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description Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Belgium, ItalyElsevier BV David, Tweats; David A, Eastmond; Anthony M, Lynch; Azeddine, Elhajouji; Roland, Froetschl; Micheline, Kirsch-Volders; Francesco, Marchetti; Kenichi, Masumura; Francesca, Pacchierotti; Maik, Schuler;Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between induced aneuploidy occurring after exposure and clonal aneuploidy present in tumours is not clear. Recent evidence indicates that the induction of chromosomal instability (CIN), may be more important than aneuploidy per se, in the carcinogenic process. Down Syndrome, trisomy 21, is associated with altered hematopoiesis in utero which, in combination with subsequent mutations, results in an increased risk for acute megakaryoblastic and lymphoblastic leukemias. In contrast, there is reduced cancer risk for most solid tumours in Down Syndrome. Mouse models with high levels of aneuploidy are also associated with increased cancer risk for particular tumours with long latencies, but paradoxically other types of tumour often show decreased incidence. The aneugens reviewed that induce cancer in humans and animals all possess other carcinogenic properties, such as mutagenicity, clastogenicity, cytotoxicity, organ toxicities, hormonal and epigenetic changes which likely account for, or interact with aneuploidy, to cause carcinogenesis. Although the role that aneuploidy plays in carcinogenesis has not been fully established, in many cases, it may not play a primary causative role. Tubulin-disrupting aneugens that do not possess other properties linked to carcinogenesis, were not carcinogenic in rodents. Similarly, in humans, for the tubulin-disrupting aneugens colchicine and albendazole, there is no reported association with increased cancer risk. There is a need for further mechanistic studies on agents that induce aneuploidy, particularly by mechanisms other than tubulin disruption and to determine the role of aneuploidy in pre-neoplastic events and in early and late stage neoplasia.
ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 NetherlandsElsevier BV Max Dahele; Shannon Pearson; Thomas G. Purdie; Jean-Pierre Bissonnette; Kevin Franks; Anthony Brade; John Cho; Alexander Sun; A. Hope; Andrea Marshall; Jane Higgins; Andrea Bezjak;pmid: 18978570
Introduction: With the anticipation of improved outcomes, especially for patients with early-stage non-small cell lung cancer, stereotactic body radiation therapy (SBRT) has been rapidly introduced into the thoracic radiation oncology community. Although at first glance lung SBRT might seem methodologically similar to conventional radiotherapy, there are important differences in its execution that require particular consideration. The objective of this paper is to highlight these and other issues to contribute to the safe and effective diffusion of lung SBRT. We discuss practical challenges that have been encountered in the implementation of lung SBRT at a single, large institution and emphasize the importance of a systematic approach to the design of lung SBRT services. Methods: Specific technical and clinical components that were identified as being important during the development of lung SBRT at Princess Margaret Hospital are described. The clinical system that evolved from these is outlined. Results: Using this clinical framework the practical topics addressed include: patient assessment, simulation and treatment planning, tumor and organ at risk delineation, trial set up before treatment, on-line image-guidance, and patient follow-up. Conclusions: The potential gain in therapeutic ratio that is theoretically possible with lung SBRT can only be realized if the tumor is adequately irradiated and normal tissue spared. A discussion of the component parts of lung SBRT is presented. It is a complex process and specific challenges need to be overcome to effect the satisfactory transition of lung SBRT into routine practice.
Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Report , Other literature type , Preprint 2018 Turkey, Italy, Italy, Germany, Portugal, Portugal, Italy, United Kingdom, Italy, Italy, Spain, Denmark, Italy, Poland, Italy, Italy, France, ItalySpringer Science and Business Media LLC Aaboud M.; Aad G.; Abbott B.; Abdinov O.; Abeloos B.; Abhayasinghe D. K.; Abidi S. H.; Abouzeid O. S.; Abraham N. L.; Abramowicz H.; Abreu H.; Abulaiti Y.; Acharya B. S.; Adachi S.; Adam L.; Adamczyk L.; Adelman J.; Adersberger M.; Adiguzel A.; Adye T.; Affolder A. A.; Afik Y.; Agheorghiesei C.; Aguilar-Saavedra J. A.; Ahmadov F.; Aielli G.; Akatsuka S.; Åkesson T. P. A.; Akilli E.; Akimov A. V.; Alberghi G. L.; Albert J.; Albicocco P.; Alconada Verzini M. J.; Alderweireldt S.; Aleksa M.; Aleksandrov I. N.; Alexa C.; Alexopoulos T.; Alhroob M.; Ali B.; Alimonti G.; Alison J.; Alkire S. P.; Allaire C.; Allbrooke B. M. M.; Allen B. W.; Allport P. P.; Aloisio A.; Alonso A.; Alonso F.; Alpigiani C.; Alshehri A. A.; Alstaty M. I.; Alvarez Gonzalez B.; Álvarez Piqueras D.; Alviggi M. G.; Amadio B. T.; Amaral Coutinho Y.; Ambler A.; Ambroz L.; Amelung C.; Amidei D.; Amor Dos Santos S. P.; Amoroso S.; Amrouche C. S.; Anastopoulos C.; Ancu L. S.; Andari N.; Andeen T.; Anders C. F.; Anders J. K.; Anderson K. J.; Andreazza A.; Andrei V.; Anelli C. R.; Angelidakis S.; Angelozzi I.; Angerami A.; Anisenkov A. V.; Annovi A.; Antel C.; Anthony M. T.; Antonelli M.; Antrim D. J. A.; Anulli F.; Aoki M.; Aparisi Pozo J. A.; Aperio Bella L.; Arabidze G.; Araque J. P.; Araujo Ferraz V.; Araujo Pereira R.; Arce A. T. H.; Ardell R. E.; Arduh F. A.; Arguin J. -F.; Argyropoulos S.; Armbruster A. J.; Armitage L. J.; Armstrong A.; Arnaez O.; Arnold H.; Arratia M.; Arslan O.; Artamonov A.; Artoni G.; Artz S.; Asai S.; Asbah N.; Asimakopoulou E. M.; Asquith L.; Assamagan K.; Astalos R.; Atkin R. J.; Atkinson M.; Atlay N. B.; Augsten K.; Avolio G.; Avramidou R.; Ayoub M. K.; Azuelos G.; Baas A. E.; Baca M. J.; Bachacou H.; Bachas K.; Backes M.; Bagnaia P.; Bahmani M.; Bahrasemani H.; Bailey A. J.; Baines J. T.; Bajic M.; Bakalis C.; Baker O. K.; Bakker P. J.; Bakshi Gupta D.; Balaji S.; Baldin E. M.; Balek P.; Balli F.; Balunas W. K.; Balz J.; Banas E.; Bandyopadhyay A.; Banerjee S.; Bannoura A. A. E.; Barak L.; Barbe W. M.; Barberio E. L.; Barberis D.; Barbero M.; Barillari T.; Barisits M. -S.; Barkeloo J.; Barklow T.; Barnea R.; Barnes S. L.; Barnett B. M.; Barnett R. M.; Barnovska-Blenessy Z.; Baroncelli A.; Barone G.; Barr A. J.; Barranco Navarro L.; Barreiro F.; Barreiro Guimarães da Costa J.; Bartoldus R.; Barton A. E.; Bartos P.; Basalaev A.; Bassalat A.; Bates R. L.; Batista S. J.; Batlamous S.; Batley J. R.; Battaglia M.; Bauce M.; Bauer F.; Bauer K. T.; Bawa H. S.; Beacham J. B.; Beau T.; Beauchemin P. H.; Bechtle P.; Beck H. C.; Beck H. P.; Becker K.; Becker M.; Becot C.; Beddall A.; Beddall A. J.; Bednyakov V. A.; Bedognetti M.; Bee C. P.; Beermann T. A.; Begalli M.; Begel M.; Behera A.; Behr J. K.; Bellagamba L.; Benchekroun D.; Benekos N.; Benjamin D. P.; Benoit M.; Berger N.; Beringer J.; Berta P.; Bessner M.; Besson N.; Bethani A.; Betti A.; Bevan A. J.; Bianchi R. M.; Biesuz N. V.; Billoud T. R. V.; Bindi M.; Biondi S.; Biswal J. P.; Blue A.; Bogavac D.; Bold T.; Bolz A. E.; Bona M.; Bortfeldt J.; Bosman M.; Bossio Sola J. D.; Bouaouda K.; Bouhova-Thacker E. V.; Boutle S. K.; Boveia A.; Brahimi N.; Brandt A.; Breaden Madden W. D.; Britton D.; Brooijmans G.; Brost E.; Broughton J. H.; Bruckman de Renstrom P. A.; Bruno S.; Bruscino N.; Buckley A. G.; Burdin S.; Burke S.; Buttar C. M.; Butterworth J. M.; Buzykaev A. R.; Cabras G.; Cai H.; Cairo V. M. M.; Cakir O.; Calafiura P.; Calandri A.; Callea G.; Calvente Lopez S.; Calvetti M.; Camarda S.; Camarri P.; Campoverde A.; Canale V.; Cantero J.; Capeans Garrido M. D. M.; Caprini I.; Caprini M.; Capua M.; Cardillo F. C.; Carli I.; Carquin E.; Carrá S.; Casado M. P.; Castillo F. L.; Castillo Gimenez V.; Castro N. F.; Caudron J.; Cavasinni V.; Cerda Alberich L.; Cerqueira A. S.; Cerri A.; Chargeishvili B.; Chelstowska M. A.; Chen C.; Chen C. H.; Chen H.; Cheng H. C.; Cheremushkina E.; Cherkaoui El Moursli R.; Chevalier L.; Chiarella V.; Chiodini G.; Chu M. C.; Chudoba J.; Chwastowski J. J.; Chytka L.; Cinca D.; Cindro V.; Citron Z. H.; Coadou Y.; Cobal M.; Coccaro A.; Coimbra A. E. C.; Colasurdo L.; Conde Muiño P.; Coniavitis E.; Corrigan E. E.; Corriveau F.; Costa M. J.; Costanzo D.; Cottin G.; Cranmer K.; Cristinziani M.; Croft V.; Crosetti G.; Cueto A.; Czodrowski P.; Dabrowski W.; Dado T.; Dahbi S.; Dallapiccola C.; Danninger M.; Dao V.; Darbo G.; Davey W.; David C.; Davidek T.; De Cecco S.; De la Torre H.; De Maria A.; De Sanctis U.; De Santis M.; De Vivie De Regie J. B.; Deliot F.; Delitzsch C. M.; Della Pietra M.; Dell’acqua A.; Delsart P. A.; Demarco D. A.; Derendarz D.; Dervan P.; Di Bello F. A.; Di Ciaccio A.; Di Ciaccio L.; Diaconu C.; Dias F. A.; Dias Do Vale T.; Dietrich J.; Dittus F.; Djama F.; Djobava T.; Doglioni C.; Doyle A. T.; Duckeck G.; Ducu O. A.; Duda D.; Duperrin A.; Duran Yildiz H.; Durglishvili A.; Dyndal M.; Dziedzic B. S.; Ellert M.; Ellinghaus F.; Ellis N.; Elsing M.; Erdmann J.; Ereditato A.; Escalier M.; Escobar C.; Estrada Pastor O.; Evans H.; Ezhilov A.; Ezzi M.; Fabbri F.; Fabiani V.; Faisca Rodrigues Pereira R. M.; Falke P. J.; Falke S.; Faltova J.; Fanti M.; Farbin A.; Farina E. M.; Farooque T.; Farrington S. M.; Fassi F.; Faucci Giannelli M.; Fawcett W. J.; Feligioni L.; Feng C.; Ferreira de Lima D. E.; Ferrere D.; Filthaut F.; Fiorini L.; Fisher W. C.; Fleck I.; Flores L. M.; Formica A.; Fox H.; Francavilla P.; Franchini M.; Franklin M.; Freund B.; Fullana Torregrosa E.; Gadow P.; Gagnon L. G.; Gamboa Goni R.; García Navarro J. E.; García Pascual J. A.; Gee C. N. P.; Genest M. H.; George S.; Ghneimat M.; Giagu S.; Giangiacomi N.; Giannetti P.; Gibson S. M.; Giordani M. P.; Giromini P.; Giugliarelli G.; Giuli F.; Gkaitatzis S.; Gkougkousis E. L.; Glasman C.; Glaysher P. C. F.; Godlewski J.; Golling T.; Gonçalo R.; Gonella G.; Gongadze A.; Gonski J. L.; González de la Hoz S.; Goossens L.; Govender N.; Grabowska-Bold I.; Gramstad E.; Grancagnolo S.; Gravila P. M.; Gravili F. G.; Gray C.; Grefe C.; Gregersen K.; Gregor I. M.; Grinstein S.; Groh S.; Grummer A.; Guenther J.; Guescini F.; Guo J.; Gustavino G.; Gutschow C.; Guzik M. P.; Gwenlan C.; Gwilliam C. B.; Haas A.; Hadavand H. K.; Hadef A.; Haley J.; Halladjian G.; Hamal P.; Han K.; Hanagaki K.; Handl D. M.; Haney B.; Hansen E.; Hansen J. B.; Hassani S.; Haug S.; Hays C. P.; Heath M. P.; Heelan L.; Heim S.; Heinrich J. J.; Heinrich L.; Heinz C.; Hejbal J.; Held A.; Herde H.; Hernández Jiménez Y.; Hill E.; Hillier S. J.; Hils M.; Hod N.; Holmes T. R.; Honda S.; Hopkins W. H.; Horn P.; Horyn L. A.; Hoya J.; Hrynevich A.; Hubaut F.; Hunter R. F. H.; Iacobucci G.; Iliadis D.; Introzzi G.; Ippolito V.; Isacson M. F.; Islam W.; Istin S.; Iuppa R.; Jackson P.; Jakobsen S.; Jakoubek T.; Jana D. K.; Jansky R.; Janssen J.; Jeanneau F.; Jeanty L.; Jia J.; Jiggins S.; Jinnouchi O.; Jon-And K.; Jones R. W. L.; Jones S. D.; Jones S.; Jorge P. M.; Jovicevic J.; Ju X.; Junggeburth J. J.; Juste Rozas A.; Kaczmarska A.; Kar D.; Karentzos E.; Karpov S. N.; Karpova Z. M.; Kay E. F.; Kazanin V. F.; Keeler R.; Kempster J. J.; Kendrick J.; Kharlamova T.; Khoo T. J.; Khramov E.; Kirk J.; Kiryunin A. E.; Klimek P.; Knue A.; Kodys P.; Koffas T.; König A. C.; Kono T.; Konoplich R.; Konstantinidis N.; Korcyl K.; Koulouris A.; Kourkoumelis C.; Kourlitis E.; Kouskoura V.; Kowalewski R.; Krasnopevtsev D.; Krauss D.; Kretzschmar J.; Kroll J.; Kruchonak U.; Kugel A.; Kukla R.; Kulchitsky Y.; Kupco A.; Kurchaninov L. L.; Kuwertz E. S.; Kuze M.; La Rosa A.; La Rosa Navarro J. L.; La Rotonda L.; Lacasta C.; Lafaye R.; Landon M. P. J.; Lange J. C.; Lapertosa A.; Lari T.; Lassnig M.; Lazzaroni M.; Leblanc M.; Lee C. A.; Lee G. R.; Lefebvre B.; Legger F.; Leight W. A.; Leisos A.; Leite M. A. L.; Leney K. J. C.; Leone R.; Leonidopoulos C.; Leroy C.; Les R.; Lester C. G.; Levchenko M.; Li B.; Li H.; Lie K.; Lin C. Y.; Lipniacka A.; Lisovyi M.; Lister A.; Litke A. M.; Little J. D.; Liu B.; Liu B. L.; Liu H. B.; Liu H.; Livan M.; Lleres A.; Llorente Merino J.; Lloyd S. L.; Lobodzinska E. M.; Loch P.; Lohwasser K.; Lokajicek M.; Longo L.; Lopez J. A.; Lorenzo Martinez N.; Losada M.; Lozano Bahilo J. J.; Luci C.; Lucotte A.; Luehring F.; Lysak R.; Macdonald C. M.; Madar R.; Madysa N.; Maeda J.; Maevskiy A. S.; Majersky O.; Makida Y.; Makovec N.; Maleev V. P.; Mamuzic J.; Mancini G.; Maneira J.; Manjarres Ramos J.; Mankinen K. H.; Manousos A.; Manzoni S.; March L.; Marcisovsky M.; Marjanovic M.; Marti-Garcia S.; Martin C. B.; Martin T. A.; Martin V. J.; Martin-Haugh S.; Marzin A.; Masetti L.; Massa L.; Massarotti P.; Mastrandrea P.; Mastroberardino A.; Masubuchi T.; Mazza S. M.; McLean K. D.; McNamara P. C.; McPherson R. A.; Meirose B.; Mellado Garcia B. R.; Mellenthin J. D.; Melo M.; Meloni F.; Mendes Gouveia E. D.; Mengarelli A.; Meoni E.; Messina A.; Mete A. S.; Mijović L.; Mikestikova M.; Millar D. A.; Mindur B.; Mistry K. P.; Mkrtchyan T.; Mogg P.; Mohapatra S.; Monk J.; Montejo Berlingen J.; Monzani S.; Morange N.; Moreno D.; Morettini P.; Morii M.; Morley A. K.; Morvaj L.; Moyse E. J. W.; Mueller F.; Mullier G. A.; Munoz Sanchez F. J.; Murray W. J.; Murrone A.; Nagasaka Y.; Nairz A. M.; Nanjo H.; Napolitano F.; Naryshkin I.; Neep T. J.; Negrini M.; Nelson M. E.; Nemecek S.; Nielsen D. S.; Nikiforou N.; Nikolopoulos K.; Nisati A.; Nishu N.; Nobe T.; Novak T.; Ntekas K.; Ocariz J.; Ochoa-Ricoux J. P.; Oda S.; Ohm C. C.; Oide H.; Okazaki Y.; Oliveira Damazio D.; Oliver J. L.; Olszewski A.; Olszowska J.; Onofre A.; Onyisi P. U. E.; Oreglia M. J.; Orestano D.; Orlando N.; Ould-Saada F.; Ozturk N.; Pachal K.; Pacheco Pages A.; Padilla Aranda C.; Palestini S.; Palka M.; Panduro Vazquez J. G.; Panizzo G.; Pasuwan P.; Pathak A.; Pedro R.; Peleganchuk S. V.; Penc O.; Perini L.; Peters K.; Petersen B. A.; Petrucci F.; Pezoa R.; Pham T.; Pianori E.; Pilkington A. D.; Pleskot V.; Poggi R.; Policicchio A.; Pollard C. S.; Ponomarenko D.; Potter C. J.; Potti H.; Poulsen T.; Poveda J.; Pralavorio P.; Primavera M.; Prince S.; Proklova N.; Prokoshin F.; Przybycien M.; Puri A.; Qian J.; Queitsch-Maitland M.; Ragusa F.; Raine J. A.; Rauch D. M.; Ravina B.; Reale M.; Rebuzzi D. M.; Redlinger G.; Reeves K.; Reichert J.; Resconi S.; Resseguie E. D.; Ricci E.; Ridel M.; Rieck P.; Rifki O.; Rimoldi A.; Ripellino G.; Rivera Vergara J. C.; Roberts R. T.; Robinson D.; Robson A.; Rocco E.; Roda C.; Rodriguez Bosca S.; Rodriguez Perez A.; Roland C. P. A.; Roloff J.; Romaniouk A.; Romano M.; Rompotis N.; Roos L.; Rosati S.; Rosbach K.; Rotaru M.; Roy D.; Rozen Y.; Rurikova Z.; Russell H. L.; Ryu S.; Ryzhov A.; Sabatini P.; Saimpert M.; Saito M.; Salazar Loyola J. E.; Salvatore D.; Salvucci A.; Sammel D.; Sanchez Pineda A.; Sankey D. P. C.; Santra A.; Sasaki O.; Sato K.; Sauvan E.; Sawyer C.; Schaefer D.; Schildgen L. K.; Schioppa E. J.; Schioppa M.; Schmidt-Sommerfeld K. R.; Schmitt C.; Schmitt S.; Schoeffel L.; Schopf E.; Schouwenberg J. F. P.; Schramm S.; Schwarz T. A.; Sciandra A.; Scornajenghi M.; Scyboz L. M.; Searcy J.; Sebastiani C. D.; Senkin S.; Serkin L.; Sessa M.; Sforza F.; Sfyrla A.; Shabalina E.; Shahinian J. D.; Shaikh N. W.; Shapiro M.; Sharma A. S.; Shi L.; Shimojima M.; Shojaii S.; Simioni E.; Simon M.; Sioli M.; Siral I.; Sliwa K.; Smirnov N.; Smirnov S. Y.; Smirnov Y.; Smirnova L. N.; Smith J. W.; Smolek K.; Smykiewicz A.; Snyder I. M.; Solovyev V.; Sommer P.; Son H.; Song W.; Sopczak A.; Sotiropoulou C. L.; Soualah R.; Sowden B. C.; Spagnolo S.; Spieker T. M.; Stabile A.; Stanecka E.; Stanislaus B.; Stark G. H.; Starovoitov P.; Stärz S.; Staszewski R.; Stevenson T. J.; Stolte P.; Straessner A.; Strandberg J.; Strizenec P.; Stucci S. A.; Stugu B.; Stupak J.; Sullivan M. J.; Sumida T.; Svatos M.; Swiatlowski M.; Sykora I.; Ta D.; Tahirovic E.; Takai H.; Tapia Araya S.; Tartarelli G. F.; Tassi E.; Taylor A. C.; Taylor A. J.; Terashi K.; Terron J.; Terzo S.; Thiele F.; Thompson A. S.; Thomson E.; Tian Y.; Ticse Torres R. E.; Tikhomirov V. O; Tisserant S.; Tokushuku K.; Tomiwa K. G.; Torró Pastor E.; Toth J.; Trigger I. M.; Trincaz-Duvoid S.; Trocmé B.; Trofymov A.; Troncon C.; Trovato F.; Truong L.; Trzebinski M.; Tsai F.; Tsuno S.; Tu Y.; Tudorache A.; Tudorache V.; Turra R.; Tzovara E.; Ughetto M.; Unal G.; Ungaro F. C.; Urquijo P.; Vadla K. O. H.; Vaidya A.; Valente M.; Valero A.; Valéry L.; Van Daalen T. R.; Van Gemmeren P.; Van Vulpen I.; Vanadia M.; Vari R.; Varvell K. E.; Vazquez Furelos D.; Veloso F.; Veneziano S.; Ventura A.; Vercesi V.; Verducci M.; Vermeulen A. T.; Vetterli M. C.; Viaux Maira N.; Vickey T.; Vickey Boeriu O. E.; Villa M.; Vincter M. G.; Vivarelli I.; Vlachos S.; von Buddenbrock S. E.; Vorobel V.; Vos M.; Vranjes N.; Vranjes Milosavljevic M.; Vukotic I.; Walder J.; Walkowiak W.; Wang A. M.; Wang C.; Wanotayaroj C.; Warburton A.; Wardrope D. R.; Watkins P. M.; Watts G.; Weber C.; Weber M. S.; Weber S. A.; Weingarten J.; Weirich M.; Weiser C.; Wenaus T.; Wengler T.; Werner M. D.; Werner P.; Whalen K.; Wickens F. J.; Wielers M.; Wiglesworth C.; Willocq S.; Winkels E.; Winklmeier F.; Winter B. T.; Wolf A.; Wolter M. W.; Wolters H.; Worm S. D.; Woźniak K. W.; Wu M.; Wu S. L.; Wu X.; Xella S.; Xi Z.; Xu D.; Xu H.; Yabsley B.; Yacoob S.; Yamaguchi D.; Yamazaki T.; Yang H. J.; Yang H. T.; Yap Y. C.; Yigitbasi E.; Yorita K.; Yu J.; Zaidan R.; Zakareishvili T.; Zakharchuk N.; Zanzi D.; Zhang D. F.; Zhang D.; Zhang F.; Zhao P.; Zhemchugov A.; Zhou B.; Zhu C. G.; Zoch K.; Zorbas T. G.;We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5
CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 30visibility views 30 download downloads 50 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1987Wiley Authors: Hartshorn, R.Timothy; Mauk, A.Grant; Mauk, Marcia R.; Moore, Geoffrey R.;Hartshorn, R.Timothy; Mauk, A.Grant; Mauk, Marcia R.; Moore, Geoffrey R.;pmid: 3030818
The interaction between horse cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b 5 in the absence and presence of [Cr(ethylenediamine)3]Cl3 was studied by 1H NMR spectroscopy. The protein‐protein interaction region on cytochrome b 5 was found to be different from the [Cr(en)3]3+ binding region. The solvent‐exposed propionate‐bearing edge of the haem of cytochrome b 5 is accessible to [Cr(en)3]3+ in the interprotein complex.
FEBS Letters arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert FEBS Letters arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017American Physical Society (APS) NSERC, UKRI | RootDetect: Remote Detect...NSERC ,UKRI| RootDetect: Remote Detection and Precision Management of Root HealthJ. P. Lees; V. Poireau; V. Tisserand; E. Grauges; A. Palano; G. Eigen; D. N. Brown; Yu. G. Kolomensky; M. Fritsch; H. Koch; T. Schroeder; C. Hearty; T. S. Mattison; J. A. McKenna; R. Y. So; V. E. Blinov; A. R. Buzykaev; V. P. Druzhinin; V. B. Golubev; E. A. Kravchenko; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu. Todyshev; A. J. Lankford; J. W. Gary; O. Long; A. M. Eisner; W. S. Lockman; W. Panduro Vazquez; D. S. Chao; C. H. Cheng; B. Echenard; K. T. Flood; D. G. Hitlin; J. Kim; T. S. Miyashita; P. Ongmongkolkul; F. C. Porter; M. Röhrken; Z. Huard; B. T. Meadows; B. G. Pushpawela; M. D. Sokoloff; J. G. Smith; S. R. Wagner; D. Bernard; M. Verderi; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Fioravanti; I. Garzia; E. Luppi; V. Santoro; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Martellotti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rotondo; A. Zallo; S. Passaggio; C. Patrignani; H. M. Lacker; B. Bhuyan; U. Mallik; C. Chen; J. Cochran; S. Prell; H. Ahmed; A. V. Gritsan; N. Arnaud; M. Davier; F. Le Diberder; A. M. Lutz; G. Wormser; D. J. Lange; D. M. Wright; J. P. Coleman; E. Gabathuler; D. E. Hutchcroft; D. J. Payne; C. Touramanis; A. J. Bevan; F. Di Lodovico; R. Sacco; G. Cowan; Sw. Banerjee; D. N. Brown; C. L. Davis; A. G. Denig; W. Gradl; K. Griessinger; A. Hafner; K. R. Schubert; R. J. Barlow; G. D. Lafferty; R. Cenci; A. Jawahery; D. A. Roberts; R. Cowan; S. H. Robertson; B. Dey; N. Neri; F. Palombo; R. Cheaib; L. Cremaldi; R. Godang; D. J. Summers; P. Taras; G. De Nardo; C. Sciacca; G. Raven; C. P. Jessop; J. M. LoSecco; K. Honscheid; R. Kass; A. Gaz; M. Margoni; M. Posocco; G. Simi; F. Simonetto; R. Stroili; S. Akar; E. Ben-Haim; M. Bomben; G. R. Bonneaud; G. Calderini; J. Chauveau; G. Marchiori; J. Ocariz; M. Biasini; E. Manoni; A. Rossi; G. Batignani; S. Bettarini; M. Carpinelli; G. Casarosa; M. Chrzaszcz; F. Forti; M. A. Giorgi; A. Lusiani; B. Oberhof; E. Paoloni; M. Rama; G. Rizzo; J. J. Walsh; A. J. S. Smith; F. Anulli; R. Faccini; F. Ferrarotto; F. Ferroni; A. Pilloni; G. Piredda; C. Bünger; S. Dittrich; O. Grünberg; M. Heß; T. Leddig; C. Voß; R. Waldi; T. Adye; F. F. Wilson; S. Emery; G. Vasseur; D. Aston; C. Cartaro; M. R. Convery; J. Dorfan; W. Dunwoodie; M. Ebert; R. C. Field; B. G. Fulsom; M. T. Graham; C. Hast; W. R. Innes; P. Kim; D. W. G. S. Leith; S. Luitz; D. B. MacFarlane; D. R. Muller; H. Neal; B. N. Ratcliff; A. Roodman; M. K. Sullivan; J. Va’vra; W. J. Wisniewski; M. V. Purohit; J. R. Wilson; A. Randle-Conde; S. J. Sekula; M. Bellis; P. R. Burchat; E. M. T. Puccio; M. S. Alam;We measure the mass difference, Δm_{+}, between the D^{*}(2010)^{+} and the D^{+} using the decay chain D^{*}(2010)^{+}→D^{+}π^{0} with D^{+}→K^{-}π^{+}π^{+}. The data were recorded with the BABAR detector at center-of-mass energies at and near the ϒ(4S) resonance, and correspond to an integrated luminosity of approximately 468 fb^{-1}. We measure Δm_{+}=(140 601.0±6.8[stat]±12.9[syst]) keV. We combine this result with a previous BABAR measurement of Δm_{0}≡m(D^{*}(2010)^{+})-m(D^{0}) to obtain Δm_{D}=m(D^{+})-m(D^{0})=(4824.9±6.8[stat]±12.9[syst]) keV. These results are compatible with and approximately five times more precise than the Particle Data Group averages.
Physical Review Lett... arrow_drop_down Physical Review LettersArticleLicense: publisher-specific, author manuscriptData sources: UnpayWallPhysical Review LettersArticle . 2017License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Physical Review Lett... arrow_drop_down Physical Review LettersArticleLicense: publisher-specific, author manuscriptData sources: UnpayWallPhysical Review LettersArticle . 2017License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 Netherlands, United Kingdom, United KingdomWiley NHMRC | THE CYCLE OF OBESITY: Two..., EC | CANDICE, NHMRC | A genome-wide search for ... +4 projectsNHMRC| THE CYCLE OF OBESITY: Two generations of a pregnancy cohort to investigate obesity epigenetics ,EC| CANDICE ,NHMRC| A genome-wide search for genes underlying the developmental origins of health and disease ,NWO| Decoding the Gene-Environment Interplay of Reading Ability ,NHMRC| Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 year follow up of a Longitudinal Cohort ,CIHR ,WT| The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.Filippo Abbondanza; Philip S. Dale; Carol A. Wang; Marianna E. Hayiou‐Thomas; Umar Toseeb; Tanner S. Koomar; Karen G. Wigg; Yu Feng; Kaitlyn M. Price; Elizabeth N. Kerr; Sharon L. Guger; Maureen W. Lovett; Lisa J. Strug; Elsje van Bergen; Conor V. Dolan; J. Bruce Tomblin; Kristina Moll; Gerd Schulte‐Körne; Nina Neuhoff; Andreas Warnke; Simon E. Fisher; Cathy L. Barr; Jacob J. Michaelson; Dorret I. Boomsma; Margaret J. Snowling; Charles Hulme; Andrew J. O. Whitehouse; Craig E. Pennell; Dianne F. Newbury; John Stein; Joel B. Talcott; Dorothy V. M. Bishop; Silvia Paracchini;Funding: Royal Society - UF150663, RGF\EA\180141; Wellcome Trust - 217065/Z/19/Z; H2020 European Research Council - 694189; NWO - 451-15-017; National Health and Medical Research Council - 1173896; Canadian Institute for Health Research - MOP-133440. Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions. Publisher PDF Peer reviewed
Vrije Universiteit A... arrow_drop_down Oxford University Research Archive; Child DevelopmentOther literature type . Article . 2022 . 2023License: CC BYOxford Brookes University: RADAROther literature type . 2023License: CC BYData sources: Oxford Brookes University: RADARadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 32visibility views 32 download downloads 110 Powered bymore_vert Vrije Universiteit A... arrow_drop_down Oxford University Research Archive; Child DevelopmentOther literature type . Article . 2022 . 2023License: CC BYOxford Brookes University: RADAROther literature type . 2023License: CC BYData sources: Oxford Brookes University: RADARadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2011 NetherlandsBMJ Alexandra Zhernakova; Eli A. Stahl; Gosia Trynka; Soumya Raychaudhuri; E Festen; Lude Franke; Rudolf S N Fehrmann; Fina A S Kurreeman; Brian Thomson; Namrata Gupta; Jihane Romanos; Ross McManus; Anthony W. Ryan; Graham Turner; Elaine F. Remmers; Luigi Greco; René E. M. Toes; Elvira Grandone; Maria Cristina Mazzilli; Anna Rybak; Bożena Cukrowska; Yonghong Li; Paul I.W. de Bakker; Peter K. Gregersen; Jane Worthington; Katherine A. Siminovitch; Lars Klareskog; Tom W J Huizinga; Cisca Wijmenga; Robert M. Plenge;handle: 1887/116730
Background and objectives Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-human leucocyte antigen (HLA) CD and RA risk loci (out of 26 loci for each disease) are shared between both diseases. The authors hypothesised that there are additional shared risk alleles, and that combining genome-wide association study (GWAS) data from each disease would increase power to identify these shared risk alleles. Materials and methods The authors performed a meta-analysis of two published GWAS on CD (4533 cases and 10 750 controls) and RA (5539 cases and 17 231 controls), and genotyping the top associated single-nucleotide polymorphisms (SNPs) in independent set of 2169 CD cases and 2255 controls, and 2845 RA cases and 4944 controls. The authors used the gene-expression dataset of peripheral blood mononuclear cell of 1469 individuals to investigate the genotype-expression correlation of associated variants. The authors also analysed the results using various pathway analysis tools. Results Above already established six shared loci, eight additional SNPs demonstrated p −8 in a combined analysis of all 50 266 samples. From the 14 shared gene loci, 7 SNPs showed a genome-wide significant effect on expression of one or more transcripts in the linkage disequilibrium block around the SNP. Pathway analysis tools indicate remarkable overrepresentation of T cell signalling molecules among the shared genes. Conclusions The authors identified 14 shared CD-RA risk loci. These associations implicate antigen presentation and T cell activation as a shared mechanism of disease pathogenesis and underscore the utility of cross-disease meta-analysis for identification of genetic risk factors with pleiotropic effects between two clinically distinct diseases.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United KingdomElsevier BV Eivind Berge; Rustam Al-Shahi Salman; H Bart van der Worp; Christian Stapf; Peter Sandercock; Nikola Sprigg; Malcolm R Macleod; Peter J Kelly; Paul J Nederkoorn; Gary A Ford; Marcel Arnold; Eivind Berge; Exuperio Diez-Tejedor; Dalius Jatuzis; Peter J Kelly; Derk W Krieger; Paul J Nederkoorn; Peter Sandercock; Christian Stapf; Christian Weimar; Gary A Ford; Rustam Al-Shahi Salman;pmid: 28414643
Stroke is a major burden to patients and society, and resources spent on stroke research must be used efficiently and produce good value in terms of improvements in human health. However, many instances of poor value from stroke research funding have resulted from the way in which stroke research topics have been chosen and how studies have been designed, conducted, analysed, regulated, managed, disseminated, or reported. A cooperative effort of European stroke researchers aimed to identify sources of inefficiency and waste, recommend approaches to increase value, and highlight examples of best practice in stroke research. Evidence suggests that progress has been made, but there is room for much improvement; researchers, funders, regulators, and other stakeholders in stroke research might consider these recommendations when planning new research.
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For further information contact us at helpdesk@openaire.eu29 citations 29 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012American Physical Society (APS) Georges Aad; S. Abdel Khalek; M. Abolins; Bobby Samir Acharya; Leszek Adamczyk; Jahred Adelman; Tim Adye; S. Aefsky; J. A. Aguilar-Saavedra; Giulio Aielli; Igor Aleksandrov; Calin Alexa; Gideon Alexander; Theodoros Alexopoulos; Muhammad Alhroob; John Alison; Alejandro Alonso; Francisco Alonso; Christoph Amelung; V. V. Ammosov; G. Anders; Alexey Anisenkov; Nuno Anjos; Alberto Annovi; S. Aoun; Aaron James Armbruster; Giacomo Artoni; Ketevi Assamagan; Markus Atkinson; Kamil Augsten; Giuseppe Avolio; Rachel Maria Avramidou; Georges Azuelos; Henri Bachacou; Konstantinos Bachas; Malte Backhaus; Paolo Bagnaia; Elzbieta Banas; Liron Barak; Dario Barberis; D. Y. Bardin; Teresa Barillari; Antonio Baroncelli; Fernando Barreiro; Adam Edward Barton; Richard Bates; Franz E. Bauer; S. Beale; Tristan Beau; Philip Bechtle; Lars Beemster; Gideon Bella; Alberto Belloni; Nektarios Benekos; D. P. Benjamin; Mathieu Benoit; Nicolas Berger; Frank Berghaus; J. Beringer; Federico Bertolucci; Nathalie Besson; Michele Bianco; Bernhard Bittner; G. Blanchot; Tomas Blazek; W. Blum; Simona Serena Bocchetta; C. R. Boddy; Michael Boehler; Marcella Bona; S. Bordoni; Guennadi Borissov; Marcello Borri; Valerio Bortolotto; Martine Bosman; Djamel Eddine Boumediene; A. Boveia; Juraj Bracinik; Andrew Brandt; Gerhard Brandt; H. M. Braun; Ian Brock; Gustaaf Brooijmans; Timothy Brooks; William Brooks; F. Bucci; Peter Buchholz; Sergey Burdin; Stephen Burke; Craig Buttar; William Buttinger; Paolo Calafiura; R. Caloi; R. Camacho Toro; Paolo Camarri; Lea Caminada; Mario Campanelli; Mihai Caprini; Marcella Capua; Roberto Cardarelli; Tancredi Carli; Edson Carquin; João Carvalho; Diego Casadei; Maria Pilar Casado; M. Cascella; Nuno Filipe Castro; P. Catastini; Andrea Catinaccio; Matteo Cavalli-Sforza; Augusto Santiago Cerqueira; Alessandro Cerri; Serkant Ali Cetin; I. Chalupkova; John Derek Chapman; Susan Cheatham; Sergei Chekanov; Sergey Chekulaev; Chunhui Chen; Yi Chen; J. T. Childers; Gabriele Chiodini; Adrian Chitan; Doris Chromek-Burckhart; Jiri Chudoba; Abbas Kenan Ciftci; Diane Cinca; Vladimir Cindro; Zvi Hirsh Citron; Mihai Ciubancan; Yann Coadou; Marina Cobal; Andrea Coccaro; Neil Collins; Elias Coniavitis; A. M. Cooper-Sarkar; Giuseppe Costa; Davide Costanzo; Kyle Cranmer; Markus Cristinziani; Giovanni Crosetti; T. Cuhadar Donszelmann; Maria Curatolo; Patrick Czodrowski; Saverio D'Auria; C. Da Via; A. Dafinca; Mogens Dam; H. O. Danielsson; Valerio Dao; Giovanni Darbo; E. Davies; William James Dearnaley; Pierre-Antoine Delsart; B. Demirkoz; Dominik Derendarz; Jamal Eddine Derkaoui; Marco Aurelio Diaz; Edward Diehl; Janet Dietrich; C. Dionisi; Fridolin Dittus; Tamar Djobava; Matt Dobbs; J. Dodd; Caterina Doglioni; T. Dohmae; Marisilvia Donadelli; Julien Donini; Jens Dopke; Alessandra Doria; Dominik Duda; Alexey Dudarev; Mattias Ellert; Nicolas Ellis; Johannes Elmsheuser; Markus Elsing; Johannes Erdmann; Antonio Ereditato; D. Errede; Carlos Escobar; Hal Evans; Laura Fabbri; Marcello Fanti; Amir Farbin; J. Farley; Trisha Farooque; Sinead Farrington; Farida Fassi; Andrea Favareto; Lorenzo Feligioni; D. Fellmann; Eric Feng; Roberto Ferrari; Antonio Ferrer; Didier Ferrere; Frank Fiedler; Andrej Filipcic; Luca Fiorini; Ivor Fleck; Andrea Formica; Daniel Fournier; Harald Fox; Paolo Francavilla; Matteo Franchini; David Francis; Marco Fraternali; O. Gabizon; S. Gadomski; Bruno Galhardo; F. Garberson; Maurice Garcia-Sciveres; Carmen García; Robert Gardner; Claudio Gatti; Gabriella Gaudio; P. Gauzzi; Claudia Gemme; Marie-Hélène Genest; Benedetto Giacobbe; Stefano Giagu; Danilo Giugni; C. Goeringer; Steven Goldfarb; Tobias Golling; L. S. Gomez Fajardo; Ricardo Gonçalo; Laura Gonella; Sergio Gonzalez-Sevilla; Luc Goossens; Petr Andreevich Gorbounov; G. Gorfine; A. Goriek; Driss Goujdami; Anna Goussiou; S. Gozpinar; Sergio Grancagnolo; Vadim Gratchev; Heather Gray; J. A. Gray; Kristian Gregersen; Philippe Grenier; Sebastian Grinstein; Jean-Francois Grivaz; J. Groth-Jensen; Phillip Gutierrez; Claude Guyot; Claire Gwenlan; Carl Gwilliam; Andy Haas; Haleh Khani Hadavand; Kazunori Hanagaki; Paul Hanke; Torsten Harenberg; Tomiyoshi Haruyama; Samira Hassani; Sigve Haug; A. D. Hawkins; Chris Hays; Stephen Haywood; Vincent Hedberg; Sarah Heim; Sophie Henrot-Versille; Luis Hervas; Nigel Hessey; J. C. Hill; Noam Hod; Mark Hodgkinson; Paul Hodgson; J. Hoffman; J-Y. Hostachy; S. R. Hou; Tetiana Hryn'ova; Fabrice Hubaut; Fabian Huegging; Giuseppe Iacobucci; Paolo Iengo; Olga Igonkina; Masahiro Ikeno; Dimitrios Iliadis; J. Inigo-Golfin; Mauro Iodice; Valerio Ippolito; W. Iwanski; Joseph Izen; Sune Jakobsen; Dilip Jana; A. Jantsch; Michel Janus; Laura Jeanty; Peter Jenni; Ask Emil Loevschall-Jensen; Jiangyong Jia; M. Jimenez Belenguer; Osamu Jinnouchi; K. E. Johansson; Tim Jones; Xiangyang Ju; Anna Kaczmarska; H. Kagan; Enrique Kajomovitz; M. Kaneda; Deepak Kar; M. Karnevskiy; Gregor Kasieczka; V. Kaushik; Kiyotomo Kawagoe; Shingo Kazama; Teng Jian Khoo; Julie Kirk; Andrey Kiryunin; Danuta Kisielewska; Uta Klein; Pawel Klimek; E. B. Klinkby; Peter Kluit; Stefan Kluth; Thomas Koffas; Els Koffeman; Z. Kohout; Hermann Kolanoski; V. I. Kolesnikov; Takanori Kono; Rostislav Konoplich; Nikolaos Konstantinidis; Krzysztof Korcyl; Vadim Kostyukhin; Christine Kourkoumelis; Vasiliki Kouskoura; W. Kozanecki; Jan Kretzschmar; Peter Krieger; Kevin Kroeninger; Jelena Krstic; Sinan Kuday; Victor Kukhtin; Emma Sian Kuwertz; Carlos Lacasta; Heiko Lacker; Remi Lafaye; Massimo Lamanna; Clemens Lange; Francesco Lanni; Mario Lassnig; Paolo Laurelli; Paul Laycock; Thomas LeCompte; Jongmin Lee; Lawrence Lee; Michel Lefebvre; Federica Legger; Rupert Leitner; Katharine Leney; Christopher Lester; G. H. Lewis; Hongbo Liao; Barbara Liberti; Ki Lie; Wolfgang Liebig; Antonio Limosani; M. Limper; Simon Lin; Anna Lipniacka; Alan Litke; Jianbei Liu; Miao Liu; Michele Livan; Annick Lleres; Ewelina Lobodzinska; T. Loddenkoetter; Kristin Lohwasser; Milos Lokajicek; Arnaud Lucotte; Olof Lundberg; David Lynn; Giovanni Maccarrone; Anna Macchiolo; Harvey Jonathan Maddocks; R. Maenner; Carmen Maidantchik; Stephanie Majewski; Yasuhiro Makida; Nikola Makovec; Bogdan Malaescu; Pa. Malecki; Fairouz Malek; Judita Mamuzic; R. Mandrysch; Alessandro Manfredini; Bruno Mansoulie; Livio Mapelli; Luis March; Jean François Marchand; Fernando Marroquim; Antoine Marzin; Anna Mastroberardino; Tatsuya Masubuchi; Steve McMahon; Robert McPherson; Sascha Mehlhase; Alberto Mengarelli; Sven Menke; Evelin Meoni; F. S. Merritt; Andrea Messina; Alaettin Serhan Mete; Liza Mijović; G. Mikenberg; David Miller; Allen Mincer; Vasiliki A Mitsou; Klaus Mönig; Soumya Mohapatra; James Monk; Fernando Monticelli; Simone Monzani; Roger Moore; Arthur Moraes; Nicolas Morange; Deywis Moreno; Anthony Keith Morley; Giuseppe Mornacchi; Ljiljana Morvaj; James Mueller; A. G. Myagkov; Miroslav Myska; Ryo Nagai; Kunihiro Nagano; Yasushi Nagasaka; Martin Nagel; Armin Michael Nairz; M. Nash; T. Nattermann; Thomas Naumann; Gabriela Navarro; H. A. Neal; Matteo Negrini; T. K. Nelson; Jason Nielsen; Nikiforos Nikiforou; Irena Nikolic-Audit; Konstantinos Nikolopoulos; Paul Nilsson; Aleandro Nisati; Takuya Nobe; Horst Oberlack; Christian Ohm; Albert Olariu; Miguel Alfonso Oliveira; Andrzej Olszewski; Jolanta Olszowska; I. Orlov; R. S. Orr; Bianca Osculati; Mohamed Ouchrif; Farid Ould-Saada; Mark Owen; S. Owen; Nurcan Ozturk; Efstathios Paganis; Sandro Palestini; Michael Andrew Parker; Fr Pastore; Gabriella Pasztor; Joleen Pater; S. Pedraza Lopez; T. Perez Cavalcanti; M. T. Pérez García-Estañ; Laura Perini; Krisztian Peters; Troels Petersen; Andreas Petridis; Fabrizio Petrucci; Andrew Pilkington; Michele Pinamonti; James Pinfold; C. Pizio; Elena Plotnikova; Alan Poppleton; Joaquin Poveda; Pascal Pralavorio; Darren Price; Kirill Prokofiev; Fedor Prokoshin; Mariusz Przybycien; Jianming Qian; Peter Radloff; Francesco Ragusa; Aidan Randle-Conde; George Redlinger; Kendall Reeves; Christoph Rembser; Silvia Resconi; Melissa Ridel; Lorenzo Rinaldi; David Robinson; Anatoli Romaniouk; Nikolaos Rompotis; Lydia Roos; Eduardo Ros; Stefano Rosati; Kilian Rosbach; G. A. Rosenbaum; Leonardo Paolo Rossi; Marina Rotaru; Christophe Royon; Yoram Rozen; Zuzana Rurikova; Martin Rybar; Iftach Sadeh; Giuseppe Salamanna; Denis Salihagic; José Salt; Daniela Salvatore; Antonio Salvucci; Andreas Salzburger; Bjørn Hallvard Samset; Arturo Sanchez; V. Sanchez Martinez; Carlos Sandoval; Osamu Sasaki; Jean-Baptiste Sauvan; Lee Sawyer; James Saxon; Antonio Sbrizzi; Jana Schaarschmidt; Peter Schacht; Dorothee Schaile; Valery Schegelsky; Carlo Schiavi; Jochen Schieck; Stefan Schmitt; Martin Johannes Schultens; Bruce Schumm; Jacob Searcy; Frank Seifert; Joao Seixas; Stephen Sekula; Nicola Semprini-Cesari; Laurent Serin; Leonid Serkin; Anna Sfyrla; Elizaveta Shabalina; Marjorie Shapiro; Pavel Shatalov; Peter Sherwood; Evgeny Shulga; Michael Shupe; Frank Siegert; Eduard Simioni; A. Sircar; Louise Skinnari; Tomas Slavicek; Vladimir Smakhtin; Yury Smirnov; Lidia Smirnova; Oxana Smirnova; Maria Smizanska; Karel Smolek; Andrei Snesarev; Scott Snyder; Urmila Soldevila; Oleg Solovyanov; Victor Solovyev; M. Sosebee; Andrey Soukharev; Stefania Spagnolo; R. Spiwoks; Martin Spousta; Robert Stanek; Marcel Michael Stanitzki; Steinar Stapnes; Evgeny Starchenko; Jan Stark; Pavel Staroba; Rafal Staszewski; A. Staude; S. Stern; Jan Andre Stillings; Mark Stockton; Arno Straessner; Jonas Strandberg; Pavol Strizenec; John Stupak; Peter Sturm; Nicholas Adam Styles; Michal Suk; Vladimir Sulin; Toshi Sumida; Michal Svatos; Ivan Sykora; Javier Sánchez; Kerstin Tackmann; Giuseppe Francesco Tartarelli; Enrico Tassi; Charles Taylor; Wendy Taylor; Pedro Teixeira-Dias; H. Ten Kate; Susumu Terada; Koji Terashi; Juan Terron; R. J. Teuscher; T. Tic; S. Timoshenko; Sylvain Tisserant; Stanislav Tokár; Katsuo Tokushuku; Makoto Tomoto; Jozsef Toth; Francois Touchard; Thomas Trefzger; L. Tremblet; Alessandro Tricoli; Sophie Trincaz-Duvoid; William Trischuk; Clara Troncon; Maciej Trzebinski; Pavel Tsiareshka; Shota Tsiskaridze; Vakhtang Tsulaia; Soshi Tsuno; A. Tua; Valentina Tudorache; Ruggero Turra; R. Ueno; Guillaume Unal; R. van der Geer; H. van der Graaf; Marco Vanadia; Riccardo Vari; Kevin Varvell; Filipe Veloso; Stefano Veneziano; Andrea Ventura; Valerio Vercesi; Trevor Vickey; Elisabetta Vilucchi; Manuella Vincter; Vladimir Vinogradov; O. Vitells; Iacopo Vivarelli; Sotirios Vlachos; V. Vorwerk; Nenad Vranjes; Marcel Vreeswijk; T. Vu Anh; Ilija Vukotic; Brian Walsh; Jian-Ping Wang; Song-Ming Wang; Stephen Watts; Marc Weber; Christian Weiser; Torre Wenaus; Thorsten Wengler; Kathleen Whalen; S. N. White; Werner Wiedenmann; Monika Wielers; Craig Wiglesworth; M. A. Wildt; Henric George Wilkens; Marcin Wladyslaw Wolter; Helmut Wolters; Krzysztof Wozniak; Xin Wu; Yanwen Wu; Benjamin Wynne; Stefania Xella; Da Xu; Sahal Yacoob; Yuji Yamazaki; Kohei Yorita; Li Yuan; Remi Zaidan; Daniele Zanzi; M. Zeman; Seth Conrad Zenz; Dirk Zerwas; Jie Zhang; J. Zhong; Bing Zhou; Daria Zieminska; Antonio Zoccoli; V. Zutshi;A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
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For further information contact us at helpdesk@openaire.eu65 citations 65 popularity Average influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Belgium, ItalyElsevier BV David, Tweats; David A, Eastmond; Anthony M, Lynch; Azeddine, Elhajouji; Roland, Froetschl; Micheline, Kirsch-Volders; Francesco, Marchetti; Kenichi, Masumura; Francesca, Pacchierotti; Maik, Schuler;Aneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemical aneugens; and chemotherapy-related malignant neoplasms. Aneuploidy is seen at various stages in carcinogenesis. However, the relationship between induced aneuploidy occurring after exposure and clonal aneuploidy present in tumours is not clear. Recent evidence indicates that the induction of chromosomal instability (CIN), may be more important than aneuploidy per se, in the carcinogenic process. Down Syndrome, trisomy 21, is associated with altered hematopoiesis in utero which, in combination with subsequent mutations, results in an increased risk for acute megakaryoblastic and lymphoblastic leukemias. In contrast, there is reduced cancer risk for most solid tumours in Down Syndrome. Mouse models with high levels of aneuploidy are also associated with increased cancer risk for particular tumours with long latencies, but paradoxically other types of tumour often show decreased incidence. The aneugens reviewed that induce cancer in humans and animals all possess other carcinogenic properties, such as mutagenicity, clastogenicity, cytotoxicity, organ toxicities, hormonal and epigenetic changes which likely account for, or interact with aneuploidy, to cause carcinogenesis. Although the role that aneuploidy plays in carcinogenesis has not been fully established, in many cases, it may not play a primary causative role. Tubulin-disrupting aneugens that do not possess other properties linked to carcinogenesis, were not carcinogenic in rodents. Similarly, in humans, for the tubulin-disrupting aneugens colchicine and albendazole, there is no reported association with increased cancer risk. There is a need for further mechanistic studies on agents that induce aneuploidy, particularly by mechanisms other than tubulin disruption and to determine the role of aneuploidy in pre-neoplastic events and in early and late stage neoplasia.
ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert ENEA Open Archive arrow_drop_down Vrije Universiteit Brussel Research Portal; ENEA Open Archive; Mutation Research/Genetic Toxicology and Environmental MutagenesisOther literature type . Article . Other ORP type . 2019License: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 NetherlandsElsevier BV Max Dahele; Shannon Pearson; Thomas G. Purdie; Jean-Pierre Bissonnette; Kevin Franks; Anthony Brade; John Cho; Alexander Sun; A. Hope; Andrea Marshall; Jane Higgins; Andrea Bezjak;pmid: 18978570
Introduction: With the anticipation of improved outcomes, especially for patients with early-stage non-small cell lung cancer, stereotactic body radiation therapy (SBRT) has been rapidly introduced into the thoracic radiation oncology community. Although at first glance lung SBRT might seem methodologically similar to conventional radiotherapy, there are important differences in its execution that require particular consideration. The objective of this paper is to highlight these and other issues to contribute to the safe and effective diffusion of lung SBRT. We discuss practical challenges that have been encountered in the implementation of lung SBRT at a single, large institution and emphasize the importance of a systematic approach to the design of lung SBRT services. Methods: Specific technical and clinical components that were identified as being important during the development of lung SBRT at Princess Margaret Hospital are described. The clinical system that evolved from these is outlined. Results: Using this clinical framework the practical topics addressed include: patient assessment, simulation and treatment planning, tumor and organ at risk delineation, trial set up before treatment, on-line image-guidance, and patient follow-up. Conclusions: The potential gain in therapeutic ratio that is theoretically possible with lung SBRT can only be realized if the tumor is adequately irradiated and normal tissue spared. A discussion of the component parts of lung SBRT is presented. It is a complex process and specific challenges need to be overcome to effect the satisfactory transition of lung SBRT into routine practice.
Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Report , Other literature type , Preprint 2018 Turkey, Italy, Italy, Germany, Portugal, Portugal, Italy, United Kingdom, Italy, Italy, Spain, Denmark, Italy, Poland, Italy, Italy, France, ItalySpringer Science and Business Media LLC Aaboud M.; Aad G.; Abbott B.; Abdinov O.; Abeloos B.; Abhayasinghe D. K.; Abidi S. H.; Abouzeid O. S.; Abraham N. L.; Abramowicz H.; Abreu H.; Abulaiti Y.; Acharya B. S.; Adachi S.; Adam L.; Adamczyk L.; Adelman J.; Adersberger M.; Adiguzel A.; Adye T.; Affolder A. A.; Afik Y.; Agheorghiesei C.; Aguilar-Saavedra J. A.; Ahmadov F.; Aielli G.; Akatsuka S.; Åkesson T. P. A.; Akilli E.; Akimov A. V.; Alberghi G. L.; Albert J.; Albicocco P.; Alconada Verzini M. J.; Alderweireldt S.; Aleksa M.; Aleksandrov I. N.; Alexa C.; Alexopoulos T.; Alhroob M.; Ali B.; Alimonti G.; Alison J.; Alkire S. P.; Allaire C.; Allbrooke B. M. M.; Allen B. W.; Allport P. P.; Aloisio A.; Alonso A.; Alonso F.; Alpigiani C.; Alshehri A. A.; Alstaty M. I.; Alvarez Gonzalez B.; Álvarez Piqueras D.; Alviggi M. G.; Amadio B. T.; Amaral Coutinho Y.; Ambler A.; Ambroz L.; Amelung C.; Amidei D.; Amor Dos Santos S. P.; Amoroso S.; Amrouche C. S.; Anastopoulos C.; Ancu L. S.; Andari N.; Andeen T.; Anders C. F.; Anders J. K.; Anderson K. J.; Andreazza A.; Andrei V.; Anelli C. R.; Angelidakis S.; Angelozzi I.; Angerami A.; Anisenkov A. V.; Annovi A.; Antel C.; Anthony M. T.; Antonelli M.; Antrim D. J. A.; Anulli F.; Aoki M.; Aparisi Pozo J. A.; Aperio Bella L.; Arabidze G.; Araque J. P.; Araujo Ferraz V.; Araujo Pereira R.; Arce A. T. H.; Ardell R. E.; Arduh F. A.; Arguin J. -F.; Argyropoulos S.; Armbruster A. J.; Armitage L. J.; Armstrong A.; Arnaez O.; Arnold H.; Arratia M.; Arslan O.; Artamonov A.; Artoni G.; Artz S.; Asai S.; Asbah N.; Asimakopoulou E. M.; Asquith L.; Assamagan K.; Astalos R.; Atkin R. J.; Atkinson M.; Atlay N. B.; Augsten K.; Avolio G.; Avramidou R.; Ayoub M. K.; Azuelos G.; Baas A. E.; Baca M. J.; Bachacou H.; Bachas K.; Backes M.; Bagnaia P.; Bahmani M.; Bahrasemani H.; Bailey A. J.; Baines J. T.; Bajic M.; Bakalis C.; Baker O. K.; Bakker P. J.; Bakshi Gupta D.; Balaji S.; Baldin E. M.; Balek P.; Balli F.; Balunas W. K.; Balz J.; Banas E.; Bandyopadhyay A.; Banerjee S.; Bannoura A. A. E.; Barak L.; Barbe W. M.; Barberio E. L.; Barberis D.; Barbero M.; Barillari T.; Barisits M. -S.; Barkeloo J.; Barklow T.; Barnea R.; Barnes S. L.; Barnett B. M.; Barnett R. M.; Barnovska-Blenessy Z.; Baroncelli A.; Barone G.; Barr A. J.; Barranco Navarro L.; Barreiro F.; Barreiro Guimarães da Costa J.; Bartoldus R.; Barton A. E.; Bartos P.; Basalaev A.; Bassalat A.; Bates R. L.; Batista S. J.; Batlamous S.; Batley J. R.; Battaglia M.; Bauce M.; Bauer F.; Bauer K. T.; Bawa H. S.; Beacham J. B.; Beau T.; Beauchemin P. H.; Bechtle P.; Beck H. C.; Beck H. P.; Becker K.; Becker M.; Becot C.; Beddall A.; Beddall A. J.; Bednyakov V. A.; Bedognetti M.; Bee C. P.; Beermann T. A.; Begalli M.; Begel M.; Behera A.; Behr J. K.; Bellagamba L.; Benchekroun D.; Benekos N.; Benjamin D. P.; Benoit M.; Berger N.; Beringer J.; Berta P.; Bessner M.; Besson N.; Bethani A.; Betti A.; Bevan A. J.; Bianchi R. M.; Biesuz N. V.; Billoud T. R. V.; Bindi M.; Biondi S.; Biswal J. P.; Blue A.; Bogavac D.; Bold T.; Bolz A. E.; Bona M.; Bortfeldt J.; Bosman M.; Bossio Sola J. D.; Bouaouda K.; Bouhova-Thacker E. V.; Boutle S. K.; Boveia A.; Brahimi N.; Brandt A.; Breaden Madden W. D.; Britton D.; Brooijmans G.; Brost E.; Broughton J. H.; Bruckman de Renstrom P. A.; Bruno S.; Bruscino N.; Buckley A. G.; Burdin S.; Burke S.; Buttar C. M.; Butterworth J. M.; Buzykaev A. R.; Cabras G.; Cai H.; Cairo V. M. M.; Cakir O.; Calafiura P.; Calandri A.; Callea G.; Calvente Lopez S.; Calvetti M.; Camarda S.; Camarri P.; Campoverde A.; Canale V.; Cantero J.; Capeans Garrido M. D. M.; Caprini I.; Caprini M.; Capua M.; Cardillo F. C.; Carli I.; Carquin E.; Carrá S.; Casado M. P.; Castillo F. L.; Castillo Gimenez V.; Castro N. F.; Caudron J.; Cavasinni V.; Cerda Alberich L.; Cerqueira A. S.; Cerri A.; Chargeishvili B.; Chelstowska M. A.; Chen C.; Chen C. H.; Chen H.; Cheng H. C.; Cheremushkina E.; Cherkaoui El Moursli R.; Chevalier L.; Chiarella V.; Chiodini G.; Chu M. C.; Chudoba J.; Chwastowski J. J.; Chytka L.; Cinca D.; Cindro V.; Citron Z. H.; Coadou Y.; Cobal M.; Coccaro A.; Coimbra A. E. C.; Colasurdo L.; Conde Muiño P.; Coniavitis E.; Corrigan E. E.; Corriveau F.; Costa M. J.; Costanzo D.; Cottin G.; Cranmer K.; Cristinziani M.; Croft V.; Crosetti G.; Cueto A.; Czodrowski P.; Dabrowski W.; Dado T.; Dahbi S.; Dallapiccola C.; Danninger M.; Dao V.; Darbo G.; Davey W.; David C.; Davidek T.; De Cecco S.; De la Torre H.; De Maria A.; De Sanctis U.; De Santis M.; De Vivie De Regie J. B.; Deliot F.; Delitzsch C. M.; Della Pietra M.; Dell’acqua A.; Delsart P. A.; Demarco D. A.; Derendarz D.; Dervan P.; Di Bello F. A.; Di Ciaccio A.; Di Ciaccio L.; Diaconu C.; Dias F. A.; Dias Do Vale T.; Dietrich J.; Dittus F.; Djama F.; Djobava T.; Doglioni C.; Doyle A. T.; Duckeck G.; Ducu O. A.; Duda D.; Duperrin A.; Duran Yildiz H.; Durglishvili A.; Dyndal M.; Dziedzic B. S.; Ellert M.; Ellinghaus F.; Ellis N.; Elsing M.; Erdmann J.; Ereditato A.; Escalier M.; Escobar C.; Estrada Pastor O.; Evans H.; Ezhilov A.; Ezzi M.; Fabbri F.; Fabiani V.; Faisca Rodrigues Pereira R. M.; Falke P. J.; Falke S.; Faltova J.; Fanti M.; Farbin A.; Farina E. M.; Farooque T.; Farrington S. M.; Fassi F.; Faucci Giannelli M.; Fawcett W. J.; Feligioni L.; Feng C.; Ferreira de Lima D. E.; Ferrere D.; Filthaut F.; Fiorini L.; Fisher W. C.; Fleck I.; Flores L. M.; Formica A.; Fox H.; Francavilla P.; Franchini M.; Franklin M.; Freund B.; Fullana Torregrosa E.; Gadow P.; Gagnon L. G.; Gamboa Goni R.; García Navarro J. E.; García Pascual J. A.; Gee C. N. P.; Genest M. H.; George S.; Ghneimat M.; Giagu S.; Giangiacomi N.; Giannetti P.; Gibson S. M.; Giordani M. P.; Giromini P.; Giugliarelli G.; Giuli F.; Gkaitatzis S.; Gkougkousis E. L.; Glasman C.; Glaysher P. C. F.; Godlewski J.; Golling T.; Gonçalo R.; Gonella G.; Gongadze A.; Gonski J. L.; González de la Hoz S.; Goossens L.; Govender N.; Grabowska-Bold I.; Gramstad E.; Grancagnolo S.; Gravila P. M.; Gravili F. G.; Gray C.; Grefe C.; Gregersen K.; Gregor I. M.; Grinstein S.; Groh S.; Grummer A.; Guenther J.; Guescini F.; Guo J.; Gustavino G.; Gutschow C.; Guzik M. P.; Gwenlan C.; Gwilliam C. B.; Haas A.; Hadavand H. K.; Hadef A.; Haley J.; Halladjian G.; Hamal P.; Han K.; Hanagaki K.; Handl D. M.; Haney B.; Hansen E.; Hansen J. B.; Hassani S.; Haug S.; Hays C. P.; Heath M. P.; Heelan L.; Heim S.; Heinrich J. J.; Heinrich L.; Heinz C.; Hejbal J.; Held A.; Herde H.; Hernández Jiménez Y.; Hill E.; Hillier S. J.; Hils M.; Hod N.; Holmes T. R.; Honda S.; Hopkins W. H.; Horn P.; Horyn L. A.; Hoya J.; Hrynevich A.; Hubaut F.; Hunter R. F. H.; Iacobucci G.; Iliadis D.; Introzzi G.; Ippolito V.; Isacson M. F.; Islam W.; Istin S.; Iuppa R.; Jackson P.; Jakobsen S.; Jakoubek T.; Jana D. K.; Jansky R.; Janssen J.; Jeanneau F.; Jeanty L.; Jia J.; Jiggins S.; Jinnouchi O.; Jon-And K.; Jones R. W. L.; Jones S. D.; Jones S.; Jorge P. M.; Jovicevic J.; Ju X.; Junggeburth J. J.; Juste Rozas A.; Kaczmarska A.; Kar D.; Karentzos E.; Karpov S. N.; Karpova Z. M.; Kay E. F.; Kazanin V. F.; Keeler R.; Kempster J. J.; Kendrick J.; Kharlamova T.; Khoo T. J.; Khramov E.; Kirk J.; Kiryunin A. E.; Klimek P.; Knue A.; Kodys P.; Koffas T.; König A. C.; Kono T.; Konoplich R.; Konstantinidis N.; Korcyl K.; Koulouris A.; Kourkoumelis C.; Kourlitis E.; Kouskoura V.; Kowalewski R.; Krasnopevtsev D.; Krauss D.; Kretzschmar J.; Kroll J.; Kruchonak U.; Kugel A.; Kukla R.; Kulchitsky Y.; Kupco A.; Kurchaninov L. L.; Kuwertz E. S.; Kuze M.; La Rosa A.; La Rosa Navarro J. L.; La Rotonda L.; Lacasta C.; Lafaye R.; Landon M. P. J.; Lange J. C.; Lapertosa A.; Lari T.; Lassnig M.; Lazzaroni M.; Leblanc M.; Lee C. A.; Lee G. R.; Lefebvre B.; Legger F.; Leight W. A.; Leisos A.; Leite M. A. L.; Leney K. J. C.; Leone R.; Leonidopoulos C.; Leroy C.; Les R.; Lester C. G.; Levchenko M.; Li B.; Li H.; Lie K.; Lin C. Y.; Lipniacka A.; Lisovyi M.; Lister A.; Litke A. M.; Little J. D.; Liu B.; Liu B. L.; Liu H. B.; Liu H.; Livan M.; Lleres A.; Llorente Merino J.; Lloyd S. L.; Lobodzinska E. M.; Loch P.; Lohwasser K.; Lokajicek M.; Longo L.; Lopez J. A.; Lorenzo Martinez N.; Losada M.; Lozano Bahilo J. J.; Luci C.; Lucotte A.; Luehring F.; Lysak R.; Macdonald C. M.; Madar R.; Madysa N.; Maeda J.; Maevskiy A. S.; Majersky O.; Makida Y.; Makovec N.; Maleev V. P.; Mamuzic J.; Mancini G.; Maneira J.; Manjarres Ramos J.; Mankinen K. H.; Manousos A.; Manzoni S.; March L.; Marcisovsky M.; Marjanovic M.; Marti-Garcia S.; Martin C. B.; Martin T. A.; Martin V. J.; Martin-Haugh S.; Marzin A.; Masetti L.; Massa L.; Massarotti P.; Mastrandrea P.; Mastroberardino A.; Masubuchi T.; Mazza S. M.; McLean K. D.; McNamara P. C.; McPherson R. A.; Meirose B.; Mellado Garcia B. R.; Mellenthin J. D.; Melo M.; Meloni F.; Mendes Gouveia E. D.; Mengarelli A.; Meoni E.; Messina A.; Mete A. S.; Mijović L.; Mikestikova M.; Millar D. A.; Mindur B.; Mistry K. P.; Mkrtchyan T.; Mogg P.; Mohapatra S.; Monk J.; Montejo Berlingen J.; Monzani S.; Morange N.; Moreno D.; Morettini P.; Morii M.; Morley A. K.; Morvaj L.; Moyse E. J. W.; Mueller F.; Mullier G. A.; Munoz Sanchez F. J.; Murray W. J.; Murrone A.; Nagasaka Y.; Nairz A. M.; Nanjo H.; Napolitano F.; Naryshkin I.; Neep T. J.; Negrini M.; Nelson M. E.; Nemecek S.; Nielsen D. S.; Nikiforou N.; Nikolopoulos K.; Nisati A.; Nishu N.; Nobe T.; Novak T.; Ntekas K.; Ocariz J.; Ochoa-Ricoux J. P.; Oda S.; Ohm C. C.; Oide H.; Okazaki Y.; Oliveira Damazio D.; Oliver J. L.; Olszewski A.; Olszowska J.; Onofre A.; Onyisi P. U. E.; Oreglia M. J.; Orestano D.; Orlando N.; Ould-Saada F.; Ozturk N.; Pachal K.; Pacheco Pages A.; Padilla Aranda C.; Palestini S.; Palka M.; Panduro Vazquez J. G.; Panizzo G.; Pasuwan P.; Pathak A.; Pedro R.; Peleganchuk S. V.; Penc O.; Perini L.; Peters K.; Petersen B. A.; Petrucci F.; Pezoa R.; Pham T.; Pianori E.; Pilkington A. D.; Pleskot V.; Poggi R.; Policicchio A.; Pollard C. S.; Ponomarenko D.; Potter C. J.; Potti H.; Poulsen T.; Poveda J.; Pralavorio P.; Primavera M.; Prince S.; Proklova N.; Prokoshin F.; Przybycien M.; Puri A.; Qian J.; Queitsch-Maitland M.; Ragusa F.; Raine J. A.; Rauch D. M.; Ravina B.; Reale M.; Rebuzzi D. M.; Redlinger G.; Reeves K.; Reichert J.; Resconi S.; Resseguie E. D.; Ricci E.; Ridel M.; Rieck P.; Rifki O.; Rimoldi A.; Ripellino G.; Rivera Vergara J. C.; Roberts R. T.; Robinson D.; Robson A.; Rocco E.; Roda C.; Rodriguez Bosca S.; Rodriguez Perez A.; Roland C. P. A.; Roloff J.; Romaniouk A.; Romano M.; Rompotis N.; Roos L.; Rosati S.; Rosbach K.; Rotaru M.; Roy D.; Rozen Y.; Rurikova Z.; Russell H. L.; Ryu S.; Ryzhov A.; Sabatini P.; Saimpert M.; Saito M.; Salazar Loyola J. E.; Salvatore D.; Salvucci A.; Sammel D.; Sanchez Pineda A.; Sankey D. P. C.; Santra A.; Sasaki O.; Sato K.; Sauvan E.; Sawyer C.; Schaefer D.; Schildgen L. K.; Schioppa E. J.; Schioppa M.; Schmidt-Sommerfeld K. R.; Schmitt C.; Schmitt S.; Schoeffel L.; Schopf E.; Schouwenberg J. F. P.; Schramm S.; Schwarz T. A.; Sciandra A.; Scornajenghi M.; Scyboz L. M.; Searcy J.; Sebastiani C. D.; Senkin S.; Serkin L.; Sessa M.; Sforza F.; Sfyrla A.; Shabalina E.; Shahinian J. D.; Shaikh N. W.; Shapiro M.; Sharma A. S.; Shi L.; Shimojima M.; Shojaii S.; Simioni E.; Simon M.; Sioli M.; Siral I.; Sliwa K.; Smirnov N.; Smirnov S. Y.; Smirnov Y.; Smirnova L. N.; Smith J. W.; Smolek K.; Smykiewicz A.; Snyder I. M.; Solovyev V.; Sommer P.; Son H.; Song W.; Sopczak A.; Sotiropoulou C. L.; Soualah R.; Sowden B. C.; Spagnolo S.; Spieker T. M.; Stabile A.; Stanecka E.; Stanislaus B.; Stark G. H.; Starovoitov P.; Stärz S.; Staszewski R.; Stevenson T. J.; Stolte P.; Straessner A.; Strandberg J.; Strizenec P.; Stucci S. A.; Stugu B.; Stupak J.; Sullivan M. J.; Sumida T.; Svatos M.; Swiatlowski M.; Sykora I.; Ta D.; Tahirovic E.; Takai H.; Tapia Araya S.; Tartarelli G. F.; Tassi E.; Taylor A. C.; Taylor A. J.; Terashi K.; Terron J.; Terzo S.; Thiele F.; Thompson A. S.; Thomson E.; Tian Y.; Ticse Torres R. E.; Tikhomirov V. O; Tisserant S.; Tokushuku K.; Tomiwa K. G.; Torró Pastor E.; Toth J.; Trigger I. M.; Trincaz-Duvoid S.; Trocmé B.; Trofymov A.; Troncon C.; Trovato F.; Truong L.; Trzebinski M.; Tsai F.; Tsuno S.; Tu Y.; Tudorache A.; Tudorache V.; Turra R.; Tzovara E.; Ughetto M.; Unal G.; Ungaro F. C.; Urquijo P.; Vadla K. O. H.; Vaidya A.; Valente M.; Valero A.; Valéry L.; Van Daalen T. R.; Van Gemmeren P.; Van Vulpen I.; Vanadia M.; Vari R.; Varvell K. E.; Vazquez Furelos D.; Veloso F.; Veneziano S.; Ventura A.; Vercesi V.; Verducci M.; Vermeulen A. T.; Vetterli M. C.; Viaux Maira N.; Vickey T.; Vickey Boeriu O. E.; Villa M.; Vincter M. G.; Vivarelli I.; Vlachos S.; von Buddenbrock S. E.; Vorobel V.; Vos M.; Vranjes N.; Vranjes Milosavljevic M.; Vukotic I.; Walder J.; Walkowiak W.; Wang A. M.; Wang C.; Wanotayaroj C.; Warburton A.; Wardrope D. R.; Watkins P. M.; Watts G.; Weber C.; Weber M. S.; Weber S. A.; Weingarten J.; Weirich M.; Weiser C.; Wenaus T.; Wengler T.; Werner M. D.; Werner P.; Whalen K.; Wickens F. J.; Wielers M.; Wiglesworth C.; Willocq S.; Winkels E.; Winklmeier F.; Winter B. T.; Wolf A.; Wolter M. W.; Wolters H.; Worm S. D.; Woźniak K. W.; Wu M.; Wu S. L.; Wu X.; Xella S.; Xi Z.; Xu D.; Xu H.; Yabsley B.; Yacoob S.; Yamaguchi D.; Yamazaki T.; Yang H. J.; Yang H. T.; Yap Y. C.; Yigitbasi E.; Yorita K.; Yu J.; Zaidan R.; Zakareishvili T.; Zakharchuk N.; Zanzi D.; Zhang D. F.; Zhang D.; Zhang F.; Zhao P.; Zhemchugov A.; Zhou B.; Zhu C. G.; Zoch K.; Zorbas T. G.;We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF(Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of comp Measurements of the azimuthal anisotropy in lead–lead collisions at sNN−−−√ = 5.02 TeV are presented using a data sample corresponding to 0.49 nb−1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where the initial state is dominated by fluctuations. The anisotropy of the charged-particle azimuthal angle distributions is characterized by the Fourier coefficients, v2–v7, which are measured using the two-particle correlation, scalar-product and event-plane methods. The goal of the paper is to provide measurements of the differential as well as integrated flow harmonics vn over wide ranges of the transverse momentum, 0.5
CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu45 citations 45 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 30visibility views 30 download downloads 50 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; European Physical Journal C: Particles and Fields; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaArticle . 2018License: CC BYData sources: Archivio Istituzionale della Ricerca- Università del Salento; Archivio della Ricerca - Università degli Studi Roma Tre; Archivio della Ricerca - Università di Pisa; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; Archivio della Ricerca - Università di Roma Tor vergata; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Archivio della ricerca - Università degli studi di Napoli Federico II; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of Trento; Archivio Istituzionale dell'Università della CalabriaRecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2018License: CC BYUniversidade do Minho: RepositoriUMOther literature type . 2018Data sources: Universidade do Minho: RepositoriUMGiresun University Institutional RepositoryArticle . 2018Data sources: Giresun University Institutional RepositoryArchivio della Ricerca - Università degli Studi Roma TreArticle . 2018Data sources: Archivio della Ricerca - Università degli Studi Roma TreArchivio della Ricerca - Università di PisaArticle . 2018Data sources: Archivio della Ricerca - Università di PisaRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTACopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemArchivio della Ricerca - Università di Roma Tor vergataArticle . 2018Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 1987Wiley Authors: Hartshorn, R.Timothy; Mauk, A.Grant; Mauk, Marcia R.; Moore, Geoffrey R.;Hartshorn, R.Timothy; Mauk, A.Grant; Mauk, Marcia R.; Moore, Geoffrey R.;pmid: 3030818
The interaction between horse cytochrome c and the tryptic fragment of bovine liver microsomal cytochrome b 5 in the absence and presence of [Cr(ethylenediamine)3]Cl3 was studied by 1H NMR spectroscopy. The protein‐protein interaction region on cytochrome b 5 was found to be different from the [Cr(en)3]3+ binding region. The solvent‐exposed propionate‐bearing edge of the haem of cytochrome b 5 is accessible to [Cr(en)3]3+ in the interprotein complex.
FEBS Letters arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert FEBS Letters arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017American Physical Society (APS) NSERC, UKRI | RootDetect: Remote Detect...NSERC ,UKRI| RootDetect: Remote Detection and Precision Management of Root HealthJ. P. Lees; V. Poireau; V. Tisserand; E. Grauges; A. Palano; G. Eigen; D. N. Brown; Yu. G. Kolomensky; M. Fritsch; H. Koch; T. Schroeder; C. Hearty; T. S. Mattison; J. A. McKenna; R. Y. So; V. E. Blinov; A. R. Buzykaev; V. P. Druzhinin; V. B. Golubev; E. A. Kravchenko; A. P. Onuchin; S. I. Serednyakov; Yu. I. Skovpen; E. P. Solodov; K. Yu. Todyshev; A. J. Lankford; J. W. Gary; O. Long; A. M. Eisner; W. S. Lockman; W. Panduro Vazquez; D. S. Chao; C. H. Cheng; B. Echenard; K. T. Flood; D. G. Hitlin; J. Kim; T. S. Miyashita; P. Ongmongkolkul; F. C. Porter; M. Röhrken; Z. Huard; B. T. Meadows; B. G. Pushpawela; M. D. Sokoloff; J. G. Smith; S. R. Wagner; D. Bernard; M. Verderi; D. Bettoni; C. Bozzi; R. Calabrese; G. Cibinetto; E. Fioravanti; I. Garzia; E. Luppi; V. Santoro; A. Calcaterra; R. de Sangro; G. Finocchiaro; S. Martellotti; P. Patteri; I. M. Peruzzi; M. Piccolo; M. Rotondo; A. Zallo; S. Passaggio; C. Patrignani; H. M. Lacker; B. Bhuyan; U. Mallik; C. Chen; J. Cochran; S. Prell; H. Ahmed; A. V. Gritsan; N. Arnaud; M. Davier; F. Le Diberder; A. M. Lutz; G. Wormser; D. J. Lange; D. M. Wright; J. P. Coleman; E. Gabathuler; D. E. Hutchcroft; D. J. Payne; C. Touramanis; A. J. Bevan; F. Di Lodovico; R. Sacco; G. Cowan; Sw. Banerjee; D. N. Brown; C. L. Davis; A. G. Denig; W. Gradl; K. Griessinger; A. Hafner; K. R. Schubert; R. J. Barlow; G. D. Lafferty; R. Cenci; A. Jawahery; D. A. Roberts; R. Cowan; S. H. Robertson; B. Dey; N. Neri; F. Palombo; R. Cheaib; L. Cremaldi; R. Godang; D. J. Summers; P. Taras; G. De Nardo; C. Sciacca; G. Raven; C. P. Jessop; J. M. LoSecco; K. Honscheid; R. Kass; A. Gaz; M. Margoni; M. Posocco; G. Simi; F. Simonetto; R. Stroili; S. Akar; E. Ben-Haim; M. Bomben; G. R. Bonneaud; G. Calderini; J. Chauveau; G. Marchiori; J. Ocariz; M. Biasini; E. Manoni; A. Rossi; G. Batignani; S. Bettarini; M. Carpinelli; G. Casarosa; M. Chrzaszcz; F. Forti; M. A. Giorgi; A. Lusiani; B. Oberhof; E. Paoloni; M. Rama; G. Rizzo; J. J. Walsh; A. J. S. Smith; F. Anulli; R. Faccini; F. Ferrarotto; F. Ferroni; A. Pilloni; G. Piredda; C. Bünger; S. Dittrich; O. Grünberg; M. Heß; T. Leddig; C. Voß; R. Waldi; T. Adye; F. F. Wilson; S. Emery; G. Vasseur; D. Aston; C. Cartaro; M. R. Convery; J. Dorfan; W. Dunwoodie; M. Ebert; R. C. Field; B. G. Fulsom; M. T. Graham; C. Hast; W. R. Innes; P. Kim; D. W. G. S. Leith; S. Luitz; D. B. MacFarlane; D. R. Muller; H. Neal; B. N. Ratcliff; A. Roodman; M. K. Sullivan; J. Va’vra; W. J. Wisniewski; M. V. Purohit; J. R. Wilson; A. Randle-Conde; S. J. Sekula; M. Bellis; P. R. Burchat; E. M. T. Puccio; M. S. Alam;We measure the mass difference, Δm_{+}, between the D^{*}(2010)^{+} and the D^{+} using the decay chain D^{*}(2010)^{+}→D^{+}π^{0} with D^{+}→K^{-}π^{+}π^{+}. The data were recorded with the BABAR detector at center-of-mass energies at and near the ϒ(4S) resonance, and correspond to an integrated luminosity of approximately 468 fb^{-1}. We measure Δm_{+}=(140 601.0±6.8[stat]±12.9[syst]) keV. We combine this result with a previous BABAR measurement of Δm_{0}≡m(D^{*}(2010)^{+})-m(D^{0}) to obtain Δm_{D}=m(D^{+})-m(D^{0})=(4824.9±6.8[stat]±12.9[syst]) keV. These results are compatible with and approximately five times more precise than the Particle Data Group averages.
Physical Review Lett... arrow_drop_down Physical Review LettersArticleLicense: publisher-specific, author manuscriptData sources: UnpayWallPhysical Review LettersArticle . 2017License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Physical Review Lett... arrow_drop_down Physical Review LettersArticleLicense: publisher-specific, author manuscriptData sources: UnpayWallPhysical Review LettersArticle . 2017License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 Netherlands, United Kingdom, United KingdomWiley NHMRC | THE CYCLE OF OBESITY: Two..., EC | CANDICE, NHMRC | A genome-wide search for ... +4 projectsNHMRC| THE CYCLE OF OBESITY: Two generations of a pregnancy cohort to investigate obesity epigenetics ,EC| CANDICE ,NHMRC| A genome-wide search for genes underlying the developmental origins of health and disease ,NWO| Decoding the Gene-Environment Interplay of Reading Ability ,NHMRC| Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 year follow up of a Longitudinal Cohort ,CIHR ,WT| The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.Filippo Abbondanza; Philip S. Dale; Carol A. Wang; Marianna E. Hayiou‐Thomas; Umar Toseeb; Tanner S. Koomar; Karen G. Wigg; Yu Feng; Kaitlyn M. Price; Elizabeth N. Kerr; Sharon L. Guger; Maureen W. Lovett; Lisa J. Strug; Elsje van Bergen; Conor V. Dolan; J. Bruce Tomblin; Kristina Moll; Gerd Schulte‐Körne; Nina Neuhoff; Andreas Warnke; Simon E. Fisher; Cathy L. Barr; Jacob J. Michaelson; Dorret I. Boomsma; Margaret J. Snowling; Charles Hulme; Andrew J. O. Whitehouse; Craig E. Pennell; Dianne F. Newbury; John Stein; Joel B. Talcott; Dorothy V. M. Bishop; Silvia Paracchini;Funding: Royal Society - UF150663, RGF\EA\180141; Wellcome Trust - 217065/Z/19/Z; H2020 European Research Council - 694189; NWO - 451-15-017; National Health and Medical Research Council - 1173896; Canadian Institute for Health Research - MOP-133440. Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions. Publisher PDF Peer reviewed
Vrije Universiteit A... arrow_drop_down Oxford University Research Archive; Child DevelopmentOther literature type . Article . 2022 . 2023License: CC BYOxford Brookes University: RADAROther literature type . 2023License: CC BYData sources: Oxford Brookes University: RADARadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 32visibility views 32 download downloads 110 Powered bymore_vert Vrije Universiteit A... arrow_drop_down Oxford University Research Archive; Child DevelopmentOther literature type . Article . 2022 . 2023License: CC BYOxford Brookes University: RADAROther literature type . 2023License: CC BYData sources: Oxford Brookes University: RADARadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2011 NetherlandsBMJ Alexandra Zhernakova; Eli A. Stahl; Gosia Trynka; Soumya Raychaudhuri; E Festen; Lude Franke; Rudolf S N Fehrmann; Fina A S Kurreeman; Brian Thomson; Namrata Gupta; Jihane Romanos; Ross McManus; Anthony W. Ryan; Graham Turner; Elaine F. Remmers; Luigi Greco; René E. M. Toes; Elvira Grandone; Maria Cristina Mazzilli; Anna Rybak; Bożena Cukrowska; Yonghong Li; Paul I.W. de Bakker; Peter K. Gregersen; Jane Worthington; Katherine A. Siminovitch; Lars Klareskog; Tom W J Huizinga; Cisca Wijmenga; Robert M. Plenge;handle: 1887/116730
Background and objectives Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-human leucocyte antigen (HLA) CD and RA risk loci (out of 26 loci for each disease) are shared between both diseases. The authors hypothesised that there are additional shared risk alleles, and that combining genome-wide association study (GWAS) data from each disease would increase power to identify these shared risk alleles. Materials and methods The authors performed a meta-analysis of two published GWAS on CD (4533 cases and 10 750 controls) and RA (5539 cases and 17 231 controls), and genotyping the top associated single-nucleotide polymorphisms (SNPs) in independent set of 2169 CD cases and 2255 controls, and 2845 RA cases and 4944 controls. The authors used the gene-expression dataset of peripheral blood mononuclear cell of 1469 individuals to investigate the genotype-expression correlation of associated variants. The authors also analysed the results using various pathway analysis tools. Results Above already established six shared loci, eight additional SNPs demonstrated p −8 in a combined analysis of all 50 266 samples. From the 14 shared gene loci, 7 SNPs showed a genome-wide significant effect on expression of one or more transcripts in the linkage disequilibrium block around the SNP. Pathway analysis tools indicate remarkable overrepresentation of T cell signalling molecules among the shared genes. Conclusions The authors identified 14 shared CD-RA risk loci. These associations implicate antigen presentation and T cell activation as a shared mechanism of disease pathogenesis and underscore the utility of cross-disease meta-analysis for identification of genetic risk factors with pleiotropic effects between two clinically distinct diseases.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United KingdomElsevier BV Eivind Berge; Rustam Al-Shahi Salman; H Bart van der Worp; Christian Stapf; Peter Sandercock; Nikola Sprigg; Malcolm R Macleod; Peter J Kelly; Paul J Nederkoorn; Gary A Ford; Marcel Arnold; Eivind Berge; Exuperio Diez-Tejedor; Dalius Jatuzis; Peter J Kelly; Derk W Krieger; Paul J Nederkoorn; Peter Sandercock; Christian Stapf; Christian Weimar; Gary A Ford; Rustam Al-Shahi Salman;pmid: 28414643
Stroke is a major burden to patients and society, and resources spent on stroke research must be used efficiently and produce good value in terms of improvements in human health. However, many instances of poor value from stroke research funding have resulted from the way in which stroke research topics have been chosen and how studies have been designed, conducted, analysed, regulated, managed, disseminated, or reported. A cooperative effort of European stroke researchers aimed to identify sources of inefficiency and waste, recommend approaches to increase value, and highlight examples of best practice in stroke research. Evidence suggests that progress has been made, but there is room for much improvement; researchers, funders, regulators, and other stakeholders in stroke research might consider these recommendations when planning new research.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu29 citations 29 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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