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description Publicationkeyboard_double_arrow_right Preprint , Article , Other literature type 2018 FranceCopernicus GmbH SNSF | Volcanic Eruptions and th..., SNSF | Future and Past Solar Inf..., EC | STRATOCLIM +1 projectsSNSF| Volcanic Eruptions and their impact on future Climate (VEC) ,SNSF| Future and Past Solar Influence on the Terrestrial Climate II ,EC| STRATOCLIM ,SNSF| Study to determine Spectral Solar Irradiance and its impact on the middle atmosphere (SIMA)Kévin Lamy; Thierry Portafaix; Béatrice Josse; Colette Brogniez; Sophie Godin-Beekmann; Hassan Bencherif; Laura E. Revell; Hideharu Akiyoshi; Slimane Bekki; Michaela I. Hegglin; Patrick Jöckel; Oliver Kirner; Virginie Marécal; Olaf Morgenstern; Andrea Stenke; Guang Zeng; N. Luke Abraham; Alexander T. Archibald; N. Butchart; Martyn P. Chipperfield; Glauco Di Genova; Makoto Deushi; Sandip Dhomse; Rong-Ming Hu; Douglas E. Kinnison; Martine Michou; Fiona M. O'Connor; Luke D. Oman; Giovanni Pitari; David A. Plummer; John A. Pyle; Eugene Rozanov; David Saint-Martin; Kengo Sudo; Taichu Tanaka; Daniele Visioni; Kohei Yoshida;We have derived values of the Ultraviolet Index (UVI) at solar noon using the Tropospheric Ultraviolet Model (TUV) driven by ozone, temperature and aerosol fields from climate simulations of the first phase of the Chemistry-Climate Model Initiative (CCMI-1). Since clouds remain one of the largest uncertainties in climate projections, we simulated only the clear-sky UVI. We compared the modelled UVI climatologies against present-day climatological values of UVI derived from both satellite data (the OMI-Aura OMUVBd product) and ground-based measurements (from the NDACC network). Depending on the region, relative differences between the UVI obtained from CCMI/TUV calculations and the ground-based measurements ranged between −5.9% and 10.6%. We then calculated the UVI evolution throughout the 21st century for the four Representative Concentration Pathways (RCPs 2.6, 4.5, 6.0 and 8.5). Compared to 1960s values, we found an average increase in the UVI in 2100 (of 2–4%) in the tropical belt (30°N-30°S). For the mid-latitudes, we observed a 1.8 to 3.4 % increase in the Southern Hemisphere for RCP 2.6, 4.5 and 6.0, and found a 2.3% decrease in RCP 8.5. Higher increases in UVI are projected in the Northern Hemisphere except for RCP 8.5. At high latitudes, ozone recovery is well identified and induces a complete return of mean UVI levels to 1960 values for RCP 8.5 in the Southern Hemisphere. In the Northern Hemisphere, UVI levels in 2100 are higher by 0.5 to 5.5% for RCP 2.6, 4.5 and 6.0 and they are lower by 7.9% for RCP 8.5. We analysed the impacts of greenhouse gases (GHGs) and ozone-depleting substances (ODSs) on UVI from 1960 by comparing CCMI sensitivity simulations (1960–2100) with fixed GHGs or ODSs at their respective 1960 levels. As expected with ODS fixed at their 1960 levels, there is no large decrease in ozone levels and consequently no sudden increase in UVI levels. With fixed GHG, we observed a delayed return of ozone to 1960 values, with a corresponding pattern of change observed on UVI, and looking at the UVI difference between 2090s values and 1960s values, we found an 8 % increase in the tropical belt during the summer of each hemisphere. Finally we show that, while in the Southern Hemisphere the UVI is mainly driven by total ozone column, in the Northern Hemisphere both total ozone column and aerosol optical depth drive UVI levels, with aerosol optical depth having twice as much influence on the UVI as total ozone column does.
https://doi.org/10.5... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-InsermArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert https://doi.org/10.5... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-InsermArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/acp-2018-525&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Preprint , Article 2022 Netherlands, Denmark, Netherlands, Netherlands, GermanyCopernicus GmbH ANR | RESTORE, EC | NunataryukANR| RESTORE ,EC| NunataryukMartine Lizotte; Bennet Juhls; Atsushi Matsuoka; Philippe Massicotte; Gaëlle Mével; David Obie James Anikina; Sofia Antonova; Guislain Bécu; Marine Béguin; Simon Bélanger; Thomas Bossé-Demers; Lisa Bröder; Flavienne Bruyant; Gwénaëlle Chaillou; Jérôme Comte; Raoul-Marie Couture; Emmanuel Devred; Gabrièle Deslongchamps; Thibaud Dezutter; Miles Dillon; David Doxaran; Aude Flamand; Frank Fell; Joannie Ferland; Marie-Hélène Forget; Michael Fritz; Thomas J. Gordon; Caroline Guilmette; Andrea Hilborn; Rachel Hussherr; Charlotte Irish; Fabien Joux; Lauren Kipp; Audrey Laberge-Carignan; Hugues Lantuit; Edouard Leymarie; Antonio Mannino; Juliette Maury; Paul Overduin; Laurent Oziel; Colin Stedmon; Crystal Thomas; Lucas Tisserand; Jean-Éric Tremblay; Jorien Vonk; Dustin Whalen; Marcel Babin;Climate warming and related drivers of soil thermal change in the Arctic are expected to modify the distribution and dynamics of carbon contained in perennially frozen grounds. Thawing of permafrost in the Mackenzie Delta region of northwestern Canada, coupled with increases in river discharge and coastal erosion, trigger the release of terrestrial organic matter (OMt) from the largest Arctic drainage basin in North America into the Arctic Ocean. While this process is ongoing, well-established, and its rate is accelerating, the fate of the newly-mobilized organic matter, as it transits from the watershed through the delta and into the marine system, remains poorly understood. In the framework of the European Horizon 2020 Nunataryuk programme, and as part of the Work Package 4 (WP4) Coastal Waters theme, four field expeditions were conducted in the Mackenzie Delta region and southern Beaufort Sea from April to September 2019. The temporal sampling design allowed the survey of ambient conditions in the coastal waters under full ice cover prior to the spring freshet, during ice break-up in summer, as well as anterior to the freeze-up period in fall. To capture the fluvial-marine transition zone, and with distinct challenges related to shallow waters and changing seasonal and meteorological conditions, the field sampling was conducted in close partnership with members of the communities of Aklavik, Inuvik and Tuktoyaktuk, using several platforms: helicopters, snowmobiles and small boats. Water column profiles of physical and optical variables were measured in situ, while surface water, groundwater and sediment samples were collected and preserved for the determination of the composition and sources of OMt, including particulate and dissolved organic carbon (POC, DOC), and chromophoric dissolved organic matter (CDOM), as well as a suite of physical, chemical and biological variables. Here we present an overview of the standardized datasets, including hydrographic profiles, remote sensing reflectance, temperature and salinity, particle absorption, nutrients, dissolved organic carbon, particulate organic carbon, particulate organic nitrogen, colored dissolved organic matter absorption, fluorescent dissolved organic matter intensity, suspended particulate matter, total particulate carbon, total particulate nitrogen, stable water isotopes, radon in water, bacterial abundance, and a string of phytoplankton pigments including total chlorophyll. Datasets and related metadata can be found in Juhls et al. 2021. https://doi.pangaea.de/10.1594/PANGAEA.937587.
Earth System Science... arrow_drop_down Electronic Publication Information CenterArticle . 2023Data sources: Electronic Publication Information CenterOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert Earth System Science... arrow_drop_down Electronic Publication Information CenterArticle . 2023Data sources: Electronic Publication Information CenterOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Medical Journals Sweden AB Authors: Alice Kieny; Valérie Kremer; Sophie Scheidecker; Dan Lipsker;Alice Kieny; Valérie Kremer; Sophie Scheidecker; Dan Lipsker;pmid: 29057423
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2340/00015555-2822&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2340/00015555-2822&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Canada, FranceConsortium Erudit Authors: Fabien Bourlon;Fabien Bourlon;doi: 10.7202/1074898ar
Avec la crise du coronavirus, les destinations lointaines de nature comme la Patagonie chilienne sont inquiètes d’un effondrement du tourisme. Les communautés locales, apeurées par les risques liés à l’accueil de visiteurs, se replient et se protègent. Les entrepreneurs espèrent un rapide retour à la « normalité » d’une zone relativement épargnée par la COVID-19, mais craignent la fin du boom touristique, car prendre l’avion restera anxiogène dans un contexte de pandémie. Ces destinations devraient recentrer leur offre afin de capter une clientèle de proximité, mais cela semble un défi peu rentable pour les zones isolées. Alors que les entrepreneurs affinent leur plan marketing et les services d’État leurs protocoles d’accueil sécurisés, les animateurs de projets touristiques écologiques, axés sur la conservation, le tourisme rural et les migrations d’agrément, font valoir leurs atouts. L’actuelle crise pourrait mettre fin au tourisme de masse, à l’hypermobilité vers des hauts lieux et aux projets basés sur la rentabilité. La crise socioenvironnementale globale est l’occasion de repenser les rapports à la nature et de renforcer les systèmes touristiques locaux, pensés comme des lieux de vie, basés sur des économies rurales respectueuses de l’environnement, les échanges culturels, scientifiques et traditionnels, attirants autant pour les clientèles nationales qu’étrangères. With the coronavirus crisis, remote nature destinations like Chilean Patagonia are worried of a possible collapse of tourism. Local communities, frightened by the risks of welcoming visitors, are withdrawing and protecting themselves. Entrepreneurs hope for a rapid return to “normality” in an area relatively untouched by COVID-19 but they fear the end of the tourism boom, as flying will remain an anxiety-provoking issue in a post-pandemic situation. These destinations have to refocus their offer in order to capture a national clientele, but this seems an unprofitable challenge for isolated areas. While entrepreneurs are refining their marketing plans and government services are establishing their secure reception protocols, leaders of ecological and conservation tourism projects along with rural tourism and leisure migration stakeholders are highlighting their assets. The current crisis could put an end to mass tourism, hypermobilities, projects based on high profitability and overtourism in iconic places. In that sense, the present global socioenvironmental crisis is an opportunity to rethink our relationship with nature and seek ways to strengthen local tourism systems, conceived as places to live and based on environmentally friendly rural economies, cultural, scientific, and traditional exchanges, attractive both to national and foreign visitors.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7202/1074898ar&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7202/1074898ar&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2015 FranceEDP Sciences NSERC, ANR | TUMSENSERC ,ANR| TUMSEFabrice Martins; A. Hervé; J. C. Bouret; W. L. F. Marcolino; Gregg A. Wade; Coralie Neiner; Evelyne Alecian; Jason Grunhut; Véronique Petit;The evolution of massive stars is still partly unconstrained. Mass, metallicity, mass loss and rotation are the main drivers of stellar evolution. Binarity and magnetic field may also significantly affect the fate of massive stars. Our goal is to investigate the evolution of single O stars in the Galaxy. For that, we use a sample of 74 objects comprising all luminosity classes and spectral types from O4 to O9.7. We rely on optical spectroscopy obtained in the context of the MiMeS survey of massive stars. We perform spectral modelling with the code CMFGEN. We determine the surface properties of the sample stars, with special emphasis on abundances of carbon, nitrogen and oxygen. Most of our sample stars have initial masses in the range 20 to 50 Msun. We show that nitrogen is more enriched and carbon/oxygen more depleted in supergiants than in dwarfs, with giants showing intermediate degrees of mixing. CNO abundances are observed in the range of values predicted by nucleosynthesis through the CNO cycle. More massive stars, within a given luminosity class, appear to be more chemically enriched than lower mass stars. We compare our results with predictions of three types of evolutionary models and show that, for two sets of models, 80% of our sample can be explained by stellar evolution including rotation. The effect of magnetism on surface abundances is unconstrained. Our study indicates that, in the 20-50 Msun mass range, the surface chemical abundances of most single O stars in the Galaxy are fairly well accounted for by stellar evolution of rotating stars. Comment: 15 pages, 12 figures. Accepted in Astronomy & Astrophysics
Astronomy and Astrop... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1051/0004-6361/201425173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu89 citations 89 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Astronomy and Astrop... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1051/0004-6361/201425173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Belgium, ItalySpringer Science and Business Media LLC Takahiro Soda; Declan M. McLoughlin; Scott R. Clark; Leif Oltedal; Ute Kessler; Jan Haavik; Chad A. Bousman; Daniel J. Smith; Miquel Bioque; Caitlin C. Clements; Colleen Loo; Fidel Vila-Rodriguez; Alessandra Minelli; Brian J. Mickey; Roumen Milev; Anna R. Docherty; Julie Langan Martin; Eric D. Achtyes; Volker Arolt; Ronny Redlich; Udo Dannlowski; Narcís Cardoner; Emily Clare; Nicholas John Craddock; Arianna Di Florio; Monika Dmitrzak-Weglarz; Liz Forty; Katherine Gordon-Smith; Mustafa M. Husain; Wendy Marie Ingram; Lisa Jones; Ian Jones; Mario Francisco Juruena; George Kirov; Mikael Landén; Daniel J. Müller; Axel Nordensköld; Erik Pålsson; Meethu Paul; Agnieszka Permoda; Bartlomiej Pliszka; Jamie Rea; Klaus Oliver Schubert; Joshua A. Sonnen; Virginia Soria; Will Stageman; Akihiro Takamiya; Mikel Urretavizacaya; Stuart Watson; Maxim Zavorotny; Allan H. Young; Eduard Vieta; Janusz K. Rybakowski; Massimo Gennarelli; Peter P. Zandi; Patrick F. Sullivan; Bernhard T. Baune;Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic studies of patients at the most severe end of the depressive disorder spectrum, those with treatment-resistant depression and who are prescribed electroconvulsive therapy (ECT), could lead to a better understanding of the genetic underpinnings of depression. Despite ECT being one of the most effective forms of treatment for severe depressive disorders, it is usually placed at the end of treatment algorithms of current guidelines. This is perhaps because ECT has controlled risk and logistical demands including use of general anaesthesia and muscle relaxants and side-effects such as short-term memory impairment. Better understanding of the genetics and biology of ECT response and of cognitive side-effects could lead to more personalized treatment decisions. To enhance the understanding of the genomics of severe depression and ECT response, researchers and ECT providers from around the world and from various depression or ECT networks, but not limited to, such as the Psychiatric Genomics Consortium, the Clinical Alliance and Research in ECT, and the National Network of Depression Centers have formed the Genetics of ECT International Consortium (Gen-ECT-ic). Gen-ECT-ic will organize the largest clinical and genetic collection to date to study the genomics of severe depressive disorders and response to ECT, aiming for 30,000 patients worldwide using a GWAS approach. At this stage it will be the largest genomic study on treatment response in depression. Retrospective data abstraction and prospective data collection will be facilitated by a uniform data collection approach that is flexible and will incorporate data from many clinical practices. Gen-ECT-ic invites all ECT providers and researchers to join its efforts. ispartof: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE vol:270 issue:7 pages:921-932 ispartof: location:Germany status: published
CORE (RIOXX-UK Aggre... arrow_drop_down European Archives of Psychiatry and Clinical NeuroscienceArticle . 2019License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
visibility 0visibility views 0 download downloads 200 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down European Archives of Psychiatry and Clinical NeuroscienceArticle . 2019License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019Springer Science and Business Media LLC Pierre-Emmanuel Bouet; Hugo Madar; Alizée Froeliger; Hady El Hachem; Elsa Schinkel; Aurelien Mattuizi; Loïc Sentilhes;Background Postpartum haemorrhage (PPH) is a major cause of maternal morbidity and one of the leading causes of maternal mortality worldwide. Many medical treatments and interventions are available nowadays, but surgical treatment is sometimes required when less invasive methods are unsuccessful. This study aimed to assess the theoretical and practical knowledge of French residents of Obstetrics and Gynecology concerning the surgical treatment of postpartum haemorrhage. Study design We performed a questionnaire study for senior residents of Obstetrics and Gynecology in France (fourth and fifth year of training). An anonymous survey was sent by email. Between December 2013 and April 2014, a total of 370 residents responded. Result The response rate was 47.6% (176/370). Only 156 questionnaires were fully completed and included for analysis. In all, 74% (115/156) of residents reported not mastering sufficiently or at all the technique for bilateral ligation of uterine arteries, 79% (123/156) for uterine compression sutures, 95% (148/156) for ligation of the internal iliac arteries, and 78% (122/156) for emergency peripartum hysterectomy. More than half of respondents (55%, 86/156) stated that they had not mastered any of these techniques. Conclusion An alarmingly high number of French senior residents in Obstetrics and Gynecology report that they have not acquired the sufficient surgical skills during their training to be able to perform the surgeries required for the management of PPH. Electronic supplementary material The online version of this article (10.1186/s12884-019-2237-3) contains supplementary material, which is available to authorized users.
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12884-019-2237-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Heighten Science Publications Corporation Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;New Insights in Obes... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.29328/journal.niogb.1001009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert New Insights in Obes... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2013 United Kingdom, Netherlands, Italy, IrelandSpringer Science and Business Media LLC EC | COGS, NIH | Genetic epidemiology of c..., NIH | Breast &prostate cancer &... +6 projectsEC| COGS ,NIH| Genetic epidemiology of cell division regulation in breast cancer ,NIH| Breast &prostate cancer &hormone-related gene variants ,CIHR ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer;the BPC3 ,NIH| Discovery Expansion and Replication ,NIH| Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3. ,NIH| Breast &Prostate Cancer &Hormone-related Gene Variants ,WTAuthors: Montserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; +215 AuthorsMontserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Nick Orr; Suhn K. Rhie; Elio Riboli; Loic Le Marchand; Julie E. Buring; Diana Eccles; Peter A. Fasching; Hiltrud Brauch; Jenny Chang-Claude; Andrew K. Godwin; Heli Nevanlinna; Graham G. Giles; Angela Cox; John L. Hopper; Manjeet K. Bolla; Qin Wang; Joe Dennis; Ed Dicks; Nils Schoof; Stig E. Bojesen; Diether Lambrechts; Annegien Broeks; Irene L. Andrulis; Pascal Guénel; Barbara Burwinkel; Antoinette Hollestelle; Olivia Fletcher; Robert Winqvist; Hermann Brenner; Arto Mannermaa; Ute Hamann; Alfons Meindl; Peter Devillee; Jan Lubinski; Vessela N. Kristensen; Anthony J. Swerdlow; Thilo Dörk; Keitaro Matsuo; Anna H. Wu; Paolo Radice; William Blot; Daehee Kang; Mikael Hartman; Suleeporn Sangrajrang; Chen-Yang Shen; Melissa C. Southey; Daniel J. Park; Fleur Hammet; Jennifer Stone; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Julian Peto; Michael G. Schrauder; Arif B. Ekici; Matthias W. Beckmann; Isabel dos Santos Silva; Nichola Johnson; Helen R. Warren; Ian Tomlinson; Michael J. Kerin; Nicola Miller; Federick Marme; Christof Sohn; Thérèse Truong; Pierre Laurent-Puig; Pierre Kerbrat; Børge G. Nordestgaard; Sune F. Nielsen; Henrik Flyger; Roger L. Milne; Jose Ignacio Arias Perez; Primitiva Menéndez; Heiko Müller; Christa Stegmaier; Magdalena Lochmann; Christina Justenhoven; Yon Ko; Taru A. Muranen; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Tuomas Heikkinen; Hidemi Ito; Hiroji Iwata; Yasushi Yatabe; Natalia Antonenkova; Sara Margolin; Vesa Kataja; Jaana M. Hartikainen; Rosemary L. Balleine; David Van Den Berg; Patrick Neven; Anne Sophie Dieudonne; Karin Leunen; Anja Rudolph; Dieter Flesch-Janys; Paolo Peterlongo; Bernard Peissel; Loris Bernard; Janet E. Olson; Xianshu Wang; Kristen N. Stevens; Gianluca Severi; Laura Baglietto; Catriona McLean; Gerhard A. Coetzee; Ye Feng; Brian E. Henderson; Fredrick R. Schumacher; Natalia Bogdanova; Martine Dumont; Cheng Har Yip; Nur Aishah Taib; Ching-Yu Cheng; Martha J. Shrubsole; Jirong Long; Katri Pylkäs; Arja Jukkola-Vuorinen; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; R.A.E.M. Tollenaar; Mieke Kriege; Maartje J. Hooning; Carolien H.M. van Deurzen; Wei Lu; Hui Cai; Sabapathy P. Balasubramanian; Simon S. Cross; Malcolm W.R. Reed; Hui Miao; Ching Wan Chan; Anna Jakubowska; Katarzyna Jaworska; Katarzyna Durda; Chia-Ni Hsiung; Pei Ei Wu; Alan Ashworth; Michael Jones; Daniel C. Tessier; Anna González-Neira; Guillermo Pita; M. Rosario Alonso; Daniel Vincent; Francois Bacot; Christine B. Ambrosone; Elisa V. Bandera; Esther M. John; Gary K. Chen; Jennifer J. Hu; Jorge L. Rodriguez-Gil; Michael F. Press; Sandra Deming-Halverson; Sarah J. Nyante; Sue A. Ingles; Quinten Waisfisz; Enes Makalic; Daniel F. Schmidt; Minh Bui; Lorna Gibson; Bertram Müller-Myhsok; Rita K. Schmutzler; Rebecca Hein; Norbert Dahmen; Lars Beckmann; Kamila Czene; Astrid Irwanto; Jianjun Liu; Clare Turnbull; Nazneen Rahman; Hanne Meijers-Heijboer; Fernando Rivadeneira; Curtis Olswold; Susan L. Slager; Robert Pilarski; Foluso O. Ademuyiwa; Irene Konstantopoulou; Nicholas G. Martin; Grant W. Montgomery; Dennis J. Slamon; Claudia Rauh; Michael P. Lux; Sebastian M. Jud; Thomas Brüning; JoEllen Weaver; Priyanka Sharma; Harsh B. Pathak; William J. Tapper; Lorraine Durcan; Rosario Tumino; Petra H.M. Peeters; Federico Canzian; Elisabete Weiderpass; Mattias Johansson; Kay-Tee Khaw; Laurence N. Kolonel; Constance Chen; Andrew H. Beck; Susan E. Hankinson; Christine D. Berg; Robert N. Hoover; Jolanta Lissowska; Jonine D. Figueroa; Daniel I. Chasman; Mia M. Gaudet; David J. Hunter; Jacques Simard; Javier Benitez; Alison M. Dunning; Mark E. Sherman; Georgia Chenevix-Trench; Stephen J. Chanock; Christopher A. Haiman; Peter Kraft;Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
CORE (RIOXX-UK Aggre... arrow_drop_down Nature Genetics; Oxford University Research Archive; NARCISOther literature type . Article . 2013 . 2016License: http://www.springer.com/tdmArchivio della Ricerca - Università di PisaArticle . 2013Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.2561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu398 citations 398 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!
visibility 13visibility views 13 download downloads 125 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Nature Genetics; Oxford University Research Archive; NARCISOther literature type . Article . 2013 . 2016License: http://www.springer.com/tdmArchivio della Ricerca - Università di PisaArticle . 2013Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.2561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu- The impact on social relationships of moving from congregated settings to personalized accommodation
description Publicationkeyboard_double_arrow_right Article 2017SAGE Publications Authors: Roy McConkey; Brendan Bunting; Fiona Keogh; Edurne Garcia Iriarte;Roy McConkey; Brendan Bunting; Fiona Keogh; Edurne Garcia Iriarte;pmid: 28651501
A natural experiment contrasted the social relationships of people with intellectual disabilities ( n = 110) before and after they moved from congregated settings to either personalized accommodation or group homes. Contrasts could also be drawn with individuals who had enduring mental health problems ( n = 46) and who experienced similar moves. Face-to-face interviews were conducted in each person’s residence on two occasions approximately 24 months apart. Multivariate statistical analyses were used to determine significant effects. Greater proportions of people living in personalized settings scored higher on the five chosen indicators of social relationships than did persons living in grouped accommodation. However, multivariate statistical analyses identified that only one in five persons increased their social relationships as a result of changes in their accommodation, particularly persons with an intellectual disability and high support needs. These findings reinforce the extent of social isolation experienced by people with disabilities and mental health problems that changes in their accommodation only partially counter.
Journal of Intellect... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1744629517716546&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Average influence Average impulse Average Powered by BIP!
more_vert Journal of Intellect... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1744629517716546&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Preprint , Article , Other literature type 2018 FranceCopernicus GmbH SNSF | Volcanic Eruptions and th..., SNSF | Future and Past Solar Inf..., EC | STRATOCLIM +1 projectsSNSF| Volcanic Eruptions and their impact on future Climate (VEC) ,SNSF| Future and Past Solar Influence on the Terrestrial Climate II ,EC| STRATOCLIM ,SNSF| Study to determine Spectral Solar Irradiance and its impact on the middle atmosphere (SIMA)Kévin Lamy; Thierry Portafaix; Béatrice Josse; Colette Brogniez; Sophie Godin-Beekmann; Hassan Bencherif; Laura E. Revell; Hideharu Akiyoshi; Slimane Bekki; Michaela I. Hegglin; Patrick Jöckel; Oliver Kirner; Virginie Marécal; Olaf Morgenstern; Andrea Stenke; Guang Zeng; N. Luke Abraham; Alexander T. Archibald; N. Butchart; Martyn P. Chipperfield; Glauco Di Genova; Makoto Deushi; Sandip Dhomse; Rong-Ming Hu; Douglas E. Kinnison; Martine Michou; Fiona M. O'Connor; Luke D. Oman; Giovanni Pitari; David A. Plummer; John A. Pyle; Eugene Rozanov; David Saint-Martin; Kengo Sudo; Taichu Tanaka; Daniele Visioni; Kohei Yoshida;We have derived values of the Ultraviolet Index (UVI) at solar noon using the Tropospheric Ultraviolet Model (TUV) driven by ozone, temperature and aerosol fields from climate simulations of the first phase of the Chemistry-Climate Model Initiative (CCMI-1). Since clouds remain one of the largest uncertainties in climate projections, we simulated only the clear-sky UVI. We compared the modelled UVI climatologies against present-day climatological values of UVI derived from both satellite data (the OMI-Aura OMUVBd product) and ground-based measurements (from the NDACC network). Depending on the region, relative differences between the UVI obtained from CCMI/TUV calculations and the ground-based measurements ranged between −5.9% and 10.6%. We then calculated the UVI evolution throughout the 21st century for the four Representative Concentration Pathways (RCPs 2.6, 4.5, 6.0 and 8.5). Compared to 1960s values, we found an average increase in the UVI in 2100 (of 2–4%) in the tropical belt (30°N-30°S). For the mid-latitudes, we observed a 1.8 to 3.4 % increase in the Southern Hemisphere for RCP 2.6, 4.5 and 6.0, and found a 2.3% decrease in RCP 8.5. Higher increases in UVI are projected in the Northern Hemisphere except for RCP 8.5. At high latitudes, ozone recovery is well identified and induces a complete return of mean UVI levels to 1960 values for RCP 8.5 in the Southern Hemisphere. In the Northern Hemisphere, UVI levels in 2100 are higher by 0.5 to 5.5% for RCP 2.6, 4.5 and 6.0 and they are lower by 7.9% for RCP 8.5. We analysed the impacts of greenhouse gases (GHGs) and ozone-depleting substances (ODSs) on UVI from 1960 by comparing CCMI sensitivity simulations (1960–2100) with fixed GHGs or ODSs at their respective 1960 levels. As expected with ODS fixed at their 1960 levels, there is no large decrease in ozone levels and consequently no sudden increase in UVI levels. With fixed GHG, we observed a delayed return of ozone to 1960 values, with a corresponding pattern of change observed on UVI, and looking at the UVI difference between 2090s values and 1960s values, we found an 8 % increase in the tropical belt during the summer of each hemisphere. Finally we show that, while in the Southern Hemisphere the UVI is mainly driven by total ozone column, in the Northern Hemisphere both total ozone column and aerosol optical depth drive UVI levels, with aerosol optical depth having twice as much influence on the UVI as total ozone column does.
https://doi.org/10.5... arrow_drop_down HAL Descartes; HAL-Pasteur; HAL-InsermArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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