Open Access mandate for Publications and Research data
Funder: EC Project Code: 101064383
Funder Contribution: 269,915 EUR
The aim of this project is to examine how commons-based peer production is impacting healthcare ecosystem dynamics and the lived experience of people with diabetes (PwD). The project focuses on communities of PwD who, collaborating online via open-source forms of knowledge exchange, are increasingly empowered to create and modify diabetes technologies to better meet their medical needs. Since its emergence in 2013, this patient-led commons has produced a range of innovations that can help improve clinical outcomes and quality-of-life. However, these innovations sit outside of commercial and regulatory processes and create dilemmas for healthcare professionals, regulators and industry. Furthermore, the central role of technology in this community has raised questions about who can participate in and benefit from its innovations. Through in-depth interviews and ethnographic observations, this project aims to capture the understandings of key stakeholders as to how and why the patient-led commons came to be as well as their visions of its role in the future of diabetes care. It ill shed light on how patient-led innovation is potentially transforming the development and diffusion of healthcare technologies and the implications of this for equity in healthcare outcomes. It is anticipated that the findings will help decision-makers to determine what sort of collaborations or partnerships can be developed between the patient-led commons and established ecosystem players to address the needs of PwD and other chronic conditions. The project includes a training programme supported by an international team of prominent scholars in science and technology studies and will provide opportunities for learning and networking that will help consolidate the Fellow as an emerging leader in patient-oriented research. Overall, the Fellowship alligns with the EC’s commitment to the inducement, uptake and scaling-up of social innovation in Europe as well as 3,5&8 of the UN SDGs.
Heat stress is a driver of current mass mortalities related to anthropogenic global warming. However, current approaches to study heat stress have not considered three major but little known aspects. These are (i) the ripple effect, which could amplify negative outcomes through propagating heat stress among organisms, (ii) heat stress as an evolutionary mutagen and (iii) genomic networks as filters for prezygotic selection, which together could speed up the process of evolutionary adaptation to rapidly changing environments. In this project, these properties of heat stress will be studied in vulnerable early life stages of three distinct aquatic ectotherms (a ragworm, a fish and a frog), to achieve an understanding of how universal these aspects of heat stress are among distinct, unrelated species. First this project will explore whether thermal stress can be propagated by means of chemical communication (stress metabolites) to naive receivers of different species. Outcomes on development will be compared with differential gene expression. We will then identify heat-induced stress metabolites and their molecular pathways of action, through RNAsequencing, Metabolomics and CRISPR-mediated gene editing. We will then test whether thermal stress and stress metabolites exposure induce higher mutation rates, through heat-induced transposon activity and reduced DNA repair capacity. gDNA sequencing will be combined with optical genome mapping to identify mutation rates and new structural variants. Lastly, we will identify the role of functional genomic network constraint in filtering such variants. We will sequence a reference genome, and explore through AI-led simulations whether networks with topological node constraints outperform those without constraint. Together, these objectives will transform our understanding of the mechanisms, and the extent to which organisms will respond to anthropogenic warming.
Open Access mandate for Publications and Research data
Funder: EC Project Code: 101063043
Funder Contribution: 199,694 EUR
At a time when fundamentalisms and populisms threaten basic human rights, it is extremely important to investigate the roots of European values such as egalitarianism and democracy, in order to contribute to popular and scholarly debates on these subjects in an informed way. Addressing the historical relationship between religion and ideas of modernity, the EuWoRD project aims to provide a better understanding of laypersons’ contribution (women and men) to the development of the Enlightenment, when democratic concepts gradually emerged as basic rights. It addresses particularly the history of a religious minority in seventeenth-century Europe, the Dutch Collegiant movement, and pursues a specific goal: to reveal how the practice of enlightened concepts and the participation of women in free-discussion meetings co-created the development of enlightened values. The theory did not cause the practice: both were mutually implicated in development. To pursue this goal, the EuWoRD project blends the methodologies of social history, gender history, history of ideas and political philosophy, and has two objectives: 1) an updated account of the Collegiants’ practices, the presence of women among their ranks, and their European network, regarding their meetings as interconfessional free associations that fostered the birth of an early public sphere; 2) an examination of the interrelations between the Collegiants’ practices and the concepts they advocated, focusing on their debates on gender equality and women’s right to free speech, and revealing how these debates were related to similar ones throughout Europe. Due to its originality and interdisciplinarity, the EuWoRD project will have a major impact on several fields of study, as well as on the general public. Indeed, research outcomes will be disseminated through academic (e.g., a digital map of the Collegiants’ network and two scholarly articles) and public (e.g., a Twitter account and blog entries) activities.