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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Michelutti, Neal; Sowell, Preston; Tapia, Pedro M.; Grooms, Christopher; +4 Authors

    AbstractPre-Hispanic artifacts and sacred architecture were recently discovered submerged in a large lake (Laguna Sibinacocha) in the Peruvian Andes. The underwater ruins indicate a dramatic shift in the region’s hydrology but the timing and triggers of this shift remain unknown. In a novel approach blending archaeology and paleoecology, we analyzed a sediment sequence from within one of the recovered artifacts, specifically a pot from the Late Intermediate Period (~1000–1400 CE). Radioisotopic dating of discrete sediment intervals sampled from the pot show a stratigraphically intact profile that preserves a history of change at this site. The pot’s basal sediment age places the timing of lake-level rise during the late ~1600s CE, which post-dates the end of the Inca Empire (1400–1532 CE) by approximately 150 years. The ubiquity of planktonic algae throughout the sediment profile suggests water levels remained high above the pot since its submergence. Paleoclimate data from the nearby Quelccaya ice core records indicate lake flooding followed a pronounced wet period beginning ~1520 CE. These data show the permanence of mean state changes in climate on the region’s hydrology, with clear implications for the study site (an important water resource for ~500,000 people) and other lakes in the rapidly warming Andes.

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    Europe PubMed Central
    Article . 2020
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    Scientific Reports
    Article . 2019
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    Scientific Reports
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    Scientific Reports
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    Scientific Reports
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    Scientific Reports
    Article . 2019
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    Scientific Reports
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    Scientific Reports
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      Europe PubMed Central
      Article . 2020
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      Scientific Reports
      Article . 2019
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      Scientific Reports
      Article . 2019
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      Scientific Reports
      Article . 2020
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      Scientific Reports
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Xia, Frances; Kheirbek, Mazen A.;

    Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Other literature type . 2020
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Trends in Neurosciences
    Article . 2020
    License: Elsevier TDM
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      Europe PubMed Central
      Other literature type . 2020
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Trends in Neurosciences
      Article . 2020
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Marie-Pier Roussel; Morin, Marika; Gagnon, Cynthia; Duchesne, Elise;

    Search words and headings. All search words and headings used in the different data bases (Medline (EBSCO), Pubmed, CINAHL (EBSCO) and EMBASE) can be found in this additional file. (DOCX 19 kb)

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    Other literature type . 2019
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      Other literature type . 2019
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Mansour, Nuha R; Paveley, Ross; Gardner, J Mark F; Bell, Andrew S; +2 Authors

    An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective against adult worms but not against the juvenile stage. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. A total of almost 300,000 compounds were screened using a high throughput assay based on motility of worm larvae and image analysis of assay plates. Hits were screened against juvenile and adult worms to identify broadly active compounds and against a mammalian cell line to assess cytotoxicity. A number of compounds were identified as promising leads for further chemical optimization. Author Summary Schistosomiasis is a parasitic infection that affects an estimated 600 million people in developing countries. Treatment is currently dependent on a single drug which is only active against the adult form of the disease. Treatment of infected patients eliminates adult worms but leaves any juveniles to survive and develop, thus continuing the infection. A drug acting equally against adult and juvenile worms is likely to be more effective at eliminating the disease. We have identified quality chemical leads with balanced activity against all life stages of the parasite and with a good window over cytotoxicity, which could form the basis of an exciting new drug discovery project.

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    Europe PubMed Central
    Article . 2016
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    PLoS Neglected Tropical Diseases
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    PLoS Neglected Tropical Diseases
    Article . 2016
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      Europe PubMed Central
      Article . 2016
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      Article . 2016
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      PLoS Neglected Tropical Diseases
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      PLoS Neglected Tropical Diseases
      Article . 2016
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    Authors: Frédéric Benoit; Alain Lesage;

    Objectif: Analyser différents enjeux de l'implantation d'un programme de Suivi intensif dans le milieu (SIM). Méthode: Des entrevues en profondeur ont été menées auprès de protagonistes d'un projet d'implantation du SIM qui s'est déroulé dans les années 1970. Une analyse qualitative a été effectuée qui évaluait les enjeux ayant empêché la généralisation de ce type d'approche ainsi que les aspects à observer lors d'implantations futures du SIM. Résultats: Des aspects sociaux, culturels, organisationnels, professionnels et économiques semblent avoir eu et auront une place déterminante dans l'intégration de ce type de programme. À l'époque, le projet d'implantation du SIM s'est développé en parallèle au mouvement de psychiatrie communautaire, sans jamais s'y arrimer. Actuellement, sur le plan social, des groupes d'entraide et de parents favorisent l'implantation de ce type de programme. L'aspect organisationnel décrit l'importance du type d'arrimage ainsi que la modification du SIM selon les services de soins en place. L'affiliation de ce type de projet à une équipe de recherche n'a pas été garante d'une implantation réussie. Un troisième théme aborde la formation ainsi que la motivation du psychiatre quant à la pratique de cette approche. Finalement, l'aspect économique se révèle de plus en plus comme étant un levier qui impose ce type d'approche. Conclusion: Cette étude nous renseigne sur différents enjeux de l'implantation d'un programme de suivi intensif dans la communauté. Ces résultats représentent autant d'hypothèses à vérifier en ce qui concerne l'implantation du SIM autant au Québec qu'ailleurs au Canada.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao The Canadian Journal...arrow_drop_down
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    The Canadian Journal of Psychiatry
    Article . 1999
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      The Canadian Journal of Psychiatry
      Article . 1999
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    Authors: Nicholas A, Mason; Scott A, Taylor;

    AbstractUnderstanding the patterns and processes that contribute to phenotypic diversity and speciation is a central goal of evolutionary biology. Recently, high‐throughput sequencing has provided unprecedented phylogenetic resolution in many lineages that have experienced rapid diversification. The Holarctic redpoll finches (Genus: Acanthis) provide an intriguing example of a recent, phenotypically diverse lineage; traditional sequencing and genotyping methods have failed to detect any genetic differences between currently recognized species, despite marked variation in plumage and morphology within the genus. We examined variation among 20 712 anonymous single nucleotide polymorphisms (SNPs) distributed throughout the redpoll genome in combination with 215 825 SNPs within the redpoll transcriptome, gene expression data and ecological niche modelling to evaluate genetic and ecological differentiation among currently recognized species. Expanding upon previous findings, we present evidence of (i) largely undifferentiated genomes among currently recognized species; (ii) substantial niche overlap across the North American Acanthis range; and (iii) a strong relationship between polygenic patterns of gene expression and continuous phenotypic variation within a sample of redpolls from North America. The patterns we report may be caused by high levels of ongoing gene flow between polymorphic populations, incomplete lineage sorting accompanying very recent or ongoing divergence, variation in cis‐regulatory elements, or phenotypic plasticity, but do not support a scenario of prolonged isolation and subsequent secondary contact. Together, these findings highlight ongoing theoretical and computational challenges presented by recent, rapid bouts of phenotypic diversification and provide new insight into the evolutionary dynamics of an intriguing, understudied non‐model system.

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    Molecular Ecology
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    Molecular Ecology
    Article . 2015
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      Molecular Ecology
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      Molecular Ecology
      Article . 2015
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    Authors: Timothy D. Barfoot; Chi Hay Tong; Simo Särkkä;

    In this paper, we revisit batch state estimation through the lens of Gaussian process (GP) regression. We consider continuous-discrete estimation problems wherein a trajectory is viewed as a one-dimensional GP, with time as the independent variable. Our continuous-time prior can be defined by any linear, time-varying stochastic differential equation driven by white noise; this allows the possibility of smoothing our trajectory estimates using a variety of vehicle dynamics models (e.g., ‘constant-velocity’). We show that this class of prior results in an inverse kernel matrix (i.e., covariance matrix between all pairs of measurement times) that is exactly sparse (block-tridiagonal) and that this can be exploited to carry out GP regression (and interpolation) very efficiently. Though the prior is continuous, we consider measurements to occur at discrete times. When the measurement model is also linear, this GP approach is equivalent to classical, discrete-time smoothing (at the measurement times). When the measurement model is nonlinear, we iterate over the whole trajectory (as is common in vision and robotics) to maximize accuracy. We test the approach experimentally on a simultaneous trajectory estimation and mapping problem using a mobile robot dataset.

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    Authors: Erika F Augustine; Adriana Pérez; Rohit Dhall; Chizoba C Umeh; +9 Authors

    Introduction To improve our understanding of sex differences in the clinical characteristics of Parkinson’s Disease, we sought to examine differences in the clinical features and disease severity of men and women with early treated Parkinson’s Disease (PD) enrolled in a large-scale clinical trial. Methods Analysis was performed of baseline data from the National Institutes of Health Exploratory Trials in Parkinson’s Disease (NET-PD) Long-term Study-1, a randomized, multi-center, double-blind, placebo-controlled study of 10 grams of oral creatine/day in individuals with early, treated PD. We compared mean age at symptom onset, age at PD diagnosis, and age at randomization between men and women using t-test statistics. Sex differences in clinical features were evaluated, including: symptoms at diagnosis (motor) and symptoms at randomization (motor, non-motor, and daily functioning). Results 1,741 participants were enrolled (62.5% male). No differences were detected in mean age at PD onset, age at PD diagnosis, age at randomization, motor symptoms, or daily functioning between men and women. Differences in non-motor symptoms were observed, with women demonstrating better performance compared to men on SCOPA-COG (Z = 5.064, p<0.0001) and Symbol Digit Modality measures (Z = 5.221, p<0.0001). Conclusions Overall, men and women did not demonstrate differences in clinical motor features early in the course of PD. However, the differences observed in non-motor cognitive symptoms suggests further assessment of the influence of sex on non-motor symptoms in later stages of PD is warranted.

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    Europe PubMed Central
    Article . 2015
    Data sources: PubMed Central
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    PLoS ONE
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    PLoS ONE
    Article . 2015
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    PLoS ONE
    Article . 2015
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    DOAJ
    Article . 2015
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      Europe PubMed Central
      Article . 2015
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      PLoS ONE
      Article . 2015
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      Article . 2015
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      Article . 2015
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Clément Gosselin; Eric Lavoie;

    This article studies the kinematic design of different types of spherical three-degree-of-freedom parallel manipulators. The mechanical architectures presented have been introduced elsewhere. However designs having at least one isotropic configuration are suggested here for the first time. Isotropic configurations are defined, in turn, as those configurations in which the Jacobian matrix, mapping the angular velocity vec tor of the effector into the joint velocities, is proportional to an orthogonal matrix. First, a review of the direct and inverse kinematics of spherical three-degree-of-freedom parallel ma nipulators is outlined, and a general form for the Jacobian matrix is given. Parallel manipulators with revolute or pris matic actuators are discussed. Then, the concept of kinematic conditioning is recalled and used as a performance index for the optimization of the manipulators. It is shown that this leads to designs having at least one isotropic configuration. Finally, a few examples of such designs are presented.

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    The International Journal of Robotics Research
    Article . 1993
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      The International Journal of Robotics Research
      Article . 1993
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    Authors: Sriretnakumar, Venuja; Harripaul, Ricardo; Vincent, John B.; Kennedy, James L.; +1 Authors

    ABSTRACTPurposeMany genetic conditions can mimic mental health disorders, with psychiatric symptoms that are difficult to treat with standard psychotropic medications. This study tests the hypothesis that psychiatric populations are enriched for pathogenic variants associated with selected treatable genetic disorders.MethodsUsing next-generation sequencing, 2046 psychiatric patients were screened for variants in genes associated with four inborn errors of metabolism (IEMs), Niemann-Pick disease type C (NPC), Wilson disease (WD), homocystinuria (HOM), and acute intermittent porphyria (AIP).ResultsAmong the 2046 cases, carrier rates of 0·83%, 0·98%, 0·20%, and 0·24% for NPC, WD, HOM, and AIP were seen respectively. An enrichment of known and likely pathogenic variants in the genes associated with NPC and AIP was found in the psychiatric cohort, and especially in schizophrenia patients.ConclusionThe results of this study support that rare genetic disease variants, such as those associated with IEMs, may contribute to the pathogenesis of psychiatric disorders. IEMs should be considered as possible causative factors for psychiatric presentations, especially in psychotic disorders, such as schizophrenia, and in the context of poor treatment response.

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    bioRxiv
    Preprint . 2018
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    Authors: Michelutti, Neal; Sowell, Preston; Tapia, Pedro M.; Grooms, Christopher; +4 Authors

    AbstractPre-Hispanic artifacts and sacred architecture were recently discovered submerged in a large lake (Laguna Sibinacocha) in the Peruvian Andes. The underwater ruins indicate a dramatic shift in the region’s hydrology but the timing and triggers of this shift remain unknown. In a novel approach blending archaeology and paleoecology, we analyzed a sediment sequence from within one of the recovered artifacts, specifically a pot from the Late Intermediate Period (~1000–1400 CE). Radioisotopic dating of discrete sediment intervals sampled from the pot show a stratigraphically intact profile that preserves a history of change at this site. The pot’s basal sediment age places the timing of lake-level rise during the late ~1600s CE, which post-dates the end of the Inca Empire (1400–1532 CE) by approximately 150 years. The ubiquity of planktonic algae throughout the sediment profile suggests water levels remained high above the pot since its submergence. Paleoclimate data from the nearby Quelccaya ice core records indicate lake flooding followed a pronounced wet period beginning ~1520 CE. These data show the permanence of mean state changes in climate on the region’s hydrology, with clear implications for the study site (an important water resource for ~500,000 people) and other lakes in the rapidly warming Andes.

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    Europe PubMed Central
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    Scientific Reports
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    Scientific Reports
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    Scientific Reports
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    Authors: Xia, Frances; Kheirbek, Mazen A.;

    Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Trends in Neurosciences
    Article . 2020
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      Trends in Neurosciences
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    Authors: Marie-Pier Roussel; Morin, Marika; Gagnon, Cynthia; Duchesne, Elise;

    Search words and headings. All search words and headings used in the different data bases (Medline (EBSCO), Pubmed, CINAHL (EBSCO) and EMBASE) can be found in this additional file. (DOCX 19 kb)

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