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Ce mémoire explore la dynamique mémorielle au sein de l’écriture. Dans la partie création, le personnage de Sam erre à l’intérieur de ses souvenirs à la recherche de sa sœur Lidie. Il s’agit d’une tentative vaine, toujours à recommencer puisque la mémoire, liée à la conscience, est sans cesse gauchie et subjective, incapable de redonner un passé objectif. La figure de Lidie se trouve ainsi être le point central inatteignable d’une circonvolution, le mouvement circulaire révélant la présence de la mémoire dans le corps du texte. La partie essai aborde la question de la liaison entre la mémoire et l’écriture dans Le Palace de Claude Simon. Reprenant l’idée du triple présent de Saint Augustin, le passé n’est alors possible que dans un présent du passé. Cette dynamique crée un mouvement circulaire ; le personnage parcourt ses souvenirs, mais il ne peut les investir que par la lorgnette d’un présent. Cela se traduit par un texte sans début ni fin, révolutionnaire, où le souvenir, plutôt qu’un retour dans le temps, fait avancer le texte et devient le temps présent de l’écriture. This master explores the dynamism of the memory within writing. In the creation part, the character of Sam wanders in his memories, searching for his sister Lidie. It is a vain attempt, always to begin again since the memory, related to the consciousness, is unceasingly subjective and distorted, unable to give back an objective past. The figure of Lidie find to be the unattainable central point of a convolution, the cercle trajectory revealing the presence of the memory in the body of the text. The essay part discusses the question of the bond between the memory and the writing in Le Palace of Claude Simon. Taking up the idea of the triple present of St. Augustine, the past is then possible only in a present of the past, and this dynamism creates a circular motion while the character goes through his memories that he can only invest by the lens of a present. This reveals a text without any beginning or end, revolutionary, where the memory, rather than a return in time, is moving forward the text and becomes the present time of the writing. Mémoire en recherche-création.

AbstractObjectiveTo evaluate trends in organisms causing early-onset neonatal sepsis (EONS). Congruent with recent reports, we hypothesized there would be an increase in EONS caused by Escherichia coli.Study DesignNational data on infants admitted to neonatal intensive care units from 2009 to 2014 were compared to previously reported data from 2003 to 2008. We report 430 cases of EONS from 2009 to 2014. Bivariate analyses were used to analyze the distribution of causative organisms over time and differences by gestational age. Linear regression was used to estimate trends in causative organisms.ResultsSince 2003, there has been a trend of increasing numbers of cases caused by E coli (P<0.01). The predominant organism was E coli in preterm infants and Group B Streptococcus in term infants.ConclusionsWith the majority of EONS cases now caused by E coli, our findings emphasize the importance of continued surveillance of causative organism patterns and developing approaches to reduce cases caused by E coli.

This dataset is composed of CT pulmonary angiograms and annotations related to pulmonary embolism. It is available at https://www.rsna.org/education/ai-resources-and-training/ai-image-challenge/rsn...

Converging evidence from biopsychosocial research in humans and animals demonstrates that chronic sensory stimulation (via excessive screen exposure) affects brain development increasing the risk of cognitive, emotional, and behavioural disorders in adolescents and young adults. Emerging evidence suggests that some of these effects are similar to those seen in adults with symptoms of mild cognitive impairment (MCI) in the early stages of dementia, including impaired concentration, orientation, acquisition of recent memories (anterograde amnesia), recall of past memories (retrograde amnesia), social functioning, and self-care. Excessive screen time is known to alter gray matter and white volumes in the brain, increase the risk of mental disorders, and impair acquisition of memories and learning which are known risk factors for dementia. Chronic sensory overstimulation (i.e., excessive screen time) during brain development increases the risk of accelerated neurodegeneration in adulthood (i.e., amnesia, early onset dementia). This relationship is affected by several mediating/moderating factors (e.g., IQ decline, learning impairments and mental illness). We hypothesize that excessive screen exposure during critical periods of development in Generation Z will lead to mild cognitive impairments in early to middle adulthood resulting in substantially increased rates of early onset dementia in later adulthood. We predict that from 2060 to 2100, the rates of Alzheimer’s disease and related dementias (ADRD) will increase significantly, far above the Centres for Disease Control (CDC) projected estimates of a two-fold increase, to upwards of a four-to-six-fold increase. The CDC estimates are based entirely on factors related to the age, sex, race and ethnicity of individuals born before 1950 who did not have access to mobile digital technology during critical periods of brain development. Compared to previous generations, the average 17–19-year-old spends approximately 6 hours a day on mobile digital devices (MDD) (smartphones, tablets, and laptop computers) whereas individuals born before 1950 at the same age spent zero. Our estimates include the documented effects of excessive screen time on individuals born after 1980, Millennials and Generation Z, who will be the majority of individuals ≥65 years old. An estimated 4-to-6-fold increase in rates of ADRD post-2060 will result in widespread societal and economic distress and the complete collapse of already overburdened healthcare systems in developed countries. Preventative measures must be set in place immediately including investments and interventions in public education, social policy, laws, and healthcare.

There is an ongoing debate on the importance of genetic factors in cancer development, where gene-centered cancer predisposition seems to show that only 5 to 10% of the cancer cases are inheritable. By conducting a systematic analysis of germline genomes of 9712 cancer patients representing 22 common cancer types along with 16,670 noncancer individuals, we identified seven cancer-associated germline genomic patterns (CGGPs), which summarized trinucleotide mutational spectra of germline genomes. A few CGGPs were consistently enriched in the germline genomes of patients whose tumors had smoking signatures or correlated with oncogenesis- and genome instability–related mutations. Furthermore, subgroups defined by the CGGPs were significantly associated with distinct oncogenic pathways, tumor histological subtypes, and prognosis in 13 common cancer types, suggesting that germline genomic patterns enable to inform treatment and clinical outcomes. These results provided evidence that cancer risk and clinical outcomes could be encoded in germline genomes. Germline variants when organized as genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes.

Brain tumors are a hazardous type of tumor, and they build pressure inside the skull when they grow, which can potentially cause brain damage or even death. Attention mechanisms are widely adopted in state-of-the-art deep learning architectures for computer vision and neural translation tasks since they enhance networks' ability to capture spatial and channel-wise relationships. We offer an attention-based image segmentation model that outlines the brain tumors in Magnetic Resonance Imaging (MRI) scans if present. In the paper, we mainly focus on integrating Squeeze-and-Excitation Block and CBAM into the commonly used segmentation model, U-Net, to resolve the problem of concatenating unnecessary information into the decoder blocks and attempt to locate the tumor boundaries. Our research clearly shows the application of the attention mechanism in U-Net, incorporates the Squeeze-and-Excitation with CBAM, and improves the performance in the brain tumor segmentation task. The model is delivered on an app with additional text to speech and chatbot features provided.

Although finite Blaschke products are a remarkable and exclusive class of functions, they appear in many important approximation problems.

Abstract The purpose of this study was to investigate the alterations with obesity, and the effects of moderate aerobic exercise or prebiotic dietary-fibre supplementation on the mechanical and biochemical properties of the tail tendon in a rat model of high-fat/high-sucrose (HFS) diet-induced obesity. Thirty-two male Sprague-Dawley rats were randomized to chow (n = 8) or HFS (n = 24) diets. After 12-weeks, the HFS fed rats were further randomized into sedentary (HFS sedentary, n = 8), exercise (HFS + E, n = 8) or prebiotic fibre supplementation (HFS + F, n = 8) groups. After another 12-weeks, rats were sacrificed, and one tail tendon was isolated and tested. Stress-relaxation and stretch-to-failure tests were performed to determine mechanical properties (peak, steady-state, yield and failure stresses, Young’s modulus, and yield and failure strains) of the tendons. The hydroxyproline content was also analyzed. The HFS sedentary and HFS + F groups had higher final body masses and fat percentages compared to the chow and HFS + E groups. Yield strain was reduced in the HFS sedentary rats compared to the chow rats. Peak and steady-state stresses, failure strain, Young’s modulus, and hydroxyproline content were not different across groups. Although the HFS + E group showed higher failure stress, yield stress, and yield strain compared to the HFS sedentary group, HFS + F animals did not produce differences in the properties of the tail tendon compared to the HFS sedentary group. These results indicate that exposure to a HFS diet led to a reduction in the yield strain of the tail tendon and aerobic exercise, but not fibre supplementation, attenuated these diet-related alterations to tendon integrity.

Abstract As human-animal studies (HAS) scholarship has grown and expanded over the past few decades, so have opportunities to bring nonhuman animals into higher education. This article presents an instructional design option for teaching the animal through interdisciplinary experiential learning. Interdisciplinary learning integrates multidisciplinary knowledge across a central theme while experiential learning encourages learners to move through a recursive process of experiencing, reflecting, thinking, and acting. The article also reflects on student learning outcomes based on a questionnaire survey conducted five years after the course completion. Preliminary insights reveal the transformative potential of this approach given students’ modified viewpoints, enhanced ethical sensitivity, enlarged horizons, and behavioral changes regarding animals. HAS scholars are encouraged to engage in animal-focused scholarship of teaching and learning in higher education by sharing instructional templates and scholarly research on HAS courses. Doing so will expand opportunities for students to appreciate, critically examine, and positively influence animal lives.