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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ida Mattsson; Johanna Majoinen; Manu Lahtinen; Thomas Sandberg; +5 Authors

    | openaire: EC/H2020/788489/EU//BioELCell Funding Information: The Graduate School of Chemical Engineering, the Parliament Office Commission of the Åland Islands, Walter and Lisi Waal's foundation, the Finnish Foundation for Technology Promotion and the Society of Swedish Literature in Finland are gratefully acknowledged for funding this work. Dr J. Rahkila, Turku Centre for Chemical and Molecular Analytics is acknowledged for HRMS analysis of the allylated sugars and NMR-related support. Dr Ville Liljeström is thanked for assistance with the SWAXS measurements. Dr J. Majoinen and Prof. O. Rojas acknowledge funding from the H2020-ERC-2017-Advanced Grant ‘BioELCell’ (788489). Prof. O. Rojas acknowledges the Canada Excellence Research Chair Program (CERC-2018-00006) and Canada Foundation for Innovation (Project number 38623). Prof. Olli Ikkala acknowledges Academy of Finland CoE LIBER (Project number 346108) and the Flagship FinnCERES. The authors acknowledge facilities and technical support by Nanomicroscopy Center at Aalto University. Publisher Copyright: © 2023 The Royal Society of Chemistry. Conformational rigidity controls the bulk self-assembly and liquid crystallinity from amphiphilic block molecules to copolymers. The effects of block stereochemistry on the self-assembly have, however, been less explored. Here, we have investigated amphiphilic block molecules involving eight open-chain monosaccharide-based polyol units possessing different stereochemistries, derived from d-glucose, d-galactose, l-arabinose, d-mannose and l-rhamnose (allylated monosaccharides t-Glc*, e-Glc*, t-Gal*, e-Gal*, t-Ara*, e-Ara*, t-Man*, and t-Rha*), end-functionalized with repulsive tetradecyl alkyl chain blocks to form well-defined amphiphiles with block molecule structures. All compounds studied showed low temperature crystalline phases due to polyol crystallization, and smectic (lamellar) and isotropic phases upon heating in bulk. Hexagonal cylindrical phase was additionally observed for the composition involving t-Man*. Cubic phases were observed for e-Glc*, e-Gal*, e-Ara*, and t-Rha* derived compounds. Therein,the rich array of WAXS-reflections suggested that the crystalline polyol domains are not ultra-confined in spheres as in classic cubic phases but instead show network-like phase continuity, which is rare in bulk liquid crystals. Importantly, the transition temperatures of the self-assemblies were observed to depend strongly on the polyol stereochemistry. The findings underpin that the stereochemistry in carbohydrate-based assemblies involves complexity, which is an important parameter to be considered in material design when developing self-assemblies for different functions. Peer reviewed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Jyväskylä University...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Soft Matter
    Article . 2023
    License: CC BY
    Data sources: Crossref
    Soft Matter
    Article . 2023
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Jyväskylä University...arrow_drop_down
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Soft Matter
      Article . 2023
      License: CC BY
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      Soft Matter
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: R. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; +164 Authors

    Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service

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    Europe PubMed Central
    Article . 2021
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    ESC Heart Failure
    Other literature type . Article . 2021
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    Apollo
    Other literature type . 2021
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    Apollo
    Article . 2021
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    ESC Heart Failure
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    ESC Heart Failure
    Article . 2021
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    ESC Heart Failure
    Article . 2022
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    Other literature type . 2021
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    Article . 2021
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    Apollo
    Article . 2021
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      Europe PubMed Central
      Article . 2021
      Data sources: PubMed Central
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      ESC Heart Failure
      Other literature type . Article . 2021
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      Other literature type . 2021
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      Apollo
      Article . 2021
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      ESC Heart Failure
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      ESC Heart Failure
      Article . 2021
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      ESC Heart Failure
      Article . 2022
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      Apollo
      Other literature type . 2021
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      Article . 2021
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      Article . 2021
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    Authors: de Rezende, Susanna F.; Meir, Or; Nordstr��m, Jakob; Pitassi, Toniann; +2 Authors

    We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof power for cutting planes with unbounded versus polynomially bounded coefficients. Specifically, we exhibit CNF formulas that can be refuted in quadratic length and constant line space in cutting planes with unbounded coefficients, but for which there are no refutations in subexponential length and subpolynomial line space if coefficients are restricted to be of polynomial magnitude. •We give the first explicit separation between monotone Boolean formulas and monotone real formulas. Specifically, we give an explicit family of functions that can be computed with monotone real formulas of nearly linear size but require monotone Boolean formulas of exponential size. Previously only a non-explicit separation was known. •We give the strongest separation to-date between monotone Boolean formulas and monotone Boolean circuits. Namely, we show that the classical GEN problem, which has polynomial-size monotone Boolean circuits, requires monotone Boolean formulas of size $2^{\Omega(n/\text{polylog}(n))}$ . An important technical ingredient, which may be of independent interest, is that we show that the Nullstellensatz degree of refuting the pebbling formula over a DAG $G$ over any field coincides exactly with the reversible pebbling price of $G$ . In particular, this implies that the standard decision tree complexity and the parity decision tree complexity of the corresponding falsified clause search problem are equal. This is an extended abstract. The full version of the paper is available at https://arxiv.org/abs/2001.02144.

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    http://arxiv.org/pdf/2001.0214...
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    https://doi.org/10.1109/focs46...
    Conference object . 2020
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      https://doi.org/10.1109/focs46...
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    Authors: Pamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; +10 Authors

    Abstract Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Implications: Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease.

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    Authors: Anne M. Archibald; Ingrid H. Stairs; Scott M. Ransom; Victoria M. Kaspi; +14 Authors

    Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase. Comment: published in Science

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    NARCIS
    Article . 2009
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    Science
    Article . 2009
    https://doi.org/10.48550/arxiv...
    Article . 2009
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    Article . 2009
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      Article . 2009
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      Article . 2009
      https://doi.org/10.48550/arxiv...
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    Authors: Soumya Raychaudhuri; Cynthia Sandor; Eli A. Stahl; Jan Freudenberg; +11 Authors

    The genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists about the identity of the causal variants in HLA-DRB1 and the presence of independent effects elsewhere in the MHC. Using existing genome-wide SNP data in 5,018 individuals with seropositive rheumatoid arthritis (cases) and 14,974 unaffected controls, we imputed and tested classical alleles and amino acid polymorphisms in HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1 and HLA-DRB1, as well as 3,117 SNPs across the MHC. Conditional and haplotype analyses identified that three amino acid positions (11, 71 and 74) in HLA-DRβ1 and single-amino-acid polymorphisms in HLA-B (at position 9) and HLA-DPβ1 (at position 9), which are all located in peptide-binding grooves, almost completely explain the MHC association to rheumatoid arthritis risk. This study shows how imputation of functional variation from large reference panels can help fine map association signals in the MHC.

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    Europe PubMed Central
    Article . 2012
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    Nature Genetics
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    Other literature type . Article . 2012
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    Article . 2012
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    Article . 2011
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    Authors: Alice Zurlo; Dino Mesa; Silvano Desidera; Sergio Messina; +36 Authors

    We present observations with the planet finder Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) of a selected sample of the most promising radial velocity (RV) companions for high-contrast imaging. Using a Monte Carlo simulation to explore all the possible inclinations of the orbit of wide RV companions, we identified the systems with companions that could potentially be detected with SPHERE. We found the most favourable RV systems to observe are: HD 142, GJ 676, HD 39091, HIP 70849, and HD 30177 and carried out observations of these systems during SPHERE Guaranteed Time Observing. To reduce the intensity of the starlight and reveal faint companions, we used principal component analysis algorithms alongside angular and spectral differential imaging. We injected synthetic planets with known flux to evaluate the self-subtraction caused by our data reduction and to determine the 5σ contrast in the J band versus separation for our reduced images. We estimated the upper limit on detectable companion mass around the selected stars from the contrast plot obtained from our data reduction. Although our observations enabled contrasts larger than 15 mag at a few tenths of arcsec from the host stars, we detected no planets. However, we were able to set upper mass limits around the stars using AMES-COND evolutionary models. We can exclude the presence of companions more massive than 25–28 MJup around these stars, confirming the substellar nature of these RV companions. Monthly Notices of the Royal Astronomical Society, 480 (1) ISSN:0035-8711 ISSN:1365-2966

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    Authors: Jordi Grinyó; Jacopo Aguzzi; Jacopo Aguzzi; Ellen Kenchington; +3 Authors

    The genus Sebastes is a morphologically and ecologically diverse genus of rockfish characterized by high longevity, late-maturity and low natural mortality. On the northwest Atlantic continental shelf, the Acadian redfish (Sebastes fasciatus) is the most common rockfish species above 300 m depth. This species has been widely exploited resulting in the depletion or collapse of most of its stocks. Management of long-lived species with intricate life-history characteristics is challenging and requires highly integrated biological and oceanographic monitoring, which allow the identification of environmental drivers and demographic and behavioral trends. The present study uses high-temporal resolution imaging and environmental data, acquired with an autonomous lander deployed for 10-months at the Sambro Bank Sponge Conservation Area (Scotian Shelf) to elucidate S. fasciatus temporal dynamics and behavioral trends in response to near-bed environmental conditions. S. fasciatus, mostly displayed passive locomotion and static behaviors, in common with other shelf-dwelling Sebastes species. Structural complexity provided by sponges positively influenced S. fasciatus presence. Fish used sponges to avoid being dragged by bottom currents. Hydrodynamics appear to act as a synchronizing factor conditioning its swimming behavior. S. fasciatus total counts exhibited a seasonal shift in rhythm’s phase likely reflecting changes in lifestyle requirements. This study provides new insights on S. fasciatus dynamics and behavior. Nonintrusive monitoring approaches, such as the one used in this study, will be key to monitor this threatened species populations. Especially, since it is expected that S. fasciatus will experience distribution shifts to higher latitudes due to future climate stressors This study is part of the SponGES project, which received funding from the European Union’s Horizon 2020 Research and Innovation Program under grant agreement no. 679849. Cruises were funded by Fisheries and Ocean’s Canada’s (DFO) International Governance Strategy awarded to EK, Bedford Institute of Oceanography, and supported by Hans Tore Rapp (University of Bergen, Norway). JG has received funding form the European Union’s Horizon 2020 research and Innovation programme. Action MSCA-IF-EF-ST fellowship, CWCC-Dynamics Grant agreement no. 101028621 14 pages, 9 figures, 1 table, supplementary material https://www.frontiersin.org/articles/10.3389/fmars.2023.1158283/full#supplementary-material.-- Data availability statement: The Raw data supporting this article are in the article/Supplementary Material. Further inquiries can be directed to the corresponding author With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) Peer reviewed

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    Frontiers in Marine Science
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    Article . 2023
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    Authors: Caron-Huot, Simon; Gardi, Einan; Reichel, Joscha; Vernazza, Leonardo;

    Scattering amplitudes of partons in QCD contain infrared divergences which can be resummed to all orders in terms of an anomalous dimension. Independently, in the limit of high-energy forward scattering, large logarithms of the energy can be resummed using Balitsky-Fadin-Kuraev-Lipatov theory. We use the latter to analyze the infrared-singular part of amplitudes to all orders in perturbation theory and to next-to-leading-logarithm accuracy in the high-energy limit, resumming the two-Reggeon contribution. Remarkably, we find a closed form for the infrared-singular part, predicting the Regge limit of the soft anomalous dimension to any loop order. 35 pages, 8 figures

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    Journal of High Energy Physics
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    Journal of High Energy Physics
    Article . 2018
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      Journal of High Energy Physics
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      Journal of High Energy Physics
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    Authors: Marco Piani; Marco Cianciaruso; Thomas R. Bromley; Carmine Napoli; +2 Authors

    Quantum states may exhibit asymmetry with respect to the action of a given group. Such an asymmetry of states can be considered as a resource in applications such as quantum metrology, and it is a concept that encompasses quantum coherence as a special case. We introduce explicitly and study the robustness of asymmetry, a quantifier of asymmetry of states that we prove to have many attractive properties, including efficient numerical computability via semidefinite programming, and an operational interpretation in a channel discrimination context. We also introduce the notion of asymmetry witnesses, whose measurement in a laboratory detects the presence of asymmetry. We prove that properly constrained asymmetry witnesses provide lower bounds to the robustness of asymmetry, which is shown to be a directly measurable quantity itself. We then focus our attention on coherence witnesses and the robustness of coherence, for which we prove a number of additional results; these include an analysis of its specific relevance in phase discrimination and quantum metrology, an analytical calculation of its value for a relevant class of quantum states, and tight bounds that relate it to another previously defined coherence monotone. 14 pages, 1 figure. Close to published version. Matlab code included in the source. See also the companion letter arXiv:1601.03781

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    https://doi.org/10.1103/physre...
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      https://doi.org/10.1103/physre...
      Article . 2016
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      Nottingham eTheses
      Article . 2016
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      https://doi.org/10.1103/PhysRe...
      Other literature type . Article . 2016
      https://doi.org/10.48550/arxiv...
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ida Mattsson; Johanna Majoinen; Manu Lahtinen; Thomas Sandberg; +5 Authors

    | openaire: EC/H2020/788489/EU//BioELCell Funding Information: The Graduate School of Chemical Engineering, the Parliament Office Commission of the Åland Islands, Walter and Lisi Waal's foundation, the Finnish Foundation for Technology Promotion and the Society of Swedish Literature in Finland are gratefully acknowledged for funding this work. Dr J. Rahkila, Turku Centre for Chemical and Molecular Analytics is acknowledged for HRMS analysis of the allylated sugars and NMR-related support. Dr Ville Liljeström is thanked for assistance with the SWAXS measurements. Dr J. Majoinen and Prof. O. Rojas acknowledge funding from the H2020-ERC-2017-Advanced Grant ‘BioELCell’ (788489). Prof. O. Rojas acknowledges the Canada Excellence Research Chair Program (CERC-2018-00006) and Canada Foundation for Innovation (Project number 38623). Prof. Olli Ikkala acknowledges Academy of Finland CoE LIBER (Project number 346108) and the Flagship FinnCERES. The authors acknowledge facilities and technical support by Nanomicroscopy Center at Aalto University. Publisher Copyright: © 2023 The Royal Society of Chemistry. Conformational rigidity controls the bulk self-assembly and liquid crystallinity from amphiphilic block molecules to copolymers. The effects of block stereochemistry on the self-assembly have, however, been less explored. Here, we have investigated amphiphilic block molecules involving eight open-chain monosaccharide-based polyol units possessing different stereochemistries, derived from d-glucose, d-galactose, l-arabinose, d-mannose and l-rhamnose (allylated monosaccharides t-Glc*, e-Glc*, t-Gal*, e-Gal*, t-Ara*, e-Ara*, t-Man*, and t-Rha*), end-functionalized with repulsive tetradecyl alkyl chain blocks to form well-defined amphiphiles with block molecule structures. All compounds studied showed low temperature crystalline phases due to polyol crystallization, and smectic (lamellar) and isotropic phases upon heating in bulk. Hexagonal cylindrical phase was additionally observed for the composition involving t-Man*. Cubic phases were observed for e-Glc*, e-Gal*, e-Ara*, and t-Rha* derived compounds. Therein,the rich array of WAXS-reflections suggested that the crystalline polyol domains are not ultra-confined in spheres as in classic cubic phases but instead show network-like phase continuity, which is rare in bulk liquid crystals. Importantly, the transition temperatures of the self-assemblies were observed to depend strongly on the polyol stereochemistry. The findings underpin that the stereochemistry in carbohydrate-based assemblies involves complexity, which is an important parameter to be considered in material design when developing self-assemblies for different functions. Peer reviewed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Jyväskylä University...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Soft Matter
    Article . 2023
    License: CC BY
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    Soft Matter
    Article . 2023
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      Soft Matter
      Article . 2023
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: R. Thomas Lumbers; Sonia Shah; Honghuang Lin; Tomasz Czuba; +164 Authors

    Abstract: Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction. Funder: Department of Medicine, Boston University School of Medicine; Id: http://dx.doi.org/10.13039/100008748 Funder: National Heart, Lung, and Blood Institute; Id: http://dx.doi.org/10.13039/100000050 Funder: Knut and Alice Wallenberg Foundation; Id: http://dx.doi.org/10.13039/501100004063 Funder: NIHR UCLH Biomedical Research Centre; Id: http://dx.doi.org/10.13039/501100012317 Funder: Skåne University Hospital; Id: http://dx.doi.org/10.13039/501100011077 Funder: Evans Medical Foundation; Id: http://dx.doi.org/10.13039/100015927 Funder: Crafoord Foundation; Id: http://dx.doi.org/10.13039/501100003173 Funder: British Heart Foundation Cardiovascular Biomedicine Funder: Swedish National Health Service

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    ESC Heart Failure
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    Apollo
    Other literature type . 2021
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    Apollo
    Article . 2021
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    ESC Heart Failure
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    ESC Heart Failure
    Article . 2021
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    ESC Heart Failure
    Article . 2022
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    Article . 2021
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      Europe PubMed Central
      Article . 2021
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      ESC Heart Failure
      Other literature type . Article . 2021
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      ESC Heart Failure
      Article . 2021
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      Article . 2022
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      Apollo
      Other literature type . 2021
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      Article . 2021
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      Apollo
      Article . 2021
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    Authors: de Rezende, Susanna F.; Meir, Or; Nordstr��m, Jakob; Pitassi, Toniann; +2 Authors

    We significantly strengthen and generalize the theorem lifting Nullstellensatz degree to monotone span program size by Pitassi and Robere (2018) so that it works for any gadget with high enough rank, in particular, for useful gadgets such as equality and greater-than. We apply our generalized theorem to solve three open problems: •We present the first result that demonstrates a separation in proof power for cutting planes with unbounded versus polynomially bounded coefficients. Specifically, we exhibit CNF formulas that can be refuted in quadratic length and constant line space in cutting planes with unbounded coefficients, but for which there are no refutations in subexponential length and subpolynomial line space if coefficients are restricted to be of polynomial magnitude. •We give the first explicit separation between monotone Boolean formulas and monotone real formulas. Specifically, we give an explicit family of functions that can be computed with monotone real formulas of nearly linear size but require monotone Boolean formulas of exponential size. Previously only a non-explicit separation was known. •We give the strongest separation to-date between monotone Boolean formulas and monotone Boolean circuits. Namely, we show that the classical GEN problem, which has polynomial-size monotone Boolean circuits, requires monotone Boolean formulas of size $2^{\Omega(n/\text{polylog}(n))}$ . An important technical ingredient, which may be of independent interest, is that we show that the Nullstellensatz degree of refuting the pebbling formula over a DAG $G$ over any field coincides exactly with the reversible pebbling price of $G$ . In particular, this implies that the standard decision tree complexity and the parity decision tree complexity of the corresponding falsified clause search problem are equal. This is an extended abstract. The full version of the paper is available at https://arxiv.org/abs/2001.02144.

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    http://arxiv.org/pdf/2001.0214...
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    https://doi.org/10.1109/focs46...
    Conference object . 2020
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    Article . 2020
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      http://arxiv.org/pdf/2001.0214...
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      https://doi.org/10.1109/focs46...
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    Authors: Pamela J. Maxwell; Melanie McKechnie; Christopher W. Armstrong; Judith M. Manley; +10 Authors

    Abstract Inhibiting androgen signaling using androgen signaling inhibitors (ASI) remains the primary treatment for castrate-resistant prostate cancer. Acquired resistance to androgen receptor (AR)-targeted therapy represents a major impediment to durable clinical response. Understanding resistance mechanisms, including the role of AR expressed in other cell types within the tumor microenvironment, will extend the clinical benefit of AR-targeted therapy. Here, we show the ASI enzalutamide induces vascular catastrophe and promotes hypoxia and microenvironment adaptation. We characterize treatment-induced hypoxia, and subsequent induction of angiogenesis, as novel mechanisms of relapse to enzalutamide, highlighting the importance of two hypoxia-regulated cytokines in underpinning relapse. We confirmed AR expression in CD34+ vascular endothelium of biopsy tissue and human vascular endothelial cells (HVEC). Enzalutamide attenuated angiogenic tubule formation and induced cytotoxicity in HVECs in vitro, and rapidly induced sustained hypoxia in LNCaP xenografts. Subsequent reoxygenation, following prolonged enzalutamide treatment, was associated with increased tumor vessel density and accelerated tumor growth. Hypoxia increased AR expression and transcriptional activity in prostate cells in vitro. Coinhibition of IL8 and VEGF-A restored tumor response in the presence of enzalutamide, confirming the functional importance of their elevated expression in enzalutamide-resistant models. Moreover, coinhibition of IL8 and VEGF-A resulted in a durable, effective resolution of enzalutamide-sensitive prostate tumors. We conclude that concurrent inhibition of two hypoxia-induced factors, IL8 and VEGF-A, prolongs tumor sensitivity to enzalutamide in preclinical models and may delay the onset of enzalutamide resistance. Implications: Targeting hypoxia-induced signaling may extend the therapeutic benefit of enzalutamide, providing an improved treatment strategy for patients with resistant disease.

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    Authors: Anne M. Archibald; Ingrid H. Stairs; Scott M. Ransom; Victoria M. Kaspi; +14 Authors

    Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase. Comment: published in Science

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    NARCIS
    Article . 2009
    Data sources: NARCIS
    Science
    Article . 2009
    https://doi.org/10.48550/arxiv...
    Article . 2009
    License: arXiv Non-Exclusive Distribution
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    UNC Dataverse
    Article . 2009
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      Science
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      Article . 2009
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      Science
      Article . 2009
      https://doi.org/10.48550/arxiv...
      Article . 2009
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      Article . 2009
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    Authors: Soumya Raychaudhuri; Cynthia Sandor; Eli A. Stahl; Jan Freudenberg; +11 Authors

    The genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists about the identity of the causal variants in HLA-DRB1 and the presence of independent effects elsewhere in the MHC. Using existing genome-wide SNP data in 5,018 individuals with seropositive rheumatoid arthritis (cases) and 14,974 unaffected controls, we imputed and tested classical alleles and amino acid polymorphisms in HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1 and HLA-DRB1, as well as 3,117 SNPs across the MHC. Conditional and haplotype analyses identified that three amino acid positions (11, 71 and 74) in HLA-DRβ1 and single-amino-acid polymorphisms in HLA-B (at position 9) and HLA-DPβ1 (at position 9), which are all located in peptide-binding grooves, almost completely explain the MHC association to rheumatoid arthritis risk. This study shows how imputation of functional variation from large reference panels can help fine map association signals in the MHC.

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    Europe PubMed Central
    Article . 2012
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    Nature Genetics
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    Nature Genetics
    Other literature type . Article . 2012
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    Nature Genetics
    Article . 2012
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    Article . 2011
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      Article . 2012
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      Nature Genetics
      Other literature type . Article . 2012
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      Nature Genetics
      Article . 2012
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      Article . 2011
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    Authors: Alice Zurlo; Dino Mesa; Silvano Desidera; Sergio Messina; +36 Authors

    We present observations with the planet finder Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) of a selected sample of the most promising radial velocity (RV) companions for high-contrast imaging. Using a Monte Carlo simulation to explore all the possible inclinations of the orbit of wide RV companions, we identified the systems with companions that could potentially be detected with SPHERE. We found the most favourable RV systems to observe are: HD 142, GJ 676, HD 39091, HIP 70849, and HD 30177 and carried out observations of these systems during SPHERE Guaranteed Time Observing. To reduce the intensity of the starlight and reveal faint companions, we used principal component analysis algorithms alongside angular and spectral differential imaging. We injected synthetic planets with known flux to evaluate the self-subtraction caused by our data reduction and to determine the 5σ contrast in the J band versus separation for our reduced images. We estimated the upper limit on detectable companion mass around the selected stars from the contrast plot obtained from our data reduction. Although our observations enabled contrasts larger than 15 mag at a few tenths of arcsec from the host stars, we detected no planets. However, we were able to set upper mass limits around the stars using AMES-COND evolutionary models. We can exclude the presence of companions more massive than 25–28 MJup around these stars, confirming the substellar nature of these RV companions. Monthly Notices of the Royal Astronomical Society, 480 (1) ISSN:0035-8711 ISSN:1365-2966

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    MPG.PuRe
    Article . 2018
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    MPG.PuRe
    Article . 2018
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    https://doi.org/10.48550/arxiv...
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      MPG.PuRe
      Article . 2018
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      https://doi.org/10.48550/arxiv...
      Article . 2018
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    Authors: Jordi Grinyó; Jacopo Aguzzi; Jacopo Aguzzi; Ellen Kenchington; +3 Authors

    The genus Sebastes is a morphologically and ecologically diverse genus of rockfish characterized by high longevity, late-maturity and low natural mortality. On the northwest Atlantic continental shelf, the Acadian redfish (Sebastes fasciatus) is the most common rockfish species above 300 m depth. This species has been widely exploited resulting in the depletion or collapse of most of its stocks. Management of long-lived species with intricate life-history characteristics is challenging and requires highly integrated biological and oceanographic monitoring, which allow the identification of environmental drivers and demographic and behavioral trends. The present study uses high-temporal resolution imaging and environmental data, acquired with an autonomous lander deployed for 10-months at the Sambro Bank Sponge Conservation Area (Scotian Shelf) to elucidate S. fasciatus temporal dynamics and behavioral trends in response to near-bed environmental conditions. S. fasciatus, mostly displayed passive locomotion and static behaviors, in common with other shelf-dwelling Sebastes species. Structural complexity provided by sponges positively influenced S. fasciatus presence. Fish used sponges to avoid being dragged by bottom currents. Hydrodynamics appear to act as a synchronizing factor conditioning its swimming behavior. S. fasciatus total counts exhibited a seasonal shift in rhythm’s phase likely reflecting changes in lifestyle requirements. This study provides new insights on S. fasciatus dynamics and behavior. Nonintrusive monitoring approaches, such as the one used in this study, will be key to monitor this threatened species populations. Especially, since it is expected that S. fasciatus will experience distribution shifts to higher latitudes due to future climate stressors This study is part of the SponGES project, which received funding from the European Union’s Horizon 2020 Research and Innovation Program under grant agreement no. 679849. Cruises were funded by Fisheries and Ocean’s Canada’s (DFO) International Governance Strategy awarded to EK, Bedford Institute of Oceanography, and supported by Hans Tore Rapp (University of Bergen, Norway). JG has received funding form the European Union’s Horizon 2020 research and Innovation programme. Action MSCA-IF-EF-ST fellowship, CWCC-Dynamics Grant agreement no. 101028621 14 pages, 9 figures, 1 table, supplementary material https://www.frontiersin.org/articles/10.3389/fmars.2023.1158283/full#supplementary-material.-- Data availability statement: The Raw data supporting this article are in the article/Supplementary Material. Further inquiries can be directed to the corresponding author With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) Peer reviewed

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    Frontiers in Marine Science
    Article . 2023
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    NIOZ Repository
    Article . 2023
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    DOAJ
    Article . 2023
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      Frontiers in Marine Science
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    Authors: Caron-Huot, Simon; Gardi, Einan; Reichel, Joscha; Vernazza, Leonardo;

    Scattering amplitudes of partons in QCD contain infrared divergences which can be resummed to all orders in terms of an anomalous dimension. Independently, in the limit of high-energy forward scattering, large logarithms of the energy can be resummed using Balitsky-Fadin-Kuraev-Lipatov theory. We use the latter to analyze the infrared-singular part of amplitudes to all orders in perturbation theory and to next-to-leading-logarithm accuracy in the high-energy limit, resumming the two-Reggeon contribution. Remarkably, we find a closed form for the infrared-singular part, predicting the Regge limit of the soft anomalous dimension to any loop order. 35 pages, 8 figures

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    Journal of High Energy Physics
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    Journal of High Energy Physics
    Article . 2018
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    Article . 2018
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    https://doi.org/10.48550/arxiv...
    Article . 2017
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      Journal of High Energy Physics
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      Journal of High Energy Physics
      Article . 2018
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      Article . 2018
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    Authors: Marco Piani; Marco Cianciaruso; Thomas R. Bromley; Carmine Napoli; +2 Authors

    Quantum states may exhibit asymmetry with respect to the action of a given group. Such an asymmetry of states can be considered as a resource in applications such as quantum metrology, and it is a concept that encompasses quantum coherence as a special case. We introduce explicitly and study the robustness of asymmetry, a quantifier of asymmetry of states that we prove to have many attractive properties, including efficient numerical computability via semidefinite programming, and an operational interpretation in a channel discrimination context. We also introduce the notion of asymmetry witnesses, whose measurement in a laboratory detects the presence of asymmetry. We prove that properly constrained asymmetry witnesses provide lower bounds to the robustness of asymmetry, which is shown to be a directly measurable quantity itself. We then focus our attention on coherence witnesses and the robustness of coherence, for which we prove a number of additional results; these include an analysis of its specific relevance in phase discrimination and quantum metrology, an analytical calculation of its value for a relevant class of quantum states, and tight bounds that relate it to another previously defined coherence monotone. 14 pages, 1 figure. Close to published version. Matlab code included in the source. See also the companion letter arXiv:1601.03781

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    CORE (RIOXX-UK Aggregator)
    Article . 2016
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    https://nottingham-repository....
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