research product . 2016

A Method for Whole Brain Ex Vivo Magnetic Resonance Imaging with Minimal Susceptibility Artifacts

Shatil, Anwar S.; Matsuda, Kant M.; Figley, Chase R.;
Open Access English
  • Published: 29 Nov 2016
  • Publisher: Frontiers Media S.A.
Magnetic resonance imaging (MRI) is a non-destructive technique that is capable of localizing pathologies and assessing other anatomical features (e.g., tissue volume, microstructure, and white matter connectivity) in postmortem, ex vivo human brains. However, when brains are removed from the skull and cerebrospinal fluid (i.e., their normal in vivo magnetic environment), air bubbles and air–tissue interfaces typically cause magnetic susceptibility artifacts that severely degrade the quality of ex vivo MRI data. In this report, we describe a relatively simple and cost-effective experimental setup for acquiring artifact-free ex vivo brain images using a clinical ...
Medical Subject Headings: equipment and supplies
free text keywords: Neuroscience, ex vivo, fixation, formalin, human brain, MRI, neuroimaging, postmortem
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  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
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