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- Publication . Article . 2013Open AccessAuthors:Li Wang; Chun Gao; Shu-Kun Yao; Bu-Shan Xie;Li Wang; Chun Gao; Shu-Kun Yao; Bu-Shan Xie;Publisher: MDPI AG
Autophagy, a self-defense mechanism, has been found to be associated with drug resistance in hepatocellular carcinoma (HCC). Our study was designed to investigate the role and related mechanisms of autophagy in matrine-induced apoptosis in hepatoma cells of HepG2 and Bel7402. Cell apoptosis was detected by flow cytometry analysis (Annexin V–FITC/PI double-staining assay), the activity and activating cleavages of caspase-3, -8, and -9. MTT assay and colony forming assay were used to assess the effect of matrine on growth and proliferation of HCC cells. Autophagic flux in HCC cells was analyzed using the expression of LC3BI/II and p62/SQSTM1, GFP-LC3 transfection, and transmission electron microscopy. Moreover, regarding to the associated mechanisms, the effects of matrine on the phosphoinositide 3-kinase/AKT/mTOR pathway and beclin-1 were studied. Our results showed that: (1) both autophagy and apoptosis could be induced by treatment with matrine; (2) using the autophagic inhibitor chloroquine and beclin-1 small-interfering RNA, cell apoptosis induced by matrine could be enhanced in a caspase-dependent manner; and (3) autophagy was induced via inhibition of PI3K/AKT/mTOR pathway and up-regulation of beclin-1. In conclusion, inhibition of autophagy could enhance matrine-induced apoptosis in human hepatoma cells.
Top 10% in popularityTop 10% in popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 1988Closed AccessAuthors:P. K. Shufflebotham; Howard C. Card; Adonios Thanailakis;P. K. Shufflebotham; Howard C. Card; Adonios Thanailakis;Publisher: Wiley
A review of amorphous silicon alloys (other than a-Si: H) is presented. The main focus is on experimental results. Methods of fabricating amorphous alloys are classified and their basic operational principles outlined. The electrical and optical properties of amorphous silicon based alloys are then described, and a summary of existing and potential applications given. Conspicuous gaps in the fabrication, understanding and application of these materials are pointed out. A comprehensive (though not exhaustive) bibliography is presented, with references to all amorphous silicon alloys studied up to the summer of 1986.
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2014Open AccessAuthors:Aad, G.; Abbott, B.; Abdallah, J.; Abdel Khalek, S.; Abdinov, O.; Aben, R.; Abi, B.; Abolins, M.; Abouzeid, O. S.; Abramowicz, H.; +190 moreAad, G.; Abbott, B.; Abdallah, J.; Abdel Khalek, S.; Abdinov, O.; Aben, R.; Abi, B.; Abolins, M.; Abouzeid, O. S.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adamczyk, L.; Adams, D. L.; Adelman, J.; Adomeit, S.; Adye, T.; Agatonovic Jovin, T.; Aguilar Saavedra, J. A.; Agustoni, M.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akerstedt, H.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Albert, J.; Albrand, S.; Alconada Verzini, M. J.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Alimonti, G.; Alio, L.; Alison, J.; Allbrooke, B. M. M.; Allison, L. J.; Allport, P. P.; Almond, J.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Altheimer, A.; Alvarez Gonzalez, B.; Alviggi, M. G.; Amako, K.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amram, N.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, G.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Anduaga, X. S.; Angelidakis, S.; Angelozzi, I.; Anger, P.; Angerami, A.; Anghinolfi, F.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antonaki, A.; Antonelli, M.; Antonov, A.; Antos, J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Apolle, R.; Arabidze, G.; Aracena, I.; Arai, Y.; Araque, J. P.; Arce, A. T. H.; Arguin, J. F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnal, V.; Arnold, H.; Arratia, M.; Arslan, O.; Artamonov, A.; Artoni, G.; Asai, S.; Asbah, N.; Ashkenazi, A.; Åsman, B.; Asquith, L.; Assamagan, K.; Astalos, R.; Atkinson, M.; Atlay, N. B.; Auerbach, B.; Augsten, K.; Aurousseau, M.; Avolio, G.; Azuelos, G.; Azuma, Y.; Baak, M. A.; Baas, A. E.; Bacci, C.; Bachacou, H.; Bachas, K.; Backes, M.; Backhaus, M.; Backus Mayes, J.; Badescu, E.; Bagiacchi, P.; Bagnaia, P.; Bai, Y.; Bain, T.; Baines, J. T.; Baker, O. K.; Balek, P.; Balli, F.; Banas, E.; Banerjee, S.w.; Bannoura, A. A. E.; Bansal, V.; Bansil, H. S.; Barak, L.; Baranov, S. P.; Barberio, E. L.; Barberis, D.; Barbero, M.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B. M.; Barnett, R. M.; Barnovska, Z.; Baroncelli, A.; Barone, G.; Barr, A. J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Bartoldus, R.; Barton, A. E.; Bartos, P.; Bartsch, V.; Bassalat, A.; Basye, A.; Bates, R. L.; Batley, J. R.; Battaglia, M.; Battistin, M.; Bauer, F.; Bawa, H. S.; Beattie, M. D.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Bechtle, P.; Beck, H. P.; Becker, K.; Becker, S.; Beckingham, M.; Becot, C.; Beddall, A. J.; Beddall, A.; Bedikian, S.; Bednyakov, V. A.; Bee, C. P.; Beemster, L. J.; Beermann, T. A.; Begel, M.; Behr, K.; Belanger Champagne, C.; Bell, P. J.; Bell, W. H.; Bella, G.; Bellerive, A.; Bellomo, M.; Belotskiy, K.; Beltramello, O.; Benary, O.; Benchekroun, D.; Bendtz, K.;
pmid: 25814877
pmc: PMC4370854
Countries: Italy, United KingdomATLAS measurements of the azimuthal anisotropy in lead–lead collisions at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sqrt{s_{\mathrm {NN}}}=2.76$$\end{document}sNN=2.76 TeV are shown using a dataset of approximately 7 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upmu $$\end{document}μb\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{-1}$$\end{document}-1 collected at the LHC in 2010. The measurements are performed for charged particles with transverse momenta \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$0.5
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.
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You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2018Open AccessAuthors:Claudio Maffeis; Niels H Birkebaek; Maia Konstantinova; Anke Schwandt; Andriani Vazeou; Kristina Casteels; Sujata M Jali; Catarina Limbert; Auste Pundziute-Lycka; Péter Tóth-Heyn; +13 moreClaudio Maffeis; Niels H Birkebaek; Maia Konstantinova; Anke Schwandt; Andriani Vazeou; Kristina Casteels; Sujata M Jali; Catarina Limbert; Auste Pundziute-Lycka; Péter Tóth-Heyn; Carine de Beaufort; Zdenek Sumnik; Valentino Cherubini; Jannet Svensson; Danièle Pacaud; Christina Kanaka-Gantenbein; Shlomit Shalitin; Natasa Bratina; Ragnar Hanas; Guy T. Alonso; Luxmi Poran; Ana L Pereira; Marco Marigliano;Publisher: Hindawi LimitedCountries: Portugal, Italy
OBJECTIVE: To assess the prevalence of underweight (UW), overweight (OW), and obesity in children and adolescents with type 1 diabetes (T1D).METHODS: An international cross-sectional study including 23 026 T1D children (2-18 years, duration of diabetes ≥1 year) participating in the SWEET prospective, multicenter diabetes registry. Body mass index SD score (BMI-SDS) was calculated using the World Health Organization BMI charts. Children were categorized as UW (BMI-SDS < -2SD), OW (+1SD < BMI-SDS ≤ +2SD), and obese (OB) (BMI-SDS > +2SD). Hierarchic regression models were applied with adjustment for sex, age, and duration of diabetes.RESULTS: The prevalence of UW, OW, and obesity was: 1.4%, 22.3%, and 7.3% in males and 0.6%, 27.2%, and 6.8% in females. Adjusted BMI-SDS was significantly higher in females than in males (mean ± SEM: 0.54 ± 0.05 vs 0.40 ± 0.05, P < 0.0001). In males, BMI-SDS significantly decreased by age (P < 0.0001) in the first three age categories 0.61 ± 0.06 (2 to <10 years), 0.47 ± 0.06 (10 to <13 years), 0.34 ± 0.05 (13 to <16 years). In females, BMI-SDS showed a U-shaped distribution by age (P < 0.0001): 0.54 ± 0.04 (2 to <10 years), 0.39 ± 0.04 (10 to <13 years), 0.55 ± 0.04 (13 to <16 years). BMI-SDS increased by diabetes duration (<2 years: 0.38 ± 0.05, 2 to <5 years: 0.44 ± 0.05, and ≥5 years: 0.50 ± 0.05, P < 0.0001). Treatment modality did not affect BMI-SDS. Adjusted HbA1c was significantly higher in females than in males (8.20% ± 0.10% vs 8.06% ± 0.10%, P < 0.0001). In both genders, the association between HbA1c and BMI-SDS was U-shaped with the highest HbA1c in the UW and obesity groups.CONCLUSIONS: The high rate of OW and obesity (31.8%) emphasize the need for developing further strategies to prevent and treat excess fat accumulation in T1D.
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You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2017Open AccessAuthors:Joey W. Trampush; M. L. Z. Yang; Jin Yu; Emma Knowles; Gary Davies; David C. Liewald; John M. Starr; Srdjan Djurovic; Ingrid Melle; Kjetil Sundet; +56 moreJoey W. Trampush; M. L. Z. Yang; Jin Yu; Emma Knowles; Gary Davies; David C. Liewald; John M. Starr; Srdjan Djurovic; Ingrid Melle; Kjetil Sundet; Andrea Christoforou; Ivar Reinvang; Pamela DeRosse; Astri J. Lundervold; Vidar M. Steen; Thomas Espeseth; Katri Räikkönen; Elisabeth Widen; Aarno Palotie; Johan G. Eriksson; Ina Giegling; Bettina Konte; Panos Roussos; Stella G. Giakoumaki; Katherine E. Burdick; Antony Payton; William E R Ollier; Michael A Horan; Ornit Chiba-Falek; Deborah K. Attix; Anna C. Need; Elizabeth T. Cirulli; Aristotle N. Voineskos; Nicholas C. Stefanis; Dimitrios Avramopoulos; Alex Hatzimanolis; Dan E. Arking; Nikolaos Smyrnis; Robert M. Bilder; Nelson A. Freimer; Tyrone D. Cannon; Edythe D. London; Russell A. Poldrack; Fred W. Sabb; Eliza Congdon; Emily Drabant Conley; Matthew A. Scult; Dwight Dickinson; Richard E. Straub; Gary Donohoe; Derek W. Morris; Aiden Corvin; M. Gill; Ahmad R. Hariri; Daniel R. Weinberger; Neil Pendleton; Panos Bitsios; Dan Rujescu; Jari Lahti; S. Le Hellard; Matthew C. Keller; Ole A. Andreassen; Ian J. Deary; David C. Glahn; Anil K. Malhotra; Todd Lencz;
pmc: PMC5322272 , PMC5659072
Publisher: Springer Science and Business Media LLCCountries: United States, Norway, Finland, United Kingdom, IrelandProject: NIH | CORONARY HEART DISEASE &S... (N01HC085081-016), NIH | CORONARY HEART DISEASE AN... (N01HC085085-006), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NIH | A Longitudinal Study of A... (5R01MH066140-08), NIH | Striatal D2/D3 Dopamine r... (1P50MH080173-01A1), NIH | Neurodevelopmental Genomi... (5RC2MH089983-02), NIH | Neural signatures of heal... (1R01AG049789-01), NIH | 1/2 Schizophrenia Heterog... (5R01MH092515-03), NIH | CARDIOVASCULAR HEALTH STU... (N01HC035129-010), NIH | Twin Study of ADHD, CD an... (5R01DA013240-10),...Abstract The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10−8). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.
Top 1% in popularityTop 1% in popularityTop 10% in influencePopularity: Citation-based measure reflecting the current impact.Top 10% in influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Other literature type . 2013Open AccessAuthors:Montserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Elio Riboli; Loic Le Marchand; Diana Eccles; Penelope Miron; Peter A. Fasching; +201 moreMontserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Elio Riboli; Loic Le Marchand; Diana Eccles; Penelope Miron; Peter A. Fasching; Hiltrud Brauch; Jenny Chang-Claude; Jane Carpenter; Andrew K. Godwin; Heli Nevanlinna; Graham G. Giles; Angela Cox; John L. Hopper; Manjeet K. Bolla; Qin Wang; Joe Dennis; Ed Dicks; Nils Schoof; Stig E. Bojesen; Diether Lambrechts; Annegien Broeks; Pascal Guénel; Barbara Burwinkel; Elinor J. Sawyer; Antoinette Hollestelle; Olivia Fletcher; Robert Winqvist; Hermann Brenner; Arto Mannermaa; Ute Hamann; Alfons Meindl; Annika Lindblom; Wei Zheng; Peter Devillee; Mark S. Goldberg; Jan Lubinski; Anthony J. Swerdlow; Hoda Anton-Culver; Thilo Dörk; Keitaro Matsuo; Anna H. Wu; Paolo Radice; Soo Hwang Teo; Xiao-Ou Shu; William Blot; Daehee Kang; Mikael Hartman; Suleeporn Sangrajrang; Chen-Yang Shen; Melissa C. Southey; Daniel J. Park; Jennifer Stone; Laura J. van't Veer; Emiel J. Th. Rutgers; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Julian Peto; Arif B. Ekici; Isabel dos Santos Silva; Nichola Johnson; Helen R. Warren; Ian Tomlinson; Michael J. Kerin; Nicola Miller; Thérèse Truong; Pierre Laurent-Puig; Børge G. Nordestgaard; Sune F. Nielsen; Henrik Flyger; Jose Ignacio Arias Perez; Primitiva Menéndez; Heiko Müller; Magdalena Lochmann; Christina Justenhoven; Yon Ko; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Tuomas Heikkinen; Hidemi Ito; Yasushi Yatabe; Sara Margolin; Vesa Kataja; Veli-Matti Kosma; Jaana M. Hartikainen; Rosemary L. Balleine; Chiu-Chen Tseng; Patrick Neven; Anne Sophie Dieudonne; Karin Leunen; Anja Rudolph; Stefan Nickels; Dieter Flesch-Janys; Paolo Peterlongo; Bernard Peissel; Loris Bernard; Janet E. Olson; Xianshu Wang; Gianluca Severi; Laura Baglietto; Catriona McLean; Gerhard A. Coetzee; Ye Feng; Fredrick R. Schumacher; Cheng Har Yip; Nur Aishah Taib; Ching-Yu Cheng; Martha J. Shrubsole; Jirong Long; Katri Pylkäs; Arja Jukkola-Vuorinen; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; R.A.E.M. Tollenaar; Mieke Kriege; Carolien H.M. van Deurzen; Wei Lu; Yu Tang Gao; Hui Cai; Sabapathy P. Balasubramanian; Simon S. Cross; Malcolm W.R. Reed; Qiuyin Cai; Hui Miao; Ching Wan Chan; Kee Seng Chia; Anna Jakubowska; Katarzyna Jaworska; Katarzyna Durda; Chia-Ni Hsiung; Pei Ei Wu; Alan Ashworth; Michael Jones; Anna González-Neira; Guillermo Pita; M. Rosario Alonso; Daniel Vincent; Francois Bacot; Christine B. Ambrosone; Elisa V. Bandera; Gary K. Chen; Jorge L. Rodriguez-Gil; Leslie Bernstein; Michael F. Press; Regina G. Ziegler; Sarah J. Nyante; Sue A. Ingles; Quinten Waisfisz; Helen Tsimiklis; Enes Makalic; Minh Bui; Rita K. Schmutzler; Norbert Dahmen; Lars Beckmann; Kirsimari Aaltonen; Kamila Czene; Astrid Irwanto; Jianjun Liu; Clare Turnbull; Nazneen Rahman; Hanne Meijers-Heijboer; André G. Uitterlinden; Fernando Rivadeneira; Curtis Olswold; Robert Pilarski; Foluso O. Ademuyiwa; Irene Konstantopoulou; Nicholas G. Martin; Grant W. Montgomery; Dennis J. Slamon; Claudia Rauh; Michael P. Lux; Sebastian M. Jud; Thomas Brüning; Priyanka Sharma; Harsh B. Pathak; William J. Tapper; Sue Gerty; Lorraine Durcan; Dimitrios Trichopoulos; Rosario Tumino; Petra H.M. Peeters; Rudolf Kaaks; Daniele Campa; Federico Canzian; Elisabete Weiderpass; Mattias Johansson; Ruth C. Travis; Françoise Clavel-Chapelon; Laurence N. Kolonel; Andrew H. Beck; Susan E. Hankinson; Christine D. Berg; Jolanta Lissowska; Jonine D. Figueroa; Daniel I. Chasman; W. Ryan Diver; Jacques Simard; Alison M. Dunning; Mark E. Sherman; Georgia Chenevix-Trench; Stephen J. Chanock; Celine M. Vachon; Peter Kraft;Publisher: Springer Science and Business Media LLCCountries: Netherlands, United Kingdom, Italy, IrelandProject: NIH | Characterizing Genetic Su... (5U01CA098710-06), WT , NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098233-06), NIH | Genetic epidemiology of c... (3R01CA122340-03S1), EC | COGS (223175), CIHR , NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | Breast &Prostate Cancer &... (1U01CA098758-01)
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
Top 1% in popularityTop 1% in popularityTop 1% in influencePopularity: Citation-based measure reflecting the current impact.Top 1% in influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2020Open AccessAuthors:Clairelyne Dupin; V Fernandes; Fernanda Hernandez-Gonzalez; Sebastiano Emanuele Torrisi; Tiago M. Alfaro; Michael Kreuter; Marlies S. Wijsenbeek; Elisabetta A. Renzoni; Elena Bargagli; Hilario Nunes; +5 moreClairelyne Dupin; V Fernandes; Fernanda Hernandez-Gonzalez; Sebastiano Emanuele Torrisi; Tiago M. Alfaro; Michael Kreuter; Marlies S. Wijsenbeek; Elisabetta A. Renzoni; Elena Bargagli; Hilario Nunes; Paolo Spagnolo; Francesco Bonella; Maria Molina-Molina; Katerina M. Antoniou; Venerino Poletti;
pmid: 33
pmc: PMC7533302 , PMC7553109
Publisher: European Respiratory Society (ERS)Countries: Italy, Belgium, NetherlandsThe 2019 European Respiratory Society (ERS) International Congress, held in Madrid, Spain, had exciting sessions regarding the field of pulmonary vascular disease. The symposia related to the new ERS/European Society of Cardiology (ESC) Guidelines for the diagnosis and management of acute pulmonary embolism were well received, as were sessions on pulmonary hypertension related to lung disease, demonstrating the concept of pulmonary hypertension not being the rarity that it was previously thought to be. The use of risk stratification in relation to pulmonary arterial hypertension (PAH) was heavily featured and the scientific sessions informing the respiratory community of potential biomarkers and targets for future therapies were thought-provoking. This article discusses highlights of the 2019 pulmonary vascular disease sessions as a summary of current knowledge and practice. We have summarised the key points from the sessions pertaining to the new ERS/ESC Guidelines for the management of acute pulmonary embolism. We have also focused on prognostic factors and potential therapies in pulmonary hypertension related to interstitial lung disease. Relating to PAH, we have reviewed the symposia on risk stratification, along with the use of noninvasive measures and the sessions relating to biomarkers in PAH. This article aims to summarise research presented at #ERSCongress 2019: the new @escardio/@EuroRespSoc guidance on acute PE diagnosis and management, PH in relation to chronic lung disease, and advances in pulmonary arterial hypertension https://bit.ly/3bAUG0o
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2006Closed AccessAuthors:George Mylonakis; Costis Syngros; George Gazetas; Takashi Tazoh;George Mylonakis; Costis Syngros; George Gazetas; Takashi Tazoh;
doi: 10.1002/eqe.543
Publisher: WileyAn investigation is presented of the collapse of a 630 m segment (Fukae section) of the elevated Hanshin Expressway during the 1995 Kobe earthquake. The earthquake has, from a geotechnical viewpoint, been associated with extensive liquefactions, lateral soil spreading, and damage to waterfront structures. Evidence is presented that soil–structure interaction (SSI) in non-liquefied ground played a detrimental role in the seismic performance of this major structure. The bridge consisted of single circular concrete piers monolithically connected to a concrete deck, founded on groups of 17 piles in layers of loose to dense sands and moderate to stiff clays. There were 18 spans in total, all of which suffered a spectacular pier failure and transverse overturning. Several factors associated with poor structural design have already been identified. The scope of this work is to extend the previous studies by investigating the role of soil in the collapse. The following issues are examined: (1) seismological and geotechnical information pertaining to the site; (2) free-field soil response; (3) response of foundation-superstructure system; (4) evaluation of results against earlier studies that did not consider SSI. Results indicate that the role of soil in the collapse was multiple: First, it modified the bedrock motion so that the frequency content of the resulting surface motion became disadvantageous for the particular structure. Second, the compliance of soil and foundation altered the vibrational characteristics of the bridge and moved it to a region of stronger response. Third, the compliance of the foundation increased the participation of the fundamental mode of the structure, inducing stronger response. It is shown that the increase in inelastic seismic demand in the piers may have exceeded 100% in comparison with piers fixed at the base. These conclusions contradict a widespread view of an always-beneficial role of seismic SSI. Copyright © 2005 John Wiley & Sons, Ltd.
Top 1% in popularityTop 1% in popularityTop 10% in influencePopularity: Citation-based measure reflecting the current impact.Top 10% in influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2018Open AccessAuthors:Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;Publisher: Heighten Science Publications CorporationAverage/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.
8,882 Research products, page 1 of 889
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- Publication . Article . 2013Open AccessAuthors:Li Wang; Chun Gao; Shu-Kun Yao; Bu-Shan Xie;Li Wang; Chun Gao; Shu-Kun Yao; Bu-Shan Xie;Publisher: MDPI AG
Autophagy, a self-defense mechanism, has been found to be associated with drug resistance in hepatocellular carcinoma (HCC). Our study was designed to investigate the role and related mechanisms of autophagy in matrine-induced apoptosis in hepatoma cells of HepG2 and Bel7402. Cell apoptosis was detected by flow cytometry analysis (Annexin V–FITC/PI double-staining assay), the activity and activating cleavages of caspase-3, -8, and -9. MTT assay and colony forming assay were used to assess the effect of matrine on growth and proliferation of HCC cells. Autophagic flux in HCC cells was analyzed using the expression of LC3BI/II and p62/SQSTM1, GFP-LC3 transfection, and transmission electron microscopy. Moreover, regarding to the associated mechanisms, the effects of matrine on the phosphoinositide 3-kinase/AKT/mTOR pathway and beclin-1 were studied. Our results showed that: (1) both autophagy and apoptosis could be induced by treatment with matrine; (2) using the autophagic inhibitor chloroquine and beclin-1 small-interfering RNA, cell apoptosis induced by matrine could be enhanced in a caspase-dependent manner; and (3) autophagy was induced via inhibition of PI3K/AKT/mTOR pathway and up-regulation of beclin-1. In conclusion, inhibition of autophagy could enhance matrine-induced apoptosis in human hepatoma cells.
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You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 1988Closed AccessAuthors:P. K. Shufflebotham; Howard C. Card; Adonios Thanailakis;P. K. Shufflebotham; Howard C. Card; Adonios Thanailakis;Publisher: Wiley
A review of amorphous silicon alloys (other than a-Si: H) is presented. The main focus is on experimental results. Methods of fabricating amorphous alloys are classified and their basic operational principles outlined. The electrical and optical properties of amorphous silicon based alloys are then described, and a summary of existing and potential applications given. Conspicuous gaps in the fabrication, understanding and application of these materials are pointed out. A comprehensive (though not exhaustive) bibliography is presented, with references to all amorphous silicon alloys studied up to the summer of 1986.
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2014Open AccessAuthors:Aad, G.; Abbott, B.; Abdallah, J.; Abdel Khalek, S.; Abdinov, O.; Aben, R.; Abi, B.; Abolins, M.; Abouzeid, O. S.; Abramowicz, H.; +190 moreAad, G.; Abbott, B.; Abdallah, J.; Abdel Khalek, S.; Abdinov, O.; Aben, R.; Abi, B.; Abolins, M.; Abouzeid, O. S.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adamczyk, L.; Adams, D. L.; Adelman, J.; Adomeit, S.; Adye, T.; Agatonovic Jovin, T.; Aguilar Saavedra, J. A.; Agustoni, M.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akerstedt, H.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Albert, J.; Albrand, S.; Alconada Verzini, M. J.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Alimonti, G.; Alio, L.; Alison, J.; Allbrooke, B. M. M.; Allison, L. J.; Allport, P. P.; Almond, J.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Altheimer, A.; Alvarez Gonzalez, B.; Alviggi, M. G.; Amako, K.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amram, N.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, G.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Anduaga, X. S.; Angelidakis, S.; Angelozzi, I.; Anger, P.; Angerami, A.; Anghinolfi, F.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antonaki, A.; Antonelli, M.; Antonov, A.; Antos, J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Apolle, R.; Arabidze, G.; Aracena, I.; Arai, Y.; Araque, J. P.; Arce, A. T. H.; Arguin, J. F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Arnaez, O.; Arnal, V.; Arnold, H.; Arratia, M.; Arslan, O.; Artamonov, A.; Artoni, G.; Asai, S.; Asbah, N.; Ashkenazi, A.; Åsman, B.; Asquith, L.; Assamagan, K.; Astalos, R.; Atkinson, M.; Atlay, N. B.; Auerbach, B.; Augsten, K.; Aurousseau, M.; Avolio, G.; Azuelos, G.; Azuma, Y.; Baak, M. A.; Baas, A. E.; Bacci, C.; Bachacou, H.; Bachas, K.; Backes, M.; Backhaus, M.; Backus Mayes, J.; Badescu, E.; Bagiacchi, P.; Bagnaia, P.; Bai, Y.; Bain, T.; Baines, J. T.; Baker, O. K.; Balek, P.; Balli, F.; Banas, E.; Banerjee, S.w.; Bannoura, A. A. E.; Bansal, V.; Bansil, H. S.; Barak, L.; Baranov, S. P.; Barberio, E. L.; Barberis, D.; Barbero, M.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B. M.; Barnett, R. M.; Barnovska, Z.; Baroncelli, A.; Barone, G.; Barr, A. J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Bartoldus, R.; Barton, A. E.; Bartos, P.; Bartsch, V.; Bassalat, A.; Basye, A.; Bates, R. L.; Batley, J. R.; Battaglia, M.; Battistin, M.; Bauer, F.; Bawa, H. S.; Beattie, M. D.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Bechtle, P.; Beck, H. P.; Becker, K.; Becker, S.; Beckingham, M.; Becot, C.; Beddall, A. J.; Beddall, A.; Bedikian, S.; Bednyakov, V. A.; Bee, C. P.; Beemster, L. J.; Beermann, T. A.; Begel, M.; Behr, K.; Belanger Champagne, C.; Bell, P. J.; Bell, W. H.; Bella, G.; Bellerive, A.; Bellomo, M.; Belotskiy, K.; Beltramello, O.; Benary, O.; Benchekroun, D.; Bendtz, K.;
pmid: 25814877
pmc: PMC4370854
Countries: Italy, United KingdomATLAS measurements of the azimuthal anisotropy in lead–lead collisions at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\sqrt{s_{\mathrm {NN}}}=2.76$$\end{document}sNN=2.76 TeV are shown using a dataset of approximately 7 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upmu $$\end{document}μb\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{-1}$$\end{document}-1 collected at the LHC in 2010. The measurements are performed for charged particles with transverse momenta \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$0.5
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.
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You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2018Open AccessAuthors:Claudio Maffeis; Niels H Birkebaek; Maia Konstantinova; Anke Schwandt; Andriani Vazeou; Kristina Casteels; Sujata M Jali; Catarina Limbert; Auste Pundziute-Lycka; Péter Tóth-Heyn; +13 moreClaudio Maffeis; Niels H Birkebaek; Maia Konstantinova; Anke Schwandt; Andriani Vazeou; Kristina Casteels; Sujata M Jali; Catarina Limbert; Auste Pundziute-Lycka; Péter Tóth-Heyn; Carine de Beaufort; Zdenek Sumnik; Valentino Cherubini; Jannet Svensson; Danièle Pacaud; Christina Kanaka-Gantenbein; Shlomit Shalitin; Natasa Bratina; Ragnar Hanas; Guy T. Alonso; Luxmi Poran; Ana L Pereira; Marco Marigliano;Publisher: Hindawi LimitedCountries: Portugal, Italy
OBJECTIVE: To assess the prevalence of underweight (UW), overweight (OW), and obesity in children and adolescents with type 1 diabetes (T1D).METHODS: An international cross-sectional study including 23 026 T1D children (2-18 years, duration of diabetes ≥1 year) participating in the SWEET prospective, multicenter diabetes registry. Body mass index SD score (BMI-SDS) was calculated using the World Health Organization BMI charts. Children were categorized as UW (BMI-SDS < -2SD), OW (+1SD < BMI-SDS ≤ +2SD), and obese (OB) (BMI-SDS > +2SD). Hierarchic regression models were applied with adjustment for sex, age, and duration of diabetes.RESULTS: The prevalence of UW, OW, and obesity was: 1.4%, 22.3%, and 7.3% in males and 0.6%, 27.2%, and 6.8% in females. Adjusted BMI-SDS was significantly higher in females than in males (mean ± SEM: 0.54 ± 0.05 vs 0.40 ± 0.05, P < 0.0001). In males, BMI-SDS significantly decreased by age (P < 0.0001) in the first three age categories 0.61 ± 0.06 (2 to <10 years), 0.47 ± 0.06 (10 to <13 years), 0.34 ± 0.05 (13 to <16 years). In females, BMI-SDS showed a U-shaped distribution by age (P < 0.0001): 0.54 ± 0.04 (2 to <10 years), 0.39 ± 0.04 (10 to <13 years), 0.55 ± 0.04 (13 to <16 years). BMI-SDS increased by diabetes duration (<2 years: 0.38 ± 0.05, 2 to <5 years: 0.44 ± 0.05, and ≥5 years: 0.50 ± 0.05, P < 0.0001). Treatment modality did not affect BMI-SDS. Adjusted HbA1c was significantly higher in females than in males (8.20% ± 0.10% vs 8.06% ± 0.10%, P < 0.0001). In both genders, the association between HbA1c and BMI-SDS was U-shaped with the highest HbA1c in the UW and obesity groups.CONCLUSIONS: The high rate of OW and obesity (31.8%) emphasize the need for developing further strategies to prevent and treat excess fat accumulation in T1D.
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You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2017Open AccessAuthors:Joey W. Trampush; M. L. Z. Yang; Jin Yu; Emma Knowles; Gary Davies; David C. Liewald; John M. Starr; Srdjan Djurovic; Ingrid Melle; Kjetil Sundet; +56 moreJoey W. Trampush; M. L. Z. Yang; Jin Yu; Emma Knowles; Gary Davies; David C. Liewald; John M. Starr; Srdjan Djurovic; Ingrid Melle; Kjetil Sundet; Andrea Christoforou; Ivar Reinvang; Pamela DeRosse; Astri J. Lundervold; Vidar M. Steen; Thomas Espeseth; Katri Räikkönen; Elisabeth Widen; Aarno Palotie; Johan G. Eriksson; Ina Giegling; Bettina Konte; Panos Roussos; Stella G. Giakoumaki; Katherine E. Burdick; Antony Payton; William E R Ollier; Michael A Horan; Ornit Chiba-Falek; Deborah K. Attix; Anna C. Need; Elizabeth T. Cirulli; Aristotle N. Voineskos; Nicholas C. Stefanis; Dimitrios Avramopoulos; Alex Hatzimanolis; Dan E. Arking; Nikolaos Smyrnis; Robert M. Bilder; Nelson A. Freimer; Tyrone D. Cannon; Edythe D. London; Russell A. Poldrack; Fred W. Sabb; Eliza Congdon; Emily Drabant Conley; Matthew A. Scult; Dwight Dickinson; Richard E. Straub; Gary Donohoe; Derek W. Morris; Aiden Corvin; M. Gill; Ahmad R. Hariri; Daniel R. Weinberger; Neil Pendleton; Panos Bitsios; Dan Rujescu; Jari Lahti; S. Le Hellard; Matthew C. Keller; Ole A. Andreassen; Ian J. Deary; David C. Glahn; Anil K. Malhotra; Todd Lencz;
pmc: PMC5322272 , PMC5659072
Publisher: Springer Science and Business Media LLCCountries: United States, Norway, Finland, United Kingdom, IrelandProject: NIH | CORONARY HEART DISEASE &S... (N01HC085081-016), NIH | CORONARY HEART DISEASE AN... (N01HC085085-006), NIH | CTSA INFRASTRUCTURE FOR A... (1UL1RR033176-01), NIH | A Longitudinal Study of A... (5R01MH066140-08), NIH | Striatal D2/D3 Dopamine r... (1P50MH080173-01A1), NIH | Neurodevelopmental Genomi... (5RC2MH089983-02), NIH | Neural signatures of heal... (1R01AG049789-01), NIH | 1/2 Schizophrenia Heterog... (5R01MH092515-03), NIH | CARDIOVASCULAR HEALTH STU... (N01HC035129-010), NIH | Twin Study of ADHD, CD an... (5R01DA013240-10),...Abstract The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10−8). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness.
Top 1% in popularityTop 1% in popularityTop 10% in influencePopularity: Citation-based measure reflecting the current impact.Top 10% in influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . Other literature type . 2013Open AccessAuthors:Montserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Elio Riboli; Loic Le Marchand; Diana Eccles; Penelope Miron; Peter A. Fasching; +201 moreMontserrat Garcia-Closas; Sara Lindström; Kyriaki Michailidou; Marjanka K. Schmidt; Mark N. Brook; Elio Riboli; Loic Le Marchand; Diana Eccles; Penelope Miron; Peter A. Fasching; Hiltrud Brauch; Jenny Chang-Claude; Jane Carpenter; Andrew K. Godwin; Heli Nevanlinna; Graham G. Giles; Angela Cox; John L. Hopper; Manjeet K. Bolla; Qin Wang; Joe Dennis; Ed Dicks; Nils Schoof; Stig E. Bojesen; Diether Lambrechts; Annegien Broeks; Pascal Guénel; Barbara Burwinkel; Elinor J. Sawyer; Antoinette Hollestelle; Olivia Fletcher; Robert Winqvist; Hermann Brenner; Arto Mannermaa; Ute Hamann; Alfons Meindl; Annika Lindblom; Wei Zheng; Peter Devillee; Mark S. Goldberg; Jan Lubinski; Anthony J. Swerdlow; Hoda Anton-Culver; Thilo Dörk; Keitaro Matsuo; Anna H. Wu; Paolo Radice; Soo Hwang Teo; Xiao-Ou Shu; William Blot; Daehee Kang; Mikael Hartman; Suleeporn Sangrajrang; Chen-Yang Shen; Melissa C. Southey; Daniel J. Park; Jennifer Stone; Laura J. van't Veer; Emiel J. Th. Rutgers; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Julian Peto; Arif B. Ekici; Isabel dos Santos Silva; Nichola Johnson; Helen R. Warren; Ian Tomlinson; Michael J. Kerin; Nicola Miller; Thérèse Truong; Pierre Laurent-Puig; Børge G. Nordestgaard; Sune F. Nielsen; Henrik Flyger; Jose Ignacio Arias Perez; Primitiva Menéndez; Heiko Müller; Magdalena Lochmann; Christina Justenhoven; Yon Ko; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Tuomas Heikkinen; Hidemi Ito; Yasushi Yatabe; Sara Margolin; Vesa Kataja; Veli-Matti Kosma; Jaana M. Hartikainen; Rosemary L. Balleine; Chiu-Chen Tseng; Patrick Neven; Anne Sophie Dieudonne; Karin Leunen; Anja Rudolph; Stefan Nickels; Dieter Flesch-Janys; Paolo Peterlongo; Bernard Peissel; Loris Bernard; Janet E. Olson; Xianshu Wang; Gianluca Severi; Laura Baglietto; Catriona McLean; Gerhard A. Coetzee; Ye Feng; Fredrick R. Schumacher; Cheng Har Yip; Nur Aishah Taib; Ching-Yu Cheng; Martha J. Shrubsole; Jirong Long; Katri Pylkäs; Arja Jukkola-Vuorinen; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; R.A.E.M. Tollenaar; Mieke Kriege; Carolien H.M. van Deurzen; Wei Lu; Yu Tang Gao; Hui Cai; Sabapathy P. Balasubramanian; Simon S. Cross; Malcolm W.R. Reed; Qiuyin Cai; Hui Miao; Ching Wan Chan; Kee Seng Chia; Anna Jakubowska; Katarzyna Jaworska; Katarzyna Durda; Chia-Ni Hsiung; Pei Ei Wu; Alan Ashworth; Michael Jones; Anna González-Neira; Guillermo Pita; M. Rosario Alonso; Daniel Vincent; Francois Bacot; Christine B. Ambrosone; Elisa V. Bandera; Gary K. Chen; Jorge L. Rodriguez-Gil; Leslie Bernstein; Michael F. Press; Regina G. Ziegler; Sarah J. Nyante; Sue A. Ingles; Quinten Waisfisz; Helen Tsimiklis; Enes Makalic; Minh Bui; Rita K. Schmutzler; Norbert Dahmen; Lars Beckmann; Kirsimari Aaltonen; Kamila Czene; Astrid Irwanto; Jianjun Liu; Clare Turnbull; Nazneen Rahman; Hanne Meijers-Heijboer; André G. Uitterlinden; Fernando Rivadeneira; Curtis Olswold; Robert Pilarski; Foluso O. Ademuyiwa; Irene Konstantopoulou; Nicholas G. Martin; Grant W. Montgomery; Dennis J. Slamon; Claudia Rauh; Michael P. Lux; Sebastian M. Jud; Thomas Brüning; Priyanka Sharma; Harsh B. Pathak; William J. Tapper; Sue Gerty; Lorraine Durcan; Dimitrios Trichopoulos; Rosario Tumino; Petra H.M. Peeters; Rudolf Kaaks; Daniele Campa; Federico Canzian; Elisabete Weiderpass; Mattias Johansson; Ruth C. Travis; Françoise Clavel-Chapelon; Laurence N. Kolonel; Andrew H. Beck; Susan E. Hankinson; Christine D. Berg; Jolanta Lissowska; Jonine D. Figueroa; Daniel I. Chasman; W. Ryan Diver; Jacques Simard; Alison M. Dunning; Mark E. Sherman; Georgia Chenevix-Trench; Stephen J. Chanock; Celine M. Vachon; Peter Kraft;Publisher: Springer Science and Business Media LLCCountries: Netherlands, United Kingdom, Italy, IrelandProject: NIH | Characterizing Genetic Su... (5U01CA098710-06), WT , NIH | Breast &prostate cancer &... (1U01CA098216-01), NIH | Characterizing Genetic Su... (5U01CA098233-06), NIH | Genetic epidemiology of c... (3R01CA122340-03S1), EC | COGS (223175), CIHR , NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | Breast &Prostate Cancer &... (1U01CA098758-01)
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
Top 1% in popularityTop 1% in popularityTop 1% in influencePopularity: Citation-based measure reflecting the current impact.Top 1% in influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2020Open AccessAuthors:Clairelyne Dupin; V Fernandes; Fernanda Hernandez-Gonzalez; Sebastiano Emanuele Torrisi; Tiago M. Alfaro; Michael Kreuter; Marlies S. Wijsenbeek; Elisabetta A. Renzoni; Elena Bargagli; Hilario Nunes; +5 moreClairelyne Dupin; V Fernandes; Fernanda Hernandez-Gonzalez; Sebastiano Emanuele Torrisi; Tiago M. Alfaro; Michael Kreuter; Marlies S. Wijsenbeek; Elisabetta A. Renzoni; Elena Bargagli; Hilario Nunes; Paolo Spagnolo; Francesco Bonella; Maria Molina-Molina; Katerina M. Antoniou; Venerino Poletti;
pmid: 33
pmc: PMC7533302 , PMC7553109
Publisher: European Respiratory Society (ERS)Countries: Italy, Belgium, NetherlandsThe 2019 European Respiratory Society (ERS) International Congress, held in Madrid, Spain, had exciting sessions regarding the field of pulmonary vascular disease. The symposia related to the new ERS/European Society of Cardiology (ESC) Guidelines for the diagnosis and management of acute pulmonary embolism were well received, as were sessions on pulmonary hypertension related to lung disease, demonstrating the concept of pulmonary hypertension not being the rarity that it was previously thought to be. The use of risk stratification in relation to pulmonary arterial hypertension (PAH) was heavily featured and the scientific sessions informing the respiratory community of potential biomarkers and targets for future therapies were thought-provoking. This article discusses highlights of the 2019 pulmonary vascular disease sessions as a summary of current knowledge and practice. We have summarised the key points from the sessions pertaining to the new ERS/ESC Guidelines for the management of acute pulmonary embolism. We have also focused on prognostic factors and potential therapies in pulmonary hypertension related to interstitial lung disease. Relating to PAH, we have reviewed the symposia on risk stratification, along with the use of noninvasive measures and the sessions relating to biomarkers in PAH. This article aims to summarise research presented at #ERSCongress 2019: the new @escardio/@EuroRespSoc guidance on acute PE diagnosis and management, PH in relation to chronic lung disease, and advances in pulmonary arterial hypertension https://bit.ly/3bAUG0o
Average/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2006Closed AccessAuthors:George Mylonakis; Costis Syngros; George Gazetas; Takashi Tazoh;George Mylonakis; Costis Syngros; George Gazetas; Takashi Tazoh;
doi: 10.1002/eqe.543
Publisher: WileyAn investigation is presented of the collapse of a 630 m segment (Fukae section) of the elevated Hanshin Expressway during the 1995 Kobe earthquake. The earthquake has, from a geotechnical viewpoint, been associated with extensive liquefactions, lateral soil spreading, and damage to waterfront structures. Evidence is presented that soil–structure interaction (SSI) in non-liquefied ground played a detrimental role in the seismic performance of this major structure. The bridge consisted of single circular concrete piers monolithically connected to a concrete deck, founded on groups of 17 piles in layers of loose to dense sands and moderate to stiff clays. There were 18 spans in total, all of which suffered a spectacular pier failure and transverse overturning. Several factors associated with poor structural design have already been identified. The scope of this work is to extend the previous studies by investigating the role of soil in the collapse. The following issues are examined: (1) seismological and geotechnical information pertaining to the site; (2) free-field soil response; (3) response of foundation-superstructure system; (4) evaluation of results against earlier studies that did not consider SSI. Results indicate that the role of soil in the collapse was multiple: First, it modified the bedrock motion so that the frequency content of the resulting surface motion became disadvantageous for the particular structure. Second, the compliance of soil and foundation altered the vibrational characteristics of the bridge and moved it to a region of stronger response. Third, the compliance of the foundation increased the participation of the fundamental mode of the structure, inducing stronger response. It is shown that the increase in inelastic seismic demand in the piers may have exceeded 100% in comparison with piers fixed at the base. These conclusions contradict a widespread view of an always-beneficial role of seismic SSI. Copyright © 2005 John Wiley & Sons, Ltd.
Top 1% in popularityTop 1% in popularityTop 10% in influencePopularity: Citation-based measure reflecting the current impact.Top 10% in influenceInfluence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2018Open AccessAuthors:Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;Marwan O. Jalambo; Basil Kanoa; Mohammed S. Ellulu; Smaher Younis; Mueen El-Kariri;Publisher: Heighten Science Publications CorporationAverage/low popularityAverage/low popularityAverage/low influencePopularity: Citation-based measure reflecting the current impact.Average/low influenceInfluence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.