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  • Closed Access
    Authors: 
    Denis H. Lynn; David J. S. Montagnes; T. Dale; G. L. Gilron; S. L. Strom;
    Publisher: Cambridge University Press (CUP)

    Strombidinopsis species were collected from theGulf of Alaska, Gulf of Mexico, Caribbean Sea, Gulf of Maine, and Barents Sea. Six strains were conservatively placed in six species: Strombidinopsis chilorhax sp. nov.; Strombidinopsis batos sp. nov.; Strombidinopsis sphaira sp. nov.;Strombidinopsis cercionis sp. nov.;Strombidinopsis acuminatum Fauré-Fremiet, 1924; and Strombidinopsis spiniferum (Leegaard, 1915) comb. nov. Based on the characters of these species, the diagnosis of the genus Strombidinopsis was revised.

  • Closed Access
    Authors: 
    Mian Huang; Cheng Lin; Sanat K. Pokharel; A. Tura; Phalguni Mukhopadhyaya;
    Publisher: Elsevier BV
    Project: NSERC

    Abstract Freeze-thaw cycles are a major cause for destabilizing pavements in cold regions. Among countermeasures for freeze-thaw damages, use of geocells to reinforce pavement bases is an effective solution in practice. However, as opposed to widespread applications, research concerning freeze-thaw behavior of geocell-reinforced bases is limited, probably due to a lack of proper devices for conducting experimental tests. This paper presents a new model-test device capable of performing both freeze-thaw tests and plate loading tests on geocell-reinforced soils. A thermodynamic numerical model was developed to assist with the design of freeze-thaw component of the device, while the design of plate loading component was developed by referring to features of existing devices. Eleven tests were run on geocell-reinforced and unreinforced sands to confirm the effectiveness of the proposed device. The test results showed the device successfully provided vertical heat transfer in sands during freeze and thaw. After five freeze-thaw cycles, geocells reduced peak frost heave and thaw settlement of sands by 18% and 34%, respectively, and increased the stiffness and bearing capacity by 40% and 253%, respectively. It was found a temperature drop occurred at the interface between cooling plate and sands, which was due to the existence of thermal contact resistance.

  • Closed Access
    Authors: 
    John Paul Archambault;
    Publisher: Elsevier BV
    Country: Canada

    Abstract A simple geometry is used to compare several of the available Monte Carlo software codes for radiation transport. EGSnrc, Geant4 and MCNP5 are all used to calculate the photon fluence produced from electrons incident on a copper target. Four energies for the isotropic point source are chosen to simulate the average and maximum emission energies of 32 P and 90 Y: (0.7, 1.71) MeV and (0.93, 2.28) MeV, respectively. The energy deposition in the copper target, the electron current at the target and the computational efficiency are also calculated. EGSnrc is found to be the only self-consistent code when comparing results calculated using the default transport parameters of the condensed history mode with those calculated in the single scattering mode.

  • Closed Access
    Authors: 
    Jeffrey S. Podoshen; Vivek Venkatesh; Zheng Jin;
    Publisher: SAGE Publications

    This article examines aspects related to the dystopic consumption and production of the musical and performance art form known as black metal. Steeped in anti-Christian motifs, surrounded by a history of violence and brutal imagery, black metal is an extreme metal art form that has been growing steadily in popularity throughout Europe, South America, and the United States. We first examine black metal culture through the eyes of both artists and consumers, using mixed qualitative methodologies. Thereafter, we derive specific theoretical interpretations from the black metal subculture that are predicated on the emerging themes of signification, identity transformation, xenophobia, and a reconstructed mythology that all point to what we present as a dystopian consumption model. The model demonstrates how dystopia, in context, is at the heart of the symbiotic relationship between consumers and producers and is encapsulated by a specific set of processes and overarching conditions. Implications and relationships to utopian models are discussed.

  • Open Access
    Authors: 
    Caroline Lamarche; Jonathan S. Maltzman;
    Publisher: Elsevier BV
  • Open Access
    Authors: 
    Pallavi Surana; Devika Kapuria; Carly Broadwell; Elizabeth C. Wright; Varun Takyar; David E. Kleiner; Marc G. Ghany; Gil Ben-Yakov; Theo Heller; T. Jake Liang; +1 more

    Abstract Background Fibrosis regression has been associated with nucleoside analogue (NA) treatment in chronic hepatitis B (CHB) patients. Although non-invasive fibrosis markers have been evaluated in CHB, their utility for monitoring on-treatment histologic regression has not been evaluated. Aims To characterize improvements in disease severity and the utility of non-invasive biomarkers in CHB NA treated patients. Methods Histology, labs, AST-to-platelet ratio index, and Fibrosis-4 (Fib-4) from treatment-naive CHB patients were evaluated at baseline and longitudinally. Relative change from baseline to various time points during treatment were evaluated. Correlative analysis of APRI and Fib-4 with histology was performed longitudinally. Results 80 CHB patients (84% male, median age 45 (IQR 32, 54)) with histology up to 17 years (median 6(IQR 3.9, 8.0)) years were studied. Median baseline Ishak fibrosis was 3 (IQR 2, 4), histologic activity index (HAI) inflammation was 9 (IQR 7, 11), and AUROC of fibrosis markers for detecting cirrhosis (Ishak ≥ 5) was >0.64. HAI improved at a rate of 54% during year 1 and 37% in year 2, both greater than in the remaining follow-up periods. Within the first year, fibrosis improved by 35%, greater than all other time periods. Non-invasive biomarkers began to correlate with histology beyond 4 years (APRI: 4–6 years: r = 0.33, p = 0.03; ≥6 years: r = 0.41, p = 0.009; Fib-4: ≥6 years: r = 0.35, p = 0.03). Conclusion Early dynamic changes in histology occur in CHB patients on NA followed by linear improvements. Non-invasive fibrosis biomarkers do not capture these dynamic changes and may demonstrate clinical utility beyond 4 years of treatment.

  • Open Access English
    Authors: 
    Josephine Ho; Constadina Panagiotopoulos; Brian W. McCrindle; Silviu Grisaru; Tamara Pringsheim;
    Publisher: Pulsus Group Inc

    Second-generation antipsychotics are commonly associated with metabolic complications. These medications are being used more frequently for the treatment of mental health disorders in children, which has stimulated the need for creating formal guidelines on monitoring their safety and effectiveness. Previous guidelines have been developed for monitoring metabolic and neurological complications. To assist practitioners who perform these monitoring procedures, a complementary set of treatment recommendations have been created for situations in which abnormal measurements or results are encountered.To create evidence-based recommendations to assist in managing metabolic complications in children being treated with second-generation antipsychotics.A systematic review of the literature on metabolic complications of second-generation antipsychotic medications in children was conducted. Members of the consensus group evaluated the information gathered from the systematic review of the literature and used a nominal group process to reach a consensus on treatment recommendations. Wherever possible, references were made to existing guidelines on the evaluation and treatment of metabolic abnormalities in children.Evidence-based recommendations are presented to assist in managing metabolic complications including weight gain; increased waist circumference; elevation in prolactin, cholesterol, triglyceride and glucose levels; abnormal liver function tests; and abnormal thyroid studies.The use of second-generation antipsychotics requires proper monitoring procedures. The present treatment guideline provides guidance to clinicians on the clinical management of metabolic complications if they occur.

  • Open Access English
    Authors: 
    Robin T. Petroze; Allison N. Martin; Edmond Ntaganda; Patrick Kyamanywa; Etienne St-Louis; Sara K. Rasmussen; James Forrest Calland; Jean Claude Byiringiro;
    Publisher: John Wiley & Sons, Ltd
    Project: NIH | Fogarty International Cli... (5R24TW007988-04), NIH | Surgical Infectious Dises... (5T32AI078875-02)

    Background Child survival initiatives historically prioritized efforts to reduce child morbidity and mortality from infectious diseases and maternal conditions. Little attention has been devoted to paediatric injuries in resource‐limited settings. This study aimed to evaluate the demographics and outcomes of paediatric injury in a sub‐Saharan African country in an effort to improve prevention and treatment. Methods A prospective trauma registry was established at the two university teaching campuses of the University of Rwanda to record systematically patient demographics, prehospital care, initial physiology and patient outcomes from May 2011 to July 2015. Univariable analysis was performed for demographic characteristics, injury mechanisms, geographical location and outcomes. Multivariable analysis was performed for mortality estimates. Results Of 11 036 patients in the registry, 3010 (27·3 per cent) were under 18 years of age. Paediatric patients were predominantly boys (69·9 per cent) and the median age was 8 years. The mortality rate was 4·8 per cent. Falls were the most common injury (45·3 per cent), followed by road traffic accidents (30·9 per cent), burns (10·7 per cent) and blunt force/assault (7·5 per cent). Patients treated in the capital city, Kigali, had a higher incidence of head injury (7·6 per cent versus 2·0 per cent in a rural town, P < 0·001; odds ratio (OR) 4·08, 95 per cent c.i. 2·61 to 6·38) and a higher overall injury‐related mortality rate (adjusted OR 3·00, 1·50 to 6·01; P = 0·019). Pedestrians had higher overall injury‐related mortality compared with other road users (adjusted OR 3·26, 1·37 to 7·73; P = 0·007). Conclusion Paediatric injury is a significant contributor to morbidity and mortality. Delineating trauma demographics is important when planning resource utilization and capacity‐building efforts to address paediatric injury in low‐resource settings and identify vulnerable populations. This study evaluated the demographics and outcomes of paediatric injury in Rwanda through a prospective trauma registry to inform capacity‐building for prevention and treatment. Patients treated in the capital city had a higher incidence of head injury and a higher overall injury‐related mortality than those in a rural town. Pedestrians had higher overall injury‐related mortality compared with other road‐users. Falls and road traffic accidents significant contributors to pediatric injury in Rwanda

  • Authors: 
    Jaroslav Opatrny;
    Publisher: Informa UK Limited

    AbstractParallel programming language constructs suitable for Divide-and-Conquer, and Branch-and- Bound algorithms are proposed. These constructs allow a simple specification of the parallelism in the Divide and-Conquer and Branch-and-Bound algorithms and their efficient execution on a bus-connected multi-processor system with a common memory.

  • Closed Access
    Authors: 
    Niels Van Steenkiste; Kevin C. Wakeman; Brian S. Leander;
    Publisher: Elsevier BV
    Project: NSERC

    Abstract Marine gastrotrichs of the Pacific Ocean are poorly known. Here, we report on the finding of a marine chaetonotid gastrotrich of the genus Diuronotus from an intertidal beach within the Sea of Japan in Hokkaido (Japan). The Japanese individual shows a very close resemblance to Diuronotus aspetos. This new record is a consequential extension of its biogeographic range; previous records for representatives of this genus are confined to West Greenland, the North Sea and the east coast of North America. This rarely encountered, but seemingly widespread genus of marine gastrotrichs exemplifies our limited understanding of meiofaunal diversity and distribution patterns caused by sampling bias and insufficient knowledge on nominal species complexes.

search
Include:
The following results are related to Canada. Are you interested to view more results? Visit OpenAIRE - Explore.
1,913,938 Research products, page 1 of 191,394
  • Closed Access
    Authors: 
    Denis H. Lynn; David J. S. Montagnes; T. Dale; G. L. Gilron; S. L. Strom;
    Publisher: Cambridge University Press (CUP)

    Strombidinopsis species were collected from theGulf of Alaska, Gulf of Mexico, Caribbean Sea, Gulf of Maine, and Barents Sea. Six strains were conservatively placed in six species: Strombidinopsis chilorhax sp. nov.; Strombidinopsis batos sp. nov.; Strombidinopsis sphaira sp. nov.;Strombidinopsis cercionis sp. nov.;Strombidinopsis acuminatum Fauré-Fremiet, 1924; and Strombidinopsis spiniferum (Leegaard, 1915) comb. nov. Based on the characters of these species, the diagnosis of the genus Strombidinopsis was revised.

  • Closed Access
    Authors: 
    Mian Huang; Cheng Lin; Sanat K. Pokharel; A. Tura; Phalguni Mukhopadhyaya;
    Publisher: Elsevier BV
    Project: NSERC

    Abstract Freeze-thaw cycles are a major cause for destabilizing pavements in cold regions. Among countermeasures for freeze-thaw damages, use of geocells to reinforce pavement bases is an effective solution in practice. However, as opposed to widespread applications, research concerning freeze-thaw behavior of geocell-reinforced bases is limited, probably due to a lack of proper devices for conducting experimental tests. This paper presents a new model-test device capable of performing both freeze-thaw tests and plate loading tests on geocell-reinforced soils. A thermodynamic numerical model was developed to assist with the design of freeze-thaw component of the device, while the design of plate loading component was developed by referring to features of existing devices. Eleven tests were run on geocell-reinforced and unreinforced sands to confirm the effectiveness of the proposed device. The test results showed the device successfully provided vertical heat transfer in sands during freeze and thaw. After five freeze-thaw cycles, geocells reduced peak frost heave and thaw settlement of sands by 18% and 34%, respectively, and increased the stiffness and bearing capacity by 40% and 253%, respectively. It was found a temperature drop occurred at the interface between cooling plate and sands, which was due to the existence of thermal contact resistance.

  • Closed Access
    Authors: 
    John Paul Archambault;
    Publisher: Elsevier BV
    Country: Canada

    Abstract A simple geometry is used to compare several of the available Monte Carlo software codes for radiation transport. EGSnrc, Geant4 and MCNP5 are all used to calculate the photon fluence produced from electrons incident on a copper target. Four energies for the isotropic point source are chosen to simulate the average and maximum emission energies of 32 P and 90 Y: (0.7, 1.71) MeV and (0.93, 2.28) MeV, respectively. The energy deposition in the copper target, the electron current at the target and the computational efficiency are also calculated. EGSnrc is found to be the only self-consistent code when comparing results calculated using the default transport parameters of the condensed history mode with those calculated in the single scattering mode.

  • Closed Access
    Authors: 
    Jeffrey S. Podoshen; Vivek Venkatesh; Zheng Jin;
    Publisher: SAGE Publications

    This article examines aspects related to the dystopic consumption and production of the musical and performance art form known as black metal. Steeped in anti-Christian motifs, surrounded by a history of violence and brutal imagery, black metal is an extreme metal art form that has been growing steadily in popularity throughout Europe, South America, and the United States. We first examine black metal culture through the eyes of both artists and consumers, using mixed qualitative methodologies. Thereafter, we derive specific theoretical interpretations from the black metal subculture that are predicated on the emerging themes of signification, identity transformation, xenophobia, and a reconstructed mythology that all point to what we present as a dystopian consumption model. The model demonstrates how dystopia, in context, is at the heart of the symbiotic relationship between consumers and producers and is encapsulated by a specific set of processes and overarching conditions. Implications and relationships to utopian models are discussed.

  • Open Access
    Authors: 
    Caroline Lamarche; Jonathan S. Maltzman;
    Publisher: Elsevier BV
  • Open Access
    Authors: 
    Pallavi Surana; Devika Kapuria; Carly Broadwell; Elizabeth C. Wright; Varun Takyar; David E. Kleiner; Marc G. Ghany; Gil Ben-Yakov; Theo Heller; T. Jake Liang; +1 more

    Abstract Background Fibrosis regression has been associated with nucleoside analogue (NA) treatment in chronic hepatitis B (CHB) patients. Although non-invasive fibrosis markers have been evaluated in CHB, their utility for monitoring on-treatment histologic regression has not been evaluated. Aims To characterize improvements in disease severity and the utility of non-invasive biomarkers in CHB NA treated patients. Methods Histology, labs, AST-to-platelet ratio index, and Fibrosis-4 (Fib-4) from treatment-naive CHB patients were evaluated at baseline and longitudinally. Relative change from baseline to various time points during treatment were evaluated. Correlative analysis of APRI and Fib-4 with histology was performed longitudinally. Results 80 CHB patients (84% male, median age 45 (IQR 32, 54)) with histology up to 17 years (median 6(IQR 3.9, 8.0)) years were studied. Median baseline Ishak fibrosis was 3 (IQR 2, 4), histologic activity index (HAI) inflammation was 9 (IQR 7, 11), and AUROC of fibrosis markers for detecting cirrhosis (Ishak ≥ 5) was >0.64. HAI improved at a rate of 54% during year 1 and 37% in year 2, both greater than in the remaining follow-up periods. Within the first year, fibrosis improved by 35%, greater than all other time periods. Non-invasive biomarkers began to correlate with histology beyond 4 years (APRI: 4–6 years: r = 0.33, p = 0.03; ≥6 years: r = 0.41, p = 0.009; Fib-4: ≥6 years: r = 0.35, p = 0.03). Conclusion Early dynamic changes in histology occur in CHB patients on NA followed by linear improvements. Non-invasive fibrosis biomarkers do not capture these dynamic changes and may demonstrate clinical utility beyond 4 years of treatment.

  • Open Access English
    Authors: 
    Josephine Ho; Constadina Panagiotopoulos; Brian W. McCrindle; Silviu Grisaru; Tamara Pringsheim;
    Publisher: Pulsus Group Inc

    Second-generation antipsychotics are commonly associated with metabolic complications. These medications are being used more frequently for the treatment of mental health disorders in children, which has stimulated the need for creating formal guidelines on monitoring their safety and effectiveness. Previous guidelines have been developed for monitoring metabolic and neurological complications. To assist practitioners who perform these monitoring procedures, a complementary set of treatment recommendations have been created for situations in which abnormal measurements or results are encountered.To create evidence-based recommendations to assist in managing metabolic complications in children being treated with second-generation antipsychotics.A systematic review of the literature on metabolic complications of second-generation antipsychotic medications in children was conducted. Members of the consensus group evaluated the information gathered from the systematic review of the literature and used a nominal group process to reach a consensus on treatment recommendations. Wherever possible, references were made to existing guidelines on the evaluation and treatment of metabolic abnormalities in children.Evidence-based recommendations are presented to assist in managing metabolic complications including weight gain; increased waist circumference; elevation in prolactin, cholesterol, triglyceride and glucose levels; abnormal liver function tests; and abnormal thyroid studies.The use of second-generation antipsychotics requires proper monitoring procedures. The present treatment guideline provides guidance to clinicians on the clinical management of metabolic complications if they occur.

  • Open Access English
    Authors: 
    Robin T. Petroze; Allison N. Martin; Edmond Ntaganda; Patrick Kyamanywa; Etienne St-Louis; Sara K. Rasmussen; James Forrest Calland; Jean Claude Byiringiro;
    Publisher: John Wiley & Sons, Ltd
    Project: NIH | Fogarty International Cli... (5R24TW007988-04), NIH | Surgical Infectious Dises... (5T32AI078875-02)

    Background Child survival initiatives historically prioritized efforts to reduce child morbidity and mortality from infectious diseases and maternal conditions. Little attention has been devoted to paediatric injuries in resource‐limited settings. This study aimed to evaluate the demographics and outcomes of paediatric injury in a sub‐Saharan African country in an effort to improve prevention and treatment. Methods A prospective trauma registry was established at the two university teaching campuses of the University of Rwanda to record systematically patient demographics, prehospital care, initial physiology and patient outcomes from May 2011 to July 2015. Univariable analysis was performed for demographic characteristics, injury mechanisms, geographical location and outcomes. Multivariable analysis was performed for mortality estimates. Results Of 11 036 patients in the registry, 3010 (27·3 per cent) were under 18 years of age. Paediatric patients were predominantly boys (69·9 per cent) and the median age was 8 years. The mortality rate was 4·8 per cent. Falls were the most common injury (45·3 per cent), followed by road traffic accidents (30·9 per cent), burns (10·7 per cent) and blunt force/assault (7·5 per cent). Patients treated in the capital city, Kigali, had a higher incidence of head injury (7·6 per cent versus 2·0 per cent in a rural town, P < 0·001; odds ratio (OR) 4·08, 95 per cent c.i. 2·61 to 6·38) and a higher overall injury‐related mortality rate (adjusted OR 3·00, 1·50 to 6·01; P = 0·019). Pedestrians had higher overall injury‐related mortality compared with other road users (adjusted OR 3·26, 1·37 to 7·73; P = 0·007). Conclusion Paediatric injury is a significant contributor to morbidity and mortality. Delineating trauma demographics is important when planning resource utilization and capacity‐building efforts to address paediatric injury in low‐resource settings and identify vulnerable populations. This study evaluated the demographics and outcomes of paediatric injury in Rwanda through a prospective trauma registry to inform capacity‐building for prevention and treatment. Patients treated in the capital city had a higher incidence of head injury and a higher overall injury‐related mortality than those in a rural town. Pedestrians had higher overall injury‐related mortality compared with other road‐users. Falls and road traffic accidents significant contributors to pediatric injury in Rwanda

  • Authors: 
    Jaroslav Opatrny;
    Publisher: Informa UK Limited

    AbstractParallel programming language constructs suitable for Divide-and-Conquer, and Branch-and- Bound algorithms are proposed. These constructs allow a simple specification of the parallelism in the Divide and-Conquer and Branch-and-Bound algorithms and their efficient execution on a bus-connected multi-processor system with a common memory.

  • Closed Access
    Authors: 
    Niels Van Steenkiste; Kevin C. Wakeman; Brian S. Leander;
    Publisher: Elsevier BV
    Project: NSERC

    Abstract Marine gastrotrichs of the Pacific Ocean are poorly known. Here, we report on the finding of a marine chaetonotid gastrotrich of the genus Diuronotus from an intertidal beach within the Sea of Japan in Hokkaido (Japan). The Japanese individual shows a very close resemblance to Diuronotus aspetos. This new record is a consequential extension of its biogeographic range; previous records for representatives of this genus are confined to West Greenland, the North Sea and the east coast of North America. This rarely encountered, but seemingly widespread genus of marine gastrotrichs exemplifies our limited understanding of meiofaunal diversity and distribution patterns caused by sampling bias and insufficient knowledge on nominal species complexes.