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3,993 research outcomes, page 1 of 400
  • publication . Article . 2010
    Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
    Open Access English
    Authors:
    Rachel M. Freathy; Dennis O. Mook-Kanamori; Ulla Sovio; Inga Prokopenko; Nicholas J. Timpson; Diane J. Berry; Nicole M. Warrington; E. Widen; Jouke-Jan Hottenga; Marika Kaakinen; ...
    Persistent Identifiers

    doi: 10.1038/ng.567

    handle: 1959.8/154560 , 1765/28299 , 20.500.11820/7582c54d-7c87-4243-aa35-9988f527d4ad , 11370/288ced31-6caa-4b25-9ea8-26b14ceeda7e , 11858/00-001M-0000-0029-54FA-A , 11858/00-001M-0000-0029-54FC-6 , 1871/34385

    pmc: PMC2862164

    pmid: 20372150

    Publisher: US : Nature Publishing Group
    Project: UKRI | Centre for molecular-base... (G0600705), UKRI | Translating genome-wide a... (G0601261), NIH | CANDIDATE GENE STUDIES OF... (3R01DK075787-07S1), NWO | Twin-family database for ... (2200125679), NIH | Genetic Epidemiology of B... (5R01DK078150-03), NWO | tweeling onderzoek, met e... (2300133572), NIH | Whole Genome Assoc. Analy... (1RL1MH083268-01), NIH | AN INTERDISCIPLINARY STRA... (5P20RR020649-02), NIH | Obesity development and C... (1R01HL085144-01), NIH | Genetic Influences on ADH... (1R01MH063706-01),...

    To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCN...

  • publication . Article . 2019
    Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research
    Open Access English
    Authors:
    Ghita, Mihaela; Brown, Kathryn H.; Kelada, Olivia J.; Graves, Edward E.; Butterworth, Karl T.;
    Persistent Identifiers

    doi: 10.3390/cancers11020170

    pmc: PMC6406472

    pmid: 30717307

    Publisher: MDPI AG
    Project: UKRI | Refinement of soft tissue... (NC/R001553/1)

    Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of ...

  • publication . Preprint . 2020
    Ultra-low DNA input into whole genome methylation assays and detection of oncogenic methylation & copy number variants in circulating tumour DNA
    Open Access
    Authors:
    Celina Whalley; Karl Payne; Enric Domingo; Andrew Blake; Susan D. Richman; Jill Brooks; Nikolaos Batis; Rachel Spruce; Hisham Mehanna; Paul Nankivell; ...
    Persistent Identifiers

    doi: 10.1101/2020.02.11.20021964

    Publisher: Cold Spring Harbor Laboratory
    Project: WT , UKRI | MICA: Stratification in C... (MR/M016587/1)

    AbstractBackgroundCpG methylation in cancer is ubiquitous and generally detected in tumour specimens using a variety of techniques at a resolution encompassing single CpG loci to genome wide. Analysis of samples with very low DNA inputs, such as formalin fixed (FFPE) bi...

  • publication . Article . Preprint . 2018
    Quantum computational chemistry
    Open Access English
    Authors:
    McArdle, Sam; Endo, Suguru; Aspuru-Guzik, Alán; Benjamin, Simon C.; Yuan, Xiao;
    Persistent Identifiers

    doi: 10.1103/revmodphys.92.015003

    Project: UKRI | UK Quantum Technology Hub... (EP/M013243/1)

    Comment: Major updates: improvements to introduction and future work sections, added examples throughout, added additional references, streamlined sections on near-term approaches

  • publication . Article . 2012
    A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans
    Open Access English
    Authors:
    Huiyun Feng; John S. Reece-Hoyes; Albertha J.M. Walhout; Ian A. Hope;
    Persistent Identifiers

    doi: 10.1016/j.gene.2011.11.042

    pmc: PMC3271191

    pmid: 22207033

    Publisher: Elsevier B.V.
    Project: NIH | Gene regulatory network s... (4R01GM082971-08), WT | Methodologies and resourc... (082603), UKRI | Systems biology of the Ca... (BB/E008038/1), NIH | Gene Regulatory Networks ... (2R01DK068429-06A1)

    Homeobox proteins are critical regulators of developmental gene transcription and cell specification. Many insights into transcriptional regulation have been gained from studies in the nematode Caenorhabditis elegans. We investigated the expression and regulation of the...

  • publication . Article . 2016
    Feralisation targets different genomic loci to domestication in the chicken
    Open Access
    Authors:
    M. Johnsson; E. Gering; P. Willis; S. Lopez; L. Van Dorp; G. Hellenthal; R. Henriksen; U. Friberg; D. Wright;
    Persistent Identifiers

    doi: 10.1038/ncomms12950

    pmc: PMC5056458

    pmid: 27686863

    Publisher: Springer Science and Business Media LLC
    Project: UKRI | Evolutionary processes sh... (BB/L009382/1), WT | Inferring human colonizat... (098386), UKRI | LSI Doctoral Training Cen... (EP/F500351/1), NSF | BEACON: An NSF Center for... (0939454)

    Feralisation occurs when a domestic population recolonizes the wild, escaping its previous restricted environment, and has been considered as the reverse of domestication. We have previously shown that Kauai Island's feral chickens are a highly variable and admixed popu...

  • publication . Article . Preprint . 2018
    The velocity anisotropy of the Milky Way satellite system
    Open Access English
    Authors:
    Riley, Alexander H; Fattahi, Azadeh; Pace, Andrew B; Strigari, Louis E; Frenk, Carlos S; Gómez, Facundo A; Grand, Robert J J; Marinacci, Federico; Navarro, Julio F; Pakmor, Rüdiger; ...
    Persistent Identifiers

    doi: 10.1093/mnras/stz973

    Project: EC | DIFERENS2 (609412), UKRI | The Virgo consortium for ... (ST/H008519/1), EC | DMIDAS (786910), UKRI | Durham DiRAC-2 petascale ... (ST/K003267/1), UKRI | Durham DiRAC-2 petascale ... (ST/K00042X/1), UKRI | Durham Astronomy Consolid... (ST/P000541/1)

    Comment: 16 pages, 8 figures. Key results are summarized in Figures 6 and 7. Accepted to MNRAS

  • publication . Preprint . Article . 2020
    Lectures on the Calabi-Yau Landscape
    Open Access English
    Authors:
    Jiakang Bao; He, Yang-Hui; Hirst, Edward; Pietromonaco, Stephen;
    Project: UKRI | Theoretical Particle Phys... (ST/J00037X/1)

    In these lecture notes, we survey the landscape of Calabi-Yau threefolds, and the use of machine learning to explore it. We begin with the compact portion of the landscape, focusing in particular on complete intersection Calabi-Yau varieties (CICYs) and elliptic fibrati...

  • publication . Other literature type . Article . Research . Preprint . 2017
    Max Point-Tolerance Graphs
    Open Access English
    Authors:
    Daniele Catanzaro; Steven Chaplick; Stefan Felsner; Bjarni V. Halldorsson; Magnús M. Halldórsson; Thomas Hixon; Juraj Stacho;
    Persistent Identifiers

    doi: 10.1016/j.dam.2015.08.019

    Project: NSERC , UKRI | Clique-width of graphs (EP/I01795X/1)

    Comment: Accepted to the Journal of Discrete Applied Mathematics

  • publication . Article . 2017
    EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction
    Open Access
    Authors:
    Dirk Mielenz; Martin Reichel; Tianye Jia; Erin Burke Quinlan; T Stöckl; M Mettang; D Zilske; Elif Kirmizi-Alsan; P Schönberger; Marc Praetner; ...
    Persistent Identifiers

    doi: 10.1038/mp.2017.63

    pmc: PMC5984092

    pmid: 28397836

    Publisher: Springer Science and Business Media LLC
    Project: WT , NIH | ENIGMA Center for Worldwi... (3U54EB020403-04S1), EC | MATRICS (603016), EC | AGGRESSOTYPE (602805), UKRI | Consortium on Vulnerabili... (MR/N000390/1), ANR | ADODEP (ANR-12-SAMA-0004), NIH | Axon, Testosterone and Me... (5R01MH085772-02), EC | IMAGEMEND (602450), EC | EU-AIMS (115300)

    In many societies, the majority of adults regularly consume alcohol. However, only a small proportion develops alcohol addiction. Individuals at risk often show a high sensation-seeking/low-anxiety behavioural phenotype. Here we asked which role EF hand domain containin...

3,993 research outcomes, page 1 of 400