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6,470 research outcomes, page 1 of 647
  • publication . Preprint . 2017
    Open Access
    Authors:
    John R. Tyson; Nigel J. O'Neil; Miten Jain; Hugh E. Olsen; Philip Hieter; Terrance P. Snutch;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Center for Big Data in Tr... (3U54HG007990-03S3), CIHR

    ABSTRACTAdvances in 3rd generation sequencing have opened new possibilities for ‘benchtop’ whole genome sequencing. The MinION is a portable device that uses nanopore technology and can sequence long DNA molecules. MinION long reads are well suited for sequencing and de...

  • publication . 2018
    Open Access English
    Authors:
    Squillario, Margherita; Tomasi, Federico; Tozzo, Veronica; Barla, Annalisa; Uberti, Daniela; for the Alzheimer’s Disease Neuroimaging Initiative;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), CIHR

    SummaryThe purpose of this study is to identify a global and robust signature characterizing Alzheimer’s Disease (AD). Two public GWAS datasets were analyzed considering a 3-fold kernel approach, based on SNPs, Genes and Pathways analysis, and two binary classifications...

  • publication . Article . 2018
    Open Access
    Authors:
    Scott, Shane; Xu, Zhi Ming; Kouzine, Fedor; Berard, Daniel J.; Shaheen, Cynthia; Gravel, Barbara; Saunders, Laura; Hofkirchner, Alexander; Leroux, Catherine; Laurin, Jill; ...
    Publisher: Oxford University Press (OUP)
    Project: NSERC

    ABSTRACTWe directly visualize the topology-mediated interactions between an unwinding site on a supercoiled DNA plasmid and a specific probe molecule designed to bind to this site, as a function of DNA supercoiling and temperature. The visualization relies on containing...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Zachary T. Sherker;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    AbstractThis project investigates the role of fisheries management in the conservation of loggerhead (Caretta caretta) and leatherback sea turtles (Dermochelys coriacea), both of which are currently listed as vulnerable by the IUCN (International Union for Conservation ...

  • publication . Preprint . 2020
    Open Access
    Authors:
    Feldman, Tzah; Bercovich, Akhiad; Moskovitz, Yoni; Chapal-Ilani, Noa; Mitchell, Amanda; Medeiros, Jessie JF; Kaushansky, Nathali; Biezuner, Tamir; Minden, Mark D; Gupta, Vikas; ...
    Persistent Identifiers
    Publisher: bioRxiv
    Project: EC | MAMLE (714731)

    The mechanisms underlying myeloid malignancies deletions are not well understood, nor is it clear why specific genomic hotspots are predisposed to particular deletions. In the current study we inspected the genomic regions around recurrent deletions in myeloid malignanc...

  • publication . Preprint . 2017
    Open Access
    Authors:
    Murdison Ts; Gunnar Blohm; Frank Bremmer;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NSERC

    AbstractDespite motion on the retina with every saccade, we perceive the world as stable. But whether this stability is a result of neurons constructing a spatial map or continually remapping a retinal representation is unclear. Previous work has focused on the perceptu...

  • publication . Article . 2019
    Open Access
    Authors:
    Shafiei, Golia; Markello, Ross D.; Makowski, Carolina; Talpalaru, Alexandra; Kirschner, Matthias; Devenyi, Gabriel A.; Guma, Elisa; Hagmann, Patric; Cashman, Neil R.; Lepage, Martin; ...
    Publisher: Elsevier BV
    Project: CIHR , SNSF | L'Union européenne et la ... (81GE-068961), NSERC , SNSF | Quantitative characteriza... (310030_156874)

    AbstractBackgroundThere is growing recognition that connectome architecture shapes cortical and sub-cortical grey matter atrophy across a spectrum of neurological and psychiatric diseases. Whether connectivity contributes to tissue volume loss in schizophrenia in the sa...

  • publication . Article . 2018
    Open Access
    Authors:
    Chen, Ran; Tu, Jie; Tan, Yaoju; Cai, Xingshan; Yang, Chengwen; Deng, Xiangyu; Su, Biyi; Ma, Shangming; Liu, Xin; Ma, Pinyun; ...
    Publisher: bioRxiv

    ABSTRACTThe toxin-antitoxin (TA) modules widely exist in bacteria, and their activities are associated with the persister phenotype of the pathogen Mycobacterium tuberculosis (M. tb). M. tb causes Tuberculosis, a contagious and severe airborne disease. There are ten Maz...

  • publication . Article . 2018
    Open Access
    Authors:
    Scott A. Stone; Jared Baker; Rob Olsen; Robbin Gibb; Jon Doan; Jon Doan; Joshua Hoetmer; Claudia L. R. Gonzalez; Claudia L. R. Gonzalez;
    Publisher: bioRxiv
    Project: NSERC

    AbstractIn 1990, Fred Previc postulated that most peri-personal space interactions occurred in the lower visual field (LVF), leading to an advantage when compared to the upper visual field (UVF). It is not clear if extensive practice can affect the difference between in...

  • publication . Preprint . 2015
    Open Access English
    Authors:
    Jessica X. Chong; Margaret J. McMillin; Kathryn M. Shively; Anita E. Beck; Colby T. Marvin; Jose R. Armenteros; Kati J. Buckingham; Naomi T. Nkinsi; Evan A. Boyle; Margaret N. Berry; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Genetic and Molecular Bas... (5R01HD048895-08), NIH | UW Center for Mendelian G... (1U54HG006493-01), NIH | Identifying the Genetic a... (5K23HD057331-02), NIH | Next Generation Mendelian... (1RC2HG005608-01)

    Freeman-Sheldon syndrome, or distal arthrogryposis type 2A (DA2A), is an autosomal dominant condition caused by mutations in MYH3 and characterized by multiple congenital contractures of the face and limbs and normal cognitive development. We identified a subset of five...

6,470 research outcomes, page 1 of 647