research product . 2011

Brain inflammation is induced by co-morbidities and risk factors for stroke

Boutin, Hervé; Crossman, David; Smigova, Alison; Drake, Caroline; Allan, Stuart M.; Francis, Sheila; Gerhard, Alexander; Jones, Matthew S.; Hinz, Rainer; Kassiou, Michael; ...
Open Access English
  • Published: 01 Jan 2011
  • Country: Canada
Abstract
Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity are associated with increased risk of stroke, which suggests that systemic inflammation may contribute to the development of stroke in humans. The hypothesis that systemic inflammation may induce brain pathology can be tested in animals, and this was the key objective of the present study. First, we assessed inflammatory changes in the brain in rodent models of chronic, systemic inflammation. PET imaging revealed increased microglia activation in the brain of JCR-LA (corpulent) rats, which develop atherosclerosis and obesity, compared to the control lean strain. Immunostainin...
Subjects
free text keywords: Brain, Risk Factors, Inflammation, Stroke, Co-Morbidity, Systemic
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