Abstract Chronic diabetes due to streptozotocin administration has been shown to induce heart dysfunction characterized by prolonged relaxation time as well as decreased Ca 2+ transport and Ca 2+ -ATPase (SERCA2) activities of the cardiac sarcoplasmic reticulum (SR). Ra...

The recently discovered CLECSF6 protein displays the features of a receptor involved in the down-modulation of leukocyte activation. Although CLECSF6 has been the focus of the interest of many researchers lately, a Western blot characterization of the protein is still l...

Differential expression during rat development of three genes for calmodulin (CaM I-III) was examined in amnion, decidua, embryo, liver, placenta, parietal and visceral yolk sacs and uterus. CaMI expression was constant except for increasing activity in VYS during gesta...

Abstract Two human lymphoblastoid cell lines and K-562 cells were found to take up radioiodinated transferrin and transferrin-bound iron in amounts comparable to reticulocytes. These cell lines were also shown to possess transferrin receptors whose numbers and affinity ...

The fusion peptide of influenza viral hemagglutinin plays a critical role in virus entry by facilitating membrane fusion between the virus and target cells. As the fusion peptide is the only universally conserved epitope in all influenza A and B viruses, it could be an ...

We had previously identified a protein kinase C (PKC) inhibitor in murine neuroblastoma cells (Chakravarthy et al. [1]). Similar PKC inhibitory activity was also found in adult rat brain. Using polyclonal antibodies raised against the partially purified PKC inhibitor fr...

Summary The crystal and molecular structure of 4-hydroperoxycyclophosphamide, an active cytostatic agent closely related to an active metabolite of the antitumor drug cyclophosphamide, has been determined by X-ray crystallography. The configuration at the phosphorus ato...

Abstract The direct action of a potent LHRH agonist, [D-Ser-(TBU) 6 , des-Gly-NH 2 10 ]LHRH ethylamide was studied in porcine granulosa cells in primary culture. The LHRH agonist inhibits by 30 to 55% the stimulatory effect of FSH on cyclic AMP accumulation up to 9 hour...

The Maf protein family consists of eight transcription factors containing a basic-leucine zipper (bZIP) domain. We have previously reported that the mRNA to one of these members, mafG/adapt66, is induced by oxidative stress in hamster HA-1 cells. It has subsequently bee...

Abstract The serum of the winter flounder Pseudopleuronectus americanus contains a freezing-point-depressing protein of a molecular weight approximately 10,000 with 60% alanine in its composition. When injected into Xenopus oőcyte, a 6–10 S, poly A-rich RNA preparation ...