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description Publicationkeyboard_double_arrow_right Article 2000American Physical Society (APS) J. Rikovska; T. Giles; N. J. Stone; K. van Esbroeck; G. White; A. Wöhr; M. Veskovic; I. S. Towner; P. F. Mantica; J. I. Prisciandaro; D. J. Morrissey; V. N. Fedoseyev; V. I. Mishin; U. Köster; W. B. Walters; null the NICOLE and ISOLDE Collaboration;The first fully on-line use of the angular distribution of beta emission in detection of NMR of nuclei oriented at low temperatures is reported. The magnetic moments of the single valence particle, intermediate mass, isotopes 67Ni(nup(-1)(1/2);1/2(-)) and 69Cu(pip(1)(3/2);3/2(-)) are measured to be +0.601(5) m(N) and +2.84(1) m(N), respectively, revealing only a small deviation from the neutron p(1/2) single-particle value in the former and a large deviation from the proton p(3/2) single-particle value in the latter. Quantitative interpretation is given in terms of core polarization and meson-exchange currents.
Physical Review Lett... arrow_drop_down Physical Review LettersArticle . 2000License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu42 citations 42 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Physical Review Lett... arrow_drop_down Physical Review LettersArticle . 2000License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 United KingdomCambridge University Press (CUP) Balmforth, NJ; Craster, RV; Hewitt, DR; Hormozi, S; Maleki, A;In the limit of a large yield stress, or equivalently at the initiation of motion, viscoplastic flows can develop narrow boundary layers that provide either surfaces of failure between rigid plugs, the lubrication between a plugged flow and a wall or buffers for regions of predominantly plastic deformation. Oldroyd (Proc. Camb. Phil. Soc., vol. 43, 1947, pp. 383–395) presented the first theoretical discussion of these viscoplastic boundary layers, offering an asymptotic reduction of the governing equations and a discussion of some model flow problems. However, the complicated nonlinear form of Oldroyd’s boundary-layer equations has evidently precluded further discussion of them. In the current paper, we revisit Oldroyd’s viscoplastic boundary-layer analysis and his canonical examples of a jet-like intrusion and flow past a thin plate. We also consider flow down channels with either sudden expansions or wavy walls. In all these examples, we verify that viscoplastic boundary layers form as envisioned by Oldroyd. For each example, we extract the dependence of the boundary-layer thickness and flow profiles on the dimensionless yield-stress parameter (Bingham number). We find that, while Oldroyd’s boundary-layer theory applies to free viscoplastic shear layers, it does not apply when the boundary layer is adjacent to a wall, as has been observed previously for two-dimensional flow around circular obstructions. Instead, the boundary-layer thickness scales in a different fashion with the Bingham number, as suggested by classical solutions for plane-parallel flows, lubrication theory and, for flow around a plate, by Piau (J. Non-Newtonian Fluid Mech., vol. 102, 2002, pp. 193–218); we rationalize this second scaling and provide an alternative boundary-layer theory.
Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryJournal of Fluid MechanicsArticle . 2017License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu28 citations 28 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 9visibility views 9 download downloads 136 Powered bymore_vert Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryJournal of Fluid MechanicsArticle . 2017License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2008Embargo end date: 01 Jan 2008arXiv NSF | CAREER: Search for Dark M..., SNSF | Search for particle dark ..., NSF | CDMS II: A Search for Col... +9 projectsNSF| CAREER: Search for Dark Matter and Mentoring Female Physics Students ,SNSF| Search for particle dark matter and for the neutrinoless double beta decay with cryogenic detectors ,NSF| CDMS II: A Search for Cold Dark Matter with Cryogenic Detectors at the Soudan Mine ,NSF| Detector Optimization for the SuperCDMS Experiment ,SNSF| Prediction of Crack Growth under Thermal Fatique Loading ,NSERC ,UKRI| AIM - AI-driven Multi-factor peptide manufacturing platform ,NSF| Experimental Particle Cosmology: Search for Dark Matter ,UKRI| AlwaysClean ,NSF| SuperCDMS Development Project: Detectors: Superconducting Electronics Systems R&D ,NSF| SuperCDMS 25 kg Experiment ,NSF| SuperCDMS Research and Development: WIMP Dark Matter Detector Performance, Scalability, and Surface BackgroundsAuthors: CDMS Collaboration;CDMS Collaboration;We report first results from the Cryogenic Dark Matter Search (CDMS II) experiment running with its full complement of 30 cryogenic particle detectors at the Soudan Underground Laboratory. This report is based on the analysis of data acquired between October 2006 and July 2007 from 15 Ge detectors (3.75 kg), giving an effective exposure of 121.3 kg-d (averaged over recoil energies 10--100 keV, weighted for a weakly interacting massive particle (WIMP) mass of 60 \gev). A blind analysis, incorporating improved techniques for event reconstruction and data quality monitoring, resulted in zero observed events. This analysis sets an upper limit on the WIMP-nucleon spin-independent cross section of 6.6$\times10^{-44}$ cm$^2$ (4.6$\times10^{-44}$ cm$^2$ when combined with previous CDMS Soudan data) at the 90% confidence level for a WIMP mass of 60 \gev. By providing the best sensitivity for dark matter WIMPs with masses above 42 GeV/c$^2$, this work significantly restricts the parameter space for some of the favored supersymmetric models. Comment: 5 pages, 4 figures, submitted to PRL 28 March 2008
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2007American Society of Hematology Evangelos Terpos; Richard J. Cook; Robert E. Coleman; Allan Lipton; James R. Berenson;Abstract Most patients with advanced multiple myeloma (MM) develop bone lesions during their disease course. Myeloma bone disease can result in potentially debilitating and life threatening skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, the need for palliative radiotherapy (RT) or surgery to bone, and hypercalcemia of malignancy. Bone-targeted therapies that prevent or delay SRE onset may maintain quality of life (QOL) and functional independence in patients with advanced MM. Yet, the risk factors for SREs in this patient population are not fully understood. Exploratory analyses were conducted to identify potential SRE risk factors in patients with bone lesions from MM who received either zoledronic acid or pamidronate every 3 to 4 weeks for up to 24 months in a large, randomized trial. Patients with complete baseline demographics, disease characteristics, and markers of bone metabolism information available were included (n=282). Dichotomous variables included sex, race (white/other), narcotic analgesics (yes/no), Eastern Cooperative Oncology Group performance status (active/impaired), prior SRE (yes/no), and values with a defined upper limit of normal (creatinine, lymphocyte %, hemoglobin, serum glutamic oxaloacetic transaminase, albumin, lactate dehydrogenase [LDH], and calcium). Continuous variables included age, weight, cancer duration, Functional Assessment of Cancer Therapy-General score, Brief Pain Inventory (BPI) score, and bone markers (eg, urinary N-telopeptide of type I collagen [NTX], deoxypyridinoline [DPD]). Paraprotein type was also included. Univariate and multivariate analyses to determine relative risks (RR) for reduced time to first SRE associated with baseline variables using Cox regression models were developed, and those that were not significant at the 5% level were removed by backward elimination to generate a reduced model. In the reduced multivariate model, lower weight (RR=0.94 per 5-kg increase; P=.021), higher BPI scores (RR=1.16 per 1-unit increase; P < .001), race other than white (RR=0.60; P=.028), need for narcotic analgesics (RR=1.61; P=.017), and high levels of NTX (RR=1.68 per 100-nmol/mmol creatinine increase; P=.005) significantly correlated with reduced time to first SRE. Pathologic fracture and RT to bone were the most common SREs; in multivariate models, lower weight and higher BPI scores were associated with increased RRs of both fractures and RT to bone. Race and DPD levels were also significant covariates for fractures, whereas high levels of LDH correlated significantly with need for RT. Because bone resorption marker levels were significant covariates, the correlation between baseline NTX and time to first SRE was assessed. High baseline NTX (≥ 50 nmol/mmol creatinine) was associated with increased risk of shorter time to first SRE: by a significant 67% in the zoledronic acid group (n=210; P=.015) and by a 57% trend in the pamidronate group (n=108; P=.114). Taken together, lower weight and pain parameters (eg, BPI or narcotic analgesics) correlated consistently with skeletal morbidity risks in patients with advanced MM. Treatments that facilitate the restoration of bone homeostasis, as evidenced by bone marker normalization, may reduce the risk of SREs, thus maintaining QOL in this patient population.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2011World Scientific Pub Co Pte Lt Authors: Dongvu Tonien; Reihaneh Safavi-Naini; Peter R. Wild;Dongvu Tonien; Reihaneh Safavi-Naini; Peter R. Wild;In this paper, we consider authentication codes where the adversary has access to a verification oracle. We formally study two attack games: offline attack and online attack. In an offline impersonation attack with verification query of order i, the adversary launches its attack through two stages. In the first stage — the query stage — the adversary can adaptively choose i distinct messages to query the verification oracle. The verification oracle will answer whether these queried messages are valid or invalid under the secret encoding rule agreed by the transmitter and the receiver. In the later stage — the spoofing stage — the adversary creates a fraudulent message which is different from all its queried messages and sends this message to the receiver. The adversary wins if the receiver accepts the fraudulent message as a valid message. In an online impersonation attack with verification query of order i, the adversary has i + 1 chances to query the verification oracle and wins as soon as one of the queries is a valid message. We make use of strategy trees, which allow optimal strategies in both attack games to be identified, to establish a number of relationships between the value of the two games. This allows us to formally prove a relationship between the value of the game when the adversary has i queries, and the one in which he does not have any. The relationship, though widely believed to be true, was only recently proved for computationally secure systems. Our result complements this latter work for the information theoretic setting.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Wiley Authors: Emma Lecavalier; Gregory Stiles;Emma Lecavalier; Gregory Stiles;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/1758-5899.13285&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Elsevier BV Ren Na; Yanjie Luo; Haoyu Bo; Jian Zhang; Ruifang Jia; Qinglin Meng; Zhou Hongyou; Jianjun Hao; Jun Zhao;Abstract Sunflower (Helianthus annuus) can be infected by the fungal pathogen Sclerotinia sclerotiorum, but its susceptibility varies depending on the cultivars. The aim of this study was to characterize and compare the biochemical responses between the R and the S sunflower cultivars after inoculation with S. sclerotiorum. The biochemical activities were detected by measuring necrotic cell, callose deposition, soluble protein content, as well as ROS accumulation at the infection site. Antioxidant enzymatic activities, the transcripts of ROS related genes and marker genes in pathways of salicylic acid (SA) and jasmonic acid (JA) were also quantified to characterize the responses. Results showed that compared to the S cultivar, the R cultivar was characterized having reduced number of necrotic cell, more callose deposition on the cell wall, increased soluble protein content, higher levels of H2O2 and ROS scavenger enzyme activities, and upregulated transcript profile of marker genes of both SA and JA pathways.
Physiological and Mo... arrow_drop_down Physiological and Molecular Plant PathologyArticle . 2018License: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert Physiological and Mo... arrow_drop_down Physiological and Molecular Plant PathologyArticle . 2018License: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2005Akademiai Kiado Zrt. Authors: Louise Brunette; Chantal Gagnon; Jonathan Hine;Louise Brunette; Chantal Gagnon; Jonathan Hine;GREVIS (Groupe de recherche en révision humaine) aimed to set up an accelerated method of revising while improving the quality of the operation. The project had a three fold objective: to strengthen the place of revision in the field of translation studies, to increase revisers' satisfaction and to help the translation industry. The hypothesis of this study was that monolingual revision was just as effective as bilingual revision, and could be done at a lower cost, because it is less time-consuming. However, the results of the study disproved this hypothesis: bilingual revision was more than twice as effective as monolingual revision. The 19,407-word corpus comprised translations from the E?F pair (translated and revised in Canada) and from the F?E pair (translated and revised in the United States). Each sub-corpus (E?F and F?E) was analyzed by a team of scholars and/or revisers, according to Louise Brunette's (1997) revision criteria: accuracy, readability, appropriateness and linguistic coding. The study looked at the number of corrections, omissions and revisor-injected errors, in relation to these four criteria.
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For further information contact us at helpdesk@openaire.eu23 citations 23 popularity Average influence Top 10% impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 AustraliaWiley Vijaya M, Musini; Kendra Ak, Lawrence; Patricia M, Fortin; Ken, Bassett; James M, Wright;pmc: PMC6478238
handle: 10453/129051
Background Hypertension is a chronic condition associated with an increased risk of mortality and morbidity. Renin is the enzyme responsible for converting angiotensinogen to angiotensin I, which is then converted to angiotensin II. Renin inhibitors are a new class of drugs that decrease blood pressure (BP) by preventing the formation of both angiotensin I and angiotensin II. Objectives To quantify the dose-related BP lowering efficacy of renin inhibitors compared to placebo in the treatment of primary hypertension. To determine the change in BP variability, pulse pressure, and heart rate and to evaluate adverse events (mortality, non-fatal serious adverse events, total adverse events, withdrawal due to adverse effects and specific adverse events such as dry cough, diarrhoea and angioedema). Search methods The Cochrane Hypertension Information Specialist searched the following databases for randomized controlled trials (RCTs) up to February 2017: the Cochrane Hypertension Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2017, Issue 2), MEDLINE (from 1946), Embase (from 1974), the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov. There was no restriction by language or publication status. We also searched the European Medicines Agency (EMA) for clinical study reports, the Novartis Clinical Study Results Database, bibliographic citations from retrieved references, and contacted authors of relevant papers regarding further published and unpublished work. Selection criteria We included randomized, double-blinded, placebo-controlled studies evaluating BP lowering efficacy of fixed-dose monotherapy with renin inhibitor compared with placebo for a minimum duration of three to 12 weeks in adult patients with primary hypertension. Data collection and analysis This systematic review is a comprehensive update which includes four additional studies and extensive detail from nine clinical study reports (CSRs) of previously included studies obtained from EMA. The remaining three CSRs are not available. Two review authors independently assessed study eligibility and extracted data. In all cases where there was a difference between the CSR and the published report, data from the CSR was used. Dichotomous outcomes were reported as risk ratio (RR) with 95% confidence intervals (CIs) and continuous outcomes as mean difference (MD) with 95% CIs. Main results 12 studies (mean duration of eight weeks) in 7439 mostly Caucasian patients (mean age 54 years) with mild-to-moderate uncomplicated hypertension were eligible for inclusion in the review. Aliskiren was the only renin inhibitor evaluated. All included studies were assessed to have high likelihood of attrition, reporting and funding bias. Aliskiren has a dose-related systolic/diastolic blood pressure (SBP/DBP) lowering effect as compared with placebo MD with 95% CI: aliskiren 75 mg (MD -2.97, 95% CI -4.76 to -1.18)/(MD -2.05, 95% CI -3.13 to -0.96) mm Hg (moderate-quality evidence), aliskiren 150 mg (MD -5.95, 95% CI -6.85 to -5.06)/ (MD -3.16, 95% CI -3.74 to -2.58) mm Hg (moderate-quality evidence), aliskiren 300 mg (MD -7.88, 95% CI -8.94 to -6.82)/ (MD -4.49, 95% CI -5.17 to -3.82) mm Hg (moderate-quality evidence), aliskiren 600 mg (MD -11.35, 95% CI -14.43 to -8.27)/ (MD -5.86, 95% CI -7.73 to -3.99) mm Hg (low-quality evidence). There was a dose-dependent decrease in blood pressure for aliskiren 75 mg, 150 mg and 300 mg. The blood pressure lowering effect of aliskiren 600 mg was not different from 300 mg (MD -0.61, 95% CI -2.78 to 1.56)/(MD -0.68, 95% CI -2.03 to 0.67). Aliskiren had no effect on blood pressure variability. Due to very limited information available regarding change in heart rate and pulse pressure, it was not possible to meta-analyze these outcomes. Mortality and non-fatal serious adverse events were not increased. This review found that in studies of eight week duration aliskiren may not increase withdrawal due to adverse events (low-quality evidence). Diarrhoea was increased in a dose-dependent manner (RR 7.00, 95% CI 2.48 to 19.72) with aliskiren 600 mg (low-quality evidence). The most frequent adverse events reported were headache, nasopharyngitis, diarrhoea, dizziness and fatigue. Authors' conclusions Compared to placebo, aliskiren lowered BP and this effect is dose-dependent. This magnitude of BP lowering effect is similar to that for angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). There is no difference in mortality, nonfatal serious adverse events or withdrawal due to adverse effects with short term aliskiren monotherapy. Diarrhoea was considerably increased with aliskiren 600 mg.
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For further information contact us at helpdesk@openaire.eu61 citations 61 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2000American Physical Society (APS) J. Rikovska; T. Giles; N. J. Stone; K. van Esbroeck; G. White; A. Wöhr; M. Veskovic; I. S. Towner; P. F. Mantica; J. I. Prisciandaro; D. J. Morrissey; V. N. Fedoseyev; V. I. Mishin; U. Köster; W. B. Walters; null the NICOLE and ISOLDE Collaboration;The first fully on-line use of the angular distribution of beta emission in detection of NMR of nuclei oriented at low temperatures is reported. The magnetic moments of the single valence particle, intermediate mass, isotopes 67Ni(nup(-1)(1/2);1/2(-)) and 69Cu(pip(1)(3/2);3/2(-)) are measured to be +0.601(5) m(N) and +2.84(1) m(N), respectively, revealing only a small deviation from the neutron p(1/2) single-particle value in the former and a large deviation from the proton p(3/2) single-particle value in the latter. Quantitative interpretation is given in terms of core polarization and meson-exchange currents.
Physical Review Lett... arrow_drop_down Physical Review LettersArticle . 2000License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu42 citations 42 popularity Average influence Top 10% impulse Top 10% Powered by BIP!more_vert Physical Review Lett... arrow_drop_down Physical Review LettersArticle . 2000License: APS Licenses for Journal Article Re-useData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2018 United States, NetherlandsAmerican Society of Clinical Oncology (ASCO) Veda N. Giri; Karen E. Knudsen; William Kevin Kelly; Wassim Abida; Gerald L. Andriole; Chris H. Bangma; Justin E. Bekelman; Mitchell C. Benson; Amie Blanco; Arthur L. Burnett; William J. Catalona; Kathleen A. Cooney; Matthew R. Cooperberg; David Crawford; Robert B. Den; Adam P. Dicker; Scott E. Eggener; Neil Fleshner; Matthew L. Freedman; Freddie C. Hamdy; Jean H. Hoffman-Censits; Mark D. Hurwitz; Colette Hyatt; William B. Isaacs; Christopher J. Kane; Philip W. Kantoff; R. Jeffrey Karnes; Lawrence Karsh; Eric A. Klein; Daniel W. Lin; Kevin R. Loughlin; Grace L. Lu-Yao; S. Bruce Malkowicz; Mark Mann; James Ryan Mark; Peter A. McCue; Martin Miner; Todd M. Morgan; Judd W. Moul; Ronald E. Myers; Sarah M. Nielsen; Elias Obeid; Christian P. Pavlovich; Stephen C. Peiper; David F. Penson; Daniel P. Petrylak; Curtis A. Pettaway; Robert Pilarski; Peter A. Pinto; Wendy Poage; Ganesh V. Raj; Timothy R. Rebbeck; Mark E. Robson; Matt T. Rosenberg; Howard M. Sandler; Oliver Sartor; Edward M. Schaeffer; Gordon F. Schwartz; Mark S. Shahin; Neal D. Shore; Brian Shuch; Howard R. Soule; Scott A. Tomlins; Edouard J. Trabulsi; Robert G. Uzzo; Donald J. Vander Griend; Patrick C. Walsh; Carol J. Weil; Richard C. Wender; Leonard G. Gomella;pmc: PMC6075860
handle: 1765/104409
Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA—a clinically heterogeneous disease.
NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu148 citations 148 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert NARCIS; Journal of C... arrow_drop_down NARCIS; Journal of Clinical OncologyArticle . 2018eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 United KingdomCambridge University Press (CUP) Balmforth, NJ; Craster, RV; Hewitt, DR; Hormozi, S; Maleki, A;In the limit of a large yield stress, or equivalently at the initiation of motion, viscoplastic flows can develop narrow boundary layers that provide either surfaces of failure between rigid plugs, the lubrication between a plugged flow and a wall or buffers for regions of predominantly plastic deformation. Oldroyd (Proc. Camb. Phil. Soc., vol. 43, 1947, pp. 383–395) presented the first theoretical discussion of these viscoplastic boundary layers, offering an asymptotic reduction of the governing equations and a discussion of some model flow problems. However, the complicated nonlinear form of Oldroyd’s boundary-layer equations has evidently precluded further discussion of them. In the current paper, we revisit Oldroyd’s viscoplastic boundary-layer analysis and his canonical examples of a jet-like intrusion and flow past a thin plate. We also consider flow down channels with either sudden expansions or wavy walls. In all these examples, we verify that viscoplastic boundary layers form as envisioned by Oldroyd. For each example, we extract the dependence of the boundary-layer thickness and flow profiles on the dimensionless yield-stress parameter (Bingham number). We find that, while Oldroyd’s boundary-layer theory applies to free viscoplastic shear layers, it does not apply when the boundary layer is adjacent to a wall, as has been observed previously for two-dimensional flow around circular obstructions. Instead, the boundary-layer thickness scales in a different fashion with the Bingham number, as suggested by classical solutions for plane-parallel flows, lubrication theory and, for flow around a plate, by Piau (J. Non-Newtonian Fluid Mech., vol. 102, 2002, pp. 193–218); we rationalize this second scaling and provide an alternative boundary-layer theory.
Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryJournal of Fluid MechanicsArticle . 2017License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu28 citations 28 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!visibility 9visibility views 9 download downloads 136 Powered bymore_vert Spiral - Imperial Co... arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2017Data sources: Spiral - Imperial College Digital RepositoryJournal of Fluid MechanicsArticle . 2017License: Cambridge Core User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2008Embargo end date: 01 Jan 2008arXiv NSF | CAREER: Search for Dark M..., SNSF | Search for particle dark ..., NSF | CDMS II: A Search for Col... +9 projectsNSF| CAREER: Search for Dark Matter and Mentoring Female Physics Students ,SNSF| Search for particle dark matter and for the neutrinoless double beta decay with cryogenic detectors ,NSF| CDMS II: A Search for Cold Dark Matter with Cryogenic Detectors at the Soudan Mine ,NSF| Detector Optimization for the SuperCDMS Experiment ,SNSF| Prediction of Crack Growth under Thermal Fatique Loading ,NSERC ,UKRI| AIM - AI-driven Multi-factor peptide manufacturing platform ,NSF| Experimental Particle Cosmology: Search for Dark Matter ,UKRI| AlwaysClean ,NSF| SuperCDMS Development Project: Detectors: Superconducting Electronics Systems R&D ,NSF| SuperCDMS 25 kg Experiment ,NSF| SuperCDMS Research and Development: WIMP Dark Matter Detector Performance, Scalability, and Surface BackgroundsAuthors: CDMS Collaboration;CDMS Collaboration;We report first results from the Cryogenic Dark Matter Search (CDMS II) experiment running with its full complement of 30 cryogenic particle detectors at the Soudan Underground Laboratory. This report is based on the analysis of data acquired between October 2006 and July 2007 from 15 Ge detectors (3.75 kg), giving an effective exposure of 121.3 kg-d (averaged over recoil energies 10--100 keV, weighted for a weakly interacting massive particle (WIMP) mass of 60 \gev). A blind analysis, incorporating improved techniques for event reconstruction and data quality monitoring, resulted in zero observed events. This analysis sets an upper limit on the WIMP-nucleon spin-independent cross section of 6.6$\times10^{-44}$ cm$^2$ (4.6$\times10^{-44}$ cm$^2$ when combined with previous CDMS Soudan data) at the 90% confidence level for a WIMP mass of 60 \gev. By providing the best sensitivity for dark matter WIMPs with masses above 42 GeV/c$^2$, this work significantly restricts the parameter space for some of the favored supersymmetric models. Comment: 5 pages, 4 figures, submitted to PRL 28 March 2008
arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down https://doi.org/10.48550/arxiv...Article . 2008License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2007American Society of Hematology Evangelos Terpos; Richard J. Cook; Robert E. Coleman; Allan Lipton; James R. Berenson;Abstract Most patients with advanced multiple myeloma (MM) develop bone lesions during their disease course. Myeloma bone disease can result in potentially debilitating and life threatening skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, the need for palliative radiotherapy (RT) or surgery to bone, and hypercalcemia of malignancy. Bone-targeted therapies that prevent or delay SRE onset may maintain quality of life (QOL) and functional independence in patients with advanced MM. Yet, the risk factors for SREs in this patient population are not fully understood. Exploratory analyses were conducted to identify potential SRE risk factors in patients with bone lesions from MM who received either zoledronic acid or pamidronate every 3 to 4 weeks for up to 24 months in a large, randomized trial. Patients with complete baseline demographics, disease characteristics, and markers of bone metabolism information available were included (n=282). Dichotomous variables included sex, race (white/other), narcotic analgesics (yes/no), Eastern Cooperative Oncology Group performance status (active/impaired), prior SRE (yes/no), and values with a defined upper limit of normal (creatinine, lymphocyte %, hemoglobin, serum glutamic oxaloacetic transaminase, albumin, lactate dehydrogenase [LDH], and calcium). Continuous variables included age, weight, cancer duration, Functional Assessment of Cancer Therapy-General score, Brief Pain Inventory (BPI) score, and bone markers (eg, urinary N-telopeptide of type I collagen [NTX], deoxypyridinoline [DPD]). Paraprotein type was also included. Univariate and multivariate analyses to determine relative risks (RR) for reduced time to first SRE associated with baseline variables using Cox regression models were developed, and those that were not significant at the 5% level were removed by backward elimination to generate a reduced model. In the reduced multivariate model, lower weight (RR=0.94 per 5-kg increase; P=.021), higher BPI scores (RR=1.16 per 1-unit increase; P < .001), race other than white (RR=0.60; P=.028), need for narcotic analgesics (RR=1.61; P=.017), and high levels of NTX (RR=1.68 per 100-nmol/mmol creatinine increase; P=.005) significantly correlated with reduced time to first SRE. Pathologic fracture and RT to bone were the most common SREs; in multivariate models, lower weight and higher BPI scores were associated with increased RRs of both fractures and RT to bone. Race and DPD levels were also significant covariates for fractures, whereas high levels of LDH correlated significantly with need for RT. Because bone resorption marker levels were significant covariates, the correlation between baseline NTX and time to first SRE was assessed. High baseline NTX (≥ 50 nmol/mmol creatinine) was associated with increased risk of shorter time to first SRE: by a significant 67% in the zoledronic acid group (n=210; P=.015) and by a 57% trend in the pamidronate group (n=108; P=.114). Taken together, lower weight and pain parameters (eg, BPI or narcotic analgesics) correlated consistently with skeletal morbidity risks in patients with advanced MM. Treatments that facilitate the restoration of bone homeostasis, as evidenced by bone marker normalization, may reduce the risk of SREs, thus maintaining QOL in this patient population.
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For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2011World Scientific Pub Co Pte Lt Authors: Dongvu Tonien; Reihaneh Safavi-Naini; Peter R. Wild;Dongvu Tonien; Reihaneh Safavi-Naini; Peter R. Wild;In this paper, we consider authentication codes where the adversary has access to a verification oracle. We formally study two attack games: offline attack and online attack. In an offline impersonation attack with verification query of order i, the adversary launches its attack through two stages. In the first stage — the query stage — the adversary can adaptively choose i distinct messages to query the verification oracle. The verification oracle will answer whether these queried messages are valid or invalid under the secret encoding rule agreed by the transmitter and the receiver. In the later stage — the spoofing stage — the adversary creates a fraudulent message which is different from all its queried messages and sends this message to the receiver. The adversary wins if the receiver accepts the fraudulent message as a valid message. In an online impersonation attack with verification query of order i, the adversary has i + 1 chances to query the verification oracle and wins as soon as one of the queries is a valid message. We make use of strategy trees, which allow optimal strategies in both attack games to be identified, to establish a number of relationships between the value of the two games. This allows us to formally prove a relationship between the value of the game when the adversary has i queries, and the one in which he does not have any. The relationship, though widely believed to be true, was only recently proved for computationally secure systems. Our result complements this latter work for the information theoretic setting.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Wiley Authors: Emma Lecavalier; Gregory Stiles;Emma Lecavalier; Gregory Stiles;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/1758-5899.13285&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Elsevier BV Ren Na; Yanjie Luo; Haoyu Bo; Jian Zhang; Ruifang Jia; Qinglin Meng; Zhou Hongyou; Jianjun Hao; Jun Zhao;Abstract Sunflower (Helianthus annuus) can be infected by the fungal pathogen Sclerotinia sclerotiorum, but its susceptibility varies depending on the cultivars. The aim of this study was to characterize and compare the biochemical responses between the R and the S sunflower cultivars after inoculation with S. sclerotiorum. The biochemical activities were detected by measuring necrotic cell, callose deposition, soluble protein content, as well as ROS accumulation at the infection site. Antioxidant enzymatic activities, the transcripts of ROS related genes and marker genes in pathways of salicylic acid (SA) and jasmonic acid (JA) were also quantified to characterize the responses. Results showed that compared to the S cultivar, the R cultivar was characterized having reduced number of necrotic cell, more callose deposition on the cell wall, increased soluble protein content, higher levels of H2O2 and ROS scavenger enzyme activities, and upregulated transcript profile of marker genes of both SA and JA pathways.
Physiological and Mo... arrow_drop_down Physiological and Molecular Plant PathologyArticle . 2018License: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.pmpp.2017.12.004&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Average impulse Average Powered by BIP!more_vert Physiological and Mo... arrow_drop_down Physiological and Molecular Plant PathologyArticle . 2018License: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.pmpp.2017.12.004&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2005Akademiai Kiado Zrt. Authors: Louise Brunette; Chantal Gagnon; Jonathan Hine;Louise Brunette; Chantal Gagnon; Jonathan Hine;GREVIS (Groupe de recherche en révision humaine) aimed to set up an accelerated method of revising while improving the quality of the operation. The project had a three fold objective: to strengthen the place of revision in the field of translation studies, to increase revisers' satisfaction and to help the translation industry. The hypothesis of this study was that monolingual revision was just as effective as bilingual revision, and could be done at a lower cost, because it is less time-consuming. However, the results of the study disproved this hypothesis: bilingual revision was more than twice as effective as monolingual revision. The 19,407-word corpus comprised translations from the E?F pair (translated and revised in Canada) and from the F?E pair (translated and revised in the United States). Each sub-corpus (E?F and F?E) was analyzed by a team of scholars and/or revisers, according to Louise Brunette's (1997) revision criteria: accuracy, readability, appropriateness and linguistic coding. The study looked at the number of corrections, omissions and revisor-injected errors, in relation to these four criteria.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1556/acr.6.2005.1.3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu23 citations 23 popularity Average influence Top 10% impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1556/acr.6.2005.1.3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 AustraliaWiley Vijaya M, Musini; Kendra Ak, Lawrence; Patricia M, Fortin; Ken, Bassett; James M, Wright;pmc: PMC6478238
handle: 10453/129051
Background Hypertension is a chronic condition associated with an increased risk of mortality and morbidity. Renin is the enzyme responsible for converting angiotensinogen to angiotensin I, which is then converted to angiotensin II. Renin inhibitors are a new class of drugs that decrease blood pressure (BP) by preventing the formation of both angiotensin I and angiotensin II. Objectives To quantify the dose-related BP lowering efficacy of renin inhibitors compared to placebo in the treatment of primary hypertension. To determine the change in BP variability, pulse pressure, and heart rate and to evaluate adverse events (mortality, non-fatal serious adverse events, total adverse events, withdrawal due to adverse effects and specific adverse events such as dry cough, diarrhoea and angioedema). Search methods The Cochrane Hypertension Information Specialist searched the following databases for randomized controlled trials (RCTs) up to February 2017: the Cochrane Hypertension Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2017, Issue 2), MEDLINE (from 1946), Embase (from 1974), the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov. There was no restriction by language or publication status. We also searched the European Medicines Agency (EMA) for clinical study reports, the Novartis Clinical Study Results Database, bibliographic citations from retrieved references, and contacted authors of relevant papers regarding further published and unpublished work. Selection criteria We included randomized, double-blinded, placebo-controlled studies evaluating BP lowering efficacy of fixed-dose monotherapy with renin inhibitor compared with placebo for a minimum duration of three to 12 weeks in adult patients with primary hypertension. Data collection and analysis This systematic review is a comprehensive update which includes four additional studies and extensive detail from nine clinical study reports (CSRs) of previously included studies obtained from EMA. The remaining three CSRs are not available. Two review authors independently assessed study eligibility and extracted data. In all cases where there was a difference between the CSR and the published report, data from the CSR was used. Dichotomous outcomes were reported as risk ratio (RR) with 95% confidence intervals (CIs) and continuous outcomes as mean difference (MD) with 95% CIs. Main results 12 studies (mean duration of eight weeks) in 7439 mostly Caucasian patients (mean age 54 years) with mild-to-moderate uncomplicated hypertension were eligible for inclusion in the review. Aliskiren was the only renin inhibitor evaluated. All included studies were assessed to have high likelihood of attrition, reporting and funding bias. Aliskiren has a dose-related systolic/diastolic blood pressure (SBP/DBP) lowering effect as compared with placebo MD with 95% CI: aliskiren 75 mg (MD -2.97, 95% CI -4.76 to -1.18)/(MD -2.05, 95% CI -3.13 to -0.96) mm Hg (moderate-quality evidence), aliskiren 150 mg (MD -5.95, 95% CI -6.85 to -5.06)/ (MD -3.16, 95% CI -3.74 to -2.58) mm Hg (moderate-quality evidence), aliskiren 300 mg (MD -7.88, 95% CI -8.94 to -6.82)/ (MD -4.49, 95% CI -5.17 to -3.82) mm Hg (moderate-quality evidence), aliskiren 600 mg (MD -11.35, 95% CI -14.43 to -8.27)/ (MD -5.86, 95% CI -7.73 to -3.99) mm Hg (low-quality evidence). There was a dose-dependent decrease in blood pressure for aliskiren 75 mg, 150 mg and 300 mg. The blood pressure lowering effect of aliskiren 600 mg was not different from 300 mg (MD -0.61, 95% CI -2.78 to 1.56)/(MD -0.68, 95% CI -2.03 to 0.67). Aliskiren had no effect on blood pressure variability. Due to very limited information available regarding change in heart rate and pulse pressure, it was not possible to meta-analyze these outcomes. Mortality and non-fatal serious adverse events were not increased. This review found that in studies of eight week duration aliskiren may not increase withdrawal due to adverse events (low-quality evidence). Diarrhoea was increased in a dose-dependent manner (RR 7.00, 95% CI 2.48 to 19.72) with aliskiren 600 mg (low-quality evidence). The most frequent adverse events reported were headache, nasopharyngitis, diarrhoea, dizziness and fatigue. Authors' conclusions Compared to placebo, aliskiren lowered BP and this effect is dose-dependent. This magnitude of BP lowering effect is similar to that for angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). There is no difference in mortality, nonfatal serious adverse events or withdrawal due to adverse effects with short term aliskiren monotherapy. Diarrhoea was considerably increased with aliskiren 600 mg.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/14651858.cd007066.pub3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu61 citations 61 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/14651858.cd007066.pub3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu