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Aquistore is a deep saline CO2 storage research and demonstration project located near Estevan, Saskatchewan where CO2 is transported via pipeline and injected into a sandstone reservoir ∼3200 m below the surface. A pre-injection time-lapse analysis performed on two sparse 3D seismic datasets was used to characterise the background time-lapse signal-to-noise level at the storage site. The time-lapse analysis revealed that the lowest global nRMS was 0.07 which was taken to represent the level above which CO2 would be detectable in the reservoir. We investigate the conditions under which the injected CO2 can be detected above the defined minimum noise level through Gassmann fluid substitution and 3D seismic forward modelling. Additionally, Wave Unix was used to simulate the seismic response of the reservoir due to the injected CO2 by generating the synthetic surface reflection seismic data from an explosive surface P-wave source. We generated noise-free synthetic seismograms for the baseline model as well as for the 2-phase fluid replacement of brine with CO2 for CO2 concentrations up to 100% within the target zone – the monitors. The baseline and monitor traces from the 3D seismic survey at Aquistore are used as the noise traces in this study, and were added to their respective baseline and monitor synthetic traces. The nRMS within the reservoir was then computed for the noisy baseline and various noisy monitor surveys and was used in the assessment of the limitation to the detection of the injected CO2 in the reservoir under the background noise level at the site. We are able to conclude that the time-lapse repeatability will not limit the ability to monitor the CO2 induced changes in the reservoir at the Aquistore storage site.