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  • Authors: Yanfei Huang; Yan Zhang; Xinying Li; Jinjun Liu; +1 Authors

    For single-phase DC-AC power conversion, power decoupling is always required due to the existence of double-line-frequency ripple caused by the instantaneous unbalanced power between AC and DC side. The typical power decoupling method utilizes a large electrolytic capacitor and consequently increases the passive components requirement. The active power decoupling scheme introduces an additional low power converter to compensate the ripple, which inevitably increases the system cost and control complexity. To overcome these drawbacks, this paper proposes a novel suppression method based on three-level topology. By optimizing the capacitance design and improved control algorithm, the instantaneous unbalanced power is dynamically redistributed between two series connected intermediate capacitors in order to make the capacitor voltage ripple complementary to each other. Thus the de-link voltage ripple can be reduced to a large extent. Simulation verifies the correctness and effectiveness of the new suppression method.

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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Mei Hua Hwang; Nikos Darzentas; Dorothee Bienzle; Peter F Moore; +2 Authors

    The ability to mount adaptive immune responses to a diverse array of pathogens is essential to maintaining the health of an individual. The outcome of adaptive immune responses is influenced by the pool of available lymphocyte antigen receptors. Understanding the composition and dynamics of immune repertoires is hence of relevance to characterizing physiologic immunological processes as well as understanding disease pathogenesis. The dog is increasingly recognized as a model for human disease. The objective of this study was to utilize NGS for comprehensive and unbiased analysis of the IGH repertoire in healthy dogs. First, the IGH locus was searched in silico for previously unidentified genes. Second, IGH transcripts from major lymphoid organs were amplified using a 5'RACE approach without V/J primer bias. Third, amplicons were sequenced on an Illumina MiSeq platform, and data were analyzed using the ARResT/Interrogate platform. Data analysis included V/J usage, V-J pairing biases, isotype frequency, CDR3 diversity, convergent recombination, and public repertoires. The results of this study provide a comprehensive IGH repertoire analysis for healthy dogs. These data will allow further improvement of V/J gene-specific primer sets and will serve as baseline for future studies investigating immune repertoires in health and disease.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Veterinary Immunolog...arrow_drop_down
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Veterinary Immunology and Immunopathology
    Article . 2018
    License: Elsevier TDM
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Veterinary Immunolog...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Veterinary Immunology and Immunopathology
      Article . 2018
      License: Elsevier TDM
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lars Olof Karlsson; Hanna Erixon; Hanna Erixon; Tino Ebbers; +6 Authors

    BackgroundAtrial fibrillation (AF) is a prevalent cause of cardiovascular morbidity, including thromboembolism and heart failure. Left ventricular dysfunction (LVD) detected in AF patients may be either precursor or consequence of the arrythmia. Successful cardioversion of chronic AF is often followed by a transient period of left atrial (LA) stunning, where depressed mechanical atrial contraction persists despite reinstitution of sinus rhythm. To determine if AF-associated LVD would improve with resolution of LA dysfunction, AF patients were examined immediately and 4 weeks after cardioversion to sinus rhythm. 4D flow cardiovascular magnetic resonance (CMR) assesses ventricular function according to the volumes and energetics of functional components of the LV volume. Previously, described 4D CMR markers of LVD include decreased volume and end-diastolic kinetic energy (KE) of the Direct flow, which is the portion of LV volume that passes directly from inflow to outflow in a single cycle. We hypothesize that impaired LV flow patterns and energetics will be found immediately after cardioversion during atrial stunning, and that those parameters will improve as atrial function returns.MethodsTen patients with a history of AF underwent CMR 2–3 h (Time-1) and 4 weeks (Time-2), following electrical cardioversion to sinus rhythm. 4D phase-contrast velocity data and morphological images were acquired at a 3T CMR system. Using a previously evaluated method, pathlines were emitted from the LV end diastolic volume (LVEDV) and traced forward and backward in time until end-systole. The LVEDV was automatically separated into four functional flow components whose volume and KE were calculated.ResultsLeft atrial fractional area change increased over the follow-up period (P = 0.001), indicating recovery of LA mechanical function. LVEF increased between Time-1 and Time-2 (P = 0.003); LVEDVI did not change (P = 0.319). Over that interval, the ratios of Direct flow/LVEDV volume and KE increased (P = 0.001 and P = 0.003, respectively), while the ratios of Residual volume/LVEDV volume and KE decreased (P = 0.001 and P = 0.005, respectively).ConclusionPost-cardioversion recovery of LA function was associated with improvements in conventional and 4D CMR markers of LV function. Flow-specific measures demonstrate the negative but potentially reversible impact of LA dysfunction on volume and energetic aspects of LV function.

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    Article . 2019
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      Article . 2019
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    Authors: Elaine C. Marqueze; Cibele A. Crispim; Claudia R. C. Moreno; Claudia R. C. Moreno;
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    Frontiers in Public Health
    Article . 2021
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    Frontiers in Public Health
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      Frontiers in Public Health
      Article . 2021
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      Frontiers in Public Health
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    Authors: Wanzhi Li; Jinman Wang; Yafu Zhang; Min Zhang;

    Abstract Soil and vegetation, as the basic structural unit of artificial ecosystems, play an important role in ecological restoration in opencast coal mining areas, and both exhibit a complex interaction. However, the traditional method cannot well characterize the inter action between the soil and vegetation. In order to reveal the interaction between soil and vegetation in the reclaimed area of opencast coalmine, and explore the interaction mechanism between soil and vegetation, the soil and vegetation data from 70 reclaimed points in Antaibao and Anjialing opencast coal mines in Shanxi province of China were selected to conduct an investigation study. Ten soil and three vegetation indicators were determined, and the joint multifractal method was innovatively introduced to characterize the relationships of soil and vegetation on multiple scales using joint multifractal spectra and grayscale images. The interaction between soil and vegetation can be clearly obtained using the joint multifractal method. The canopy density was negatively correlated with soil bulk density, silt content, and pH; whereas, it was positively correlated with rock content, sand content, total nitrogen, soil organic matter, available phosphorus, and available potassium content. The average diameter at breast height was negatively correlated with soil bulk density, clay content, and pH; however, it was positively correlated with silt content, sand content, total nitrogen, soil organic matter, available phosphorus, and available potassium content. The herb coverage was negatively correlated with rock content, silt content, clay content, pH, soil organic matter, available phosphorus and available potassium content. Soil bulk density and clay content showed negative correlation with herb coverage. Compared to the traditional method, the novel joint multifractal method can more accurately charecterize the correlations from multiple scales. This novel method can be used to study the interaction between soil and vegetation.

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    Ecological Indicators
    Article . 2021
    License: CC BY NC ND
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      Ecological Indicators
      Article . 2021
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: JingYang, Xu; Connie, Le; Baowei, Chen; Hongquan, Zhang;
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of Environme...arrow_drop_down
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    Journal of Environmental Sciences
    Article . 2019
    License: Elsevier TDM
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    Journal of Environmental Sciences
    Other literature type . 2019
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of Environme...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Journal of Environmental Sciences
      Article . 2019
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      Other literature type . 2019
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    Authors: Xia, Frances; Kheirbek, Mazen A.;

    Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.

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    Europe PubMed Central
    Other literature type . 2020
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    Trends in Neurosciences
    Article . 2020
    License: Elsevier TDM
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      Europe PubMed Central
      Other literature type . 2020
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      Trends in Neurosciences
      Article . 2020
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    Authors: Jiapeng Qu; Denis Réale; Quinn E. Fletcher; Yanming Zhang;

    Abstract Background Animals inhabiting high altitudes consistently show slow life-histories. The pace-of-life syndrome (POLS) hypothesis posits behavioural, physiological and/or morphological traits that mediate the trade-off between current and future reproduction or survival, which have coevolved along a slow-fast life history continuum. Previous studies have shown that the life histories of plateau pikas varied across altitude, high-altitude individuals showed slow pace of life which were characterized by few litters per year with small litter sizes. Thus, we hypothesized that pikas populations at higher altitudes would also express personalities characteristic associated with slow life history, such as high sociability, low activity or aggressiveness. We tested this hypothesis by comparing the activity and docility of three plateau pika (Ochotona curzoniae) populations distributed along an altitudinal gradient of the Tibetan Plateau. We predicted that high-altitude pika would be more docile and less active. Results The behaviour of 556 pikas, from which 120 individuals were measured at least twice, was quantified. We observed that plateau pikas at high altitudes were less active and more docile than pika at lower altitudes. Activity and docility were significantly and negatively correlated in populations from high altitudes but not in populations from low altitudes. Conclusions Our results support the POLS hypothesis, highlight the existence of personality variation among populations distributed along an altitudinal gradient and emphasise the importance of environmental selection on personality divergence.

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    Authors: Jing Wang; Zhang Zhang; Yi-Nan Zhang; Dong Han; +4 Authors

    Abstract Glass forming ability (GFA) of Mg-Zn alloys with Sr addition has been experimentally studied coupled with CALPHAD method. Two series of metallic glasses (MGs), Mg98−xZnxSr2 (x = 38, 36, 33, 30, 28) and Mg95−xZnxSr5 (x = 37, 33, 30, 27, 23), were designed and prepared successfully for the first time. The crystallization characteristics of these MGs were investigated by differential scanning calorimetry (DSC), X-ray diffraction (XRD). All results indicate that the extraordinary GFA should locate at the composition regions of Mg68Zn27Sr5 to Mg60Zn35Sr5 for Mg95−xZnxSr5, and Mg68Zn30Sr2 to Mg64Zn34Sr2 for Mg98−xZnxSr2, respectively.

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    Materials Letters
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    Authors: Yihao, Wu; Zhi, Zhang; Zhe, Chen; Chen, Fu; +5 Authors
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  • Authors: Yanfei Huang; Yan Zhang; Xinying Li; Jinjun Liu; +1 Authors

    For single-phase DC-AC power conversion, power decoupling is always required due to the existence of double-line-frequency ripple caused by the instantaneous unbalanced power between AC and DC side. The typical power decoupling method utilizes a large electrolytic capacitor and consequently increases the passive components requirement. The active power decoupling scheme introduces an additional low power converter to compensate the ripple, which inevitably increases the system cost and control complexity. To overcome these drawbacks, this paper proposes a novel suppression method based on three-level topology. By optimizing the capacitance design and improved control algorithm, the instantaneous unbalanced power is dynamically redistributed between two series connected intermediate capacitors in order to make the capacitor voltage ripple complementary to each other. Thus the de-link voltage ripple can be reduced to a large extent. Simulation verifies the correctness and effectiveness of the new suppression method.

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    Authors: Mei Hua Hwang; Nikos Darzentas; Dorothee Bienzle; Peter F Moore; +2 Authors

    The ability to mount adaptive immune responses to a diverse array of pathogens is essential to maintaining the health of an individual. The outcome of adaptive immune responses is influenced by the pool of available lymphocyte antigen receptors. Understanding the composition and dynamics of immune repertoires is hence of relevance to characterizing physiologic immunological processes as well as understanding disease pathogenesis. The dog is increasingly recognized as a model for human disease. The objective of this study was to utilize NGS for comprehensive and unbiased analysis of the IGH repertoire in healthy dogs. First, the IGH locus was searched in silico for previously unidentified genes. Second, IGH transcripts from major lymphoid organs were amplified using a 5'RACE approach without V/J primer bias. Third, amplicons were sequenced on an Illumina MiSeq platform, and data were analyzed using the ARResT/Interrogate platform. Data analysis included V/J usage, V-J pairing biases, isotype frequency, CDR3 diversity, convergent recombination, and public repertoires. The results of this study provide a comprehensive IGH repertoire analysis for healthy dogs. These data will allow further improvement of V/J gene-specific primer sets and will serve as baseline for future studies investigating immune repertoires in health and disease.

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    Veterinary Immunology and Immunopathology
    Article . 2018
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      Veterinary Immunology and Immunopathology
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    Authors: Lars Olof Karlsson; Hanna Erixon; Hanna Erixon; Tino Ebbers; +6 Authors

    BackgroundAtrial fibrillation (AF) is a prevalent cause of cardiovascular morbidity, including thromboembolism and heart failure. Left ventricular dysfunction (LVD) detected in AF patients may be either precursor or consequence of the arrythmia. Successful cardioversion of chronic AF is often followed by a transient period of left atrial (LA) stunning, where depressed mechanical atrial contraction persists despite reinstitution of sinus rhythm. To determine if AF-associated LVD would improve with resolution of LA dysfunction, AF patients were examined immediately and 4 weeks after cardioversion to sinus rhythm. 4D flow cardiovascular magnetic resonance (CMR) assesses ventricular function according to the volumes and energetics of functional components of the LV volume. Previously, described 4D CMR markers of LVD include decreased volume and end-diastolic kinetic energy (KE) of the Direct flow, which is the portion of LV volume that passes directly from inflow to outflow in a single cycle. We hypothesize that impaired LV flow patterns and energetics will be found immediately after cardioversion during atrial stunning, and that those parameters will improve as atrial function returns.MethodsTen patients with a history of AF underwent CMR 2–3 h (Time-1) and 4 weeks (Time-2), following electrical cardioversion to sinus rhythm. 4D phase-contrast velocity data and morphological images were acquired at a 3T CMR system. Using a previously evaluated method, pathlines were emitted from the LV end diastolic volume (LVEDV) and traced forward and backward in time until end-systole. The LVEDV was automatically separated into four functional flow components whose volume and KE were calculated.ResultsLeft atrial fractional area change increased over the follow-up period (P = 0.001), indicating recovery of LA mechanical function. LVEF increased between Time-1 and Time-2 (P = 0.003); LVEDVI did not change (P = 0.319). Over that interval, the ratios of Direct flow/LVEDV volume and KE increased (P = 0.001 and P = 0.003, respectively), while the ratios of Residual volume/LVEDV volume and KE decreased (P = 0.001 and P = 0.005, respectively).ConclusionPost-cardioversion recovery of LA function was associated with improvements in conventional and 4D CMR markers of LV function. Flow-specific measures demonstrate the negative but potentially reversible impact of LA dysfunction on volume and energetic aspects of LV function.

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    Authors: Elaine C. Marqueze; Cibele A. Crispim; Claudia R. C. Moreno; Claudia R. C. Moreno;
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    Authors: Wanzhi Li; Jinman Wang; Yafu Zhang; Min Zhang;

    Abstract Soil and vegetation, as the basic structural unit of artificial ecosystems, play an important role in ecological restoration in opencast coal mining areas, and both exhibit a complex interaction. However, the traditional method cannot well characterize the inter action between the soil and vegetation. In order to reveal the interaction between soil and vegetation in the reclaimed area of opencast coalmine, and explore the interaction mechanism between soil and vegetation, the soil and vegetation data from 70 reclaimed points in Antaibao and Anjialing opencast coal mines in Shanxi province of China were selected to conduct an investigation study. Ten soil and three vegetation indicators were determined, and the joint multifractal method was innovatively introduced to characterize the relationships of soil and vegetation on multiple scales using joint multifractal spectra and grayscale images. The interaction between soil and vegetation can be clearly obtained using the joint multifractal method. The canopy density was negatively correlated with soil bulk density, silt content, and pH; whereas, it was positively correlated with rock content, sand content, total nitrogen, soil organic matter, available phosphorus, and available potassium content. The average diameter at breast height was negatively correlated with soil bulk density, clay content, and pH; however, it was positively correlated with silt content, sand content, total nitrogen, soil organic matter, available phosphorus, and available potassium content. The herb coverage was negatively correlated with rock content, silt content, clay content, pH, soil organic matter, available phosphorus and available potassium content. Soil bulk density and clay content showed negative correlation with herb coverage. Compared to the traditional method, the novel joint multifractal method can more accurately charecterize the correlations from multiple scales. This novel method can be used to study the interaction between soil and vegetation.

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    DOAJ-Articles
    Article . 2021
    Data sources: DOAJ-Articles
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Ecological Indicators
    Article . 2021
    License: CC BY NC ND
    Data sources: Crossref