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description Publicationkeyboard_double_arrow_right Other literature type , Article 2020 CanadaInforma UK Limited Jing Chen; Youxiu Zhong; Yu Liu; Chongfa Tang; Yanbin Zhang; Bo Wei; Wangxue Chen; Meiying Liu;Under the trend of antibiotic resistance of H. pylori leading to the decrease of eradication rate, the development of a vaccine is the best choice to fight against H. pylori. In this study, we attempted to reduce the amounts of required antigens by using three different parenteral routes of immunization and an adjuvant cGAMP (cyclic guanosine monophosphate-adenosine monophosphate) to enhance the immunogenicity of the vaccine candidate. The immune protection and post-challenge immune responses were assessed and compared in mice immunized with recombinant Helicobacter pylori urease A, urease B, and neutrophil-activating protein adjuvanted with cGAMP. The gastric mucosal colonization by H. pylori was significantly reduced in mice immunized by intranasal and, to a less degree, subcutaneous route, but not by intramuscular route. All immunized mice, regardless of the route of immunization, displayed significant, but comparable, increases in antigen-specific serum IgG and mucosal IgA responses 5 weeks post-challenge. The magnitude of the vaccine-induced protection appeared to be associated with the level of antigen-specific Th1 and particularly Th17 responses, as IL-17 responses were only detected in intranasally immunized mice. Taken together, we explored and confirmed the possibility of using a novel adjuvant (cGAMP) to induce significant protective immunity with 10% of oral vaccine antigen dosage through parenteral immunization, especially intranasal immunization. This may provide an alternative approach to oral immunization for the development of effective H. pylori vaccines.
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For further information contact us at helpdesk@openaire.eu15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2003 CanadaWiley J. Taylor; J. A. Beraldin; Guy Godin; Luc Cournoyer; R. Baribeau; Francois Blais; Marc Rioux; J. Domey;doi: 10.1002/vis.311
The National Research Council of Canada (NRC) has developed and patented three high-resolution 3D imaging systems and processing algorithms which have been applied to a wide range of museum and heritage recording applications. The systems have been designed for different imaging applications and, in collaboration with a number of national and international museums and cultural agencies, have been used to scan a wide variety of objects and sites. The objective of this paper is to present a summary of the 3D technology and examples of its heritage applications. Copyright © 2003 John Wiley & Sons, Ltd.
The Journal of Visua... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Average influence Top 10% impulse Average Powered by BIP!
more_vert The Journal of Visua... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/vis.311&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2010 CanadaSpringer Science and Business Media LLC Authors: Taijiro Sato; James J. Beaudoin;Taijiro Sato; James J. Beaudoin;Freezing and thawing properties of cement paste were studied using an alternating current impedance spectroscopy (ACIS) technique coupled with the thermomechanical analysis (TMA). The measurements from the ACIS were analyzed in association with the length change of the cement paste determined by TMA. The micro-scale behavior of cement paste observed by the ACIS technique was well correlated with the residual expansion of cement paste after the freezing and thawing cycle. The efficacy of the ACIS technique for assessing the durability of cement paste to frost action was confirmed.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1617/s11527-010-9635-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Top 10% influence Top 10% impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1617/s11527-010-9635-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2019 CanadaMDPI AG Bassel Akache; Lise Deschatelets; Blair A. Harrison; Renu Dudani; Felicity C. Stark; Yimei Jia; Amir Landi; John Lok Man Law; Michael Logan; Darren Hockman; Juthika Kundu; D. Lorne Tyrrell; Lakshmi Krishnan; Michael Houghton; Michael J McCluskie;Infection by Hepatitis C virus (HCV) can lead to liver cirrhosis/hepatocellular carcinoma and remains a major cause of serious disease morbidity and mortality worldwide. However, current treatment regimens remain inaccessible to most patients, particularly in developing countries, and, therefore, the development of a novel vaccine capable of protecting subjects from chronic infection by HCV could greatly reduce the rates of HCV infection, subsequent liver pathogenesis, and in some cases death. Herein, we evaluated two different semi-synthetic archaeosome formulations as an adjuvant to the E1/E2 HCV envelope protein in a murine model and compared antigen-specific humoral (levels of anti-E1/E2 IgG and HCV pseudoparticle neutralization) and cellular responses (numbers of antigen-specific cytokine-producing T cells) to those generated with adjuvant formulations composed of mimetics of commercial adjuvants including a squalene oil-in-water emulsion, aluminum hydroxide/monophosphoryl lipid A (MPLA) and liposome/MPLA/QS-21. In addition, we measured the longevity of these responses, tracking humoral, and cellular responses up to 6 months following vaccination. Overall, we show that the strength and longevity of anti-HCV responses can be influenced by adjuvant selection. In particular, a simple admixed sulfated S-lactosylarchaeol (SLA) archaeosome formulation generated strong levels of HCV neutralizing antibodies and polyfunctional antigen-specific CD4 T cells producing multiple cytokines such as IFN-&gamma , and IL-2. While liposome/MPLA/QS-21 as adjuvant generated superior cellular responses, the SLA E1/E2 admixed formulation was superior or equivalent to the other tested formulations in all immune parameters tested. , TNF-&alpha
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu22 citations 22 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2009 CanadaAuthors: Leblanc, G.; Hurley, J.;Leblanc, G.; Hurley, J.;unclassified unlimited available
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2004 Canada EnglishAuthors: Mukhopadhyaya, P.;Mukhopadhyaya, P.;Aussi disponible en français: À la recherche de collaborateurs industriels pour un projet sur les PIV
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______1674::00cd9c5b52a04ce1c673de2a466ac293&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2006 CanadaElsevier BV B. Tancowny; C. Sheen; Leslie C. Grammer; Robert P. Schleimer; Marianna Kulka;unlimited available public
Immunology arrow_drop_down NRC Publications Archive; ImmunologyOther literature type . Article . 2008add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jaci.2005.12.274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu383 citations 383 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Immunology arrow_drop_down NRC Publications Archive; ImmunologyOther literature type . Article . 2008add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jaci.2005.12.274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Conference object 2010 CanadaIEEE Authors: Rachel Ellaway; Jeremy R. Cooperstock; Bruce Spencer;Rachel Ellaway; Jeremy R. Cooperstock; Bruce Spencer;Funded as part of the ‘Network-Enabled Platforms’ program, the Health Services Virtual Organization (HSVO) Project has developed a network-enabled platform (NEP) consisting of a messaging specification, a collection of devices, a bus interface architecture and a middleware hub (SAVOIR) that can support the authoring execution and tracking of multiple independent and integrated simulation activities. The HSVO NEP allows web devices to be coordinated, to talk to each other, to control each other, to use services from elsewhere and to use each other as services. This means that instructors and learners can have access to any services and devices at any time and location thereby supporting both scheduled and on-demand practice or instruction. Fifth International Conference on Digital Information Management, July 5-8, 2010, Lakehead University, Thunder Bay, Ontario
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icdim.2010.5664229&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icdim.2010.5664229&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2005 United States, Canada, United KingdomSpringer Science and Business Media LLC A. Martinez-Sansigre; Steve Rawlings; Mark Lacy; Dario Fadda; Francine R. Marleau; Chris Simpson; Chris J. Willott; Matt J. Jarvis;pmid: 16079838
Supermassive black holes underwent periods of exponential growth during which we seem them as quasars in the distant Universe. The summed emission from these quasars generates the cosmic X-ray background, the spectrum of which has been used to argue that most black-hole growth is obscured. There are clear examples of obscured black-hole growth in the form of `type-2' quasars, but their numbers are fewer than expected from modelling of the X-ray background. Here we report on the direct detection of a population of distant type-2 quasars which is at least comparable in size to the well-known unobscured type-1 population. We selected objects that have mid-infrared and radio emissions characteristic of quasars, but which are faint at near-infrared and optical wavelengths. This population is responsible for most of the black hole growth in the young Universe and, throughout cosmic history, black-hole growth occurs in the dusty, gas-rich centres of active galaxies. Comment: 10 pages, 2 figures, to appear in Nature on 4th August. Title and opening paragraph modified to Nature house style. Minor rearrangement and correction to table 1. Supplementary Information can be found at http://www-astro.physics.ox.ac.uk/~ams/
Caltech Authors arrow_drop_down Nature; Oxford University Research ArchiveOther literature type . Article . 2005 . 2016License: http://www.springer.com/tdmadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature03829&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu152 citations 152 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Caltech Authors arrow_drop_down Nature; Oxford University Research ArchiveOther literature type . Article . 2005 . 2016License: http://www.springer.com/tdmadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nature03829&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2009 CanadaSAGE Publications Authors: Kenneth C. Cole;Kenneth C. Cole;pmid: 20030978
The intercalation of molten polymer into layered silicates (nanoclays) is a critical step in the fabrication of commercial polymer nanocomposite products, so it is therefore very important to understand the process of intercalation and exfoliation, as well as to properly characterize the final state achieved. Following on our recent work demonstrating the potential of transmission infrared spectroscopy for this purpose, we show in this work how the attenuated total reflection technique can be used to study the intercalation process in real time. Although various aspects of the Si–O stretching bands near 1150–950 cm−1 are sensitive to the intercalation, the most sensitive parameter is the relative intensity of the out-of-plane band near 1077 cm−1. A method based on the second derivative of the spectrum has been developed to quantify this aspect. The application of this approach is described in detail and examples are given involving different polymers.
NRC Publications Arc... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Average influence Average impulse Average Powered by BIP!
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description Publicationkeyboard_double_arrow_right Other literature type , Article 2020 CanadaInforma UK Limited Jing Chen; Youxiu Zhong; Yu Liu; Chongfa Tang; Yanbin Zhang; Bo Wei; Wangxue Chen; Meiying Liu;Under the trend of antibiotic resistance of H. pylori leading to the decrease of eradication rate, the development of a vaccine is the best choice to fight against H. pylori. In this study, we attempted to reduce the amounts of required antigens by using three different parenteral routes of immunization and an adjuvant cGAMP (cyclic guanosine monophosphate-adenosine monophosphate) to enhance the immunogenicity of the vaccine candidate. The immune protection and post-challenge immune responses were assessed and compared in mice immunized with recombinant Helicobacter pylori urease A, urease B, and neutrophil-activating protein adjuvanted with cGAMP. The gastric mucosal colonization by H. pylori was significantly reduced in mice immunized by intranasal and, to a less degree, subcutaneous route, but not by intramuscular route. All immunized mice, regardless of the route of immunization, displayed significant, but comparable, increases in antigen-specific serum IgG and mucosal IgA responses 5 weeks post-challenge. The magnitude of the vaccine-induced protection appeared to be associated with the level of antigen-specific Th1 and particularly Th17 responses, as IL-17 responses were only detected in intranasally immunized mice. Taken together, we explored and confirmed the possibility of using a novel adjuvant (cGAMP) to induce significant protective immunity with 10% of oral vaccine antigen dosage through parenteral immunization, especially intranasal immunization. This may provide an alternative approach to oral immunization for the development of effective H. pylori vaccines.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/21645515.2020.1744364&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/21645515.2020.1744364&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2003 CanadaWiley J. Taylor; J. A. Beraldin; Guy Godin; Luc Cournoyer; R. Baribeau; Francois Blais; Marc Rioux; J. Domey;doi: 10.1002/vis.311
The National Research Council of Canada (NRC) has developed and patented three high-resolution 3D imaging systems and processing algorithms which have been applied to a wide range of museum and heritage recording applications. The systems have been designed for different imaging applications and, in collaboration with a number of national and international museums and cultural agencies, have been used to scan a wide variety of objects and sites. The objective of this paper is to present a summary of the 3D technology and examples of its heritage applications. Copyright © 2003 John Wiley & Sons, Ltd.
The Journal of Visua... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/vis.311&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Average influence Top 10% impulse Average Powered by BIP!
more_vert The Journal of Visua... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/vis.311&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2010 CanadaSpringer Science and Business Media LLC Authors: Taijiro Sato; James J. Beaudoin;Taijiro Sato; James J. Beaudoin;Freezing and thawing properties of cement paste were studied using an alternating current impedance spectroscopy (ACIS) technique coupled with the thermomechanical analysis (TMA). The measurements from the ACIS were analyzed in association with the length change of the cement paste determined by TMA. The micro-scale behavior of cement paste observed by the ACIS technique was well correlated with the residual expansion of cement paste after the freezing and thawing cycle. The efficacy of the ACIS technique for assessing the durability of cement paste to frost action was confirmed.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1617/s11527-010-9635-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu21 citations 21 popularity Top 10% influence Top 10% impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- docu