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description Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1200/jco.2017.74.1173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/ehf2.13517&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 Australia, NetherlandsCambridge University Press (CUP) NSF | SI2-SSE: The Next Generat...NSF| SI2-SSE: The Next Generation of the Montage Mosaic EngineSarah V. White; Thomas M. O. Franzen; C. J. Riseley; O. Ivy Wong; Anna D. Kapińska; Natasha Hurley-Walker; Joseph R. Callingham; Kshitij Thorat; Chen Wu; Paul Hancock; Richard W. Hunstead; Nick Seymour; Jesse Swan; Randall B. Wayth; John Morgan; Rajan Chhetri; C. A. Jackson; Stuart Weston; Martin Bell; Bryan Gaensler; Melanie Johnston-Hollitt; A. R. Offringa; Lister Staveley-Smith;handle: 1887/3201328 , 10453/146872
The entire southern sky (Declination, $\delta $ 4 Jy) in the extragalactic catalogue (Galactic latitude, $|b| >$ 10 deg). We refer to these 1,863 sources as the GLEAM 4-Jy (G4Jy) Sample, and use radio images (of $\leq$ 45-arcsec resolution), and multi-wavelength information, to assess their morphology and identify the galaxy that is hosting the radio emission (where appropriate). Details of how to access all of the overlays used for this work are available at https://github.com/svw26/G4Jy. Alongside this we conduct further checks against the literature, which we document in this paper for individual sources. Whilst the vast majority of the G4Jy Sample are active galactic nuclei with powerful radio-jets, we highlight that it also contains a nebula, two nearby, star-forming galaxies, a cluster relic, and a cluster halo. There are also three extended sources for which we are unable to infer the mechanism that gives rise to the low-frequency emission. In the G4Jy catalogue we provide mid-infrared identifications for 86% of the sources, and flag the remainder as: having an uncertain identification (129 sources), having a faint/uncharacterised mid-infrared host (126 sources), or it being inappropriate to specify a host (2 sources). For the subset of 129 sources, there is ambiguity concerning candidate host-galaxies, and this includes four sources (B0424$-$728, B0703$-$451, 3C 198, and 3C 403.1) where we question the existing identification. Comment: 37 pages (24 MB in size), 23 figures, 3 tables, accepted for publication in PASA, and now updated to match the final proof. Full-resolution images will be used for the published version, available through the journal
arXiv.org e-Print Ar... arrow_drop_down Publications of the Astronomical Society of Australia; NARCISArticle . 2020License: Cambridge Core User Agreementhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down Publications of the Astronomical Society of Australia; NARCISArticle . 2020License: Cambridge Core User Agreementhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 NetherlandsElsevier BV Max Dahele; Shannon Pearson; Thomas G. Purdie; Jean-Pierre Bissonnette; Kevin Franks; Anthony Brade; John Cho; Alexander Sun; A. Hope; Andrea Marshall; Jane Higgins; Andrea Bezjak;pmid: 18978570
Introduction: With the anticipation of improved outcomes, especially for patients with early-stage non-small cell lung cancer, stereotactic body radiation therapy (SBRT) has been rapidly introduced into the thoracic radiation oncology community. Although at first glance lung SBRT might seem methodologically similar to conventional radiotherapy, there are important differences in its execution that require particular consideration. The objective of this paper is to highlight these and other issues to contribute to the safe and effective diffusion of lung SBRT. We discuss practical challenges that have been encountered in the implementation of lung SBRT at a single, large institution and emphasize the importance of a systematic approach to the design of lung SBRT services. Methods: Specific technical and clinical components that were identified as being important during the development of lung SBRT at Princess Margaret Hospital are described. The clinical system that evolved from these is outlined. Results: Using this clinical framework the practical topics addressed include: patient assessment, simulation and treatment planning, tumor and organ at risk delineation, trial set up before treatment, on-line image-guidance, and patient follow-up. Conclusions: The potential gain in therapeutic ratio that is theoretically possible with lung SBRT can only be realized if the tumor is adequately irradiated and normal tissue spared. A discussion of the component parts of lung SBRT is presented. It is a complex process and specific challenges need to be overcome to effect the satisfactory transition of lung SBRT into routine practice.
Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2009 NetherlandsAmerican Association for the Advancement of Science (AAAS) EC | PULSARS WITH LOFAR, NSERCEC| PULSARS WITH LOFAR ,NSERCAnne M. Archibald; Ingrid H. Stairs; Scott M. Ransom; Victoria M. Kaspi; V. I. Kondratiev; Duncan R. Lorimer; Maura McLaughlin; Jason Boyles; Jason W. T. Hessels; Ryan S. Lynch; Joeri van Leeuwen; Mallory S. E. Roberts; Frederick Jenet; David Champion; R. Rosen; Brad N. Barlow; B. H. Dunlap; Ronald A. Remillard;handle: 11245/1.313487
pmid: 19520945
Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase. Comment: published in Science
Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu434 citations 434 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 Netherlands, France, FranceSpringer Science and Business Media LLC NSF | 2010 Project: Arabidopsis...NSF| 2010 Project: Arabidopsis 2010: Transcriptomes for Functional and Evolutionary StudiesHaudry, Annabelle, A.; Platts, Adrian; Vello, Emilio; Hoen, Douglas; Leclercq, Mickael; Williamson, Robert; Forczek, Ewa; Joly-Lopez, Zoé; Steffen, Joshua; Hazzouri, Khaled; Dewar, Ken; Stinchcombe, John; Schoen, Daniel; Wang, Xiaowu; Schmutz, Jeremy; Town, Christopher; Edger, Patrick; Pires, J Chris; Schumaker, Karen; Jarvis, David; Mandáková, Terezie; Lysak, Martin; van den Bergh, Erik; Schranz, M Eric; Harrison, Paul; Moses, Alan; Bureau, Thomas, E; Wright, Stephen; Blanchette, Mathieu;doi: 10.1038/ng.2684
pmid: 23817568
Despite the central importance of noncoding DNA to gene regulation and evolution, understanding of the extent of selection on plant noncoding DNA remains limited compared to that of other organisms. Here we report sequencing of genomes from three Brassicaceae species (Leavenworthia alabamica, Sisymbrium irio and Aethionema arabicum) and their joint analysis with six previously sequenced crucifer genomes. Conservation across orthologous bases suggests that at least 17% of the Arabidopsis thaliana genome is under selection, with nearly one-quarter of the sequence under selection lying outside of coding regions. Much of this sequence can be localized to approximately 90,000 conserved noncoding sequences (CNSs) that show evidence of transcriptional and post-transcriptional regulation. Population genomics analyses of two crucifer species, A. thaliana and Capsella grandiflora, confirm that most of the identified CNSs are evolving under medium to strong purifying selection. Overall, these CNSs highlight both similarities and several key differences between the regulatory DNA of plants and other species.
NARCIS; Research@WUR arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu326 citations 326 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert NARCIS; Research@WUR arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2008 Netherlands, United KingdomEDP Sciences Munari, U.; Tomasella, L.; Fiorucci, M.; Bienayme, O.; Binney, J.; Bland-Hawthorn, J.; Boeche, C.; Campbell, R.; Freeman, K. C.; Gibson, B.; Gilmore, G.; Grebel, E. K.; Helmi, A.; Navarro, J. F.; Parker, Q. A.; Seabroke, G. M.; Siebert, A.; Siviero, A.; Steinmetz, M.; Watson, F. G.; Williams, M.; Wyse, R. F. G.; Zwitter, T.;We have used spectra of hot stars from the RAVE Survey in order to investigate the visibility and properties of five diffuse interstellar bands previously reported in the literature. The RAVE spectroscopic survey for Galactic structure and kinematics records CCD spectra covering the 8400-8800 Ang wavelength region at 7500 resolving power. The spectra are obtained with the UK Schmidt at the AAO, equipped with the 6dF multi-fiber positioner. The DIB at 8620.4 Ang is by far the strongest and cleanest of all DIBs occurring within the RAVE wavelength range, with no interference by underlying absorption stellar lines in hot stars. It correlates so tightly with reddening that it turns out to be a reliable tool to measure it, following the relation E(B-V) = 2.72 (+/- 0.03) x E.W.(Ang), valid throughout the general interstellar medium of our Galaxy. The presence of a DIB at 8648 Ang is confirmed. Its intensity appears unrelated to reddening, in agreement with scanty and preliminary reports available in the literature, and its measurability is strongly compromised by severe blending with underlying stellar HeI doublet at 8649 Ang. The two weak DIBS at 8531 and 8572 Ang do not appear real and should actually be blends of underlying stellar lines. The very weak DIB at 8439 Ang cannot be resolved within the profile of the much stronger underlying hydrogen Paschen 18 stellar line. Comment: Accepted in press by A&A
CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research Archive; Astronomy and AstrophysicsOther literature type . Article . 2016 . 2008NARCIS; Astronomy and AstrophysicsArticle . 2008https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu48 citations 48 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 19 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research Archive; Astronomy and AstrophysicsOther literature type . Article . 2016 . 2008NARCIS; Astronomy and AstrophysicsArticle . 2008https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2014 NetherlandsCambridge University Press (CUP) Lubbers, L.A.; Weijs, J.H.; Botto, L.; Das, S.; Andreotti, B.; Snoeijer, J.H.;AbstractThe equilibrium shape of liquid drops on elastic substrates is determined by minimizing elastic and capillary free energies, focusing on thick incompressible substrates. The problem is governed by three length scales: the size of the drop $R$, the molecular size $a$ and the ratio of surface tension to elastic modulus $\gamma /E$. We show that the contact angles undergo two transitions upon changing the substrate from rigid to soft. The microscopic wetting angles deviate from Young’s law when $\gamma /(Ea)\gg 1$, while the apparent macroscopic angle only changes in the very soft limit $\gamma /(ER)\gg 1$. The elastic deformations are worked out for the simplifying case where the solid surface energy is assumed to be constant. The total free energy turns out to be lower on softer substrates, consistent with recent experiments.
NARCIS arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu85 citations 85 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Spain, NetherlandsWiley NIH | Genetic predictors of met..., NIH | Epidemiology of Precursor..., NIH | THE FRAMINGHAM HEART STUD... +2 projectsNIH| Genetic predictors of metabolic responses to dairy ,NIH| Epidemiology of Precursors to Type 2 Diabetes ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,SFI| Dietary fatty acids: impact on inflammasome driven adipose inflammation and insulin resistance – novel therapeutic targets ,NIH| Rare Sequence Variation and Diabetes Quantitative TraitsAoife M. Murphy; Caren E. Smith; Leanne M Murphy; Jack L. Follis; Toshiko Tanaka; Kris Richardson; Raymond Noordam; Rozenn N. Lemaitre; Mika Kähönen; Josée Dupuis; Trudy Voortman; Eirini Marouli; Dennis O. Mook-Kanamori; Olli T. Raitakari; Jaeyoung Hong; Abbas Dehghan; George Dedoussis; Renée de Mutsert; Terho Lehtimäki; Ching-Ti Liu; Fernando Rivadeneira; Panagiotis Deloukas; Vera Mikkilä; James B. Meigs; André G. Uitterlinden; Mohammad Arfan Ikram; Oscar H. Franco; Maria Hughes; Peadar Ó Gaora; Jose M. Ordovas; Helen M. Roche;SCOPE: Insulin resistance (IR) and inflammation are hallmarks of type 2 diabetes (T2D). The nod-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL-1β inflammation and IR. Interactions between SFA intake and NLRP3-related genetic variants may alter T2D risk factors. METHODS: Meta-analyses of six Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 19 005) tested interactions between SFA and NLRP3-related single-nucleotide polymorphisms (SNPs) and modulation of fasting insulin, fasting glucose, and homeostasis model assessment of insulin resistance. RESULTS: SFA interacted with rs12143966, wherein each 1% increase in SFA intake increased insulin by 0.0063 IU mL-1 (SE ± 0.002, p = 0.001) per each major (G) allele copy. rs4925663, interacted with SFA (β ± SE = -0.0058 ± 0.002, p = 0.004) to increase insulin by 0.0058 IU mL-1 , per additional copy of the major (C) allele. Both associations are close to the significance threshold (p < 0.0001). rs4925663 causes a missense mutation affecting NLRP3 expression. CONCLUSION: Two NLRP3-related SNPs showed potential interaction with SFA to modulate fasting insulin. Greater dietary SFA intake accentuates T2D risk, which, subject to functional validation, may be further elaborated depending on NLRP3-related genetic variants. Sí
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NCData sources: Recolector de Ciencia Abierta, RECOLECTALUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NCData sources: Recolector de Ciencia Abierta, RECOLECTALUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Denmark, Sweden, France, Netherlands, Denmark, Denmark, Sweden, United Kingdom, United Kingdom, FranceWiley NIH | Heart Failure Clinical Tr..., EC | inHForm, NIH | UCLA Clinical Translation... +10 projectsNIH| Heart Failure Clinical Trials Network ,EC| inHForm ,NIH| UCLA Clinical Translational Science Institute ,NIH| Renal Sympathetic Denervation in Congestive Heart Failure ,EC| BigData Heart ,NIH| Heart Failure Clinical Research Network Coordinating Center ,NIH| Genomics of Cardiac Arrhythmias ,NIH| SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial) ,NIH| Heart Failure Clinical Research Network Regional Clinical Center (U10) ,NIH| Mayo Heart Failure Regional Clinical Center ,NIH| Harvard Regional Clinical Center of the NHLBI Heart Failure Network ,NIH| Mid Atlantic Heart Failure Network ,NIH| New England, New York and Quebec Regional Clinical CenterR. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; Albert Henry; Daniel I. Swerdlow; Anders Mälarstig; Charlotte Andersson; Niek Verweij; Michael V. Holmes; Johan Ärnlöv; Per H. Svensson; Harry Hemingway; Neneh Sallah; Peter Almgren; Krishna G. Aragam; Géraldine Asselin; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Eric Boersma; Jeffrey Brandimarto; Michael R. Brown; Hans-Peter Brunner-La Rocca; David J. Carey; Mark Chaffin; Daniel I. Chasman; Olympe Chazara; Xing Chen; Xu Chen; Jonathan H. Chung; William A. Chutkow; John G.F. Cleland; James P. Cook; Simon de Denus; Graciela E. Delgado; Spiros Denaxas; Alex S. F. Doney; Marcus Dörr; Samuel C. Dudley; Gunnar Engström; Ghazaleh Fatemifar; Chris Finan; Ian Ford; Francoise Fougerousse; René Fouodjio; Mohsen Ghanbari; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Hongsheng Gui; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Åsa K. Hedman; Anna Helgadottir; Hans L. Hillege; Craig L. Hyde; Jaison Jacob; J. Wouter Jukema; Frederick K. Kamanu; Isabella Kardys; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Bill Kraus; Karoline Kuchenbaecker; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian'an Luan; Patrik K. E. Magnusson; Anubha Mahajan; Douglas L. Mann; Kenneth B. Margulies; Nicholas A Marston; Winfried März; John J.V. McMurray; Olle Melander; Giorgio E. M. Melloni; Ify R. Mordi; Michael Morley; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Christopher Newton-Cheh; Alexander Niessner; Teemu J. Niiranen; Christoph Nowak; Michelle L. O'Donoghue; Anjali T. Owens; Colin N. A. Palmer; Guillaume Paré; Markus Perola; Louis Philippe Lemieux Perreault; Eliana Portilla-Fernandez; Kenneth Rice; Paul M. Ridker; Simon P. R. Romaine; Carolina Roselli; Jerome I. Rotter; Christian T. Ruff; Marc S. Sabatine; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa Shalaby; Diane T. Smelser; Nicholas L. Smith; Kari Stefansson; Steen Stender; David J. Stott; G Sveinbjörnsson; Mari Liis Tammesoo; Jean-Claude Tardif; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Danny Tuckwell; Benoit Tyl; André G. Uitterlinden; Felix Vaura; Abirami Veluchamy; Peter M. Visscher; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Peter Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Jian Yang; Yifan Yang; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Faye Zhao; Jemma B. Wilk; Hilma Holm; Naveed Sattar; Steven A. Lubitz; David E. Lanfear; Svati H. Shah; Michael E. Dunn; Quinn S. Wells; Folkert W. Asselbergs; Aroon D. Hingorani; Marie-Pierre Dubé; Nilesh J. Samani; Chim C. Lang; Thomas P. Cappola; Patrick T. Ellinor; Ramachandran S. Vasan; J. Gustav Smith;Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service
NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 3visibility views 3 download downloads 43 Powered bymore_vert NARCIS arrow_drop_down NARCIS; ESC Heart FailureArticle . 2021NARCIS; ESC Heart FailureArticle . 2021ESC Heart Failure; Aalborg University Research PortalArticle . 2021Copenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemLUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYVBN; Aalborg University Research PortalArticle . 2021NARCIS; ESC Heart FailureArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 United Kingdom, Netherlands, ItalyElsevier BV Alessandro Zattoni; Michael A. Witt; William Q. Judge; Till Talaulicar; Jean Jinghan Chen; Krista B. Lewellyn; Helen Wei Hu; Jonas Gabrielsson; Jose Luis Rivas; Sheila M. Puffer; Dhirendra Shukla; Félix A. López; Emmanuel Adegbite; Yves Fassin; Sibel Yamak; Stav Fainshmidt; Hans van Ees;The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Prior evidence suggests that board independence may enhance financial performance, but this relationship has been tested almost exclusively for Anglo-American countries. To explore the boundary conditions of this prominent governance mechanism, we examine the impact of the formal and information institutions of 18 national business systems on the board independence-financial performance relationship. Our results show that while the direct effect of independence is weak, national-level institutions significantly moderate the independence-performance relationship. Our findings suggest that the efficacy of board structures is likely to be contingent on the specific national context, but the type of legal system is insignificant.
NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu49 citations 49 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 150 Powered bymore_vert NARCIS arrow_drop_down De Montfort University Open Research ArchiveArticle . 2017Data sources: De Montfort University Open Research ArchiveIRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017IRIS Catalogo dei prodotti della ricerca scientifica LUISSArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2020 Australia, NetherlandsCambridge University Press (CUP) NSF | SI2-SSE: The Next Generat...NSF| SI2-SSE: The Next Generation of the Montage Mosaic EngineSarah V. White; Thomas M. O. Franzen; C. J. Riseley; O. Ivy Wong; Anna D. Kapińska; Natasha Hurley-Walker; Joseph R. Callingham; Kshitij Thorat; Chen Wu; Paul Hancock; Richard W. Hunstead; Nick Seymour; Jesse Swan; Randall B. Wayth; John Morgan; Rajan Chhetri; C. A. Jackson; Stuart Weston; Martin Bell; Bryan Gaensler; Melanie Johnston-Hollitt; A. R. Offringa; Lister Staveley-Smith;handle: 1887/3201328 , 10453/146872
The entire southern sky (Declination, $\delta $ 4 Jy) in the extragalactic catalogue (Galactic latitude, $|b| >$ 10 deg). We refer to these 1,863 sources as the GLEAM 4-Jy (G4Jy) Sample, and use radio images (of $\leq$ 45-arcsec resolution), and multi-wavelength information, to assess their morphology and identify the galaxy that is hosting the radio emission (where appropriate). Details of how to access all of the overlays used for this work are available at https://github.com/svw26/G4Jy. Alongside this we conduct further checks against the literature, which we document in this paper for individual sources. Whilst the vast majority of the G4Jy Sample are active galactic nuclei with powerful radio-jets, we highlight that it also contains a nebula, two nearby, star-forming galaxies, a cluster relic, and a cluster halo. There are also three extended sources for which we are unable to infer the mechanism that gives rise to the low-frequency emission. In the G4Jy catalogue we provide mid-infrared identifications for 86% of the sources, and flag the remainder as: having an uncertain identification (129 sources), having a faint/uncharacterised mid-infrared host (126 sources), or it being inappropriate to specify a host (2 sources). For the subset of 129 sources, there is ambiguity concerning candidate host-galaxies, and this includes four sources (B0424$-$728, B0703$-$451, 3C 198, and 3C 403.1) where we question the existing identification. Comment: 37 pages (24 MB in size), 23 figures, 3 tables, accepted for publication in PASA, and now updated to match the final proof. Full-resolution images will be used for the published version, available through the journal
arXiv.org e-Print Ar... arrow_drop_down Publications of the Astronomical Society of Australia; NARCISArticle . 2020License: Cambridge Core User Agreementhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/pasa.2020.10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down Publications of the Astronomical Society of Australia; NARCISArticle . 2020License: Cambridge Core User Agreementhttps://doi.org/10.48550/arxiv...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/pasa.2020.10&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2008 NetherlandsElsevier BV Max Dahele; Shannon Pearson; Thomas G. Purdie; Jean-Pierre Bissonnette; Kevin Franks; Anthony Brade; John Cho; Alexander Sun; A. Hope; Andrea Marshall; Jane Higgins; Andrea Bezjak;pmid: 18978570
Introduction: With the anticipation of improved outcomes, especially for patients with early-stage non-small cell lung cancer, stereotactic body radiation therapy (SBRT) has been rapidly introduced into the thoracic radiation oncology community. Although at first glance lung SBRT might seem methodologically similar to conventional radiotherapy, there are important differences in its execution that require particular consideration. The objective of this paper is to highlight these and other issues to contribute to the safe and effective diffusion of lung SBRT. We discuss practical challenges that have been encountered in the implementation of lung SBRT at a single, large institution and emphasize the importance of a systematic approach to the design of lung SBRT services. Methods: Specific technical and clinical components that were identified as being important during the development of lung SBRT at Princess Margaret Hospital are described. The clinical system that evolved from these is outlined. Results: Using this clinical framework the practical topics addressed include: patient assessment, simulation and treatment planning, tumor and organ at risk delineation, trial set up before treatment, on-line image-guidance, and patient follow-up. Conclusions: The potential gain in therapeutic ratio that is theoretically possible with lung SBRT can only be realized if the tumor is adequately irradiated and normal tissue spared. A discussion of the component parts of lung SBRT is presented. It is a complex process and specific challenges need to be overcome to effect the satisfactory transition of lung SBRT into routine practice.
Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/jto.0b013e31818b1771&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu41 citations 41 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Journal of Thoracic ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/jto.0b013e31818b1771&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2009 NetherlandsAmerican Association for the Advancement of Science (AAAS) EC | PULSARS WITH LOFAR, NSERCEC| PULSARS WITH LOFAR ,NSERCAnne M. Archibald; Ingrid H. Stairs; Scott M. Ransom; Victoria M. Kaspi; V. I. Kondratiev; Duncan R. Lorimer; Maura McLaughlin; Jason Boyles; Jason W. T. Hessels; Ryan S. Lynch; Joeri van Leeuwen; Mallory S. E. Roberts; Frederick Jenet; David Champion; R. Rosen; Brad N. Barlow; B. H. Dunlap; Ronald A. Remillard;handle: 11245/1.313487
pmid: 19520945
Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase. Comment: published in Science
Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1172740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu434 citations 434 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Science arrow_drop_down ScienceOther literature type . Article . 2009https://doi.org/10.48550/arxiv...Article . 2009License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/science.1172740&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 Netherlands, France, FranceSpringer Science and Business Media LLC NSF | 2010 Project: Arabidopsis...NSF| 2010 Project: Arabidopsis 2010: Transcriptomes for Functional and Evolutionary StudiesHaudry, Annabelle, A.; Platts, Adrian; Vello, Emilio; Hoen, Douglas; Leclercq, Mickael; Williamson, Robert; Forczek, Ewa; Joly-Lopez, Zoé; Steffen, Joshua; Hazzouri, Khaled; Dewar, Ken; Stinchcombe, John; Schoen, Daniel; Wang, Xiaowu; Schmutz, Jeremy; Town, Christopher; Edger, Patrick; Pires, J Chris; Schumaker, Karen; Jarvis, David; Mandáková, Terezie; Lysak, Martin; van den Bergh, Erik; Schranz, M Eric; Harrison, Paul; Moses, Alan; Bureau, Thomas, E; Wright, Stephen; Blanchette, Mathieu;doi: 10.1038/ng.2684
pmid: 23817568
Despite the central importance of noncoding DNA to gene regulation and evolution, understanding of the extent of selection on plant noncoding DNA remains limited compared to that of other organisms. Here we report sequencing of genomes from three Brassicaceae species (Leavenworthia alabamica, Sisymbrium irio and Aethionema arabicum) and their joint analysis with six previously sequenced crucifer genomes. Conservation across orthologous bases suggests that at least 17% of the Arabidopsis thaliana genome is under selection, with nearly one-quarter of the sequence under selection lying outside of coding regions. Much of this sequence can be localized to approximately 90,000 conserved noncoding sequences (CNSs) that show evidence of transcriptional and post-transcriptional regulation. Population genomics analyses of two crucifer species, A. thaliana and Capsella grandiflora, confirm that most of the identified CNSs are evolving under medium to strong purifying selection. Overall, these CNSs highlight both similarities and several key differences between the regulatory DNA of plants and other species.
NARCIS; Research@WUR arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.2684&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu326 citations 326 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert NARCIS; Research@WUR arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.2684&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2008 Netherlands, United KingdomEDP Sciences Munari, U.; Tomasella, L.; Fiorucci, M.; Bienayme, O.; Binney, J.; Bland-Hawthorn, J.; Boeche, C.; Campbell, R.; Freeman, K. C.; Gibson, B.; Gilmore, G.; Grebel, E. K.; Helmi, A.; Navarro, J. F.; Parker, Q. A.; Seabroke, G. M.; Siebert, A.; Siviero, A.; Steinmetz, M.; Watson, F. G.; Williams, M.; Wyse, R. F. G.; Zwitter, T.;We have used spectra of hot stars from the RAVE Survey in order to investigate the visibility and properties of five diffuse interstellar bands previously reported in the literature. The RAVE spectroscopic survey for Galactic structure and kinematics records CCD spectra covering the 8400-8800 Ang wavelength region at 7500 resolving power. The spectra are obtained with the UK Schmidt at the AAO, equipped with the 6dF multi-fiber positioner. The DIB at 8620.4 Ang is by far the strongest and cleanest of all DIBs occurring within the RAVE wavelength range, with no interference by underlying absorption stellar lines in hot stars. It correlates so tightly with reddening that it turns out to be a reliable tool to measure it, following the relation E(B-V) = 2.72 (+/- 0.03) x E.W.(Ang), valid throughout the general interstellar medium of our Galaxy. The presence of a DIB at 8648 Ang is confirmed. Its intensity appears unrelated to reddening, in agreement with scanty and preliminary reports available in the literature, and its measurability is strongly compromised by severe blending with underlying stellar HeI doublet at 8649 Ang. The two weak DIBS at 8531 and 8572 Ang do not appear real and should actually be blends of underlying stellar lines. The very weak DIB at 8439 Ang cannot be resolved within the profile of the much stronger underlying hydrogen Paschen 18 stellar line. Comment: Accepted in press by A&A
CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research Archive; Astronomy and AstrophysicsOther literature type . Article . 2016 . 2008NARCIS; Astronomy and AstrophysicsArticle . 2008https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1051/0004-6361:200810232&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu48 citations 48 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 0visibility views 0 download downloads 19 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Oxford University Research Archive; Astronomy and AstrophysicsOther literature type . Article . 2016 . 2008NARCIS; Astronomy and AstrophysicsArticle . 2008https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1051/0004-6361:200810232&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2014 NetherlandsCambridge University Press (CUP) Lubbers, L.A.; Weijs, J.H.; Botto, L.; Das, S.; Andreotti, B.; Snoeijer, J.H.;AbstractThe equilibrium shape of liquid drops on elastic substrates is determined by minimizing elastic and capillary free energies, focusing on thick incompressible substrates. The problem is governed by three length scales: the size of the drop $R$, the molecular size $a$ and the ratio of surface tension to elastic modulus $\gamma /E$. We show that the contact angles undergo two transitions upon changing the substrate from rigid to soft. The microscopic wetting angles deviate from Young’s law when $\gamma /(Ea)\gg 1$, while the apparent macroscopic angle only changes in the very soft limit $\gamma /(ER)\gg 1$. The elastic deformations are worked out for the simplifying case where the solid surface energy is assumed to be constant. The total free energy turns out to be lower on softer substrates, consistent with recent experiments.
NARCIS arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/jfm.2014.152&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu85 citations 85 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2013License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/jfm.2014.152&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 Spain, NetherlandsWiley NIH | Genetic predictors of met..., NIH | Epidemiology of Precursor..., NIH | THE FRAMINGHAM HEART STUD... +2 projectsNIH| Genetic predictors of metabolic responses to dairy ,NIH| Epidemiology of Precursors to Type 2 Diabetes ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,SFI| Dietary fatty acids: impact on inflammasome driven adipose inflammation and insulin resistance – novel therapeutic targets ,NIH| Rare Sequence Variation and Diabetes Quantitative TraitsAoife M. Murphy; Caren E. Smith; Leanne M Murphy; Jack L. Follis; Toshiko Tanaka; Kris Richardson; Raymond Noordam; Rozenn N. Lemaitre; Mika Kähönen; Josée Dupuis; Trudy Voortman; Eirini Marouli; Dennis O. Mook-Kanamori; Olli T. Raitakari; Jaeyoung Hong; Abbas Dehghan; George Dedoussis; Renée de Mutsert; Terho Lehtimäki; Ching-Ti Liu; Fernando Rivadeneira; Panagiotis Deloukas; Vera Mikkilä; James B. Meigs; André G. Uitterlinden; Mohammad Arfan Ikram; Oscar H. Franco; Maria Hughes; Peadar Ó Gaora; Jose M. Ordovas; Helen M. Roche;SCOPE: Insulin resistance (IR) and inflammation are hallmarks of type 2 diabetes (T2D). The nod-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL-1β inflammation and IR. Interactions between SFA intake and NLRP3-related genetic variants may alter T2D risk factors. METHODS: Meta-analyses of six Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 19 005) tested interactions between SFA and NLRP3-related single-nucleotide polymorphisms (SNPs) and modulation of fasting insulin, fasting glucose, and homeostasis model assessment of insulin resistance. RESULTS: SFA interacted with rs12143966, wherein each 1% increase in SFA intake increased insulin by 0.0063 IU mL-1 (SE ± 0.002, p = 0.001) per each major (G) allele copy. rs4925663, interacted with SFA (β ± SE = -0.0058 ± 0.002, p = 0.004) to increase insulin by 0.0058 IU mL-1 , per additional copy of the major (C) allele. Both associations are close to the significance threshold (p < 0.0001). rs4925663 causes a missense mutation affecting NLRP3 expression. CONCLUSION: Two NLRP3-related SNPs showed potential interaction with SFA to modulate fasting insulin. Greater dietary SFA intake accentuates T2D risk, which, subject to functional validation, may be further elaborated depending on NLRP3-related genetic variants. Sí
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NCData sources: Recolector de Ciencia Abierta, RECOLECTALUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/mnfr.201900226&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NCData sources: Recolector de Ciencia Abierta, RECOLECTALUMC Scholarly Publications; NARCISOther literature type . Article . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/mnfr.201900226&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu