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Variations in fatty acid synthesis and desaturation in dogs receiving normal and high sugar diets using on‐line gas chromatography/pyrolysis/isotope ratio mass spectrometry
descriptionPublicationkeyboard_double_arrow_right Article 2007Wiley
Authors: Ruifang Wang; Kevin P. Bateman; Scott V Harding; Brian K. Kennedy; +1 Authors
Ruifang Wang; Kevin P. Bateman; Scott V Harding; Brian K. Kennedy; Peter B. Jones;
doi: 10.1096/fasebj.21.5.a701-a
doi: 10.1096/fasebj.21.5.a701-a
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Article . 2007
License: http://onlinelibrary.wiley.com/termsAndConditions#vor
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SPRED1 in quadriceps of patients with mild chronic obstructive pulmonary disease (1102.21)
descriptionPublicationkeyboard_double_arrow_right Article 2014Wiley
Authors: Alexandra Porlier; Annie Dubé; Richard Debigaré; François Maltais;
Alexandra Porlier; Annie Dubé; Richard Debigaré; François Maltais;
doi: 10.1096/fasebj.28.1_supplement.1102.21
doi: 10.1096/fasebj.28.1_supplement.1102.21
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Article . 2014
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The origins of the clonal selection theory of immunity as a case study for evaluation in science
descriptionPublicationkeyboard_double_arrow_right Article 1995Wiley
Authors: Donald R. Forsdyke;
Donald R. Forsdyke;
doi: 10.1096/fasebj.9.2.7781918
pmid: 7781918
doi: 10.1096/fasebj.9.2.7781918
pmid: 7781918
Evaluation of high achievement forms part of an evaluation continuum operating throughout the scientific enterprise. Correct evaluation of individuals and their work means that the best work is published and the most able individuals obtain researchgrants and awards. It is important that evaluations be carried out fairly and objectively. This paper reviews evaluations of the roles of Ehrlich, Jerne, Talmage, and Burnet in the conception and development of the clonal selection theory. These evaluations show varying degrees of bias; in particular, the major role of Ehrlich tends to be overlooked. The objective record shows that Talmage first conceived clonal selection. The proclivity of evaluation in science toward error suggests that our evaluation processes should be redesigned to take this into account.
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Article . 1995
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Article . 1995
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32
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Article . 1995
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Reducing Turbulent Airflow Lowers Healthy Females Work Of Breathing During Exercise To A Level Similar To Males
descriptionPublicationkeyboard_double_arrow_right Article 2020Wiley
Authors: Emily A. Granger; Leah M Mann; Jason S. Chan; Annie Yu; +1 Authors
Emily A. Granger; Leah M Mann; Jason S. Chan; Annie Yu; Paolo B. Dominelli;
doi: 10.1096/fasebj.2020.34.s1.05355
doi: 10.1096/fasebj.2020.34.s1.05355
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Article . 2020
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Effects of nitric oxide on HIF‐1α and FIH‐1 following Clostridium difficile toxin exposure
descriptionPublicationkeyboard_double_arrow_right Article 2010Wiley CIHR
CIHR
Authors: Joshua Youngun Lee; Simon A. Hirota; Danya Traboulsi; Paul L. Beck; +1 Authors
Joshua Youngun Lee; Simon A. Hirota; Danya Traboulsi; Paul L. Beck; Justin A. MacDonald;
doi: 10.1096/fasebj.24.1_supplement.lb658
doi: 10.1096/fasebj.24.1_supplement.lb658
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Article . 2010
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Separating genetic and hemodynamic defects in neuropilin 1
descriptionPublicationkeyboard_double_arrow_right Article 2009Wiley NSERC
NSERC
Authors: Elizabeth A. V. Jones; Li Yuan; Christiane Bréant; Ryan J. Watts; +1 Authors
Elizabeth A. V. Jones; Li Yuan; Christiane Bréant; Ryan J. Watts; Anne Eichmann;
doi: 10.1096/fasebj.23.1_supplement.311.1
doi: 10.1096/fasebj.23.1_supplement.311.1
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Article . 2009
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Autophagy and Heat Shock Responses in Human Peripheral Blood Mononuclear Cells During Physiologically Relevant Heat Stress Conditions
descriptionPublicationkeyboard_double_arrow_right Article 2020Wiley
Authors: Kelli E. King; James J. McCormick; Melissa D. Côté; Morgan K. McManus; +2 Authors
Kelli E. King; James J. McCormick; Melissa D. Côté; Morgan K. McManus; Serena Topshee; Glen P. Kenny;
doi: 10.1096/fasebj.2020.34.s1.05200
doi: 10.1096/fasebj.2020.34.s1.05200
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Comparative structural biology of human and opossum AT 1 Rs reveals different ARB binding sites
descriptionPublicationkeyboard_double_arrow_right Article 2015Wiley
Authors: Andrew Chandler; Tomomi Kurita; Abdelaziz Alsamarah; Rhye-Samuel Kanassatega; +2 Authors
Andrew Chandler; Tomomi Kurita; Abdelaziz Alsamarah; Rhye-Samuel Kanassatega; Yun Luo; Bradley T. Andresen;
doi: 10.1096/fasebj.29.1_supplement.971.1
doi: 10.1096/fasebj.29.1_supplement.971.1
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Article . 2015
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Examining the Correlation Between Cellular and Gross Morphological Changes In the Developing Mouse Skull
descriptionPublicationkeyboard_double_arrow_right Article 2018Wiley NSERC
NSERC
Authors: Sommer G.E. Jarvis; Jae Eun Lee; Gregory M. Kelly; Katherine E. Willmore;
Sommer G.E. Jarvis; Jae Eun Lee; Gregory M. Kelly; Katherine E. Willmore;
doi: 10.1096/fasebj.2018.32.1_supplement.232.2
doi: 10.1096/fasebj.2018.32.1_supplement.232.2
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Article . 2018
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Role of Reactive Oxygen Species in the Neural and Hormonal Regulation of the PNMT Gene in PC12 Cells
descriptionPublicationkeyboard_double_arrow_right Article 2011Hindawi Limited NSERC
NSERC
Authors: James Crispo; Dominique Ansell; Gino Ubriaco; T. C. Tai;
James Crispo; Dominique Ansell; Gino Ubriaco; T. C. Tai;
doi: 10.1155/2011/756938 , 10.1096/fasebj.25.1_supplement.lb579
pmid: 22007271
pmc: PMC3189585
doi: 10.1155/2011/756938 , 10.1096/fasebj.25.1_supplement.lb579
pmid: 22007271
pmc: PMC3189585
The stress hormone, epinephrine, is produced predominantly by adrenal chromaffin cells and its biosynthesis is regulated by the enzyme phenylethanolamine N-methyltransferase (PNMT). Studies have demonstrated that PNMT may be regulated hormonally via the hypothalamic-pituitary-adrenal axis and neurally via the stimulation of the splanchnic nerve. Additionally, hypoxia has been shown to play a key role in the regulation of PNMT. The purpose of this study was to examine the impact of reactive oxygen species (ROS) produced by the hypoxia mimetic agent CoCl2, on the hormonal and neural stimulation of PNMT in an in vitro cell culture model, utilizing the rat pheochromocytoma (PC12) cell line. RT-PCR analyses show inductions of the PNMT intron-retaining and intronless mRNA splice variants by CoCl2(3.0- and 1.76-fold, respectively). Transient transfection assays of cells treated simultaneously with CoCl2and the synthetic glucocorticoid, dexamethasone, show increased promoter activity (18.5-fold), while mRNA levels of both splice variants do not demonstrate synergistic effects. Similar results were observed when investigating the effects of CoCl2-induced ROS on the neural stimulation of PNMT via forskolin. Our findings demonstrate that CoCl2-induced ROS have synergistic effects on hormonal and neural activation of the PNMT promoter.
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Oxidative Medicine and Cellular Longevity
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4,633 Research products

Variations in fatty acid synthesis and desaturation in dogs receiving normal and high sugar diets using on‐line gas chromatography/pyrolysis/isotope ratio mass spectrometry
descriptionPublicationkeyboard_double_arrow_right Article 2007Wiley
Authors: Ruifang Wang; Kevin P. Bateman; Scott V Harding; Brian K. Kennedy; +1 Authors
Ruifang Wang; Kevin P. Bateman; Scott V Harding; Brian K. Kennedy; Peter B. Jones;
doi: 10.1096/fasebj.21.5.a701-a
doi: 10.1096/fasebj.21.5.a701-a
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SPRED1 in quadriceps of patients with mild chronic obstructive pulmonary disease (1102.21)
descriptionPublicationkeyboard_double_arrow_right Article 2014Wiley
Authors: Alexandra Porlier; Annie Dubé; Richard Debigaré; François Maltais;
Alexandra Porlier; Annie Dubé; Richard Debigaré; François Maltais;
doi: 10.1096/fasebj.28.1_supplement.1102.21
doi: 10.1096/fasebj.28.1_supplement.1102.21
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The FASEB Journal
Article . 2014
License: http://onlinelibrary.wiley.com/termsAndConditions#vor
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The origins of the clonal selection theory of immunity as a case study for evaluation in science
descriptionPublicationkeyboard_double_arrow_right Article 1995Wiley
Authors: Donald R. Forsdyke;
Donald R. Forsdyke;
doi: 10.1096/fasebj.9.2.7781918
pmid: 7781918
doi: 10.1096/fasebj.9.2.7781918
pmid: 7781918
Evaluation of high achievement forms part of an evaluation continuum operating throughout the scientific enterprise. Correct evaluation of individuals and their work means that the best work is published and the most able individuals obtain researchgrants and awards. It is important that evaluations be carried out fairly and objectively. This paper reviews evaluations of the roles of Ehrlich, Jerne, Talmage, and Burnet in the conception and development of the clonal selection theory. These evaluations show varying degrees of bias; in particular, the major role of Ehrlich tends to be overlooked. The objective record shows that Talmage first conceived clonal selection. The proclivity of evaluation in science toward error suggests that our evaluation processes should be redesigned to take this into account.
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Article . 1995
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Reducing Turbulent Airflow Lowers Healthy Females Work Of Breathing During Exercise To A Level Similar To Males
descriptionPublicationkeyboard_double_arrow_right Article 2020Wiley
Authors: Emily A. Granger; Leah M Mann; Jason S. Chan; Annie Yu; +1 Authors
Emily A. Granger; Leah M Mann; Jason S. Chan; Annie Yu; Paolo B. Dominelli;
doi: 10.1096/fasebj.2020.34.s1.05355
doi: 10.1096/fasebj.2020.34.s1.05355
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Effects of nitric oxide on HIF‐1α and FIH‐1 following Clostridium difficile toxin exposure
descriptionPublicationkeyboard_double_arrow_right Article 2010Wiley CIHR
CIHR
Authors: Joshua Youngun Lee; Simon A. Hirota; Danya Traboulsi; Paul L. Beck; +1 Authors
Joshua Youngun Lee; Simon A. Hirota; Danya Traboulsi; Paul L. Beck; Justin A. MacDonald;
doi: 10.1096/fasebj.24.1_supplement.lb658
doi: 10.1096/fasebj.24.1_supplement.lb658
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The FASEB Journal

Variations in fatty acid synthesis and desaturation in dogs receiving normal and high sugar diets using on‐line gas chromatography/pyrolysis/isotope ratio mass spectrometry

SPRED1 in quadriceps of patients with mild chronic obstructive pulmonary disease (1102.21)

The origins of the clonal selection theory of immunity as a case study for evaluation in science

Reducing Turbulent Airflow Lowers Healthy Females Work Of Breathing During Exercise To A Level Similar To Males

Effects of nitric oxide on HIF‐1α and FIH‐1 following Clostridium difficile toxin exposure

Separating genetic and hemodynamic defects in neuropilin 1

Autophagy and Heat Shock Responses in Human Peripheral Blood Mononuclear Cells During Physiologically Relevant Heat Stress Conditions

Comparative structural biology of human and opossum AT 1 Rs reveals different ARB binding sites

Examining the Correlation Between Cellular and Gross Morphological Changes In the Developing Mouse Skull

Role of Reactive Oxygen Species in the Neural and Hormonal Regulation of the PNMT Gene in PC12 Cells

Variations in fatty acid synthesis and desaturation in dogs receiving normal and high sugar diets using on‐line gas chromatography/pyrolysis/isotope ratio mass spectrometry

SPRED1 in quadriceps of patients with mild chronic obstructive pulmonary disease (1102.21)

The origins of the clonal selection theory of immunity as a case study for evaluation in science

Reducing Turbulent Airflow Lowers Healthy Females Work Of Breathing During Exercise To A Level Similar To Males

Effects of nitric oxide on HIF‐1α and FIH‐1 following Clostridium difficile toxin exposure

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	citations	32
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