• Canada

Carrying capacity is one of the most important, yet least understood and rarely estimated, parameters in population management and modeling. A simple behavioral metric of carrying capacity would advance theory, conservation, and management of biological populations. Such a metric should be possible because behavior is finely attuned to variation in environment including population density. We connect optimal foraging theory with population dynamics and life history to develop a simple model that predicts this sort of adaptive density-dependent change in food consumption. We then confirm the model's unexpected and manifold predictions with field experiments. The theory predicts reproductive thresholds that alter the marginal value of energy as well as the value of time. Both effects cause a pronounced discontinuity in quitting-harvest rate that we revealed with foraging experiments. Red-backed voles maintained across a range of high densities foraged at a lower density-dependent rate than the same animals exposed to low-density treatments. The change in harvest rate is diagnostic of populations that exceed their carrying capacity. Ecologists, conservation biologists, and wildlife managers may thus be able to use simple and efficient foraging experiments to estimate carrying capacity and habitat quality.

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Obese patients have a decreased risk of death on dialysis but an increased risk of death after transplantation, and may derive a lower survival benefit from transplantation. Using data from the United States between 1995 and 2007 and multivariate non-proportional hazards analyses we determined the relative risk of death in transplant recipients grouped by body mass index (BMI) compared to wait-listed candidates with the same BMI (n = 208 498). One year after transplantation the survival benefit of transplantation varied by BMI: Standard criteria donor transplantation was associated with a 48% reduction in the risk of death in patients with BMI ≥ 40 kg/m(2) but a ≥ 66% reduction in patients with BMI40 kg/m2. Living donor transplantation was associated with ≥ 66% reduction in the risk of death in all BMI groups. In sub-group analyses, transplantation from any donor source was associated with a survival benefit in obese patients ≥ 50 years, and diabetic patients, but a survival benefit was not demonstrated in Black patients with BMI ≥ 40 kg/m(2). Although most obese patients selected for transplantation derive a survival benefit, the benefit is lower when BMI is ≥ 40 kg/m(2), and uncertain in Black patients with BMI ≥ 40 kg/m(2).

When leaning toward a partner for a kiss, the direction that individuals turn their head when planting the kiss is found to vary based on the kiss’s context; romantic kissing between adult couples is consistently directed rightward, though recently, a non-romantic kiss between parent–child couples was observed to be leftward. The current study further examines the lateral head-turning direction between non-romantic couples using a novel context: a first kiss between strangers. Observing strangers kissing was feasible due to a unique social media phenomenon; since 2014, 23 “First Kiss” online videos have emerged which depict kisses facilitated by the video’s director between consenting strangers. The turning direction of 230 kissing couples were coded from the 23 First Kiss videos, and the proportion of right to left turns were almost equal; 51% of couples displayed a right-turn kiss, and 49% conveyed a left-turn kiss. Further, the proportion of right and left turns observed from our sample of strangers kissing were compared to Gunturkun’s (in Nature 421:711, https://doi.org/10.1038/421711a , 2003) original study that examined authentic kissing between adult couples. A significantly different turning bias was exhibited. Because the kissing criterion was parallel between these studies, our study demonstrates that the context influenced the direction of bias, namely, that of a non-romantic kiss. We discuss the potential role of context and emotional lateralization on kissing laterality, and propose future directions to test these predictions.

<div> <div> <div> <p>Small-molecule (micro)arrays were developed to measure three metabolites simultaneously by surface plasmon resonance imaging for the first time. To tackle the low sensitivity challenge associated with small molecule detection, antibodies were employed as the signal amplifiers. This work demonstrates both inhibition and displacement formats are applicable for sensitive multiplex metabolites detection. </p> </div> </div> </div>

We report the first direct turbulence observations in the Samoan Passage (SP), a 40 km wide notch in the South Pacific bathymetry through which flows most of the water supplying the North Pacific abyssal circulation. The observed turbulence is 1000 to 10,000 times typical abyssal levels —strong enough to completely mix away the densest water entering the passage—confirming inferences from previous coarser temperature and salinity sections. Accompanying towed measurements of velocity and temperature with horizontal resolution of about 250 m indicate the dominant processes responsible for the turbulence. Specifically, the flow accelerates substantially at the primary sill within the passage, reaching speeds as great as 0.55 m s−1. A strong hydraulic response is seen, with layers first rising to clear the sill and then plunging hundreds of meters downward. Turbulence results from high shear at the interface above the densest fluid as it descends and from hydraulic jumps that form downstream of the sill. In addition to the primary sill, other locations along the multiple interconnected channels through the Samoan Passage also have an effect on the mixing of the dense water. In fact, quite different hydraulic responses and turbulence levels are observed at seafloor features separated laterally by a few kilometers, suggesting that abyssal mixing depends sensitively on bathymetric details on small scales.

Abstract: Neuronal injury during acute hypoxia, ischemia, and following reperfusion are partially attributable to oxidative damage caused by deleterious fluctuations of reactive oxygen species (ROS). In particular, mitochondrial superoxide (O2•-) production is believed to upsurge during lowoxygen conditions and also following reperfusion, before being dismutated to H2O2 and released into the cell. However, disruptions of redox homeostasis may be beneficially attenuated in the brain of hypoxia-tolerant species, such as the naked mole-rat (NMR, Heterocephalus glaber). As such, we hypothesized that ROS homeostasis is better maintained in the brain of NMRs during severe hypoxic/ ischemic insults and following reperfusion. We predicted that NMR brain would not exhibit substantial fluctuations in ROS during hypoxia or reoxygenation, unlike previous reports from hypoxiaintolerant mouse brain. To test this hypothesis, we measured cortical ROS flux using corrected total cell fluorescence measurements from live brain slices loaded with the MitoSOX red superoxide (O2•-) indicator or chloromethyl 2’,7’-dichlorodihydrofluorescein diacetate (CM-H2-DCFDA; which fluoresces with whole-cell hydrogen peroxide (H2O2) production) during various low-oxygen treatments, exogenous oxidative stress, and reperfusion. We found that NMR cortex maintained ROS homeostasis during low-oxygen conditions, while mouse cortex exhibited a ~40% increase and a ~30% decrease in mitochondrial O2•- and cellular H2O2 production, respectively. Mitochondrial ROS homeostasis in NMRs was only disrupted following sodium cyanide application, which was similarly observed in mice. Our results suggest that NMRs have evolved strategies to maintain ROS homeostasis during acute bouts of hypoxia and reoxygenation, potentially as an adaptation to life in an intermittently hypoxic environment.

We have derived values of the Ultraviolet Index (UVI) at solar noon using the Tropospheric Ultraviolet Model (TUV) driven by ozone, temperature and aerosol fields from climate simulations of the first phase of the Chemistry-Climate Model Initiative (CCMI-1). Since clouds remain one of the largest uncertainties in climate projections, we simulated only the clear-sky UVI. We compared the modelled UVI climatologies against present-day climatological values of UVI derived from both satellite data (the OMI-Aura OMUVBd product) and ground-based measurements (from the NDACC network). Depending on the region, relative differences between the UVI obtained from CCMI/TUV calculations and the ground-based measurements ranged between −5.9% and 10.6%. We then calculated the UVI evolution throughout the 21st century for the four Representative Concentration Pathways (RCPs 2.6, 4.5, 6.0 and 8.5). Compared to 1960s values, we found an average increase in the UVI in 2100 (of 2–4%) in the tropical belt (30°N-30°S). For the mid-latitudes, we observed a 1.8 to 3.4 % increase in the Southern Hemisphere for RCP 2.6, 4.5 and 6.0, and found a 2.3% decrease in RCP 8.5. Higher increases in UVI are projected in the Northern Hemisphere except for RCP 8.5. At high latitudes, ozone recovery is well identified and induces a complete return of mean UVI levels to 1960 values for RCP 8.5 in the Southern Hemisphere. In the Northern Hemisphere, UVI levels in 2100 are higher by 0.5 to 5.5% for RCP 2.6, 4.5 and 6.0 and they are lower by 7.9% for RCP 8.5. We analysed the impacts of greenhouse gases (GHGs) and ozone-depleting substances (ODSs) on UVI from 1960 by comparing CCMI sensitivity simulations (1960–2100) with fixed GHGs or ODSs at their respective 1960 levels. As expected with ODS fixed at their 1960 levels, there is no large decrease in ozone levels and consequently no sudden increase in UVI levels. With fixed GHG, we observed a delayed return of ozone to 1960 values, with a corresponding pattern of change observed on UVI, and looking at the UVI difference between 2090s values and 1960s values, we found an 8 % increase in the tropical belt during the summer of each hemisphere. Finally we show that, while in the Southern Hemisphere the UVI is mainly driven by total ozone column, in the Northern Hemisphere both total ozone column and aerosol optical depth drive UVI levels, with aerosol optical depth having twice as much influence on the UVI as total ozone column does.