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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: LiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; +187 Authors

    This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivio Istituziona...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    https://doi.org/10.48550/arxiv...
    Article . 2022
    License: arXiv Non-Exclusive Distribution
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivio Istituziona...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      https://doi.org/10.48550/arxiv...
      Article . 2022
      License: arXiv Non-Exclusive Distribution
      Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Aaboud M.; Aad G.; Abbott B.; Abdinov O.; +1,011 Authors

    We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ CORE (RIOXX-UK Aggre...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    CORE (RIOXX-UK Aggregator)
    Article . 2018
    License: CC BY
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Repositório Comum
    Article . 2018
    Data sources: Repositório Comum
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    CERN Document Server
    Other literature type . 2018
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Apollo
    Other literature type . 2018
    License: CC BY
    Data sources: Apollo
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    Apollo
    Article . 2019
    License: CC BY
    Data sources: Datacite
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    DOAJ
    Article . 2018
    Data sources: DOAJ
    https://doi.org/10.48550/arxiv...
    Article . 2018
    License: CC BY
    Data sources: Datacite
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Savary, E.; Rojas, K.; Maus, M.; Clément, B.; +15 Authors

    We present a search for galaxy-scale strong gravitational lenses in the initial 2 500 square degrees of the Canada-France Imaging Survey (CFIS). We designed a convolutional neural network (CNN) committee that we applied to a selection of 2 344 002 exquisite-seeing $r$-band images of color-selected luminous red galaxies (LRGs). Our classification uses a realistic training set where the lensing galaxies and the lensed sources are both taken from real data, namely the CFIS $r$-band images themselves and the Hubble Space Telescope (HST). A total of 9 460 candidates obtain a score above 0.5 with the CNN committee. After a visual inspection of the candidates, we find a total of 133 lens candidates, of which 104 are completely new. The set of false positives mainly contains ring, spiral, and merger galaxies, and to a lesser extent galaxies with nearby companions. We classify 32 of the lens candidates as secure lenses and 101 as maybe lenses. For the 32 highest quality lenses, we also fit a singular isothermal ellipsoid mass profile with external shear along with an elliptical Sersic profile for the lens and source light. This automated modeling step provides distributions of properties for both sources and lenses that have Einstein radii in the range $0.5\arcsec<θ_E<2.5\arcsec$. Finally, we introduce a new lens and/or source single-band deblending algorithm based on auto-encoder representation of our candidates. This is the first time an end-to-end lens-finding and modeling pipeline is assembled together, in view of future lens searches in a single band, as will be possible with Euclid. 29 pages, 21 figures, accepted by A&A, in press

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    Astronomy and Astrophysics
    Article . 2022
    License: CC BY
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    https://doi.org/10.48550/arxiv...
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      Astronomy and Astrophysics
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      https://doi.org/10.48550/arxiv...
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    Authors: Spyros Papapetropoulos; Spyros Papapetropoulos; Angela Pontius; Elizabeth Finger; +16 Authors

    A comprehensive review of published literature was conducted to elucidate the genetics, neuropathology, imaging findings, prevalence, clinical course, diagnosis/clinical evaluation, potential biomarkers, and current and proposed treatments for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare, debilitating, and life-threatening neurodegenerative disorder for which disease-modifying therapies are not currently available. Details on potential efficacy endpoints for future interventional clinical trials in patients with ALSP and data related to the burden of the disease on patients and caregivers were also reviewed. The information in this position paper lays a foundation to establish an effective clinical rationale and address the clinical gaps for creation of a robust strategy to develop therapeutic agents for ALSP, as well as design future clinical trials, that have clinically meaningful and convergent endpoints.

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    Frontiers in Neurology
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    Frontiers in Neurology
    Article . 2022
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    Frontiers in Neurology
    Article . 2022
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    Scholarship@Western
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      Frontiers in Neurology
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      Frontiers in Neurology
      Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Frontiers in Neurology
      Article . 2022
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    Authors: Marini, P.; Bonasera, A.; Mcintosh, A.; Boisjoli, M.; +2 Authors

    The impact of the secondary de-excitation on isotopic distributions commonly used as observable to extract information on the symmetry energy is pointed out. A comparison of three methods differently affected by secondary decay shows a good agreement of the results up to A = 20, suggesting a lack of secondary decay effects in our data within our resolution. Data from the 4π detector INDRA and the VAMOS spectrometer could extend this work to higher A. The same data allow us to perform a primary fragment reconstruction, which opens up the possibility of planning a program on charged particle spectroscopy of exotic nuclei.

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    Journal of Physics : Conference Series
    Article . 2013
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      Journal of Physics : Conference Series
      Article . 2013
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    Authors: Susan Hunter; Alison Divine; Humberto Omana; Edward Madou; +1 Authors

    Abstract Background Balance and gait problems are common and progressive in dementia. Use of a mobility aid provides physical support and confidence. Yet, mobility aid use in people with dementia increases falls three-fold. An assessment tool of mobility aid safety in people with dementia does not currently exist. The objectives of this study were: 1) to develop a tool for the evaluation of physical function and safe use of a 4-wheeled walker in people with dementia, and 2) to evaluate its construct and criterion validity, inter-rater and test-retest reliability and minimal detectable change. Methods Healthcare professionals (HCP) experienced in rehabilitation of people with dementia participated in focus groups for item generation of the new tool, The Safe Use of Mobility Aid Checklist (SUMAC). The SUMAC evaluates physical function (PF) and safe use of the equipment (EQ) on nine tasks of daily life. Reliability was evaluated by HCP (n = 5) scored participant videos of people with dementia (n = 10) using a 4-wheeled walker performing the SUMAC. Inter-rater and test-retest reliability was assessed using intra-class correlation coefficients (ICC). Construct validity evaluated scores of the HCPs to a consensus HCP panel using Spearman’s rank-order correlations. Criterion validity evaluated SUMAC-PF to the Performance-Oriented Mobility Assessment (POMA) gait subscale using Spearman’s rank-order correlations. Results Three focus groups (n = 17) generated a tool comprised of nine tasks and the components within each task for physical function and safe use. Inter-rater reliability was statistically significant for SUMAC-PF (ICC = 0.92, 95%CI (0.81, 0.98), p < 0.001) and SUMAC-EQ. (ICC = 0.82, 95%CI (0.54, 0.95), p < 0.001). Test-retest reliability was statistically significant for SUMAC-PF (ICC = 0.89, 95%CI (0.81, 0.94), p < 0.001) and SUMAC-EQ. (ICC = 0.88, 95%CI (0.79, 0.93), p < 0.001). As hypothesized, the POMA gait subscale correlated strongly with the SUMAC-PF (rs = 0.84), but not EQ (rs = 0.39). Conclusions The focus groups and research team developed a tool of nine tasks with evaluation on physical function and safe use of a 4-wheeled walker for people with dementia. The SUMAC tool has demonstrated content validity for the whole scale and good construct and criterion validity for the SUMAC-PF and SUMAC-EQ. The subscores of the SUMAC demonstrated excellent to good inter-rater and test-retest reliability.

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    Europe PubMed Central
    Article . 2020
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    Scholarship@Western
    Article . 2020
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    https://doi.org/10.21203/rs.2....
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    https://doi.org/10.21203/rs.2....
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    https://doi.org/10.21203/rs.2....
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    BMC Geriatrics
    Article . 2020
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    Article . 2020
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    https://doi.org/10.21203/rs.2....
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      Europe PubMed Central
      Article . 2020
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      Scholarship@Western
      Article . 2020
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      https://doi.org/10.21203/rs.2....
      Preprint . 2020
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      https://doi.org/10.21203/rs.2....
      Preprint . 2020
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      https://doi.org/10.21203/rs.2....
      Preprint . 2020
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      BMC Geriatrics
      Article . 2020
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      BMC Geriatrics
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      BMC Geriatrics
      Article . 2020
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      https://doi.org/10.21203/rs.2....
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    Authors: Aras Kayvanrad; Stephen R. Arnott; Nathan W. Churchill; Stefanie Hassel; +16 Authors

    Quality assurance (QA) is crucial in longitudinal and/or multi-site studies, which involve the collection of data from a group of subjects over time and/or at different locations. It is important to regularly monitor the performance of the scanners over time and at different locations to detect and control for intrinsic differences (e.g., due to manufacturers) and changes in scanner performance (e.g., due to gradual component aging, software and/or hardware upgrades, etc.). As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners. QA parameters were calculated for each scan using the functional Biomarker Imaging Research Network's (fBIRN) QA phantom and pipeline to capture between- and within-scanner variability. We also describe a QA protocol to measure the full-width-at-half-maximum (FWHM) of slice-wise point spread functions (PSF), used in conjunction with the fBIRN QA parameters. Variations in image resolution measured by the FWHM are a primary source of variance over time for many sites, as well as between sites and between manufacturers. We also identify an unexpected range of instabilities affecting individual slices in a number of scanners, which may amount to a substantial contribution of unexplained signal variance to their data. Finally, we identify a preliminary preprocessing approach to reduce this variance and/or alleviate the slice anomalies, and in a small human data set show that this change in preprocessing can have a significant impact on seed-based connectivity measurements for some individual subjects. We expect that other fMRI centres will find this approach to identifying and controlling scanner instabilities useful in similar studies.

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    Scholarship@Western
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    Authors: Palma, David A.; Olson, Robert; Harrow, Stephen; Correa, Rohann J.M.; +21 Authors

    Background Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evaluated SABR in a group of patients with a small burden of oligometastatic disease (mostly with 1–3 metastatic lesions), and found that SABR was associated with benefits in progression-free survival and overall survival. The goal of this phase III trial is to assess the impact of SABR in patients with 4–10 metastatic cancer lesions. Methods One hundred and fifty-nine patients will be randomized in a 1:2 ratio between the control arm (consisting of standard of care palliative-intent treatments), and the SABR arm (consisting of standard of care treatment + SABR to all sites of known disease). Randomization will be stratified by two factors: histology (Group 1: prostate, breast, or renal; Group 2: all others), and type of pre-specified systemic therapy (Group 1: immunotherapy/targeted; Group 2: cytotoxic; Group 3: observation). SABR is to be completed within 2 weeks, allowing for rapid initiation of systemic therapy. Recommended SABR doses are 20 Gy in 1 fraction, 30 Gy in 3 fractions, or 35 Gy in 5 fractions, chosen to minimize risks of toxicity. The primary endpoint is overall survival, and secondary endpoints include progression-free survival, time to development of new metastatic lesions, quality of life, and toxicity. Translational endpoints include assessment of circulating tumor cells, cell-free DNA, and tumor tissue as prognostic and predictive markers, including assessment of immunological predictors of response and long-term survival. Discussion This study will provide an assessment of the impact of SABR on clinical outcomes and quality of life, to determine if long-term survival can be achieved for selected patients with 4–10 oligometastatic lesions. Trial registration Clinicaltrials.gov identifier: NCT03721341. Date of registration: October 26, 2018. Electronic supplementary material The online version of this article (10.1186/s12885-019-5977-6) contains supplementary material, which is available to authorized users.

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    Europe PubMed Central
    Article . 2019
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    BMC Cancer
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    Authors: Carrie Anne Marshall; Leonie Boland; Lee Ann Westover; Roxanne Isard; +1 Authors

    Background: Although systematic and scoping reviews have identified a range of interventions for persons experiencing homelessness, no known reviews have captured the range and quality of intervention studies aimed at supporting a transition from homelessness. Objectives: To capture the range and quality of occupational therapy intervention studies aimed at supporting a transition to housing following homelessness. Method: Using Joanna Briggs Institute (JBI) guidelines, we conducted a systematic review including a critical appraisal and narrative synthesis of experimental studies. Results: Eleven studies were included. Critical appraisal scores ranged from 33.3 to 88.9 of a possible score of 100 (Mdn = 62.5; IQR = 33.4). The majority of studies evaluated interventions for the development of life skills (n = 9; 81.8%), and all were conducted in the USA. Several of the included studies were exploratory evaluation and feasibility studies, and all were quasi-experimental in design. Only three studies (27.2%) incorporated a control group. Intervention strategies included (1) integrated group and individual life skills interventions (n = 6); (2) group-based life skills interventions (n = 3); and (3) psychosocial and consultative interventions (n = 2). Conclusions: Research evaluating occupational therapy interventions aimed at supporting homeless individuals as they transition to housing is in an early stage of development. Significance: Implications for research and practice are discussed.

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    Authors: R T Duffy; C H A Logan; B J Maughan; D Eckert; +10 Authors

    We use deep follow-up XMM-Newton observations of 6 clusters discovered in the XXL Survey at $z>1$ to gain robust measurements of their X-ray properties and to investigate the extent to which scaling relations at low redshift are valid at $z>1$. This sample is unique as it has been investigated for AGN contamination, which ensures measurements are not undermined by systematic uncertainties, and pushes to lower mass at higher redshift than is usually possible, for example with Sunyaev-Zel'dovich (SZ) selected clusters. We determine the flux contribution of point sources to the XXL cluster flux in order to test for the presence of AGN in other high-redshift cluster candidates, and find 3XLSS J231626.8-533822 to be a point source misclassified as a cluster and 3XLSS J232737.3-541618 to be a genuine cluster. We present the first attempt to measure the hydrostatic masses in a bright subsample of $z>1$ X-ray selected galaxy clusters with a known selection function. Periods of high particle background significantly reduced the effective exposure times of observations (losing >50% in some cases) limiting the power of this study. When combined with complementary SZ selected cluster samples at higher masses, the data appear broadly consistent with the self-similar evolution of the low redshift scaling relations between ICM properties and cluster mass, suggesting that properties such as the X-ray temperature, gas mass and SZ signal remain reliable mass proxies even at high redshift. Comment: 13 pages, 7 figures, published in MNRAS

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    Monthly Notices of the Royal Astronomical Society
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      Monthly Notices of the Royal Astronomical Society
      Article . 2022
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    Authors: LiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; +187 Authors

    This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed

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    https://doi.org/10.48550/arxiv...
    Article . 2022
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      https://doi.org/10.48550/arxiv...
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    Authors: Aaboud M.; Aad G.; Abbott B.; Abdinov O.; +1,011 Authors

    We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5

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    https://doi.org/10.48550/arxiv...
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    Authors: Savary, E.; Rojas, K.; Maus, M.; Clément, B.; +15 Authors

    We present a search for galaxy-scale strong gravitational lenses in the initial 2 500 square degrees of the Canada-France Imaging Survey (CFIS). We designed a convolutional neural network (CNN) committee that we applied to a selection of 2 344 002 exquisite-seeing $r$-band images of color-selected luminous red galaxies (LRGs). Our classification uses a realistic training set where the lensing galaxies and the lensed sources are both taken from real data, namely the CFIS $r$-band images themselves and the Hubble Space Telescope (HST). A total of 9 460 candidates obtain a score above 0.5 with the CNN committee. After a visual inspection of the candidates, we find a total of 133 lens candidates, of which 104 are completely new. The set of false positives mainly contains ring, spiral, and merger galaxies, and to a lesser extent galaxies with nearby companions. We classify 32 of the lens candidates as secure lenses and 101 as maybe lenses. For the 32 highest quality lenses, we also fit a singular isothermal ellipsoid mass profile with external shear along with an elliptical Sersic profile for the lens and source light. This automated modeling step provides distributions of properties for both sources and lenses that have Einstein radii in the range $0.5\arcsec<θ_E<2.5\arcsec$. Finally, we introduce a new lens and/or source single-band deblending algorithm based on auto-encoder representation of our candidates. This is the first time an end-to-end lens-finding and modeling pipeline is assembled together, in view of future lens searches in a single band, as will be possible with Euclid. 29 pages, 21 figures, accepted by A&A, in press

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    Astronomy and Astrophysics
    Article . 2022
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    https://doi.org/10.48550/arxiv...
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      Astronomy and Astrophysics
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      https://doi.org/10.48550/arxiv...
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    Authors: Spyros Papapetropoulos; Spyros Papapetropoulos; Angela Pontius; Elizabeth Finger; +16 Authors

    A comprehensive review of published literature was conducted to elucidate the genetics, neuropathology, imaging findings, prevalence, clinical course, diagnosis/clinical evaluation, potential biomarkers, and current and proposed treatments for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare, debilitating, and life-threatening neurodegenerative disorder for which disease-modifying therapies are not currently available. Details on potential efficacy endpoints for future interventional clinical trials in patients with ALSP and data related to the burden of the disease on patients and caregivers were also reviewed. The information in this position paper lays a foundation to establish an effective clinical rationale and address the clinical gaps for creation of a robust strategy to develop therapeutic agents for ALSP, as well as design future clinical trials, that have clinically meaningful and convergent endpoints.

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    Frontiers in Neurology
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    Frontiers in Neurology
    Article . 2022
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    Frontiers in Neurology
    Article . 2022
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      Frontiers in Neurology
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      Frontiers in Neurology
      Article . 2022
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      Frontiers in Neurology
      Article . 2022
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    Authors: Marini, P.; Bonasera, A.; Mcintosh, A.; Boisjoli, M.; +2 Authors

    The impact of the secondary de-excitation on isotopic distributions commonly used as observable to extract information on the symmetry energy is pointed out. A comparison of three methods differently affected by secondary decay shows a good agreement of the results up to A = 20, suggesting a lack of secondary decay effects in our data within our resolution. Data from the 4π detector INDRA and the VAMOS spectrometer could extend this work to higher A. The same data allow us to perform a primary fragment reconstruction, which opens up the possibility of planning a program on charged particle spectroscopy of exotic nuclei.

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    Journal of Physics : Conference Series
    Article . 2013
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      Journal of Physics : Conference Series
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    Authors: Susan Hunter; Alison Divine; Humberto Omana; Edward Madou; +1 Authors

    Abstract Background Balance and gait problems are common and progressive in dementia. Use of a mobility aid provides physical support and confidence. Yet, mobility aid use in people with dementia increases falls three-fold. An assessment tool of mobility aid safety in people with dementia does not currently exist. The objectives of this study were: 1) to develop a tool for the evaluation of physical function and safe use of a 4-wheeled walker in people with dementia, and 2) to evaluate its construct and criterion validity, inter-rater and test-retest reliability and minimal detectable change. Methods Healthcare professionals (HCP) experienced in rehabilitation of people with dementia participated in focus groups for item generation of the new tool, The Safe Use of Mobility Aid Checklist (SUMAC). The SUMAC evaluates physical function (PF) and safe use of the equipment (EQ) on nine tasks of daily life. Reliability was evaluated by HCP (n = 5) scored participant videos of people with dementia (n = 10) using a 4-wheeled walker performing the SUMAC. Inter-rater and test-retest reliability was assessed using intra-class correlation coefficients (ICC). Construct validity evaluated scores of the HCPs to a consensus HCP panel using Spearman’s rank-order correlations. Criterion validity evaluated SUMAC-PF to the Performance-Oriented Mobility Assessment (POMA) gait subscale using Spearman’s rank-order correlations. Results Three focus groups (n = 17) generated a tool comprised of nine tasks and the components within each task for physical function and safe use. Inter-rater reliability was statistically significant for SUMAC-PF (ICC = 0.92, 95%CI (0.81, 0.98), p < 0.001) and SUMAC-EQ. (ICC = 0.82, 95%CI (0.54, 0.95), p < 0.001). Test-retest reliability was statistically significant for SUMAC-PF (ICC = 0.89, 95%CI (0.81, 0.94), p < 0.001) and SUMAC-EQ. (ICC = 0.88, 95%CI (0.79, 0.93), p < 0.001). As hypothesized, the POMA gait subscale correlated strongly with the SUMAC-PF (rs = 0.84), but not EQ (rs = 0.39). Conclusions The focus groups and research team developed a tool of nine tasks with evaluation on physical function and safe use of a 4-wheeled walker for people with dementia. The SUMAC tool has demonstrated content validity for the whole scale and good construct and criterion validity for the SUMAC-PF and SUMAC-EQ. The subscores of the SUMAC demonstrated excellent to good inter-rater and test-retest reliability.

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    Europe PubMed Central
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    Scholarship@Western
    Article . 2020
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    https://doi.org/10.21203/rs.2....
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    https://doi.org/10.21203/rs.2....
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    https://doi.org/10.21203/rs.2....
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    BMC Geriatrics
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      Scholarship@Western
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      https://doi.org/10.21203/rs.2....
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      https://doi.org/10.21203/rs.2....
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      https://doi.org/10.21203/rs.2....
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      BMC Geriatrics
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      https://doi.org/10.21203/rs.2....
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    Authors: Aras Kayvanrad; Stephen R. Arnott; Nathan W. Churchill; Stefanie Hassel; +16 Authors

    Quality assurance (QA) is crucial in longitudinal and/or multi-site studies, which involve the collection of data from a group of subjects over time and/or at different locations. It is important to regularly monitor the performance of the scanners over time and at different locations to detect and control for intrinsic differences (e.g., due to manufacturers) and changes in scanner performance (e.g., due to gradual component aging, software and/or hardware upgrades, etc.). As part of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND), QA phantom scans were conducted approximately monthly for three to four years at 13 sites across Canada with 3T research MRI scanners. QA parameters were calculated for each scan using the functional Biomarker Imaging Research Network's (fBIRN) QA phantom and pipeline to capture between- and within-scanner variability. We also describe a QA protocol to measure the full-width-at-half-maximum (FWHM) of slice-wise point spread functions (PSF), used in conjunction with the fBIRN QA parameters. Variations in image resolution measured by the FWHM are a primary source of variance over time for many sites, as well as between sites and between manufacturers. We also identify an unexpected range of instabilities affecting individual slices in a number of scanners, which may amount to a substantial contribution of unexplained signal variance to their data. Finally, we identify a preliminary preprocessing approach to reduce this variance and/or alleviate the slice anomalies, and in a small human data set show that this change in preprocessing can have a significant impact on seed-based connectivity measurements for some individual subjects. We expect that other fMRI centres will find this approach to identifying and controlling scanner instabilities useful in similar studies.

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    Scholarship@Western
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    Authors: Palma, David A.; Olson, Robert; Harrow, Stephen; Correa, Rohann J.M.; +21 Authors

    Background Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control for primary tumors or metastases. A recent randomized phase II trial evaluated SABR in a group of patients with a small burden of oligometastatic disease (mostly with 1–3 metastatic lesions), and found that SABR was associated with benefits in progression-free survival and overall survival. The goal of this phase III trial is to assess the impact of SABR in patients with 4–10 metastatic cancer lesions. Methods One hundred and fifty-nine patients will be randomized in a 1:2 ratio between the control arm (consisting of standard of care palliative-intent treatments), and the SABR arm (consisting of standard of care treatment + SABR to all sites of known disease). Randomization will be stratified by two factors: histology (Group 1: prostate, breast, or renal; Group 2: all others), and type of pre-specified systemic therapy (Group 1: immunotherapy/targeted; Group 2: cytotoxic; Group 3: observation). SABR is to be completed within 2 weeks, allowing for rapid initiation of systemic therapy. Recommended SABR doses are 20 Gy in 1 fraction, 30 Gy in 3 fractions, or 35 Gy in 5 fractions, chosen to minimize risks of toxicity. The primary endpoint is overall survival, and secondary endpoints include progression-free survival, time to development of new metastatic lesions, quality of life, and toxicity. Translational endpoints include assessment of circulating tumor cells, cell-free DNA, and tumor tissue as prognostic and predictive markers, including assessment of immunological predictors of response and long-term survival. Discussion This study will provide an assessment of the impact of SABR on clinical outcomes and quality of life, to determine if long-term survival can be achieved for selected patients with 4–10 oligometastatic lesions. Trial registration Clinicaltrials.gov identifier: NCT03721341. Date of registration: October 26, 2018. Electronic supplementary material The online version of this article (10.1186/s12885-019-5977-6) contains supplementary material, which is available to authorized users.

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    Europe PubMed Central
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    BMC Cancer
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    Authors: Carrie Anne Marshall; Leonie Boland; Lee Ann Westover; Roxanne Isard; +1 Authors

    Background: Although systematic and scoping reviews have identified a range of interventions for persons experiencing homelessness, no known reviews have captured the range and quality of intervention studies aimed at supporting a transition from homelessness. Objectives: To capture the range and quality of occupational therapy intervention studies aimed at supporting a transition to housing following homelessness. Method: Using Joanna Briggs Institute (JBI) guidelines, we conducted a systematic review including a critical appraisal and narrative synthesis of experimental studies. Results: Eleven studies were included. Critical appraisal scores ranged from 33.3 to 88.9 of a possible score of 100 (Mdn = 62.5; IQR = 33.4). The majority of studies evaluated interventions for the development of life skills (n = 9; 81.8%), and all were conducted in the USA. Several of the included studies were exploratory evaluation and feasibility studies, and all were quasi-experimental in design. Only three studies (27.2%) incorporated a control group. Intervention strategies included (1) integrated group and individual life skills interventions (n = 6); (2) group-based life skills interventions (n = 3); and (3) psychosocial and consultative interventions (n = 2). Conclusions: Research evaluating occupational therapy interventions aimed at supporting homeless individuals as they transition to housing is in an early stage of development. Significance: Implications for research and practice are discussed.

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    Authors: R T Duffy; C H A Logan; B J Maughan; D Eckert; +10 Authors

    We use deep follow-up XMM-Newton observations of 6 clusters discovered in the XXL Survey at $z>1$ to gain robust measurements of their X-ray properties and to investigate the extent to which scaling relations at low redshift are valid at $z>1$. This sample is unique as it has been investigated for AGN contamination, which ensures measurements are not undermined by systematic uncertainties, and pushes to lower mass at higher redshift than is usually possible, for example with Sunyaev-Zel'dovich (SZ) selected clusters. We determine the flux contribution of point sources to the XXL cluster flux in order to test for the presence of AGN in other high-redshift cluster candidates, and find 3XLSS J231626.8-533822 to be a point source misclassified as a cluster and 3XLSS J232737.3-541618 to be a genuine cluster. We present the first attempt to measure the hydrostatic masses in a bright subsample of $z>1$ X-ray selected galaxy clusters with a known selection function. Periods of high particle background significantly reduced the effective exposure times of observations (losing >50% in some cases) limiting the power of this study. When combined with complementary SZ selected cluster samples at higher masses, the data appear broadly consistent with the self-similar evolution of the low redshift scaling relations between ICM properties and cluster mass, suggesting that properties such as the X-ray temperature, gas mass and SZ signal remain reliable mass proxies even at high redshift. Comment: 13 pages, 7 figures, published in MNRAS

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    Monthly Notices of the Royal Astronomical Society
    Article . 2022
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      Monthly Notices of the Royal Astronomical Society
      Article . 2022
      License: OUP Standard Publication Reuse
      Data sources: Crossref
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      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.