research product . Other ORP type . 2015

The role of cleaved TRPM7 kinase in cell cycle progression and histone H3 phosphorylation

Beaton, Natalie;
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  • Published: 12 May 2015
  • Country: Canada
Abstract
TRPM7, a transient receptor potential cation channel, is an ion channel fused with a kinase domain at the C-terminus. The kinase domain is cleaved from the channel by the activation of a caspase, which elicits two distinct functional proteins, both a channel and kinase. These two proteins can now differentially localize. It has been recently shown that cleaved TRPM7 C-terminal fragments can be found in the cell nucleus. The TRPM7 kinase is a functional protein that is able to phosphorylate histone H3 on serine and threonine residues in vitro. I hypothesize that cleaved TRPM7 kinase phosphorylates the DNA-associating protein, histone H3, which in turn, condenses ...
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free text keywords: TRPM7, histone, phosphorylation, H3
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Other ORP type . 2015
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