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Chronic pain (CP) and posttraumatic stress disorder (PTSD) are both frequent and often comorbid in refugees. To date, few controlled trials have studied the efficacy of treatments targeting this comorbidity; no treatment guidelines yet exist. The authors examined the feasibility and efficacy of short-term cognitive behavioural biofeedback (BF) addressing CP in traumatised refugees. The sample comprised 11 severely traumatised refugees with CP and PTSD (mean age = 36 years, SD = 6), who underwent assessment with the Mini International Neuropsychiatric Interview, Posttraumatic Diagnostic Scale, Pain Disability Index, and Visual Rating Scale. Additionally, coping with pain and psychotherapy tolerance were assessed. Acceptance of BF was high. Pre-post effects were small to medium for increased pain management and associated heart rate reactivity but large for coping with pain. The results encourage further research to confirm whether BF is indicated as a treatment component, but not a stand-alone treatment, for traumatised refugees with comorbid CP and PTSD.

Abstract The continental crust and sub-continental lithospheric mantle (SCLM) are co-dependent reservoirs in terms of their geochemistry, tectonics, and long-term evolution. Obtaining insight into the mechanisms of lithosphere formation and differentiation requires robust constraint on the complex petrological history of mantle rocks. This has proven difficult as samples from the deep mantle are rare and, although many may have formed in the Archean, no such age has been obtained directly from mantle-derived silicate minerals. Lutetium-hafnium geochronology of garnet has the potential of overcoming this limitation. In this study, this technique was applied on fragments of the SCLM exposed in the Norwegian Caledonides. The chronologic record of these rocks is rich and extensive, yet it is difficult to interpret and is, in part, inconsistent. Our Lu–Hf results from supersilicic pyrope in dunite provide the first Archean internal isochron ages for mantle rocks. These ages are consistent with a period of juvenile crust formation worldwide and provide a record of deeply sourced mantle upwellings from >350 km depth. Results from fertile rock types indicate that melting and isotope re-equilibration occurred in sync with two Proterozoic supercontinent break-up events that are recorded in the Laurentian and Baltic lithospheres. Together, the results indicate that since its extraction during a period of rapid Archean crustal growth, the SCLM appears to have largely been at petro-physical and chemical stasis, with the exception of major episodes of continental break-up. The evolution of the SCLM is thus, highly punctuated and ultimately controlled by the Wilson cycle.

Dissolved organic matter (DOM) is a master variable in aquatic systems. Modern fluorescence techniques couple measurements of excitation emission matrix (EEM) spectra and parallel factor analysis (PARAFAC) to determine fluorescent DOM (FDOM) components and DOM quality. However, the molecular signatures associated with PARAFAC components are poorly defined. In the current study we characterized river water samples from boreal Quebec, Canada, using EEM/PARAFAC analysis and ultrahigh resolution mass spectrometry (FTICR-MS). Spearman’s correlation of FTICR-MS peak and PARAFAC component relative intensities determined the molecular families associated with 6 PARAFAC components. Molecular families associated with PARAFAC components numbered from 39 to 572 FTICR-MS derived elemental formulas. Detailed molecular properties for each of the classical humic- and protein-like FDOM components are presented. FTICR-MS formulas assigned to PARAFAC components represented 39% of the total number of formulas identified and 59% of total FTICR-MS peak intensities, and included significant numbers compounds that are highly unlikely to fluoresce. Thus, fluorescence measurements offer insight into the biogeochemical cycling of a large proportion of the DOM pool, including a broad suite of unseen molecules that apparently follow the same gradients as FDOM in the environment.

‘Is political science out of step with the world?’ This question, raised by John E. Trent in a recent issue, is part of a recurring debate about the development of our discipline. In that article, and in a subsequent book with his colleague Michael Stein, John Trent blames adherents of the ‘scientific method’ for political science’s growing irrelevance. We challenge this claim by arguing that Trent falls back on outdated polarities between ‘objective and normative’, and ‘explanation and interpretation’, in order to justify his allegation. We argue for the need to review our methods continuously, rather than dig up a fruitless and biased division between qualitative and quantitative approaches.

Collaborative Mixed Reality (MR) systems are at a critical point in time as they are soon to become more commonplace. However, MR technology has only recently matured to the point where researchers can focus deeply on the nuances of supporting collaboration, rather than needing to focus on creating the enabling technology. In parallel, but largely independently, the field of Computer Supported Cooperative Work (CSCW) has focused on the fundamental concerns that underlie human communication and collaboration over the past 30-plus years. Since MR research is now on the brink of moving into the real world, we reflect on three decades of collaborative MR research and try to reconcile it with existing theory from CSCW, to help position MR researchers to pursue fruitful directions for their work. To do this, we review the history of collaborative MR systems, investigating how the common taxonomies and frameworks in CSCW and MR research can be applied to existing work on collaborative MR systems, exploring where they have fallen behind, and look for new ways to describe current trends. Through identifying emergent trends, we suggest future directions for MR, and also find where CSCW researchers can explore new theory that more fully represents the future of working, playing and being with others Refereed/Peer-reviewed

Background: The diagnosis of solitary cutaneous mastocytoma is mainly clinical, based on lesion morphology, the presence of a positive Darier sign, and the absence of systemic involvement. Knowledge of this condition is important so that an accurate diagnosis can be made. Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of a solitary cutaneous mastocytoma. Methods: A PubMed search was completed in Clinical Queries using the key term "solitary cutaneous mastocytoma". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. Only papers published in English language were included. The information retrieved from the above search was used in the compilation of the present article. Results: Typically, a solitary cutaneous mastocytoma presents as an indurated, erythematous, yellow- brown or reddish-brown macule, papule, plaque or nodule, usually measuring up to 5 cm in diameter. The lesion often has a peau d'orange appearance and a leathery or rubbery consistency. A solitary cutaneous mastocytoma may urticate spontaneously or when stroked or rubbed (Darier sign). Organomegaly and lymphadenopathy are characteristically absent. The majority of patients with skin lesions that erupt within the first two years of life have spontaneous resolution of the lesions before puberty. Treatment is mainly symptomatic. Reassurance and avoidance of triggering factors suffice in most cases. Conclusion: The diagnosis is mainly clinical, based on the morphology of the lesion, the presence of a positive Darier sign, and the absence of systemic involvement. A skin biopsy is usually not necessary unless the diagnosis is in doubt.

A recent joint meeting was held on January 30, 2014, with the US Food and Drug Administration (FDA), National Cancer Institute (NCI), clinical scientists, imaging experts, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocate groups to discuss imaging endpoints for clinical trials in glioblastoma. This workshop developed a set of priorities and action items including the creation of a standardized MRI protocol for multicenter studies. The current document outlines consensus recommendations for a standardized Brain Tumor Imaging Protocol (BTIP), along with the scientific and practical justifications for these recommendations, resulting from a series of discussions between various experts involved in aspects of neuro-oncology neuroimaging for clinical trials. The minimum recommended sequences include: (i) parameter-matched precontrast and postcontrast inversion recovery-prepared, isotropic 3D T1-weighted gradient-recalled echo; (ii) axial 2D T2-weighted turbo spin-echo acquired after contrast injection and before postcontrast 3D T1-weighted images to control timing of images after contrast administration; (iii) precontrast, axial 2D T2-weighted fluid-attenuated inversion recovery; and (iv) precontrast, axial 2D, 3-directional diffusion-weighted images. Recommended ranges of sequence parameters are provided for both 1.5 T and 3 T MR systems.

We have used spectra of hot stars from the RAVE Survey in order to investigate the visibility and properties of five diffuse interstellar bands previously reported in the literature. The RAVE spectroscopic survey for Galactic structure and kinematics records CCD spectra covering the 8400-8800 Ang wavelength region at 7500 resolving power. The spectra are obtained with the UK Schmidt at the AAO, equipped with the 6dF multi-fiber positioner. The DIB at 8620.4 Ang is by far the strongest and cleanest of all DIBs occurring within the RAVE wavelength range, with no interference by underlying absorption stellar lines in hot stars. It correlates so tightly with reddening that it turns out to be a reliable tool to measure it, following the relation E(B-V) = 2.72 (+/- 0.03) x E.W.(Ang), valid throughout the general interstellar medium of our Galaxy. The presence of a DIB at 8648 Ang is confirmed. Its intensity appears unrelated to reddening, in agreement with scanty and preliminary reports available in the literature, and its measurability is strongly compromised by severe blending with underlying stellar HeI doublet at 8649 Ang. The two weak DIBS at 8531 and 8572 Ang do not appear real and should actually be blends of underlying stellar lines. The very weak DIB at 8439 Ang cannot be resolved within the profile of the much stronger underlying hydrogen Paschen 18 stellar line. Accepted in press by A&A

Background: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one disorder in relatives of the other, but sufficiently powered data sets are difficult to achieve. The genomics era presents an alternative paradigm for investigating the genetic relationship between two uncommon disorders. Methods: We use genome-wide common single nucleotide polymorphism (SNP) data from independently collected SZ and RA case-control cohorts to estimate the SNP correlation between the disorders. We test a genotype X environment (GxE) hypothesis for SZ with environment defined as winter- vs summer-born. Results: We estimate a small but significant negative SNP-genetic correlation between SZ and RA (−0.046, s.e. 0.026, P = 0.036). The negative correlation was stronger for the SNP set attributed to coding or regulatory regions (−0.174, s.e. 0.071, P = 0.0075). Our analyses led us to hypothesize a gene-environment interaction for SZ in the form of immune challenge. We used month of birth as a proxy for environmental immune challenge and estimated the genetic correlation between winter-born and non-winter born SZ to be significantly less than 1 for coding/regulatory region SNPs (0.56, s.e. 0.14, P = 0.00090). Conclusions: Our results are consistent with epidemiological observations of a negative relationship between SZ and RA reflecting, at least in part, genetic factors. Results of the month of birth analysis are consistent with pleiotropic effects of genetic variants dependent on environmental context. Refereed/Peer-reviewed

Single crystals of Ga-containing MAX-phases Ti{sub 2}GaC, Ti{sub 4}GaC{sub 3}, and Cr{sub 2}GaC were grown from a metallic melt generated by an excess of Ga. This technique allows the crystal growth at different temperatures to control the product distribution. Compounds developed were Ti{sub 2}GaC and TiC at 1500 deg. C, and Ti{sub 2}GaC and Ti{sub 4}GaC{sub 3} at 1300 deg. C. Crystal structures were refined from single crystal data. Ti{sub 2}GaC and Cr{sub 2}GaC were previously known, and belong to the Cr{sub 2}AlC type as well as the solid solutions V{sub 2}Ga{sub 1-x}Al{sub x}C and Cr{sub 2}Ga{sub 1-x}Al{sub x}C. Ti{sub 4}GaC{sub 3} is one of the few 413-phases (P6{sub 3}/mmc, a=3.0690(4) A, c=23.440(5) A) and the first Ga-containing representative. The crystal structures of MAX-phases are intergrowths of layers of an intermetallic MGa in a hexagonal stacking sequence with carbidic layers (MC){sub n} of the NaCl type. The thickness of the layer depends from the value of n. The results of the structure refinements also demonstrate that also the structural details follow this description. - Graphical abstract: Single crystals of Ga-containing MAX-Phases (TiC){sub n}(TiGa) (n=1, 3) were grown from a metallic melt including and characterised by X-ray diffraction. Ti{sub 4}GaC{sub 3}more » is one of the few 413-phase and the first containing Ga.« less