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  • Open Access
    Authors: 
    Jimmy A. Irwin; W. Peter Maksym; Gregory R. Sivakoff; Aaron J. Romanowsky; Dacheng Lin; Tyler Speegle; Ian Prado; David T. Mildebrath; Jay Strader; Jifeng Liu; +1 more
    Publisher: Springer Science and Business Media LLC
    Project: NSERC , NSF | Collaborative Research: R... (1515084), NSF | Collaborative Research: R... (1514763), NSF | Black Holes in Globular C... (1308124)

    An X-ray flaring source was found near the galaxy NGC 4697. Two flares were seen, separated by four years. The flux increased by a factor of 90 on a timescale of about one minute. Both flares were very brief. There is no optical counterpart at the position of the flares, but if the source was at the distance of NGC 4697, the luminosities were 10^39 erg/s. Here we report the results of a search of archival X-ray data for 70 nearby galaxies looking for similar such flares. We found two flaring sources in globular clusters or ultra-compact dwarf companions of parent elliptical galaxies. One source flared once to a peak luminosity of 9 x 10^40 erg/s, while the other flared five times to 10^40 erg/s. All of the flare rise times were <1 minute, and they then decayed over about an hour. When not flaring, the sources appear to be normal accreting neutron star or black hole X-ray binaries, but they are located in old stellar populations, unlike the magnetars, anomalous X-ray pulsars or soft gamma repeaters that have repetitive flares of similar luminosities. Published in the Oct 20 2016 issue of Nature

  • Publication . Article . Other literature type . 2013
    Open Access
    Authors: 
    Maimoona A. Zariwala; Heon Yung Gee; Małgorzata Kurkowiak; Dalal A. Al-Mutairi; Margaret W. Leigh; Toby W. Hurd; Rim Hjeij; Sharon D. Dell; Moumita Chaki; Gerard W. Dougherty; +48 more
    Publisher: Elsevier BV
    Countries: France, Croatia, Germany
    Project: NIH | Novel genetics, pathobiol... (5R01DK068306-17), NIH | Identifying all Meckel-li... (1RC4DK090917-01), NIH | Genetic Disorder of Mucoc... (5U54HL096458-14), NIH | Pathogenesis of PCD Lung ... (5R01HL071798-04), WT , NIH | Colorado Clinical and Tra... (3UL1TR000154-05S1)

    Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function. © 2013 The American Society of Human Genetics.

  • Open Access English
    Authors: 
    Leclère, Brice; Buckeridge, David L.; Boëlle, Pierre-Yves; Astagneau, Pascal; Lepelletier, Didier;
    Publisher: HAL CCSD
    Country: France

    International audience; ObjectivesSeveral automated algorithms for epidemiological surveillance in hospitals have been proposed. However, the usefulness of these methods to detect nosocomial outbreaks remains unclear. The goal of this review was to describe outbreak detection algorithms that have been tested within hospitals, consider how they were evaluated, and synthesize their results.MethodsWe developed a search query using keywords associated with hospital outbreak detection and searched the MEDLINE database. To ensure the highest sensitivity, no limitations were initially imposed on publication languages and dates, although we subsequently excluded studies published before 2000. Every study that described a method to detect outbreaks within hospitals was included, without any exclusion based on study design. Additional studies were identified through citations in retrieved studies.ResultsTwenty-nine studies were included. The detection algorithms were grouped into 5 categories: simple thresholds (n = 6), statistical process control (n = 12), scan statistics (n = 6), traditional statistical models (n = 6), and data mining methods (n = 4). The evaluation of the algorithms was often solely descriptive (n = 15), but more complex epidemiological criteria were also investigated (n = 10). The performance measures varied widely between studies: e.g., the sensitivity of an algorithm in a real world setting could vary between 17 and 100%.ConclusionEven if outbreak detection algorithms are useful complementary tools for traditional surveillance, the heterogeneity in results among published studies does not support quantitative synthesis of their performance. A standardized framework should be followed when evaluating outbreak detection methods to allow comparison of algorithms across studies and synthesis of results.

  • Open Access
    Authors: 
    Montserrat Garcia-Closas; Fergus J. Couch; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Nick Orr; Suhn K. Rhie; Elio Riboli; Heather Spencer Feigelson; Loic Le Marchand; +207 more
    Publisher: Springer Nature
    Countries: Netherlands, Ireland, United Kingdom, United Kingdom
    Project: CIHR , NIH | Characterizing Genetic Su... (5U01CA098233-06), NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Breast &Prostate Cancer &... (1U01CA098758-01), WT , EC | COGS (223175), NIH | Characterizing Genetic Su... (5U01CA098710-06), NIH | Genetic epidemiology of c... (3R01CA122340-03S1)

    Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P&gt; 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

  • Closed Access English
    Authors: 
    Axel S. Merseburger; Daniel Castellano; Thomas Powles; Yohann Loriot; Margitta Retz; Jens Voortman; Robert Huddart; Craig Gedye; Michiel S. van der Heijden; Howard Gurney; +5 more
    Country: Netherlands

    PURPOSE: Atezolizumab is an established treatment option for pretreated urothelial carcinoma, demonstrating efficacy in phase II/III trials. The SAUL study enrolled a broader patient population to determine safety and efficacy in underrepresented subgroups. MATERIALS AND METHODS: Patients with metastatic urinary tract carcinoma received atezolizumab 1,200 mg every 3 weeks until disease progression, unacceptable toxicity, loss of clinical benefit, or patient/physician decision. The primary endpoint was safety. Efficacy was a secondary endpoint. Analyses by programmed cell death ligand-1 (PD-L1) status, age, Eastern Cooperative Oncology Group performance status (ECOG PS) and renal impairment were prespecified; post hoc analyses explored outcomes by tumor location. RESULTS: A total of 1,004 patients were enrolled. Subgroup analyses in patients with older age, renal impairment, or upper tract urothelial carcinoma showed safety and efficacy similar to those in patients without these characteristics. Patients with ECOG PS 2 had clinical features typically associated with aggressive disease; median overall survival was 2.3 months versus 10.0 months in patients with ECOG PS0/1. Patients with PD-L1 expression on ≥5% of tumor-infiltrating immune cells tended to have better outcomes than those with <5% PD-L1 expression, although conclusions on the relative efficacy of atezolizumab cannot be drawn from this single-arm study. CONCLUSIONS: The understudied populations included in the SAUL study had similar outcomes to those in more selected populations included in phase II/III trials of atezolizumab, except for those with ECOG PS 2. Age ≥80 years and/or creatinine clearance <30 ml/minute does not preclude administration of atezolizumab; however, treatment risk versus benefit must be carefully assessed in patients with ECOG PS 2.

  • Open Access
    Authors: 
    Marie-Eve Naud; Étienne Artigau; Lison Malo; Loïc Albert; René Doyon; David Lafrenière; Jonathan Gagné; Didier Saumon; Caroline V. Morley; France Allard; +4 more
    Publisher: American Astronomical Society
    Country: United States
    Project: EC | PEPS (247060), NSERC

    We present the discovery of a co-moving planetary-mass companion ~42" (~2000 AU) from a young M3 star, GU Psc, likely member of the young AB Doradus Moving Group (ABDMG). The companion was first identified via its distinctively red i - z color (> 3.5) through a survey made with Gemini-S/GMOS. Follow-up Canada-France-Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate a spectral type of T3.5+-1 and reveal signs of low gravity which we attribute to youth. Keck/Adaptive Optics NIR observations did not resolve the companion as a binary. A comparison with atmosphere models indicates Teff = 1000-1100 K and logg = 4.5-5.0. Based on evolution models, this temperature corresponds to a mass of 9-13 MJup for the age of ABDMG (70-130 Myr). The relatively well-constrained age of this companion and its very large angular separation to its host star will allow its thorough characterization and will make it a valuable comparison for planetary-mass companions that will be uncovered by forthcoming planet-finder instruments such as Gemini Planet Imager and SPHERE. 18 p., 10 fig., published in ApJ. May 20th, 2014: Small corrections compared to the journal version: 1) addition of the an important reference to 1RSX 1609-2105b from Lafreni\`ere et al. 2008, 2010, 2) update of the url for Andrew Mann metallicity calibration, 3) correction of a few factual mistakes in section 2.2.4), 4) aesthetic reformatting of urls

  • Open Access
    Authors: 
    T. Aaltonen; Ronen Alon; S. Amerio; A. Anastassov; Alberto Annovi; Giorgio Apollinari; J. A. Appel; J. Asaadi; W. Ashmanskas; A. Aurisano; +207 more
    Publisher: arXiv
    Countries: Spain, Italy
    Project: EC | TAUKITFORNEWPHYSICS (302103), SNSF | Measurements of Higgs bos... (153664), NSERC

    This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the Korean World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, United Kingdom; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R&D Agency; the Academy of Finland; the Australian Research Council (ARC); and the EU community Marie Curie Fellowship Contract No. 302103. This work was also supported by the Shrum Foundation, the Weizman Institute of Science and the Israel Science Foundation. Results of a study of the substructure of the highest transverse momentum (pT) jets observed by the CDF Collaboration are presented. Events containing at least one jet with pT>400 GeV/c in a sample corresponding to an integrated luminosity of 5.95 fb−1, collected in 1.96 TeV proton-antiproton collisions at the Fermilab Tevatron collider, are selected. A study of the jet mass, angularity, and planar-flow distributions is presented, and the measurements are compared with predictions of perturbative quantum chromodynamics. A search for boosted top-quark production is also described, leading to a 95% confidence level upper limit of 38 fb on the production cross section of top quarks with pT>400 GeV/c. Peer Reviewed et al.

  • Open Access
    Authors: 
    Elaine Ruth Martyn;
    Publisher: University of New Brunswick Libraries - UNB
    Country: Canada
  • Open Access English
    Authors: 
    G. Maxin; D.R. Ouellet; Hélène Lapierre;
    Publisher: HAL CCSD
    Country: France

    International audience; Different protein sources, such as canola meal (CM) or dried distillers grains (DDG), are currently used in dairy rations to replace soybean meal (SBM). However, little data exists comparing their rumen degradation in a single study. Therefore, the objective of this study was to compare the ruminal degradation of dry matter (DM), crude protein (CP), and AA of SBM, CM, high-protein corn DDG (HPDDG), and wheat DDG plus solubles (WDDGS). In situ studies were conducted with 4 rumen-fistulated lactating Holstein cows fed a diet containing 38% grass hay and 62% corn-based concentrate. Each protein source was incubated in the rumen of each cow in nylon bags for 0, 2, 4, 8, 16, 24, and 48 h to determine DM and CP rumen degradation kinetics, whereas additional bags were also incubated for 16 h to evaluate AA ruminal disappearance. Rumen DM and CP degradability was calculated from rumenundegraded residues corrected or not for small particle loss. Data were fitted to an exponential model to estimate degradation parameters and effective degradability (ED) was calculated with a passage rate of 0.074 h(-1). The WDDGS and SBM had higher uncorrected ED (DM =- 75.0 and 72.6%; CP = 84.8 and 66.0%, respectively) than CM and HPDDG (DM = 57.2 and 55.5%; CP = 59.3 and 48.2%, respectively), due to higher soluble fraction in WDDGS and a combination of higher potentially degradable fraction and rate of degradation in SBM. Correction for small particle loss from bags, higher for WDDGS than for the other protein sources, decreased estimated ED but did not alter feed ranking. The ruminal disappearance of AA after 16 h of incubation reflected the overall pattern of CP degradation between protein supplements, but the ruminal disappearance of individual AA differed between protein supplements. Overall, these results indicate that, in the current study, (1) SBM and WDDGS were more degradable in the rumen than CM and HPDDG, and (2) that small particle loss correction is relevant but does not alter this ranking.

  • Open Access English
    Authors: 
    Salumbides, E. J.; Bailly, D.; Vervloet, M.; Ubachs, W.;

    Accurate absolute level energies of the $B\,^1\Sigma^{+}_{u}$, $v=0-8, N$ and $EF\,^{1}\Sigma^{+}_{g}$, $v=0-21, N$ rovibrational quantum states of molecular deuterium are derived by combining results from a Doppler-free two-photon laser excitation study on several lines in the $EF\,{}^{1}\Sigma_{g}^{+}-X\,{}^{1}\Sigma_{g}^{+}$ (0,0) band, with results from a Fourier-transform spectroscopic emission study on a low-pressure hydrogen discharge. Level energy uncertainties as low as 0.0005 cm$^{-1}$ are obtained for some low-lying $E\,^{1}\Sigma^{+}_{g}$ inner-well rovibrational levels, while uncertainties for higher-lying rovibrational levels and those of the $F\,^{1}\Sigma^{+}_{g}$ outer-well states are nominally 0.005 cm$^{-1}$. Level energies of $B\,^1\Sigma^{+}_{u}$ rovibrational levels, for $v \leq 8$ and $N \leq 10$ are determined at an accuracy of 0.001 cm$^{-1}$. Computed wavelengths of D$_2$ Lyman transitions in the $B\,^1\Sigma^{+}_{u}-X\,^{1}\Sigma^{+}_{g}$ ($v,0$) bands are also tabulated for future applications. Comment: appears in Journal of Molecular Spectroscopy (2014)

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Include:
The following results are related to Canada. Are you interested to view more results? Visit OpenAIRE - Explore.
162,636 Research products, page 1 of 16,264
  • Open Access
    Authors: 
    Jimmy A. Irwin; W. Peter Maksym; Gregory R. Sivakoff; Aaron J. Romanowsky; Dacheng Lin; Tyler Speegle; Ian Prado; David T. Mildebrath; Jay Strader; Jifeng Liu; +1 more
    Publisher: Springer Science and Business Media LLC
    Project: NSERC , NSF | Collaborative Research: R... (1515084), NSF | Collaborative Research: R... (1514763), NSF | Black Holes in Globular C... (1308124)

    An X-ray flaring source was found near the galaxy NGC 4697. Two flares were seen, separated by four years. The flux increased by a factor of 90 on a timescale of about one minute. Both flares were very brief. There is no optical counterpart at the position of the flares, but if the source was at the distance of NGC 4697, the luminosities were 10^39 erg/s. Here we report the results of a search of archival X-ray data for 70 nearby galaxies looking for similar such flares. We found two flaring sources in globular clusters or ultra-compact dwarf companions of parent elliptical galaxies. One source flared once to a peak luminosity of 9 x 10^40 erg/s, while the other flared five times to 10^40 erg/s. All of the flare rise times were <1 minute, and they then decayed over about an hour. When not flaring, the sources appear to be normal accreting neutron star or black hole X-ray binaries, but they are located in old stellar populations, unlike the magnetars, anomalous X-ray pulsars or soft gamma repeaters that have repetitive flares of similar luminosities. Published in the Oct 20 2016 issue of Nature

  • Publication . Article . Other literature type . 2013
    Open Access
    Authors: 
    Maimoona A. Zariwala; Heon Yung Gee; Małgorzata Kurkowiak; Dalal A. Al-Mutairi; Margaret W. Leigh; Toby W. Hurd; Rim Hjeij; Sharon D. Dell; Moumita Chaki; Gerard W. Dougherty; +48 more
    Publisher: Elsevier BV
    Countries: France, Croatia, Germany
    Project: NIH | Novel genetics, pathobiol... (5R01DK068306-17), NIH | Identifying all Meckel-li... (1RC4DK090917-01), NIH | Genetic Disorder of Mucoc... (5U54HL096458-14), NIH | Pathogenesis of PCD Lung ... (5R01HL071798-04), WT , NIH | Colorado Clinical and Tra... (3UL1TR000154-05S1)

    Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function. © 2013 The American Society of Human Genetics.

  • Open Access English
    Authors: 
    Leclère, Brice; Buckeridge, David L.; Boëlle, Pierre-Yves; Astagneau, Pascal; Lepelletier, Didier;
    Publisher: HAL CCSD
    Country: France

    International audience; ObjectivesSeveral automated algorithms for epidemiological surveillance in hospitals have been proposed. However, the usefulness of these methods to detect nosocomial outbreaks remains unclear. The goal of this review was to describe outbreak detection algorithms that have been tested within hospitals, consider how they were evaluated, and synthesize their results.MethodsWe developed a search query using keywords associated with hospital outbreak detection and searched the MEDLINE database. To ensure the highest sensitivity, no limitations were initially imposed on publication languages and dates, although we subsequently excluded studies published before 2000. Every study that described a method to detect outbreaks within hospitals was included, without any exclusion based on study design. Additional studies were identified through citations in retrieved studies.ResultsTwenty-nine studies were included. The detection algorithms were grouped into 5 categories: simple thresholds (n = 6), statistical process control (n = 12), scan statistics (n = 6), traditional statistical models (n = 6), and data mining methods (n = 4). The evaluation of the algorithms was often solely descriptive (n = 15), but more complex epidemiological criteria were also investigated (n = 10). The performance measures varied widely between studies: e.g., the sensitivity of an algorithm in a real world setting could vary between 17 and 100%.ConclusionEven if outbreak detection algorithms are useful complementary tools for traditional surveillance, the heterogeneity in results among published studies does not support quantitative synthesis of their performance. A standardized framework should be followed when evaluating outbreak detection methods to allow comparison of algorithms across studies and synthesis of results.

  • Open Access
    Authors: 
    Montserrat Garcia-Closas; Fergus J. Couch; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Nick Orr; Suhn K. Rhie; Elio Riboli; Heather Spencer Feigelson; Loic Le Marchand; +207 more
    Publisher: Springer Nature
    Countries: Netherlands, Ireland, United Kingdom, United Kingdom
    Project: CIHR , NIH | Characterizing Genetic Su... (5U01CA098233-06), NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Breast &Prostate Cancer &... (1U01CA098758-01), WT , EC | COGS (223175), NIH | Characterizing Genetic Su... (5U01CA098710-06), NIH | Genetic epidemiology of c... (3R01CA122340-03S1)

    Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P&gt; 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

  • Closed Access English
    Authors: 
    Axel S. Merseburger; Daniel Castellano; Thomas Powles; Yohann Loriot; Margitta Retz; Jens Voortman; Robert Huddart; Craig Gedye; Michiel S. van der Heijden; Howard Gurney; +5 more
    Country: Netherlands

    PURPOSE: Atezolizumab is an established treatment option for pretreated urothelial carcinoma, demonstrating efficacy in phase II/III trials. The SAUL study enrolled a broader patient population to determine safety and efficacy in underrepresented subgroups. MATERIALS AND METHODS: Patients with metastatic urinary tract carcinoma received atezolizumab 1,200 mg every 3 weeks until disease progression, unacceptable toxicity, loss of clinical benefit, or patient/physician decision. The primary endpoint was safety. Efficacy was a secondary endpoint. Analyses by programmed cell death ligand-1 (PD-L1) status, age, Eastern Cooperative Oncology Group performance status (ECOG PS) and renal impairment were prespecified; post hoc analyses explored outcomes by tumor location. RESULTS: A total of 1,004 patients were enrolled. Subgroup analyses in patients with older age, renal impairment, or upper tract urothelial carcinoma showed safety and efficacy similar to those in patients without these characteristics. Patients with ECOG PS 2 had clinical features typically associated with aggressive disease; median overall survival was 2.3 months versus 10.0 months in patients with ECOG PS0/1. Patients with PD-L1 expression on ≥5% of tumor-infiltrating immune cells tended to have better outcomes than those with <5% PD-L1 expression, although conclusions on the relative efficacy of atezolizumab cannot be drawn from this single-arm study. CONCLUSIONS: The understudied populations included in the SAUL study had similar outcomes to those in more selected populations included in phase II/III trials of atezolizumab, except for those with ECOG PS 2. Age ≥80 years and/or creatinine clearance <30 ml/minute does not preclude administration of atezolizumab; however, treatment risk versus benefit must be carefully assessed in patients with ECOG PS 2.

  • Open Access
    Authors: 
    Marie-Eve Naud; Étienne Artigau; Lison Malo; Loïc Albert; René Doyon; David Lafrenière; Jonathan Gagné; Didier Saumon; Caroline V. Morley; France Allard; +4 more
    Publisher: American Astronomical Society
    Country: United States
    Project: EC | PEPS (247060), NSERC

    We present the discovery of a co-moving planetary-mass companion ~42" (~2000 AU) from a young M3 star, GU Psc, likely member of the young AB Doradus Moving Group (ABDMG). The companion was first identified via its distinctively red i - z color (> 3.5) through a survey made with Gemini-S/GMOS. Follow-up Canada-France-Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate a spectral type of T3.5+-1 and reveal signs of low gravity which we attribute to youth. Keck/Adaptive Optics NIR observations did not resolve the companion as a binary. A comparison with atmosphere models indicates Teff = 1000-1100 K and logg = 4.5-5.0. Based on evolution models, this temperature corresponds to a mass of 9-13 MJup for the age of ABDMG (70-130 Myr). The relatively well-constrained age of this companion and its very large angular separation to its host star will allow its thorough characterization and will make it a valuable comparison for planetary-mass companions that will be uncovered by forthcoming planet-finder instruments such as Gemini Planet Imager and SPHERE. 18 p., 10 fig., published in ApJ. May 20th, 2014: Small corrections compared to the journal version: 1) addition of the an important reference to 1RSX 1609-2105b from Lafreni\`ere et al. 2008, 2010, 2) update of the url for Andrew Mann metallicity calibration, 3) correction of a few factual mistakes in section 2.2.4), 4) aesthetic reformatting of urls

  • Open Access
    Authors: 
    T. Aaltonen; Ronen Alon; S. Amerio; A. Anastassov; Alberto Annovi; Giorgio Apollinari; J. A. Appel; J. Asaadi; W. Ashmanskas; A. Aurisano; +207 more
    Publisher: arXiv
    Countries: Spain, Italy
    Project: EC | TAUKITFORNEWPHYSICS (302103), SNSF | Measurements of Higgs bos... (153664), NSERC

    This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the Korean World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, United Kingdom; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R&D Agency; the Academy of Finland; the Australian Research Council (ARC); and the EU community Marie Curie Fellowship Contract No. 302103. This work was also supported by the Shrum Foundation, the Weizman Institute of Science and the Israel Science Foundation. Results of a study of the substructure of the highest transverse momentum (pT) jets observed by the CDF Collaboration are presented. Events containing at least one jet with pT>400 GeV/c in a sample corresponding to an integrated luminosity of 5.95 fb−1, collected in 1.96 TeV proton-antiproton collisions at the Fermilab Tevatron collider, are selected. A study of the jet mass, angularity, and planar-flow distributions is presented, and the measurements are compared with predictions of perturbative quantum chromodynamics. A search for boosted top-quark production is also described, leading to a 95% confidence level upper limit of 38 fb on the production cross section of top quarks with pT>400 GeV/c. Peer Reviewed et al.

  • Open Access
    Authors: 
    Elaine Ruth Martyn;
    Publisher: University of New Brunswick Libraries - UNB
    Country: Canada
  • Open Access English
    Authors: 
    G. Maxin; D.R. Ouellet; Hélène Lapierre;
    Publisher: HAL CCSD
    Country: France

    International audience; Different protein sources, such as canola meal (CM) or dried distillers grains (DDG), are currently used in dairy rations to replace soybean meal (SBM). However, little data exists comparing their rumen degradation in a single study. Therefore, the objective of this study was to compare the ruminal degradation of dry matter (DM), crude protein (CP), and AA of SBM, CM, high-protein corn DDG (HPDDG), and wheat DDG plus solubles (WDDGS). In situ studies were conducted with 4 rumen-fistulated lactating Holstein cows fed a diet containing 38% grass hay and 62% corn-based concentrate. Each protein source was incubated in the rumen of each cow in nylon bags for 0, 2, 4, 8, 16, 24, and 48 h to determine DM and CP rumen degradation kinetics, whereas additional bags were also incubated for 16 h to evaluate AA ruminal disappearance. Rumen DM and CP degradability was calculated from rumenundegraded residues corrected or not for small particle loss. Data were fitted to an exponential model to estimate degradation parameters and effective degradability (ED) was calculated with a passage rate of 0.074 h(-1). The WDDGS and SBM had higher uncorrected ED (DM =- 75.0 and 72.6%; CP = 84.8 and 66.0%, respectively) than CM and HPDDG (DM = 57.2 and 55.5%; CP = 59.3 and 48.2%, respectively), due to higher soluble fraction in WDDGS and a combination of higher potentially degradable fraction and rate of degradation in SBM. Correction for small particle loss from bags, higher for WDDGS than for the other protein sources, decreased estimated ED but did not alter feed ranking. The ruminal disappearance of AA after 16 h of incubation reflected the overall pattern of CP degradation between protein supplements, but the ruminal disappearance of individual AA differed between protein supplements. Overall, these results indicate that, in the current study, (1) SBM and WDDGS were more degradable in the rumen than CM and HPDDG, and (2) that small particle loss correction is relevant but does not alter this ranking.

  • Open Access English
    Authors: 
    Salumbides, E. J.; Bailly, D.; Vervloet, M.; Ubachs, W.;

    Accurate absolute level energies of the $B\,^1\Sigma^{+}_{u}$, $v=0-8, N$ and $EF\,^{1}\Sigma^{+}_{g}$, $v=0-21, N$ rovibrational quantum states of molecular deuterium are derived by combining results from a Doppler-free two-photon laser excitation study on several lines in the $EF\,{}^{1}\Sigma_{g}^{+}-X\,{}^{1}\Sigma_{g}^{+}$ (0,0) band, with results from a Fourier-transform spectroscopic emission study on a low-pressure hydrogen discharge. Level energy uncertainties as low as 0.0005 cm$^{-1}$ are obtained for some low-lying $E\,^{1}\Sigma^{+}_{g}$ inner-well rovibrational levels, while uncertainties for higher-lying rovibrational levels and those of the $F\,^{1}\Sigma^{+}_{g}$ outer-well states are nominally 0.005 cm$^{-1}$. Level energies of $B\,^1\Sigma^{+}_{u}$ rovibrational levels, for $v \leq 8$ and $N \leq 10$ are determined at an accuracy of 0.001 cm$^{-1}$. Computed wavelengths of D$_2$ Lyman transitions in the $B\,^1\Sigma^{+}_{u}-X\,^{1}\Sigma^{+}_{g}$ ($v,0$) bands are also tabulated for future applications. Comment: appears in Journal of Molecular Spectroscopy (2014)