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description Publicationkeyboard_double_arrow_right Article 2022Royal Society of Chemistry (RSC) Hongliang Fu; Yue Lian; Yongqing Bai; Zhifeng Wang; Yongfeng Hu; Jing Zhao; Huaihao Zhang;doi: 10.1039/d2nr05020j
A bifunctional nanocomposite, FeNb11O29−x@C, formed by morphology control (porous biscuit-like nanoplates and carbon layers) and microstructure modification (oxygen vacancies and lattice defects), displays high rate performance and a low overpotential in LIBs and the OER.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022Cambridge University Press (CUP) SSHRCSSHRCAuthors: Song, Kyungchul;Song, Kyungchul;Diffusion over a network refers to the phenomenon of a change of state of a cross-sectional unit in one period leading to a change of state of its neighbors in the network in the next period. One may estimate or test for diffusion by estimating a cross-sectionally aggregated correlation between neighbors over time from data. However, the estimated diffusion can be misleading if the diffusion is confounded by omitted covariates. This paper focuses on the measure of diffusion proposed by He and Song (2022, Preprint, arXiv:1812.04195v4 [stat.ME]), provides a method of decomposition analysis to measure the role of the covariates on the estimated diffusion, and develops an asymptotic inference procedure for the decomposition analysis in such a situation. This paper also presents results from a Monte Carlo study on the small sample performance of the inference procedure.
Econometric Theory arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2019License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s026646662200024x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Econometric Theory arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2019License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 GermanyAmerican Geophysical Union (AGU) Dieng, Diarra; Cannon, Alex J.; Laux, Patrick; Hald, Cornelius; Adeyeri, Oluwafemi; Rahimi, Jaber; Srivastava, Amit K.; Mbaye, Mamadou Lamine; Kunstmann, Harald; Cannon, Alex J.; 2 Environment and Climate Change Canada Victoria BC Canada; Laux, Patrick; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Hald, Cornelius; 4 Meteorological Observatory Hohenpeißenberg German Weather Service Hohenpeißenberg Germany; Adeyeri, Oluwafemi; 5 School of Energy and Environment City University of Hong Kong Kowloon Hong‐Kong; Rahimi, Jaber; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Srivastava, Amit K.; 6 Institute of Crop Science and Resource Conservation University of Bonn Bonn Germany; Mbaye, Mamadou Lamine; 7 Laboratoire d’Océanographie des Sciences de l’Environnement et du Climat (LOSEC) Université Assane SECK de Ziguinchor Ziguinchor Senegal; Kunstmann, Harald; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany;A multivariate bias correction based on N‐dimensional probability density function transform (MBCn) technique is applied to four different high‐resolution regional climate change simulations and key meteorological variables, namely precipitation, mean near‐surface air temperature, near‐surface maximum air temperature, near‐surface minimum air temperature, surface downwelling solar radiation, relative humidity, and wind speed. The impact of bias‐correction on the historical (1980–2005) period, the inter‐variable relationships, and the measures of spatio‐temporal consistency are investigated. The focus is on the discrepancies between the original and the bias‐corrected results over five agro‐ecological zones. We also evaluate relevant indices for agricultural applications such as climate extreme indices, under current and future (2020–2050) climate change conditions based on the RCP4.5. Results show that MBCn successfully corrects the seasonal biases in spatial patterns and intensities for all variables, their intervariable correlation, and the distributions of most of the analyzed variables. Relatively large bias reductions during the historical period give indication of possible benefits of MBCn when applied to future scenarios. Although the four regional climate models do not agree on the same positive/negative sign of the change of the seven climate variables for all grid points, the model ensemble mean shows a statistically significant change in rainfall, relative humidity in the Northern zone and wind speed in the Coastal zone of West Africa and increasing maximum summer temperature up to 2°C in the Sahara. Key Points: Multivariate bias‐correction (MBCn) of key meteorological variables accounting for their interdependency. MBCn effectively removes the statistical biases as indicated by several measures and improves the representation of the probability density. The corrected model ensemble mean preserves the climate change signal with a statistically significant change in precipitation. Climate Change and Health in sub‐Saharan Africa project https://doi.org/10.1594/PANGAEA.880512 http://doi.org/10.5281/zenodo.1255882
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1029/2021jd034836&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 Italy, France, Italy, Italy, Italy, Spain, ItalyOxford University Press (OUP) UKRI | AlwaysClean, UKRI | Integrated Mobile Welding...UKRI| AlwaysClean ,UKRI| Integrated Mobile Welding For High Strength In-Field Pipe ManufacturingLiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; Aurlien, R.; Azzoni, S.; Baccigalupi, C.; Banday, A. J.; Banerji, R.; Barreiro, R. B.; Bartolo, N.; Bautista, L.; Beck, D.; Beckman, S.; Bersanelli, M.; Boulanger, F.; Brilenkov, M.; Bucher, M.; Calabrese, E.; Campeti, P.; Carones, A.; Casas, F. J.; Catalano, A.; Chan, V.; Cheung, K.; Chinone, Y.; Clark, S. E.; Columbro, F.; D'Alessandro, G.; de Bernardis, P.; de Haan, T.; de la Hoz, E.; De Petris, M.; Della Torre, S.; Diego-Palazuelos, P.; Dobbs, M.; Dotani, T.; Duval, J. M.; Elleflot, T.; Eriksen, H. K.; Errard, J.; Essinger-Hileman, T.; Finelli, F.; Flauger, R.; Franceschet, C.; Fuskeland, U.; Galloway, M.; Ganga, K.; Gerbino, M.; Gervasi, M.; Génova-Santos, R. T.; Ghigna, T.; Giardiello, S.; Gjerløw, E.; Grain, J.; Grupp, F.; Gruppuso, A.; Gudmundsson, J. E.; Halverson, N. W.; Hargrave, P.; Hasebe, T.; Hasegawa, M.; Hazumi, M.; Henrot-Versillé, S.; Hensley, B.; Hergt, L. T.; Herman, D.; Hivon, E.; Hlozek, R. A.; Hornsby, A. L.; Hoshino, Y.; Hubmayr, J.; Ichiki, K.; Iida, T.; Imada, H.; Ishino, H.; Jaehnig, G.; Katayama, N.; Kato, A.; Keskitalo, R.; Kisner, T.; Kobayashi, Y.; Kogut, A.; Kohri, K.; Komatsu, E.; Komatsu, K.; Konishi, K.; Krachmalnicoff, N.; Kuo, C. L.; Lamagna, L.; Lattanzi, M.; Lee, A. T.; Leloup, C.; Levrier, F.; Linder, E.; Luzzi, G.; Macias-Perez, J.; Maciaszek, T.; Maffei, B.; Maino, D.; Mandelli, S.; Martínez-González, E.; Masi, S.; Massa, M.; Matarrese, S.; Matsuda, F. T.; Matsumura, T.; Mele, L.; Migliaccio, M.; Minami, Y.; Moggi, A.; Montgomery, J.; Montier, L.; Morgante, G.; Mot, B.; Nagano, Y.; Nagasaki, T.; Nagata, R.; Nakano, R.; Namikawa, T.; Nati, F.; Natoli, P.; Nerval, S.; Noviello, F.; Odagiri, K.; Oguri, S.; Ohsaki, H.; Pagano, L.; Paiella, A.; Paoletti, D.; Passerini, A.; Patanchon, G.; Piacentini, F.; Piat, M.; Pisano, G.; Polenta, G.; Poletti, D.; Prouvé, T.; Puglisi, G.; Rambaud, D.; Raum, C.; Realini, S.; Reinecke, M.; Remazeilles, M.; Ritacco, A.; Roudil, G.; Rubino-Martin, J. A.; Russell, M.; Sakurai, H.; Sakurai, Y.; Sasaki, M.; Scott, D.; Sekimoto, Y.; Shinozaki, K.; Shiraishi, M.; Shirron, P.; Signorelli, G.; Spinella, F.; Stever, S.; Stompor, R.; Sugiyama, S.; Sullivan, R. M.; Suzuki, A.; Svalheim, T. L.; Switzer, E.; Takaku, R.; Takakura, H.; Takase, Y.; Tartari, A.; Terao, Y.; Thermeau, J.; Thommesen, H.; Thompson, K. L.; Tomasi, M.; Tominaga, M.; Tristram, M.; Tsuji, M.; Tsujimoto, M.; Vacher, L.; Vielva, P.; Vittorio, N.; Wang, W.; Watanuki, K.; Wehus, I. K.; Weller, J.; Westbrook, B.; Wilms, J.; Winter, B.; Wollack, E. J.; Yumoto, J.; Zannoni, M.;handle: 20.500.11767/132550 , 2434/947309 , 11577/3467499 , 10261/306493 , 11573/1685127
This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/ptep/ptac150&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 EnglishFrontiers Media S.A. ARC | Linkage Projects - Grant ...ARC| Linkage Projects - Grant ID: LP200100261Matt W. Hayward; Matt W. Hayward; Matt W. Hayward; Ninon F. V. Meyer; Ninon F. V. Meyer; Ninon F. V. Meyer; Niko Balkenhol; Chad T. Beranek; Cassandra K. Bugir; Kathleen V. Bushell; Alex Callen; Amy J. Dickman; Andrea S. Griffin; Peter M. Haswell; Peter M. Haswell; Lachlan G. Howell; Christopher A. Jordan; Kaya Klop-Toker; Remington J. Moll; Remington J. Moll; Robert A. Montgomery; Tutilo Mudumba; Tutilo Mudumba; Liudmila Osipova; Stéphanie Périquet; Rafael Reyna-Hurtado; William J. Ripple; Lilian P. Sales; Lilian P. Sales; Florian J. Weise; Ryan R. Witt; Peter A. Lindsey; Peter A. Lindsey; Peter A. Lindsey; Peter A. Lindsey;All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::232549f5f89d74792f293b654d9be92a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::232549f5f89d74792f293b654d9be92a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Royal Society of Chemistry (RSC) Libin Shi; Yiming Zhou; Xiao Tan; Suitao Qi; Kevin J. Smith; Chunhai Yi; Bolun Yang; Shida Liu;doi: 10.1039/d1cy01652k
The carboxylate groups on Pt/Al2O3 catalysts increase the proportion of Pt (1 1 1) and Pt (1 0 0) planes that facilitate H18-DBT dehydrogenation.
Catalysis Science & ... arrow_drop_down Catalysis Science & TechnologyArticle . 2022License: Royal Society of Chemistry Licence to PublishData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1039/d1cy01652k&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Catalysis Science & ... arrow_drop_down Catalysis Science & TechnologyArticle . 2022License: Royal Society of Chemistry Licence to PublishData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1039/d1cy01652k&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomAmerican Association for Cancer Research (AACR) EC | SITlessEC| SITlessAuthors: Pamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; +10 AuthorsPamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; Chee Wee Ong; Jenny Worthington; Ian G. Mills; Daniel B. Longley; James P. Quigley; Amina Zoubeidi; Johann S. de Bono; Elena Deryugina; Melissa J. LaBonte; David J.J. Waugh;Abstract Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Implications: Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease.
Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 4visibility views 4 download downloads 5 Powered bymore_vert Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Institute of Electrical and Electronics Engineers (IEEE) Wufeng Xue; Zejian Chen; Tianfu Wang; Shuo Li; Dong Ni;pmid: 35320110
Regional cardiac motion scoring aims to classify the motion status of each myocardium segment into one of the four categories (normal, hypokinetic, akinetic, and dyskinetic) from multiple short-axis MR sequences. It is essential for prognosis and early diagnosis for various cardiac diseases. However, the complex motion procedure of the myocardium and the invisible pattern differences pose great challenges, leading to low performance for automatic methods. Most existing works mitigate the task by differentiating the normal motion patterns from the abnormal ones, without fine-grained motion scoring. We propose an effective method for the task of cardiac motion scoring by connecting a bottom-up and another top-down branch with a novel motion-based spatial attention module in multi-scale space. Specifically, we use the convolution blocks for low-level feature extraction that acts as a bottom-up mechanism, and the task of optical flow for explicit motion extraction that acts as a top-down mechanism for high-level allocation of spatial attention. To this end, a newly designed Multi-scale Motion-based Spatial Attention (MMSA) module is used as the pivot connecting the bottom-up part and the top-down part, and adaptively weight the low-level features according to the motion information. Experimental results on a newly constructed dataset of 1440 myocardium segments from 90 subjects demonstrate that the proposed MMSA can accurately analyze the regional myocardium motion, with accuracies of 79.3% for 4-way motion scoring, 89.0% for abnormality detection, and correlation of 0.943 for estimation of motion score index. This work has great potential for practical assessmentof cardiac motion function.
IEEE Journal of Biom... arrow_drop_down IEEE Journal of Biomedical and Health InformaticsArticle . 2022License: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert IEEE Journal of Biom... arrow_drop_down IEEE Journal of Biomedical and Health InformaticsArticle . 2022License: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Frontiers Media SA Xiaona Wei; Xiangdong Wang; Rui Zhang; Peifen Liang; Bo Liu; Lin Wang; Shuling Yue; Xiaojuan Li; Wenfang Chen; Qiongqiong Yang;Fibronectin glomerulopathy (FNG) is a rare inherited kidney disease characterized by extensive deposition of fibronectin in the glomeruli, especially in the mesangial and subendothelial regions. The disease progresses slowly and eventually leads to kidney failure in 15–20 years. Here, we report an interesting case. The patient presented with proteinuria and was diagnosed with immune complex–mediated glomerulonephritis, and lupus nephritis was suspected. This patient progressed to end-stage renal disease after 18 years and received an allogeneic kidney transplant. However, proteinuria recurred 27 months after kidney transplantation. The renal biopsy found extensive deposition in glomeruli, and the patient was diagnosed with FNG using mass spectrometry analysis and confirmed by immunohistochemistry in both the native and transplanted kidneys. Gene sequencing revealed that a missense mutation in the fibronectin 1 (FN1) gene caused reduced binding to heparin, endothelial cells, and podocytes and impaired stress fiber formation. The patient had stable renal function but persistent nephrotic proteinuria after 6 months of follow-up. Given the persistence of abnormal circulating fibronectin levels, FNG can relapse following renal transplantation. The circulating fibronectin deposits on grafts, and renal function progressively deteriorates after recurrence. Therefore, whether renal transplantation is an acceptable treatment for FNG is still debatable.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Informa UK Limited CIHRCIHRAuthors: Alexander F. Palazzo; Jomon Joseph; Ming Lim; Kiran T. Thakur;Alexander F. Palazzo; Jomon Joseph; Ming Lim; Kiran T. Thakur;Dominant missense mutations in RanBP2/Nup358 cause Acute Necrotizing Encephalopathy (ANE), a pediatric disease where seemingly healthy individuals develop a cytokine storm that is restricted to the central nervous system in response to viral infection. Untreated, this condition leads to seizures, coma, long-term neurological damage and a high rate of mortality. The exact mechanism by which RanBP2 mutations contribute to the development of ANE remains elusive. In November 2021, a number of clinicians and basic scientists presented their work on this disease and on the interactions between RanBP2/Nup358, viral infections, the innate immune response and other cellular processes.
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For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2022Royal Society of Chemistry (RSC) Hongliang Fu; Yue Lian; Yongqing Bai; Zhifeng Wang; Yongfeng Hu; Jing Zhao; Huaihao Zhang;doi: 10.1039/d2nr05020j
A bifunctional nanocomposite, FeNb11O29−x@C, formed by morphology control (porous biscuit-like nanoplates and carbon layers) and microstructure modification (oxygen vacancies and lattice defects), displays high rate performance and a low overpotential in LIBs and the OER.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1039/d2nr05020j&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022Cambridge University Press (CUP) SSHRCSSHRCAuthors: Song, Kyungchul;Song, Kyungchul;Diffusion over a network refers to the phenomenon of a change of state of a cross-sectional unit in one period leading to a change of state of its neighbors in the network in the next period. One may estimate or test for diffusion by estimating a cross-sectionally aggregated correlation between neighbors over time from data. However, the estimated diffusion can be misleading if the diffusion is confounded by omitted covariates. This paper focuses on the measure of diffusion proposed by He and Song (2022, Preprint, arXiv:1812.04195v4 [stat.ME]), provides a method of decomposition analysis to measure the role of the covariates on the estimated diffusion, and develops an asymptotic inference procedure for the decomposition analysis in such a situation. This paper also presents results from a Monte Carlo study on the small sample performance of the inference procedure.
Econometric Theory arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2019License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s026646662200024x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Econometric Theory arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2019License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1017/s026646662200024x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 GermanyAmerican Geophysical Union (AGU) Dieng, Diarra; Cannon, Alex J.; Laux, Patrick; Hald, Cornelius; Adeyeri, Oluwafemi; Rahimi, Jaber; Srivastava, Amit K.; Mbaye, Mamadou Lamine; Kunstmann, Harald; Cannon, Alex J.; 2 Environment and Climate Change Canada Victoria BC Canada; Laux, Patrick; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Hald, Cornelius; 4 Meteorological Observatory Hohenpeißenberg German Weather Service Hohenpeißenberg Germany; Adeyeri, Oluwafemi; 5 School of Energy and Environment City University of Hong Kong Kowloon Hong‐Kong; Rahimi, Jaber; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany; Srivastava, Amit K.; 6 Institute of Crop Science and Resource Conservation University of Bonn Bonn Germany; Mbaye, Mamadou Lamine; 7 Laboratoire d’Océanographie des Sciences de l’Environnement et du Climat (LOSEC) Université Assane SECK de Ziguinchor Ziguinchor Senegal; Kunstmann, Harald; 1 Karlsruhe Institute of Technology (KIT) Campus Alpin Institute of Meteorology and Climate Research ‐ Atmospheric Environmental Research (IMK‐IFU) Garmisch‐Partenkirchen Germany;A multivariate bias correction based on N‐dimensional probability density function transform (MBCn) technique is applied to four different high‐resolution regional climate change simulations and key meteorological variables, namely precipitation, mean near‐surface air temperature, near‐surface maximum air temperature, near‐surface minimum air temperature, surface downwelling solar radiation, relative humidity, and wind speed. The impact of bias‐correction on the historical (1980–2005) period, the inter‐variable relationships, and the measures of spatio‐temporal consistency are investigated. The focus is on the discrepancies between the original and the bias‐corrected results over five agro‐ecological zones. We also evaluate relevant indices for agricultural applications such as climate extreme indices, under current and future (2020–2050) climate change conditions based on the RCP4.5. Results show that MBCn successfully corrects the seasonal biases in spatial patterns and intensities for all variables, their intervariable correlation, and the distributions of most of the analyzed variables. Relatively large bias reductions during the historical period give indication of possible benefits of MBCn when applied to future scenarios. Although the four regional climate models do not agree on the same positive/negative sign of the change of the seven climate variables for all grid points, the model ensemble mean shows a statistically significant change in rainfall, relative humidity in the Northern zone and wind speed in the Coastal zone of West Africa and increasing maximum summer temperature up to 2°C in the Sahara. Key Points: Multivariate bias‐correction (MBCn) of key meteorological variables accounting for their interdependency. MBCn effectively removes the statistical biases as indicated by several measures and improves the representation of the probability density. The corrected model ensemble mean preserves the climate change signal with a statistically significant change in precipitation. Climate Change and Health in sub‐Saharan Africa project https://doi.org/10.1594/PANGAEA.880512 http://doi.org/10.5281/zenodo.1255882
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 Italy, France, Italy, Italy, Italy, Spain, ItalyOxford University Press (OUP) UKRI | AlwaysClean, UKRI | Integrated Mobile Welding...UKRI| AlwaysClean ,UKRI| Integrated Mobile Welding For High Strength In-Field Pipe ManufacturingLiteBIRD Collaboration; Allys, E.; Arnold, K.; Aumont, J.; Aurlien, R.; Azzoni, S.; Baccigalupi, C.; Banday, A. J.; Banerji, R.; Barreiro, R. B.; Bartolo, N.; Bautista, L.; Beck, D.; Beckman, S.; Bersanelli, M.; Boulanger, F.; Brilenkov, M.; Bucher, M.; Calabrese, E.; Campeti, P.; Carones, A.; Casas, F. J.; Catalano, A.; Chan, V.; Cheung, K.; Chinone, Y.; Clark, S. E.; Columbro, F.; D'Alessandro, G.; de Bernardis, P.; de Haan, T.; de la Hoz, E.; De Petris, M.; Della Torre, S.; Diego-Palazuelos, P.; Dobbs, M.; Dotani, T.; Duval, J. M.; Elleflot, T.; Eriksen, H. K.; Errard, J.; Essinger-Hileman, T.; Finelli, F.; Flauger, R.; Franceschet, C.; Fuskeland, U.; Galloway, M.; Ganga, K.; Gerbino, M.; Gervasi, M.; Génova-Santos, R. T.; Ghigna, T.; Giardiello, S.; Gjerløw, E.; Grain, J.; Grupp, F.; Gruppuso, A.; Gudmundsson, J. E.; Halverson, N. W.; Hargrave, P.; Hasebe, T.; Hasegawa, M.; Hazumi, M.; Henrot-Versillé, S.; Hensley, B.; Hergt, L. T.; Herman, D.; Hivon, E.; Hlozek, R. A.; Hornsby, A. L.; Hoshino, Y.; Hubmayr, J.; Ichiki, K.; Iida, T.; Imada, H.; Ishino, H.; Jaehnig, G.; Katayama, N.; Kato, A.; Keskitalo, R.; Kisner, T.; Kobayashi, Y.; Kogut, A.; Kohri, K.; Komatsu, E.; Komatsu, K.; Konishi, K.; Krachmalnicoff, N.; Kuo, C. L.; Lamagna, L.; Lattanzi, M.; Lee, A. T.; Leloup, C.; Levrier, F.; Linder, E.; Luzzi, G.; Macias-Perez, J.; Maciaszek, T.; Maffei, B.; Maino, D.; Mandelli, S.; Martínez-González, E.; Masi, S.; Massa, M.; Matarrese, S.; Matsuda, F. T.; Matsumura, T.; Mele, L.; Migliaccio, M.; Minami, Y.; Moggi, A.; Montgomery, J.; Montier, L.; Morgante, G.; Mot, B.; Nagano, Y.; Nagasaki, T.; Nagata, R.; Nakano, R.; Namikawa, T.; Nati, F.; Natoli, P.; Nerval, S.; Noviello, F.; Odagiri, K.; Oguri, S.; Ohsaki, H.; Pagano, L.; Paiella, A.; Paoletti, D.; Passerini, A.; Patanchon, G.; Piacentini, F.; Piat, M.; Pisano, G.; Polenta, G.; Poletti, D.; Prouvé, T.; Puglisi, G.; Rambaud, D.; Raum, C.; Realini, S.; Reinecke, M.; Remazeilles, M.; Ritacco, A.; Roudil, G.; Rubino-Martin, J. A.; Russell, M.; Sakurai, H.; Sakurai, Y.; Sasaki, M.; Scott, D.; Sekimoto, Y.; Shinozaki, K.; Shiraishi, M.; Shirron, P.; Signorelli, G.; Spinella, F.; Stever, S.; Stompor, R.; Sugiyama, S.; Sullivan, R. M.; Suzuki, A.; Svalheim, T. L.; Switzer, E.; Takaku, R.; Takakura, H.; Takase, Y.; Tartari, A.; Terao, Y.; Thermeau, J.; Thommesen, H.; Thompson, K. L.; Tomasi, M.; Tominaga, M.; Tristram, M.; Tsuji, M.; Tsujimoto, M.; Vacher, L.; Vielva, P.; Vittorio, N.; Wang, W.; Watanuki, K.; Wehus, I. K.; Weller, J.; Westbrook, B.; Wilms, J.; Winter, B.; Wollack, E. J.; Yumoto, J.; Zannoni, M.;handle: 20.500.11767/132550 , 2434/947309 , 11577/3467499 , 10261/306493 , 11573/1685127
This work is supported in Japan by ISAS/JAXA for Pre-Phase A2 studies, by the acceleration program of JAXA research and development directorate, by the World Premier International Research Center Initiative (WPI) of MEXT, by the JSPS Core-to-Core Program, and by JSPS KAKENHI. The Italian LiteBIRD phase A contribution is supported by the Italian Space Agency (ASI Grants No. 2020-9-HH.0 and 2016-24-H.1-2018), the National Institute for Nuclear Physics (INFN), the National Institute for Astrophysics (INAF), and a PGR grant from the Italian Ministry of Foreign Affairs and International Cooperation. The French LiteBIRD phase A contribution is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifique (CNRS), and by the Commissariat a l’Energie Atomique (CEA). The Canadian contribution is supported by the Canadian Space Agency. The US contribution is supported by NASA grant no. 80NSSC18K0132. Norwegian participation in LiteBIRD is supported by the Research Council of Norway (Grant No. 263011). The Spanish LiteBIRD phase A contribution is supported by the Spanish Agencia Estatal de Investigacion (AEI), project refs. PID2019-110610RBC21 and AYA2017-84185-P. Funds that support the Swedish contributions come from the Swedish National Space Agency (SNSA/Rymdstyrelsen) and the Swedish Research Council (Reg. no. 2019-03959). The German participation in LiteBIRD is supported in part by the Excellence Cluster ORIGINS, which is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (Grant No. EXC-2094- 390783311). LiteBIRD work has received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme. This research used resources of the Central Computing System owned and operated by the Computing Research Center at KEK, as well as resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility supported by the Office of Science of the U.S. Department of Energy. LiteBIRD the Lite (Light) satellite for the study of B-mode polarization and Inflation from cosmic background Radiation Detection, is a space mission for primordial cosmology and fundamental physics. The Japan Aerospace Exploration Agency (JAXA) selected LiteBIRD in May 2019 as a strategic large-class (L-class) mission, with an expected launch in the late 2020s using JAXA’s H3 rocket. LiteBIRD is planned to orbit the Sun-Earth Lagrangian point L2, where it will map the cosmic microwave background (CMB) polarization over the entire sky for three years, with three telescopes in 15 frequency bands between 34 and 448 GHz, to achieve an unprecedented total sensitivity of 2.2 μK-arcmin, with a typical angular resolution of 0.5○ at 100 GHz. The primary scientific objective of LiteBIRD is to search for the signal from cosmic inflation, either making a discovery or ruling out well-motivated inflationary models. The measurements of LiteBIRD will also provide us with insight into the quantum nature of gravity and other new physics beyond the standard models of particle physics and cosmology. We provide an overview of the LiteBIRD project, including scientific objectives, mission and system requirements, operation concept, spacecraft and payload module design, expected scientific outcomes, potential design extensions and synergies with other projects. Subject Index LiteBIRD cosmic inflation, cosmic microwave background, B-mode polarization, primordial gravitational waves, quantum gravity, space telescope LiteBIRD Collaboration: et al. Peer reviewed
Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu54 citations 54 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio della ricerca- Università di Roma La SapienzaArticle . 2023Data sources: Archivio della ricerca- Università di Roma La SapienzaBOA - Bicocca Open Archive; Progress of Theoretical and Experimental PhysicsArticle . 2023 . 2022License: CC BYRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022Mémoires en Sciences de l'Information et de la Communication; HAL-CEA; HAL-IRDArticle . 2023License: CC BYhttps://doi.org/10.48550/arxiv...Article . 2022License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 EnglishFrontiers Media S.A. ARC | Linkage Projects - Grant ...ARC| Linkage Projects - Grant ID: LP200100261Matt W. Hayward; Matt W. Hayward; Matt W. Hayward; Ninon F. V. Meyer; Ninon F. V. Meyer; Ninon F. V. Meyer; Niko Balkenhol; Chad T. Beranek; Cassandra K. Bugir; Kathleen V. Bushell; Alex Callen; Amy J. Dickman; Andrea S. Griffin; Peter M. Haswell; Peter M. Haswell; Lachlan G. Howell; Christopher A. Jordan; Kaya Klop-Toker; Remington J. Moll; Remington J. Moll; Robert A. Montgomery; Tutilo Mudumba; Tutilo Mudumba; Liudmila Osipova; Stéphanie Périquet; Rafael Reyna-Hurtado; William J. Ripple; Lilian P. Sales; Lilian P. Sales; Florian J. Weise; Ryan R. Witt; Peter A. Lindsey; Peter A. Lindsey; Peter A. Lindsey; Peter A. Lindsey;All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::232549f5f89d74792f293b654d9be92a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=doajarticles::232549f5f89d74792f293b654d9be92a&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Royal Society of Chemistry (RSC) Libin Shi; Yiming Zhou; Xiao Tan; Suitao Qi; Kevin J. Smith; Chunhai Yi; Bolun Yang; Shida Liu;doi: 10.1039/d1cy01652k
The carboxylate groups on Pt/Al2O3 catalysts increase the proportion of Pt (1 1 1) and Pt (1 0 0) planes that facilitate H18-DBT dehydrogenation.
Catalysis Science & ... arrow_drop_down Catalysis Science & TechnologyArticle . 2022License: Royal Society of Chemistry Licence to PublishData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1039/d1cy01652k&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Catalysis Science & ... arrow_drop_down Catalysis Science & TechnologyArticle . 2022License: Royal Society of Chemistry Licence to PublishData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1039/d1cy01652k&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomAmerican Association for Cancer Research (AACR) EC | SITlessEC| SITlessAuthors: Pamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; +10 AuthorsPamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; Chee Wee Ong; Jenny Worthington; Ian G. Mills; Daniel B. Longley; James P. Quigley; Amina Zoubeidi; Johann S. de Bono; Elena Deryugina; Melissa J. LaBonte; David J.J. Waugh;Abstract Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Implications: Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease.
Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1158/1541-7786.mcr-21-0780&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!visibility 4visibility views 4 download downloads 5 Powered bymore_vert Queen's University R... arrow_drop_down Oxford University Research Archive; Molecular Cancer ResearchOther literature type . Article . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1158/1541-7786.mcr-21-0780&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Institute of Electrical and Electronics Engineers (IEEE) Wufeng Xue; Zejian Chen; Tianfu Wang; Shuo Li; Dong Ni;pmid: 35320110
Regional cardiac motion scoring aims to classify the motion status of each myocardium segment into one of the four categories (normal, hypokinetic, akinetic, and dyskinetic) from multiple short-axis MR sequences. It is essential for prognosis and early diagnosis for various cardiac diseases. However, the complex motion procedure of the myocardium and the invisible pattern differences pose great challenges, leading to low performance for automatic methods. Most existing works mitigate the task by differentiating the normal motion patterns from the abnormal ones, without fine-grained motion scoring. We propose an effective method for the task of cardiac motion scoring by connecting a bottom-up and another top-down branch with a novel motion-based spatial attention module in multi-scale space. Specifically, we use the convolution blocks for low-level feature extraction that acts as a bottom-up mechanism, and the task of optical flow for explicit motion extraction that acts as a top-down mechanism for high-level allocation of spatial attention. To this end, a newly designed Multi-scale Motion-based Spatial Attention (MMSA) module is used as the pivot connecting the bottom-up part and the top-down part, and adaptively weight the low-level features according to the motion information. Experimental results on a newly constructed dataset of 1440 myocardium segments from 90 subjects demonstrate that the proposed MMSA can accurately analyze the regional myocardium motion, with accuracies of 79.3% for 4-way motion scoring, 89.0% for abnormality detection, and correlation of 0.943 for estimation of motion score index. This work has great potential for practical assessmentof cardiac motion function.
IEEE Journal of Biom... arrow_drop_down IEEE Journal of Biomedical and Health InformaticsArticle . 2022License: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/jbhi.2022.3161666&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert IEEE Journal of Biom... arrow_drop_down IEEE Journal of Biomedical and Health InformaticsArticle . 2022License: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/jbhi.2022.3161666&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Frontiers Media SA Xiaona Wei; Xiangdong Wang; Rui Zhang; Peifen Liang; Bo Liu; Lin Wang; Shuling Yue; Xiaojuan Li; Wenfang Chen; Qiongqiong Yang;Fibronectin glomerulopathy (FNG) is a rare inherited kidney disease characterized by extensive deposition of fibronectin in the glomeruli, especially in the mesangial and subendothelial regions. The disease progresses slowly and eventually leads to kidney failure in 15–20 years. Here, we report an interesting case. The patient presented with proteinuria and was diagnosed with immune complex–mediated glomerulonephritis, and lupus nephritis was suspected. This patient progressed to end-stage renal disease after 18 years and received an allogeneic kidney transplant. However, proteinuria recurred 27 months after kidney transplantation. The renal biopsy found extensive deposition in glomeruli, and the patient was diagnosed with FNG using mass spectrometry analysis and confirmed by immunohistochemistry in both the native and transplanted kidneys. Gene sequencing revealed that a missense mutation in the fibronectin 1 (FN1) gene caused reduced binding to heparin, endothelial cells, and podocytes and impaired stress fiber formation. The patient had stable renal function but persistent nephrotic proteinuria after 6 months of follow-up. Given the persistence of abnormal circulating fibronectin levels, FNG can relapse following renal transplantation. The circulating fibronectin deposits on grafts, and renal function progressively deteriorates after recurrence. Therefore, whether renal transplantation is an acceptable treatment for FNG is still debatable.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fgene.2022.839703&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fgene.2022.839703&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Informa UK Limited CIHRCIHRAuthors: Alexander F. Palazzo; Jomon Joseph; Ming Lim; Kiran T. Thakur;Alexander F. Palazzo; Jomon Joseph; Ming Lim; Kiran T. Thakur;Dominant missense mutations in RanBP2/Nup358 cause Acute Necrotizing Encephalopathy (ANE), a pediatric disease where seemingly healthy individuals develop a cytokine storm that is restricted to the central nervous system in response to viral infection. Untreated, this condition leads to seizures, coma, long-term neurological damage and a high rate of mortality. The exact mechanism by which RanBP2 mutations contribute to the development of ANE remains elusive. In November 2021, a number of clinicians and basic scientists presented their work on this disease and on the interactions between RanBP2/Nup358, viral infections, the innate immune response and other cellular processes.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/19491034.2022.2069071&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/19491034.2022.2069071&type=result"></script>'); --> </script>
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