denmark, Australia, Sweden, Netherlands, DenmarkBMJ Alison Kitson; Devin Carr; Tiffany Conroy; Rebecca Feo; Mette Grønkjær; Getty Huisman-de Waal; Debra Jackson; Lianne Jeffs; Jane Merkley; Åsa Muntlin Athlin; Jennifer Parr; David Richards; Erik Elgaard Sørensen; Yvonne Wengström;pmid: 31822543
pmc: PMC6924742
OBJECTIVE: The International Learning Collaborative (ILC) is an organisation dedicated to understanding why fundamental care, the care required by all patients regardless of clinical condition, fails to be provided in healthcare systems globally. At its 11th annual meeting in 2019, nursing leaders from 11 countries, together with patient representatives, confirmed that patients' fundamental care needs are still being ignored and nurses are still afraid to 'speak up' when these care failures occur. While the ILC's efforts over the past decade have led to increased recognition of the importance of fundamental care, it is not enough. To generate practical, sustainable solutions, we need to substantially rethink fundamental care and its contribution to patient outcomes and experiences, staff well-being, safety and quality, and the economic viability of healthcare systems. KEY ARGUMENTS: We present five propositions for radically transforming fundamental care delivery:Value: fundamental care must be foundational to all caring activities, systems and institutionsTalk: fundamental care must be explicitly articulated in all caring activities, systems and institutions.Do: fundamental care must be explicitly actioned and evaluated in all caring activities, systems and institutions.Own: fundamental care must be owned by each individual who delivers care, works in a system that is responsible for care or works in an institution whose mission is to deliver care. RESEARCH: fundamental care must undergo systematic and high-quality investigations to generate the evidence needed to inform care practices and shape health systems and education curricula. CONCLUSION: For radical transformation within health systems globally, we must move beyond nursing and ensure all members of the healthcare team-educators, students, consumers, clinicians, leaders, researchers, policy-makers and politicians-value, talk, do, own and research fundamental care. It is only through coordinated, collaborative effort that we will, and must, achieve real change. Contains fulltext : 215530.pdf (Publisher’s version ) (Open Access)
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjopen-2019-033077&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu27 citations 27 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2022 CanadaFrontiers Media SA NIH | ARTFL LEFFTDS Longitudina..., CIHRNIH| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) ,CIHRAuthors: Spyros Papapetropoulos; Spyros Papapetropoulos; Angela Pontius; Elizabeth Finger; +16 AuthorsSpyros Papapetropoulos; Spyros Papapetropoulos; Angela Pontius; Elizabeth Finger; Virginija Karrenbauer; Virginija Karrenbauer; David S. Lynch; Matthew Brennan; Samantha Zappia; Wolfgang Koehler; Ludger Schoels; Ludger Schoels; Stefanie N. Hayer; Stefanie N. Hayer; Takuya Konno; Takeshi Ikeuchi; Troy Lund; Jennifer Orthmann-Murphy; Florian Eichler; Zbigniew K. Wszolek;A comprehensive review of published literature was conducted to elucidate the genetics, neuropathology, imaging findings, prevalence, clinical course, diagnosis/clinical evaluation, potential biomarkers, and current and proposed treatments for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare, debilitating, and life-threatening neurodegenerative disorder for which disease-modifying therapies are not currently available. Details on potential efficacy endpoints for future interventional clinical trials in patients with ALSP and data related to the burden of the disease on patients and caregivers were also reviewed. The information in this position paper lays a foundation to establish an effective clinical rationale and address the clinical gaps for creation of a robust strategy to develop therapeutic agents for ALSP, as well as design future clinical trials, that have clinically meaningful and convergent endpoints.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu22 citations 22 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 CanadaResearch Square Platform LLC Susan Hunter; Alison Divine; Humberto Omana; Edward Madou; Jeffrey Holmes;Abstract Background Balance and gait problems are common and progressive in dementia. Use of a mobility aid provides physical support and confidence. Yet, mobility aid use in people with dementia increases falls three-fold. An assessment tool of mobility aid safety in people with dementia does not currently exist. The objectives of this study were: 1) to develop a tool for the evaluation of physical function and safe use of a 4-wheeled walker in people with dementia, and 2) to evaluate its construct and criterion validity, inter-rater and test-retest reliability and minimal detectable change. Methods Healthcare professionals (HCP) experienced in rehabilitation of people with dementia participated in focus groups for item generation of the new tool, The Safe Use of Mobility Aid Checklist (SUMAC). The SUMAC evaluates physical function (PF) and safe use of the equipment (EQ) on nine tasks of daily life. Reliability was evaluated by HCP (n = 5) scored participant videos of people with dementia (n = 10) using a 4-wheeled walker performing the SUMAC. Inter-rater and test-retest reliability was assessed using intra-class correlation coefficients (ICC). Construct validity evaluated scores of the HCPs to a consensus HCP panel using Spearman’s rank-order correlations. Criterion validity evaluated SUMAC-PF to the Performance-Oriented Mobility Assessment (POMA) gait subscale using Spearman’s rank-order correlations. Results Three focus groups (n = 17) generated a tool comprised of nine tasks and the components within each task for physical function and safe use. Inter-rater reliability was statistically significant for SUMAC-PF (ICC = 0.92, 95%CI (0.81, 0.98), p < 0.001) and SUMAC-EQ. (ICC = 0.82, 95%CI (0.54, 0.95), p < 0.001). Test-retest reliability was statistically significant for SUMAC-PF (ICC = 0.89, 95%CI (0.81, 0.94), p < 0.001) and SUMAC-EQ. (ICC = 0.88, 95%CI (0.79, 0.93), p < 0.001). As hypothesized, the POMA gait subscale correlated strongly with the SUMAC-PF (rs = 0.84), but not EQ (rs = 0.39). Conclusions The focus groups and research team developed a tool of nine tasks with evaluation on physical function and safe use of a 4-wheeled walker for people with dementia. The SUMAC tool has demonstrated content validity for the whole scale and good construct and criterion validity for the SUMAC-PF and SUMAC-EQ. The subscores of the SUMAC demonstrated excellent to good inter-rater and test-retest reliability.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Average influence Average impulse Average Powered by BIP!visibility 2visibility views 2 download downloads 12 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.2.22127/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 CanadaElsevier BV Aras Kayvanrad; Stephen R. Arnott; Nathan W. Churchill; Stefanie Hassel; Aditi Chemparathy; Fan Dong; Mojdeh Zamyadi; Tom Gee; Robert Bartha; Sandra E. Black; Jane M. Lawrence-Dewar; Christopher J.M. Scott; Sean P. Symons; Andrew D. Davis; Geoffrey B. Hall; Jacqueline K. Harris; Nancy J. Lobaugh; Glenda MacQueen; Cindy Woo; Stephen C. Strother;pmid: 34029737
Quality assurance (QA) is crucial in longitudinal and/or multi-site studies, which involve the collection of data from a group of subjects over time and/or at different locations. It is important to regularly monitor the performance of the scanners over time and at different locations to detect and control for intrinsic differences (e.g., due to manufacturers) and changes in scanner performance (e.g., due to gradual component aging, software and/or hardware upgrades, etc.). As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners. QA parameters were calculated for each scan using the functional Biomarker Imaging Research Network's (fBIRN) QA phantom and pipeline to capture between- and within-scanner variability. We also describe a QA protocol to measure the full-width-at-half-maximum (FWHM) of slice-wise point spread functions (PSF), used in conjunction with the fBIRN QA parameters. Variations in image resolution measured by the FWHM are a primary source of variance over time for many sites, as well as between sites and between manufacturers. We also identify an unexpected range of instabilities affecting individual slices in a number of scanners, which may amount to a substantial contribution of unexplained signal variance to their data. Finally, we identify a preliminary preprocessing approach to reduce this variance and/or alleviate the slice anomalies, and in a small human data set show that this change in preprocessing can have a significant impact on seed-based connectivity measurements for some individual subjects. We expect that other fMRI centres will find this approach to identifying and controlling scanner instabilities useful in similar studies.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 Netherlands, BelgiumImpact Journals, LLC NIH | Genes, Hormones &Environm..., NIH | UCLA Clinical and Transla..., NIH | Mayo Clinic SPORE in Ovar... +45 projectsNIH| Genes, Hormones &Environment in an Ovarian Cancer Model ,NIH| UCLA Clinical and Translational Science Institute ,NIH| Mayo Clinic SPORE in Ovarian Cancer ,NIH| OVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERS ,NIH| USC CANCER CENTER EPIDEMIOLOGY &BIOSTATISTICS UNIT ,NIH| Regulatory T Cell Function in Ovarian Cancer ,NIH| Haplotype-Based Genome Screen for Ovarian Cancer Loci ,NIH| GENETIC EPIDEMIOLOGY OF OVARIAN CANCER ,NIH| HEREDITARY BREAST CANCER--GENETIC AND MOLECULAR STUDIES ,NIH| MOUSE GENETICS ,NIH| Epidemiology of Ovarian Cancer:New Hypotheses ,NIH| MHC-Restricted and MHC-Non-Restricted Targeting of Ovarian Cancer by alphaDC1 ,NIH| ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER ,NIH| Moffitt Cancer Center Support Grant ,NHMRC| Risk and prognostic factors for breast cancer of different immunohistochemical subtypes ,NHMRC| Towards cancer control: Population and molecular strategies ,NIH| SURVEILLANCE EPIDEMIOLOGY AND END RESULTS (SEER) ,NIH| PRE SURGICAL O6 BENZYLGUANINE TREATMENT OF PTS W/ MALIGNANT GLIOMA ,NIH| Inflammation and Ovarian Cancer ,NIH| The Progesterone Receptor Gene and Ovarian Cancer Risk ,NIH| Ovarian Cancer and Gonadotropin Signaling ,NIH| Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI) ,NIH| Steroid Hormone Genes and Ovarian Cancer Risk ,NIH| Obesity in ovarian cancer prognosis ,NIH| Phytoestrogens, alcohol, and endometrial cancer risk ,NIH| Core--Tissue Banking and Pathology ,NIH| USC COMPREHENSIVE CANCER CENTER (CORE) SUPPORT ,NIH| ROSWELL PARK MEMORIAL INSTITUTE CENTER CORE GRANT ,NIH| SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM ,NIH| COLLABORATIVE STUDY OF OVARIAN CANCER IN TWO RISK GROUPS ,NIH| Mitochondrial DNA and Ovarian Cancer Risk and Survival ,NIH| SURVEILLANCE EPIDEMIOLOGY AND END RESULTS ,NIH| RISK FACTORS AND PROGNOSTIC FACTORS FOR OVARIAN CANCER ,NIH| The Mitochondrial Genome and Ovarian Cancer Risk ,NIH| Premenopausal Hormone Levels and Risk of Breast Cancer ,NHMRC| Epidemiology of Chronic Disease, Health Interventions and DNA Studies ,NIH| CANCER CENTER SUPPORT GRANT ,NIH| Life Course Cancer Epidemiology Cohort in Women ,NIH| SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS PROGRAM ,NIH| CASE-CONTROL STUDY OF OVARIAN CANCER IN LOS ANGELES ,NHMRC| Molecular Epidemiology of Ovarian Cancer: The Australian Ovarian Cancer Study National Clinical Follow-Up Core ,NIH| Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology ,CIHR ,NIH| Genetic Epidemiology of Ovarian and Prostate Cancer ,NIH| MOFFITT CANCER CENTER SUPPORT GRANT ,NIH| Mayo Comprehensive Cancer Center Grant ,NIH| PREVENTION OF HEREDITARY BREAST AND OVARIAN CANCER ,NIH| NORTHERN CALIFORNIA COOPERATIVE FAMILY REGISTRYJennifer B. Permuth; Brett M. Reid; Madalene Earp; Y. Ann Chen; Alvaro N.A. Monteiro; Zhihua Chen; Georgia Chenevix-Trench; Peter A. Fasching; Matthias W. Beckmann; Diether Lambrechts; Adriaan Vanderstichele; Els Van Niewenhuyse; Ignace Vergote; Mary Anne Rossing; Jennifer A. Doherty; Jenny Chang-Claude; Kirsten B. Moysich; Kunle Odunsi; Marc T. Goodman; Yurii B. Shvetsov; Lynne R. Wilkens; Pamela J. Thompson; Thilo Dörk; Natalia Bogdanova; Ralf Bützow; Heli Nevanlinna; Liisa M. Pelttari; Arto Leminen; Francesmary Modugno; Robert P. Edwards; Roberta B. Ness; Joseph L. Kelley; Florian Heitz; Beth Y. Karlan; Jenny Lester; Susanne K. Kjaer; Allan Jensen; Graham G. Giles; Michelle A.T. Hildebrandt; Dong Liang; Karen H. Lu; Xifeng Wu; Douglas A. Levine; Maria Bisogna; Andrew Berchuck; Daniel W. Cramer; Kathryn L. Terry; Shelley S. Tworoger; Elizabeth M. Poole; Elisa V. Bandera; Brooke L. Fridley; Julie M. Cunningham; Stacey J. Winham; Sara H. Olson; Irene Orlow; Line Bjørge; Lambertus A. Kiemeney; Leon F.A.G. Massuger; Tanja Pejovic; Melissa Moffitt; Nhu D. Le; Linda S. Cook; Angela Brooks-Wilson; Linda E. Kelemen; Jacek Gronwald; Jan Lubinski; Nicolas Wentzensen; Louise A. Brinton; Jolanta Lissowska; Hanna Yang; Estrid Høgdall; Claus Høgdall; Lene Lundvall; Paul D.P. Pharoah; Honglin Song; Ian G. Campbell; Diana Eccles; Iain A. McNeish; Alice S. Whittemore; Valerie McGuire; Weiva Sieh; Joseph H. Rothstein; Catherine M. Phelan; Harvey A. Risch; Steven A. Narod; John McLaughlin; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A. Gayther; Susan J. Ramus; Aleksandra Gentry-Maharaj; Celeste Leigh Pearce; Anna H. Wu; Jolanta Kupryjanczyk; Agnieszka Dansonka-Mieszkowska; Joellen M. Schildkraut; Jin Q. Cheng; Ellen L. Goode; Thomas A. Sellers;pmc: PMC5340123
pmid: 27911851
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene expression. Using directly genotyped and imputed data from 10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI), with adjustment for European ancestry. We conducted gene-level analyses using the Admixture Maximum Likelihood (AML) test and the Sequence-Kernel Association test for common and rare variants (SKAT-CR). Association analysis revealed top risk-associated SNP rs77027562 (OR (95% CI)= 1.39 (1.17-1.64), P=1.0x10-4) in ADAR3 and rs185455523 in SND1 (OR (95% CI)= 0.68 (0.56-0.83), P=2.0x10-4). When restricting to serous histology (n=6,500), the magnitude of association strengthened for rs185455523 (OR=0.60, P=1.0x10-4). Gene-level analyses revealed that variation in ADAR was associated (P<0.05) with EOC susceptibility, with PAML=0.022 and PSKAT-CR=0.020. Expression quantitative trait locus analysis in EOC tissue revealed significant associations (P<0.05) with ADAR expression for several SNPs in ADAR, including rs1127313 (G/A), a SNP in the 3' untranslated region. In summary, germline variation involving RNA editing genes may influence EOC susceptibility, warranting further investigation of inherited and acquired alterations affecting RNA editing. Contains fulltext : 172820.pdf (Publisher’s version ) (Open Access)
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For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 1visibility views 1 download downloads 0 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Netherlands, CanadaSpringer Science and Business Media LLC Palma, David A.; Olson, Robert; Harrow, Stephen; Correa, Rohann J.M.; Schneiders, Famke; Haasbeek, Cornelis J.A.; Rodrigues, George B.; Lock, Michael; Yaremko, Brian P.; Bauman, Glenn S.; Ahmad, Belal; Schellenberg, Devin; Liu, Mitchell; Gaede, Stewart; Laba, Joanna; Mulroy, Liam; Senthi, Sashendra; Louie, Alexander V.; Swaminath, Anand; Chalmers, Anthony; Warner, Andrew; Slotman, Ben J.; de Gruijl, Tanja D.; Allan, Alison; Senan, Suresh;Background Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evaluated SABR in a group of patients with a small burden of oligometastatic disease (mostly with 1–3 metastatic lesions), and found that SABR was associated with benefits in progression-free survival and overall survival. The goal of this phase III trial is to assess the impact of SABR in patients with 4–10 metastatic cancer lesions. Methods One hundred and fifty-nine patients will be randomized in a 1:2 ratio between the control arm (consisting of standard of care palliative-intent treatments), and the SABR arm (consisting of standard of care treatment + SABR to all sites of known disease). Randomization will be stratified by two factors: histology (Group 1: prostate, breast, or renal; Group 2: all others), and type of pre-specified systemic therapy (Group 1: immunotherapy/targeted; Group 2: cytotoxic; Group 3: observation). SABR is to be completed within 2 weeks, allowing for rapid initiation of systemic therapy. Recommended SABR doses are 20 Gy in 1 fraction, 30 Gy in 3 fractions, or 35 Gy in 5 fractions, chosen to minimize risks of toxicity. The primary endpoint is overall survival, and secondary endpoints include progression-free survival, time to development of new metastatic lesions, quality of life, and toxicity. Translational endpoints include assessment of circulating tumor cells, cell-free DNA, and tumor tissue as prognostic and predictive markers, including assessment of immunological predictors of response and long-term survival. Discussion This study will provide an assessment of the impact of SABR on clinical outcomes and quality of life, to determine if long-term survival can be achieved for selected patients with 4–10 oligometastatic lesions. Trial registration Clinicaltrials.gov identifier: NCT03721341. Date of registration: October 26, 2018. Electronic supplementary material The online version of this article (10.1186/s12885-019-5977-6) contains supplementary material, which is available to authorized users.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu169 citations 169 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 0visibility views 0 download downloads 6 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Review 2020 CanadaInforma UK Limited Carrie Anne Marshall; Leonie Boland; Lee Ann Westover; Roxanne Isard; Sharon A. Gutman;Background: Although systematic and scoping reviews have identified a range of interventions for persons experiencing homelessness, no known reviews have captured the range and quality of intervention studies aimed at supporting a transition from homelessness. Objectives: To capture the range and quality of occupational therapy intervention studies aimed at supporting a transition to housing following homelessness. Method: Using Joanna Briggs Institute (JBI) guidelines, we conducted a systematic review including a critical appraisal and narrative synthesis of experimental studies. Results: Eleven studies were included. Critical appraisal scores ranged from 33.3 to 88.9 of a possible score of 100 (Mdn = 62.5; IQR = 33.4). The majority of studies evaluated interventions for the development of life skills (n = 9; 81.8%), and all were conducted in the USA. Several of the included studies were exploratory evaluation and feasibility studies, and all were quasi-experimental in design. Only three studies (27.2%) incorporated a control group. Intervention strategies included (1) integrated group and individual life skills interventions (n = 6); (2) group-based life skills interventions (n = 3); and (3) psychosocial and consultative interventions (n = 2). Conclusions: Research evaluating occupational therapy interventions aimed at supporting homeless individuals as they transition to housing is in an early stage of development. Significance: Implications for research and practice are discussed.
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For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2006 NetherlandsSpringer Science and Business Media LLC Rhydderch, S.M.; Edwards, A.; Marshall, M.; Elwyn, G.; Grol, R.P.T.M.;pmc: PMC1526440
pmid: 16784540
BACKGROUND: The relationship between effective organisation of general practices and health improvement is widely accepted. The Maturity Matrix is an instrument designed to assess organisational development in general practice settings and to stimulate quality improvement. It is undertaken by a practice team with the aid of a facilitator. There is a tradition in the primary care systems in many countries of using practice visitors to educate practice teams about how to improve. However the role of practice visitors as facilitators who enable teams to plan practice-led organisational development using quality improvement instruments is less well understood. The objectives of the study were to develop and explore a facilitation model to support practice teams in stimulating organisational development using a quality improvement instrument called the Maturity Matrix. A qualitative study based on transcript analysis was adopted. METHOD: A model of facilitation was constructed based on a review of relevant literature. Audio tapes of Maturity Matrix assessment sessions with general practices were transcribed and facilitator skills were compared to the model. The sample consisted of two facilitators working with twelve general practices based in UK primary care. RESULTS: The facilitation model suggested that four areas describing eighteen skills were important. The four areas are structuring the session, obtaining consensus, handling group dynamics and enabling team learning. Facilitators effectively employed skills associated with the first three areas, but less able to consistently stimulate team learning. CONCLUSION: This study suggests that facilitators need careful preparation for their role and practices need protected time in order to make best use of practice-led quality improvement instruments. The role of practice visitor as a facilitator is becoming important as the need to engender ownership of the quality improvement process by practices increases. Contains fulltext : 50032.pdf ( ) (Open Access)
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For further information contact us at helpdesk@openaire.eu24 citations 24 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 1 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 United Kingdom, Italy, Italy, Germany, Italy, Italy, Netherlands, Italy, Belgium, Italy, ItalyAmerican Medical Association (AMA) Bellani, Giacomo; Laffey, John G.; Pham, Tài; Fan, Eddy; Brochard, Laurent; Esteban, Andres; Gattinoni, Luciano; van Haren, Frank; Larsson, Anders; McAuley, Daniel F.; Ranieri, Marco; Rubenfeld, Gordon; Thompson, B. Taylor; Wrigge, Hermann; Slutsky, Arthur S.; Pesenti, Antonio; LUNG SAFE Investigators; ESICM Trials Group; Wittebole, Xavier; Berghe, Caroline; Bulpa, Pierre; Dive, Alain-Michel;pmid: 30023112
pmc: PMC6036017
handle: 2078.1/172166 , 2434/381160 , 2066/172480 , 2318/1588268 , 10807/88347 , 11573/859307 , 10807/88635
pmid: 30023112
pmc: PMC6036017
handle: 2078.1/172166 , 2434/381160 , 2066/172480 , 2318/1588268 , 10807/88347 , 11573/859307 , 10807/88635
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation management, and use of adjuncts-for example prone positioning-in routine clinical practice for patients fulfilling the ARDS Berlin Definition. DESIGN, SETTING, AND PARTICIPANTS: The Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients undergoing invasive or noninvasive ventilation, conducted during 4 consecutive weeks in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across 5 continents. EXPOSURES: Acute respiratory distress syndrome. MAIN OUTCOMES AND MEASURES: The primary outcome was ICU incidence of ARDS. Secondary outcomes included assessment of clinician recognition of ARDS, the application of ventilatory management, the use of adjunctive interventions in routine clinical practice, and clinical outcomes from ARDS. RESULTS: Of 29,144 patients admitted to participating ICUs, 3022 (10.4%) fulfilled ARDS criteria. Of these, 2377 patients developed ARDS in the first 48 hours and whose respiratory failure was managed with invasive mechanical ventilation. The period prevalence of mild ARDS was 30.0% (95% CI, 28.2%-31.9%); of moderate ARDS, 46.6% (95% CI, 44.5%-48.6%); and of severe ARDS, 23.4% (95% CI, 21.7%-25.2%). ARDS represented 0.42 cases per ICU bed over 4 weeks and represented 10.4% (95% CI, 10.0%-10.7%) of ICU admissions and 23.4% of patients requiring mechanical ventilation. Clinical recognition of ARDS ranged from 51.3% (95% CI, 47.5%-55.0%) in mild to 78.5% (95% CI, 74.8%-81.8%) in severe ARDS. Less than two-thirds of patients with ARDS received a tidal volume 8 of mL/kg or less of predicted body weight. Plateau pressure was measured in 40.1% (95% CI, 38.2-42.1), whereas 82.6% (95% CI, 81.0%-84.1%) received a positive end-expository pressure (PEEP) of less than 12 cm H2O. Prone positioning was used in 16.3% (95% CI, 13.7%-19.2%) of patients with severe ARDS. Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning. Hospital mortality was 34.9% (95% CI, 31.4%-38.5%) for those with mild, 40.3% (95% CI, 37.4%-43.3%) for those with moderate, and 46.1% (95% CI, 41.9%-50.4%) for those with severe ARDS. CONCLUSIONS AND RELEVANCE: Among ICUs in 50 countries, the period prevalence of ARDS was 10.4% of ICU admissions. This syndrome appeared to be underrecognized and undertreated and associated with a high mortality rate. These findings indicate the potential for improvement in the management of patients with ARDS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT02010073. Contains fulltext : 172480.pdf (Publisher’s version ) (Closed access)
Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu3K citations 3,278 popularity Top 0.01% influence Top 0.01% impulse Top 0.01% Powered by BIP!more_vert Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della ricerca- Università di Roma La SapienzaArticle . 2016Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2016 United Kingdom, Australia, United Kingdom, United Kingdom, United Kingdom, NetherlandsBMJ Trisha Greenhalgh; Ellen Annandale; Richard Ashcroft; James Barlow; Nick Black; Alan Bleakley; Ruth Boaden; Jeffrey Braithwaite; Nicky Britten; Franco A. Carnevale; Katherine Checkland; Julianne Cheek; Alexander M. Clark; Simon Cohn; Jack Coulehan; Benjamin F. Crabtree; Steven Cummins; Frank Davidoff; Huw Davies; Robert Dingwall; Mary Dixon-Woods; Glyn Elwyn; Eivind Engebretsen; Ewan Ferlie; Naomi Fulop; John Gabbay; Marie-Pierre Gagnon; Dariusz Galasiński; Ruth Garside; Lucy Gilson; Peter Griffiths; Penny Hawe; Jan-Kees Helderman; Brian Hodges; David J. Hunter; Margaret H. Kearney; Celia Kitzinger; Jenny Kitzinger; Ayelet Kuper; Saville Kushner; Andrée le May; Lorelei Lingard; Louise Locock; Jill Maben; Mary Ellen Macdonald; Frances S. Mair; Russell Mannion; Martin Marshall; Carl May; Nicholas Mays; Lorna McKee; Marissa Miraldo; David G. Morgan; Janice M. Morse; Sarah Nettleton; Sandy Oliver; Warrren Pearce; Pierre Pluye; Catherine Pope; Glenn Robert; Celia Roberts; Stefania Rodella; Jo Rycroft-Malone; Margarete Sandelowski; Paul G. Shekelle; Fiona Stevenson; Sharon E. Straus; Deborah Swinglehurst; Sally Thorne; Göran Tomson; Gerd Westert; Sue Wilkinson; Brian Williams; Terry Young; Sue Ziebland;doi: 10.1136/bmj.i563
pmid: 26980743
Seventy six senior academics from 11 countries invite The BMJ ’s editors to reconsider their policy of rejecting qualitative research on the grounds of low priority. They challenge the journal to develop a proactive, scholarly, and pluralist approach to research that aligns with its stated mission
NARCIS; Radboud Repo... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu287 citations 287 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 43visibility views 43 download downloads 1,033 Powered bymore_vert NARCIS; Radboud Repo... arrow_drop_down Oxford University Research ArchiveOther literature type . 2016Data sources: Oxford University Research ArchiveSpiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Denmark, Australia, Sweden, Netherlands, DenmarkBMJ Alison Kitson; Devin Carr; Tiffany Conroy; Rebecca Feo; Mette Grønkjær; Getty Huisman-de Waal; Debra Jackson; Lianne Jeffs; Jane Merkley; Åsa Muntlin Athlin; Jennifer Parr; David Richards; Erik Elgaard Sørensen; Yvonne Wengström;pmid: 31822543
pmc: PMC6924742
OBJECTIVE: The International Learning Collaborative (ILC) is an organisation dedicated to understanding why fundamental care, the care required by all patients regardless of clinical condition, fails to be provided in healthcare systems globally. At its 11th annual meeting in 2019, nursing leaders from 11 countries, together with patient representatives, confirmed that patients' fundamental care needs are still being ignored and nurses are still afraid to 'speak up' when these care failures occur. While the ILC's efforts over the past decade have led to increased recognition of the importance of fundamental care, it is not enough. To generate practical, sustainable solutions, we need to substantially rethink fundamental care and its contribution to patient outcomes and experiences, staff well-being, safety and quality, and the economic viability of healthcare systems. KEY ARGUMENTS: We present five propositions for radically transforming fundamental care delivery:Value: fundamental care must be foundational to all caring activities, systems and institutionsTalk: fundamental care must be explicitly articulated in all caring activities, systems and institutions.Do: fundamental care must be explicitly actioned and evaluated in all caring activities, systems and institutions.Own: fundamental care must be owned by each individual who delivers care, works in a system that is responsible for care or works in an institution whose mission is to deliver care. RESEARCH: fundamental care must undergo systematic and high-quality investigations to generate the evidence needed to inform care practices and shape health systems and education curricula. CONCLUSION: For radical transformation within health systems globally, we must move beyond nursing and ensure all members of the healthcare team-educators, students, consumers, clinicians, leaders, researchers, policy-makers and politicians-value, talk, do, own and research fundamental care. It is only through coordinated, collaborative effort that we will, and must, achieve real change. Contains fulltext : 215530.pdf (Publisher’s version ) (Open Access)
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjopen-2019-033077&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu27 citations 27 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjopen-2019-033077&type=result"></script>'); --> </script>
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