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description Publicationkeyboard_double_arrow_right Preprint , Article 2011Embargo end date: 01 Jan 2011arXiv NSERCNSERCAuthors: Rivera-Ingraham, A.; Martin, P. G.; Polychroni, D.; Moore, T. J. T.;Rivera-Ingraham, A.; Martin, P. G.; Polychroni, D.; Moore, T. J. T.;In this work we have carried out an in-depth analysis of the young stellar content in the W3 GMC. The YSO population was identified and classified in the IRAC/MIPS color-magnitude space according to the `Class' scheme and compared to other classifications based on intrinsic properties. Class 0/I and II candidates were also compared to low/intermediate-mass pre-main-sequence stars selected through their colors and magnitudes in 2MASS. We find that a reliable color/magnitude selection of low-mass PMS stars in the infrared requires prior knowledge of the protostar population, while intermediate mass objects can be more reliably identified. By means of the MST algorithm and our YSO spatial distribution and age maps we investigated the YSO groups and the star formation history in W3. We find signatures of clustered and distributed star formation in both triggered and quiescent environments. The central/western parts of the GMC are dominated by large scale turbulence likely powered by isolated bursts of star formation that triggered secondary star formation events. Star formation in the eastern high density layer also shows signs of extended periods of star formation. While our findings support triggering as a key factor for inducing and enhancing some of the major star forming activity in the HDL (e.g., W3 Main/W3(OH)), we argue that some degree of quiescent or spontaneous star formation is required to explain the observed YSO population. Our results also support previous studies claiming an spontaneous origin for the isolated massive star(s) powering KR 140. Comment: Accepted for publication in ApJ
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1110.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1110.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Conference object , Article 2020 Czech RepublicIEEE NSERC, EC | UTHOTPNSERC ,EC| UTHOTPde Rezende, Susanna F.; Meir, Or; Nordstr��m, Jakob; Pitassi, Toniann; Robere, Robert; Vinyals, Marc;handle: 11104/0317277
We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof power for cutting planes with unbounded versus polynomially bounded coefficients. Specifically, we exhibit CNF formulas that can be refuted in quadratic length and constant line space in cutting planes with unbounded coefficients, but for which there are no refutations in subexponential length and subpolynomial line space if coefficients are restricted to be of polynomial magnitude. •We give the first explicit separation between monotone Boolean formulas and monotone real formulas. Specifically, we give an explicit family of functions that can be computed with monotone real formulas of nearly linear size but require monotone Boolean formulas of exponential size. Previously only a non-explicit separation was known. •We give the strongest separation to-date between monotone Boolean formulas and monotone Boolean circuits. Namely, we show that the classical GEN problem, which has polynomial-size monotone Boolean circuits, requires monotone Boolean formulas of size $2^{\Omega(n/\text{polylog}(n))}$ . An important technical ingredient, which may be of independent interest, is that we show that the Nullstellensatz degree of refuting the pebbling formula over a DAG $G$ over any field coincides exactly with the reversible pebbling price of $G$ . In particular, this implies that the standard decision tree complexity and the parity decision tree complexity of the corresponding falsified clause search problem are equal. This is an extended abstract. The full version of the paper is available at https://arxiv.org/abs/2001.02144.
arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/focs46700.2020.00011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/focs46700.2020.00011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020British Editorial Society of Bone & Joint Surgery Alexander Aarvold; Ryan Lohre; Harpreet Chhina; Kishore Mulpuri; Anthony Cooper;Aims Though the pathogenesis of Legg-Calve-Perthes disease (LCPD) is unknown, repetitive microtrauma resulting in deformity has been postulated. The purpose of this study is to trial a novel upright MRI scanner, to determine whether any deformation occurs in femoral heads affected by LCPD with weightbearing. Methods Children affected by LCPD were recruited for analysis. Children received both standing weightbearing and supine scans in the MROpen upright MRI scanner, for coronal T1 GFE sequences, both hips in field of view. Parameters of femoral head height, width, and lateral extrusion of affected and unaffected hips were assessed by two independent raters, repeated at a one month interval. Inter- and intraclass correlation coefficients were determined. Standing and supine measurements were compared for each femoral head. Results Following rigorous protocol development in healthy age-matched volunteers, successful scanning was performed in 11 LCPD-affected hips in nine children, with seven unaffected hips therefore available for comparison. Five hips were in early stage (1 and 2) and six were in late stage (3 and 4). The mean age was 5.3 years. All hips in early-stage LCPD demonstrated dynamic deformity on weightbearing. Femoral head height decreased (mean 1.2 mm, 12.4% decrease), width increased (mean 2.5 mm, 7.2% increase), and lateral extrusion increased (median 2.5 mm, 23% increase) on standing weightbearing MRI compared to supine scans. Negligible deformation was observed in contra-lateral unaffected hips, with less deformation observed in late-stage hips. Inter- and intraclass reliability for all measured parameters was good to excellent. Conclusion This pilot study has described an effective novel research investigation for children with LCPD. Femoral heads in early-stage LCPD demonstrated dynamic deformity on weightbearing not previously seen, while unaffected hips did not. Expansion of this protocol will allow further translational study into the effects of loading hips with LCPD. Cite this article: Bone Joint Open 2020;1-7:364–369.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1302/2633-1462.17.bjo-2020-0030.r1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 United KingdomAmerican Medical Association (AMA) Almoudaris, A; Mamidanna, R; Bottle, A; Aylin, P; Vincent, C; Faiz, O; Hanna, G;pmid: 23553312
IMPORTANCE: Gastroesophageal cancer resections are associated with significant reintervention and perioperative mortality rates. OBJECTIVE: To compare outcomes following operative and nonoperative reinterventions between high- and low-mortality gastroesophageal cancer surgical units in England. DESIGN: All elective esophageal and gastric resections for cancer between 2000 and 2010 in English public hospitals were identified from a national administrative database. Units were divided into low- and high-mortality units (LMUs and HMUs, respectively) using a threshold of 5% or less for 30-day adjusted mortality. The groups were compared for reoperations and nonoperative reinterventions following complications. SETTING: Both LMUs and HMUs. PARTICIPANTS: Patients who underwent esophageal and gastric resections for cancer. EXPOSURE: Elective esophageal and gastric resections for cancer, with reoperations and nonoperative reinterventions following complications. MAIN OUTCOMES AND MEASURES: Failure to rescue is defined as the death of a patient following a complication; failure to rescue-surgical is defined as the death of a patient following reoperation for a surgical complication. RESULTS: There were 14 955 esophagectomies and 10 671 gastrectomies performed in 141 units. For gastroesophageal resections combined, adjusted mortality rates were 3.0% and 8.3% (P < .001) for LMUs and HMUs, respectively. Complications rates preceding reoperation were similar (5.4% for LMUs vs. 4.9% for HMUs; P = .11). The failure to rescue-surgical rates were lower in LMUs than in HMUs (15.3% vs. 24.1%; P < .001). The LMUs performed more nonoperative reinterventions than the HMUs did (6.7% vs. 4.7%; P < .001), with more patients surviving in LMUs than in HMUs (failure to rescue rate, 7.0% vs. 12.5%; P < .001). Overall, LMUs reintervened more than HMUs did (12.2% vs 9.6%; P < .001), and LMUs had lower failure to rescue rates following reintervention than HMUs did (9.0% vs. 18.3%; P = .001). All P values stated refer to 2-sided values. CONCLUSIONS AND RELEVANCE: Overall, LMUs were more likely to reintervene and rescue patients following gastroesophageal cancer resections in England. Patients were more likely to survive following both reoperations and nonsurgical interventions in LMUs.
JAMA Surgery; Oxford... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert JAMA Surgery; Oxford... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1001/jamasurg.2013.791&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 GermanyAmerican Geophysical Union (AGU) Dieng, Diarra; Cannon, Alex J.; Laux, Patrick; Hald, Cornelius; Adeyeri, Oluwafemi; Rahimi, Jaber; Srivastava, Amit K.; Mbaye, Mamadou Lamine; Kunstmann, Harald; Cannon, Alex J.; 2 Environment and Climate Change Canada Victoria BC Canada; Laux, Patrick; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Hald, Cornelius; 4 Meteorological Observatory Hohenpeißenberg German Weather Service Hohenpeißenberg Germany; Adeyeri, Oluwafemi; 5 School of Energy and Environment City University of Hong Kong Kowloon Hong‐Kong; Rahimi, Jaber; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Srivastava, Amit K.; 6 Institute of Crop Science and Resource Conservation University of Bonn Bonn Germany; Mbaye, Mamadou Lamine; 7 Laboratoire d’Océanographie des Sciences de l’Environnement et du Climat (LOSEC) Université Assane SECK de Ziguinchor Ziguinchor Senegal; Kunstmann, Harald; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany;A multivariate bias correction based on N‐dimensional probability density function transform (MBCn) technique is applied to four different high‐resolution regional climate change simulations and key meteorological variables, namely precipitation, mean near‐surface air temperature, near‐surface maximum air temperature, near‐surface minimum air temperature, surface downwelling solar radiation, relative humidity, and wind speed. The impact of bias‐correction on the historical (1980–2005) period, the inter‐variable relationships, and the measures of spatio‐temporal consistency are investigated. The focus is on the discrepancies between the original and the bias‐corrected results over five agro‐ecological zones. We also evaluate relevant indices for agricultural applications such as climate extreme indices, under current and future (2020–2050) climate change conditions based on the RCP4.5. Results show that MBCn successfully corrects the seasonal biases in spatial patterns and intensities for all variables, their intervariable correlation, and the distributions of most of the analyzed variables. Relatively large bias reductions during the historical period give indication of possible benefits of MBCn when applied to future scenarios. Although the four regional climate models do not agree on the same positive/negative sign of the change of the seven climate variables for all grid points, the model ensemble mean shows a statistically significant change in rainfall, relative humidity in the Northern zone and wind speed in the Coastal zone of West Africa and increasing maximum summer temperature up to 2°C in the Sahara. Key Points: Multivariate bias‐correction (MBCn) of key meteorological variables accounting for their interdependency. MBCn effectively removes the statistical biases as indicated by several measures and improves the representation of the probability density. The corrected model ensemble mean preserves the climate change signal with a statistically significant change in precipitation. Climate Change and Health in sub‐Saharan Africa project https://doi.org/10.1594/PANGAEA.880512 http://doi.org/10.5281/zenodo.1255882
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1029/2021jd034836&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1029/2021jd034836&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United KingdomCambridge University Press (CUP) Authors: Nichole, Fairbrother; Dana S, Thordarson; Fiona L, Challacombe; John K, Sakaluk;Nichole, Fairbrother; Dana S, Thordarson; Fiona L, Challacombe; John K, Sakaluk;pmid: 29461178
Background: Unwanted, intrusive thoughts of infant-related harm are a normal, albeit distressing experience for most new mothers. The occurrence of these thoughts can represent a risk factor for the development of obsessive compulsive disorder (OCD). As the early postpartum period represents a time of increased risk for OCD development, the transition to parenthood provides a unique opportunity to better understand OCD development. Aims: The purpose of this study was to assess components of cognitive behavioural conceptualizations of postpartum OCD in relation to new mothers’ thoughts of infant-related harm. Method: English-speaking pregnant women (n = 100) participated. Questionnaires were completed at approximately 36 weeks of gestation, and at 4 and 12 weeks postpartum. An interview to assess postpartum harm thoughts was administered at 4 and 12 weeks postpartum. Questionnaires assessed OC symptoms, OC-related beliefs, fatigue, sleep difficulties and negative mood. Results: Prenatal OC-related beliefs predicted postpartum OC symptoms, as well as harm thought characteristics and behavioural responses to harm thoughts. The severity of behavioural responses to early postpartum harm thoughts did not predict later postpartum OC symptoms, but did predict frequency and time occupation of accidental harm thoughts, and interference in parenting by intentional harm thoughts. Strong relationships between OC symptoms and harm thought characteristics, and concurrent sleep difficulties, negative mood and fatigue were also found. Conclusions: Findings provide support for cognitive behavioural conceptualizations of postpartum OCD and emphasize the importance of maternal sleep, fatigue and negative mood in the relationship between OC-related beliefs and maternal cognitive and behavioural responses to postpartum harm thoughts.
King's Research Port... arrow_drop_down Behavioural and Cognitive PsychotherapyArticle . 2018License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s1352465817000765&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 0visibility views 0 download downloads 42 Powered bymore_vert King's Research Port... arrow_drop_down Behavioural and Cognitive PsychotherapyArticle . 2018License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s1352465817000765&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 GermanyBMJ Winau, L.; Baydes, R.H.; Braner, A.; Drott, U.; Burkhardt, H.; Sangle, S.; D'Cruz, D.P.; Carr-White, G.; Marber, M.; Schnoes, K.; Arendt, C.; Klingel, K.; Vogl, T.J.; Zeiher, A.M.; Nagel, E.; Puntmann, V.O.;pmid: 30077990
BackgroundCardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic resonance (CMR).Methods and resultsThis is a two-centre (London and Frankfurt) CMR imaging study at 3.0 Tesla of consecutive 92 patients with SLE free of cardiac symptoms, undergoing screening for cardiac involvement. Venous samples were drawn and analysed post-hoc for cardiac biomarkers, including hs-TropT, high-sensitive C reactive protein and N-terminal pro brain natriuretic peptide. Compared with age-matched/gender-matched non-SLE controls (n=78), patients had significantly raised cardiac biomarker levels, native T1 and T2, aortic and ventricular stiffness, and reduced global longitudinal strain (p<0.01). In SLE, hs-TropT was significantly and independently associated with native T2, followed by the models including native T1 and aortic stiffness (Χ2 0.462, p<0.01). There were no relationships between hs-TropT and age, gender, CV risk factors, duration of systemic disease, cardiac structure or function, or late gadolinium enhancement.ConclusionsPatients with SLE have a high prevalence of subclinical myocardial injury as demonstrated by raised high-sensitive troponin levels. CMR with T2 mapping reveals myocardial oedema as the strongest predictor of hs-TropT release, underscoring the inflammatory interstitial remodelling as the main mechanism of injury. Patients without active myocardial inflammation demonstrate diffuse interstitial remodelling and increased vascular stiffness. These findings substantiate the role of CMR in screening of subclinical cardiac involvement.Trial registration numerNCT02407197; Results.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2001Oxford University Press (OUP) P, Marcato; G, Mulvey; R J, Read; , Vander Helm K; P N, Nation; G D, Armstrong;doi: 10.1086/318080
pmid: 11133375
The Shiga toxins Stx1 and Stx2 contribute to the development of enterohemorrhagic O157: H7 Escherichia coli‐mediated colitis and hemolytic-uremic syndrome in humans. The Stx2 B subunit, which binds to globotriaosylceramide (GB3) receptors on target cells, was cloned. This involved replacing the Stx2 B subunit leader peptide nucleotide sequences with those from the Stx1 B subunit. The construct was expressed in the TOPP3 E. coli strain. The Stx2 B subunits from this strain assembled into a pentamer and bound to a GB3 receptor analogue. The cloned Stx2 B subunit was not cytotoxic to Vero cells or apoptogenic in Burkitt’s lymphoma cells. Although their immune response to the Stx2 B subunit was variable, rabbits that developed Stx2 B subunit‐specific antibodies, as determined by immunoblot and in vitro cytotoxicity neutralization assays, survived a challenge with Stx2 holotoxin. This is thought to be the first demonstration of the immunoprophylactic potential of the Stx2 B subunit.
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For further information contact us at helpdesk@openaire.eu78 citations 78 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1086/318080&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 Italy, France, Italy, Italy, Italy, Spain, ItalyOxford University Press (OUP) UKRI | AlwaysClean, UKRI | Integrated Mobile Welding...UKRI| AlwaysClean ,UKRI| Integrated Mobile Welding For High Strength In-Field Pipe ManufacturingLiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; Aurlien, R.; Azzoni, S.; Baccigalupi, C.; Banday, A. J.; Banerji, R.; Barreiro, R. B.; Bartolo, N.; Bautista, L.; Beck, D.; Beckman, S.; Bersanelli, M.; Boulanger, F.; Brilenkov, M.; Bucher, M.; Calabrese, E.; Campeti, P.; Carones, A.; Casas, F. J.; Catalano, A.; Chan, V.; Cheung, K.; Chinone, Y.; Clark, S. E.; Columbro, F.; D'Alessandro, G.; de Bernardis, P.; de Haan, T.; de la Hoz, E.; De Petris, M.; Della Torre, S.; Diego-Palazuelos, P.; Dobbs, M.; Dotani, T.; Duval, J. M.; Elleflot, T.; Eriksen, H. K.; Errard, J.; Essinger-Hileman, T.; Finelli, F.; Flauger, R.; Franceschet, C.; Fuskeland, U.; Galloway, M.; Ganga, K.; Gerbino, M.; Gervasi, M.; Génova-Santos, R. T.; Ghigna, T.; Giardiello, S.; Gjerløw, E.; Grain, J.; Grupp, F.; Gruppuso, A.; Gudmundsson, J. E.; Halverson, N. W.; Hargrave, P.; Hasebe, T.; Hasegawa, M.; Hazumi, M.; Henrot-Versillé, S.; Hensley, B.; Hergt, L. T.; Herman, D.; Hivon, E.; Hlozek, R. A.; Hornsby, A. L.; Hoshino, Y.; Hubmayr, J.; Ichiki, K.; Iida, T.; Imada, H.; Ishino, H.; Jaehnig, G.; Katayama, N.; Kato, A.; Keskitalo, R.; Kisner, T.; Kobayashi, Y.; Kogut, A.; Kohri, K.; Komatsu, E.; Komatsu, K.; Konishi, K.; Krachmalnicoff, N.; Kuo, C. L.; Lamagna, L.; Lattanzi, M.; Lee, A. T.; Leloup, C.; Levrier, F.; Linder, E.; Luzzi, G.; Macias-Perez, J.; Maciaszek, T.; Maffei, B.; Maino, D.; Mandelli, S.; Martínez-González, E.; Masi, S.; Massa, M.; Matarrese, S.; Matsuda, F. T.; Matsumura, T.; Mele, L.; Migliaccio, M.; Minami, Y.; Moggi, A.; Montgomery, J.; Montier, L.; Morgante, G.; Mot, B.; Nagano, Y.; Nagasaki, T.; Nagata, R.; Nakano, R.; Namikawa, T.; Nati, F.; Natoli, P.; Nerval, S.; Noviello, F.; Odagiri, K.; Oguri, S.; Ohsaki, H.; Pagano, L.; Paiella, A.; Paoletti, D.; Passerini, A.; Patanchon, G.; Piacentini, F.; Piat, M.; Pisano, G.; Polenta, G.; Poletti, D.; Prouvé, T.; Puglisi, G.; Rambaud, D.; Raum, C.; Realini, S.; Reinecke, M.; Remazeilles, M.; Ritacco, A.; Roudil, G.; Rubino-Martin, J. A.; Russell, M.; Sakurai, H.; Sakurai, Y.; Sasaki, M.; Scott, D.; Sekimoto, Y.; Shinozaki, K.; Shiraishi, M.; Shirron, P.; Signorelli, G.; Spinella, F.; Stever, S.; Stompor, R.; Sugiyama, S.; Sullivan, R. M.; Suzuki, A.; Svalheim, T. L.; Switzer, E.; Takaku, R.; Takakura, H.; Takase, Y.; Tartari, A.; Terao, Y.; Thermeau, J.; Thommesen, H.; Thompson, K. L.; Tomasi, M.; Tominaga, M.; Tristram, M.; Tsuji, M.; Tsujimoto, M.; Vacher, L.; Vielva, P.; Vittorio, N.; Wang, W.; Watanuki, K.; Wehus, I. K.; Weller, J.; Westbrook, B.; Wilms, J.; Winter, B.; Wollack, E. J.; Yumoto, J.; Zannoni, M.;handle: 20.500.11767/132550 , 2434/947309 , 11577/3467499 , 10261/306493 , 11573/1685127
This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Preprint , Article 2011Embargo end date: 01 Jan 2011arXiv NSERCNSERCAuthors: Rivera-Ingraham, A.; Martin, P. G.; Polychroni, D.; Moore, T. J. T.;Rivera-Ingraham, A.; Martin, P. G.; Polychroni, D.; Moore, T. J. T.;In this work we have carried out an in-depth analysis of the young stellar content in the W3 GMC. The YSO population was identified and classified in the IRAC/MIPS color-magnitude space according to the `Class' scheme and compared to other classifications based on intrinsic properties. Class 0/I and II candidates were also compared to low/intermediate-mass pre-main-sequence stars selected through their colors and magnitudes in 2MASS. We find that a reliable color/magnitude selection of low-mass PMS stars in the infrared requires prior knowledge of the protostar population, while intermediate mass objects can be more reliably identified. By means of the MST algorithm and our YSO spatial distribution and age maps we investigated the YSO groups and the star formation history in W3. We find signatures of clustered and distributed star formation in both triggered and quiescent environments. The central/western parts of the GMC are dominated by large scale turbulence likely powered by isolated bursts of star formation that triggered secondary star formation events. Star formation in the eastern high density layer also shows signs of extended periods of star formation. While our findings support triggering as a key factor for inducing and enhancing some of the major star forming activity in the HDL (e.g., W3 Main/W3(OH)), we argue that some degree of quiescent or spontaneous star formation is required to explain the observed YSO population. Our results also support previous studies claiming an spontaneous origin for the isolated massive star(s) powering KR 140. Comment: Accepted for publication in ApJ
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1110.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2011License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Conference object , Article 2020 Czech RepublicIEEE NSERC, EC | UTHOTPNSERC ,EC| UTHOTPde Rezende, Susanna F.; Meir, Or; Nordstr��m, Jakob; Pitassi, Toniann; Robere, Robert; Vinyals, Marc;handle: 11104/0317277
We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof power for cutting planes with unbounded versus polynomially bounded coefficients. Specifically, we exhibit CNF formulas that can be refuted in quadratic length and constant line space in cutting planes with unbounded coefficients, but for which there are no refutations in subexponential length and subpolynomial line space if coefficients are restricted to be of polynomial magnitude. •We give the first explicit separation between monotone Boolean formulas and monotone real formulas. Specifically, we give an explicit family of functions that can be computed with monotone real formulas of nearly linear size but require monotone Boolean formulas of exponential size. Previously only a non-explicit separation was known. •We give the strongest separation to-date between monotone Boolean formulas and monotone Boolean circuits. Namely, we show that the classical GEN problem, which has polynomial-size monotone Boolean circuits, requires monotone Boolean formulas of size $2^{\Omega(n/\text{polylog}(n))}$ . An important technical ingredient, which may be of independent interest, is that we show that the Nullstellensatz degree of refuting the pebbling formula over a DAG $G$ over any field coincides exactly with the reversible pebbling price of $G$ . In particular, this implies that the standard decision tree complexity and the parity decision tree complexity of the corresponding falsified clause search problem are equal. This is an extended abstract. The full version of the paper is available at https://arxiv.org/abs/2001.02144.
arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/focs46700.2020.00011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down Repository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesConference object . 2020Data sources: Repository of the Czech Academy of Scienceshttps://doi.org/10.1109/focs46...Conference object . 2020License: IEEE CopyrightData sources: Crossrefhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/focs46700.2020.00011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020British Editorial Society of Bone & Joint Surgery Alexander Aarvold; Ryan Lohre; Harpreet Chhina; Kishore Mulpuri; Anthony Cooper;Aims Though the pathogenesis of Legg-Calve-Perthes disease (LCPD) is unknown, repetitive microtrauma resulting in deformity has been postulated. The purpose of this study is to trial a novel upright MRI scanner, to determine whether any deformation occurs in femoral heads affected by LCPD with weightbearing. Methods Children affected by LCPD were recruited for analysis. Children received both standing weightbearing and supine scans in the MROpen upright MRI scanner, for coronal T1 GFE sequences, both hips in field of view. Parameters of femoral head height, width, and lateral extrusion of affected and unaffected hips were assessed by two independent raters, repeated at a one month interval. Inter- and intraclass correlation coefficients were determined. Standing and supine measurements were compared for each femoral head. Results Following rigorous protocol development in healthy age-matched volunteers, successful scanning was performed in 11 LCPD-affected hips in nine children, with seven unaffected hips therefore available for comparison. Five hips were in early stage (1 and 2) and six were in late stage (3 and 4). The mean age was 5.3 years. All hips in early-stage LCPD demonstrated dynamic deformity on weightbearing. Femoral head height decreased (mean 1.2 mm, 12.4% decrease), width increased (mean 2.5 mm, 7.2% increase), and lateral extrusion increased (median 2.5 mm, 23% increase) on standing weightbearing MRI compared to supine scans. Negligible deformation was observed in contra-lateral unaffected hips, with less deformation observed in late-stage hips. Inter- and intraclass reliability for all measured parameters was good to excellent. Conclusion This pilot study has described an effective novel research investigation for children with LCPD. Femoral heads in early-stage LCPD demonstrated dynamic deformity on weightbearing not previously seen, while unaffected hips did not. Expansion of this protocol will allow further translational study into the effects of loading hips with LCPD. Cite this article: Bone Joint Open 2020;1-7:364–369.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 United KingdomAmerican Medical Association (AMA) Almoudaris, A; Mamidanna, R; Bottle, A; Aylin, P; Vincent, C; Faiz, O; Hanna, G;pmid: 23553312
IMPORTANCE: Gastroesophageal cancer resections are associated with significant reintervention and perioperative mortality rates. OBJECTIVE: To compare outcomes following operative and nonoperative reinterventions between high- and low-mortality gastroesophageal cancer surgical units in England. DESIGN: All elective esophageal and gastric resections for cancer between 2000 and 2010 in English public hospitals were identified from a national administrative database. Units were divided into low- and high-mortality units (LMUs and HMUs, respectively) using a threshold of 5% or less for 30-day adjusted mortality. The groups were compared for reoperations and nonoperative reinterventions following complications. SETTING: Both LMUs and HMUs. PARTICIPANTS: Patients who underwent esophageal and gastric resections for cancer. EXPOSURE: Elective esophageal and gastric resections for cancer, with reoperations and nonoperative reinterventions following complications. MAIN OUTCOMES AND MEASURES: Failure to rescue is defined as the death of a patient following a complication; failure to rescue-surgical is defined as the death of a patient following reoperation for a surgical complication. RESULTS: There were 14 955 esophagectomies and 10 671 gastrectomies performed in 141 units. For gastroesophageal resections combined, adjusted mortality rates were 3.0% and 8.3% (P < .001) for LMUs and HMUs, respectively. Complications rates preceding reoperation were similar (5.4% for LMUs vs. 4.9% for HMUs; P = .11). The failure to rescue-surgical rates were lower in LMUs than in HMUs (15.3% vs. 24.1%; P < .001). The LMUs performed more nonoperative reinterventions than the HMUs did (6.7% vs. 4.7%; P < .001), with more patients surviving in LMUs than in HMUs (failure to rescue rate, 7.0% vs. 12.5%; P < .001). Overall, LMUs reintervened more than HMUs did (12.2% vs 9.6%; P < .001), and LMUs had lower failure to rescue rates following reintervention than HMUs did (9.0% vs. 18.3%; P = .001). All P values stated refer to 2-sided values. CONCLUSIONS AND RELEVANCE: Overall, LMUs were more likely to reintervene and rescue patients following gastroesophageal cancer resections in England. Patients were more likely to survive following both reoperations and nonsurgical interventions in LMUs.
JAMA Surgery; Oxford... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert JAMA Surgery; Oxford... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 GermanyAmerican Geophysical Union (AGU) Dieng, Diarra; Cannon, Alex J.; Laux, Patrick; Hald, Cornelius; Adeyeri, Oluwafemi; Rahimi, Jaber; Srivastava, Amit K.; Mbaye, Mamadou Lamine; Kunstmann, Harald; Cannon, Alex J.; 2 Environment and Climate Change Canada Victoria BC Canada; Laux, Patrick; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Hald, Cornelius; 4 Meteorological Observatory Hohenpeißenberg German Weather Service Hohenpeißenberg Germany; Adeyeri, Oluwafemi; 5 School of Energy and Environment City University of Hong Kong Kowloon Hong‐Kong; Rahimi, Jaber; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Srivastava, Amit K.; 6 Institute of Crop Science and Resource Conservation University of Bonn Bonn Germany; Mbaye, Mamadou Lamine; 7 Laboratoire d’Océanographie des Sciences de l’Environnement et du Climat (LOSEC) Université Assane SECK de Ziguinchor Ziguinchor Senegal; Kunstmann, Harald; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany;A multivariate bias correction based on N‐dimensional probability density function transform (MBCn) technique is applied to four different high‐resolution regional climate change simulations and key meteorological variables, namely precipitation, mean near‐surface air temperature, near‐surface maximum air temperature, near‐surface minimum air temperature, surface downwelling solar radiation, relative humidity, and wind speed. The impact of bias‐correction on the historical (1980–2005) period, the inter‐variable relationships, and the measures of spatio‐temporal consistency are investigated. The focus is on the discrepancies between the original and the bias‐corrected results over five agro‐ecological zones. We also evaluate relevant indices for agricultural applications such as climate extreme indices, under current and future (2020–2050) climate change conditions based on the RCP4.5. Results show that MBCn successfully corrects the seasonal biases in spatial patterns and intensities for all variables, their intervariable correlation, and the distributions of most of the analyzed variables. Relatively large bias reductions during the historical period give indication of possible benefits of MBCn when applied to future scenarios. Although the four regional climate models do not agree on the same positive/negative sign of the change of the seven climate variables for all grid points, the model ensemble mean shows a statistically significant change in rainfall, relative humidity in the Northern zone and wind speed in the Coastal zone of West Africa and increasing maximum summer temperature up to 2°C in the Sahara. Key Points: Multivariate bias‐correction (MBCn) of key meteorological variables accounting for their interdependency. MBCn effectively removes the statistical biases as indicated by several measures and improves the representation of the probability density. The corrected model ensemble mean preserves the climate change signal with a statistically significant change in precipitation. Climate Change and Health in sub‐Saharan Africa project https://doi.org/10.1594/PANGAEA.880512 http://doi.org/10.5281/zenodo.1255882
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 United KingdomCambridge University Press (CUP) Authors: Nichole, Fairbrother; Dana S, Thordarson; Fiona L, Challacombe; John K, Sakaluk;Nichole, Fairbrother; Dana S, Thordarson; Fiona L, Challacombe; John K, Sakaluk;pmid: 29461178
Background: Unwanted, intrusive thoughts of infant-related harm are a normal, albeit distressing experience for most new mothers. The occurrence of these thoughts can represent a risk factor for the development of obsessive compulsive disorder (OCD). As the early postpartum period represents a time of increased risk for OCD development, the transition to parenthood provides a unique opportunity to better understand OCD development. Aims: The purpose of this study was to assess components of cognitive behavioural conceptualizations of postpartum OCD in relation to new mothers’ thoughts of infant-related harm. Method: English-speaking pregnant women (n = 100) participated. Questionnaires were completed at approximately 36 weeks of gestation, and at 4 and 12 weeks postpartum. An interview to assess postpartum harm thoughts was administered at 4 and 12 weeks postpartum. Questionnaires assessed OC symptoms, OC-related beliefs, fatigue, sleep difficulties and negative mood. Results: Prenatal OC-related beliefs predicted postpartum OC symptoms, as well as harm thought characteristics and behavioural responses to harm thoughts. The severity of behavioural responses to early postpartum harm thoughts did not predict later postpartum OC symptoms, but did predict frequency and time occupation of accidental harm thoughts, and interference in parenting by intentional harm thoughts. Strong relationships between OC symptoms and harm thought characteristics, and concurrent sleep difficulties, negative mood and fatigue were also found. Conclusions: Findings provide support for cognitive behavioural conceptualizations of postpartum OCD and emphasize the importance of maternal sleep, fatigue and negative mood in the relationship between OC-related beliefs and maternal cognitive and behavioural responses to postpartum harm thoughts.
King's Research Port... arrow_drop_down Behavioural and Cognitive PsychotherapyArticle . 2018License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s1352465817000765&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 0visibility views 0 download downloads 42 Powered bymore_vert King's Research Port... arrow_drop_down Behavioural and Cognitive PsychotherapyArticle . 2018License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s1352465817000765&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 GermanyBMJ Winau, L.; Baydes, R.H.; Braner, A.; Drott, U.; Burkhardt, H.; Sangle, S.; D'Cruz, D.P.; Carr-White, G.; Marber, M.; Schnoes, K.; Arendt, C.; Klingel, K.; Vogl, T.J.; Zeiher, A.M.; Nagel, E.; Puntmann, V.O.;pmid: 30077990
BackgroundCardiovascular (CV) involvement in patients with systemic lupus erythematosus (SLE) is presumably subclinical for the major part of its evolution. We evaluated the associations between high-sensitive troponin T (hs-TropT), a sensitive marker of myocardial injury, and CV involvement using cardiac magnetic resonance (CMR).Methods and resultsThis is a two-centre (London and Frankfurt) CMR imaging study at 3.0 Tesla of consecutive 92 patients with SLE free of cardiac symptoms, undergoing screening for cardiac involvement. Venous samples were drawn and analysed post-hoc for cardiac biomarkers, including hs-TropT, high-sensitive C reactive protein and N-terminal pro brain natriuretic peptide. Compared with age-matched/gender-matched non-SLE controls (n=78), patients had significantly raised cardiac biomarker levels, native T1 and T2, aortic and ventricular stiffness, and reduced global longitudinal strain (p<0.01). In SLE, hs-TropT was significantly and independently associated with native T2, followed by the models including native T1 and aortic stiffness (Χ2 0.462, p<0.01). There were no relationships between hs-TropT and age, gender, CV risk factors, duration of systemic disease, cardiac structure or function, or late gadolinium enhancement.ConclusionsPatients with SLE have a high prevalence of subclinical myocardial injury as demonstrated by raised high-sensitive troponin levels. CMR with T2 mapping reveals myocardial oedema as the strongest predictor of hs-TropT release, underscoring the inflammatory interstitial remodelling as the main mechanism of injury. Patients without active myocardial inflammation demonstrate diffuse interstitial remodelling and increased vascular stiffness. These findings substantiate the role of CMR in screening of subclinical cardiac involvement.Trial registration numerNCT02407197; Results.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/annrheumdis-2018-213661&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2001Oxford University Press (OUP) P, Marcato; G, Mulvey; R J, Read; , Vander Helm K; P N, Nation; G D, Armstrong;doi: 10.1086/318080
pmid: 11133375
The Shiga toxins Stx1 and Stx2 contribute to the development of enterohemorrhagic O157: H7 Escherichia coli‐mediated colitis and hemolytic-uremic syndrome in humans. The Stx2 B subunit, which binds to globotriaosylceramide (GB3) receptors on target cells, was cloned. This involved replacing the Stx2 B subunit leader peptide nucleotide sequences with those from the Stx1 B subunit. The construct was expressed in the TOPP3 E. coli strain. The Stx2 B subunits from this strain assembled into a pentamer and bound to a GB3 receptor analogue. The cloned Stx2 B subunit was not cytotoxic to Vero cells or apoptogenic in Burkitt’s lymphoma cells. Although their immune response to the Stx2 B subunit was variable, rabbits that developed Stx2 B subunit‐specific antibodies, as determined by immunoblot and in vitro cytotoxicity neutralization assays, survived a challenge with Stx2 holotoxin. This is thought to be the first demonstration of the immunoprophylactic potential of the Stx2 B subunit.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1086/318080&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu78 citations 78 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1086/318080&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jwb.2017.04.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 Italy, France, Italy, Italy, Italy, Spain, ItalyOxford University Press (OUP) UKRI | AlwaysClean, UKRI | Integrated Mobile Welding...UKRI| AlwaysClean ,UKRI| Integrated Mobile Welding For High Strength In-Field Pipe ManufacturingLiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; Aurlien, R.; Azzoni, S.; Baccigalupi, C.; Banday, A. J.; Banerji, R.; Barreiro, R. B.; Bartolo, N.; Bautista, L.; Beck, D.; Beckman, S.; Bersanelli, M.; Boulanger, F.; Brilenkov, M.; Bucher, M.; Calabrese, E.; Campeti, P.; Carones, A.; Casas, F. J.; Catalano, A.; Chan, V.; Cheung, K.; Chinone, Y.; Clark, S. E.; Columbro, F.; D'Alessandro, G.; de Bernardis, P.; de Haan, T.; de la Hoz, E.; De Petris, M.; Della Torre, S.; Diego-Palazuelos, P.; Dobbs, M.; Dotani, T.; Duval, J. M.; Elleflot, T.; Eriksen, H. K.; Errard, J.; Essinger-Hileman, T.; Finelli, F.; Flauger, R.; Franceschet, C.; Fuskeland, U.; Galloway, M.; Ganga, K.; Gerbino, M.; Gervasi, M.; Génova-Santos, R. T.; Ghigna, T.; Giardiello, S.; Gjerløw, E.; Grain, J.; Grupp, F.; Gruppuso, A.; Gudmundsson, J. E.; Halverson, N. W.; Hargrave, P.; Hasebe, T.; Hasegawa, M.; Hazumi, M.; Henrot-Versillé, S.; Hensley, B.; Hergt, L. T.; Herman, D.; Hivon, E.; Hlozek, R. A.; Hornsby, A. L.; Hoshino, Y.; Hubmayr, J.; Ichiki, K.; Iida, T.; Imada, H.; Ishino, H.; Jaehnig, G.; Katayama, N.; Kato, A.; Keskitalo, R.; Kisner, T.; Kobayashi, Y.; Kogut, A.; Kohri, K.; Komatsu, E.; Komatsu, K.; Konishi, K.; Krachmalnicoff, N.; Kuo, C. L.; Lamagna, L.; Lattanzi, M.; Lee, A. T.; Leloup, C.; Levrier, F.; Linder, E.; Luzzi, G.; Macias-Perez, J.; Maciaszek, T.; Maffei, B.; Maino, D.; Mandelli, S.; Martínez-González, E.; Masi, S.; Massa, M.; Matarrese, S.; Matsuda, F. T.; Matsumura, T.; Mele, L.; Migliaccio, M.; Minami, Y.; Moggi, A.; Montgomery, J.; Montier, L.; Morgante, G.; Mot, B.; Nagano, Y.; Nagasaki, T.; Nagata, R.; Nakano, R.; Namikawa, T.; Nati, F.; Natoli, P.; Nerval, S.; Noviello, F.; Odagiri, K.; Oguri, S.; Ohsaki, H.; Pagano, L.; Paiella, A.; Paoletti, D.; Passerini, A.; Patanchon, G.; Piacentini, F.; Piat, M.; Pisano, G.; Polenta, G.; Poletti, D.; Prouvé, T.; Puglisi, G.; Rambaud, D.; Raum, C.; Realini, S.; Reinecke, M.; Remazeilles, M.; Ritacco, A.; Roudil, G.; Rubino-Martin, J. A.; Russell, M.; Sakurai, H.; Sakurai, Y.; Sasaki, M.; Scott, D.; Sekimoto, Y.; Shinozaki, K.; Shiraishi, M.; Shirron, P.; Signorelli, G.; Spinella, F.; Stever, S.; Stompor, R.; Sugiyama, S.; Sullivan, R. M.; Suzuki, A.; Svalheim, T. L.; Switzer, E.; Takaku, R.; Takakura, H.; Takase, Y.; Tartari, A.; Terao, Y.; Thermeau, J.; Thommesen, H.; Thompson, K. L.; Tomasi, M.; Tominaga, M.; Tristram, M.; Tsuji, M.; Tsujimoto, M.; Vacher, L.; Vielva, P.; Vittorio, N.; Wang, W.; Watanuki, K.; Wehus, I. K.; Weller, J.; Westbrook, B.; Wilms, J.; Winter, B.; Wollack, E. J.; Yumoto, J.; Zannoni, M.;handle: 20.500.11767/132550 , 2434/947309 , 11577/3467499 , 10261/306493 , 11573/1685127
This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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