research product . 2011

The mapping and characterization of a novel binding site on HIV-1 gp120 for the broadly neutralizing monoclonal antibody IgG1 b12

Waruk, Jillian;
Open Access
  • Published: 09 Dec 2011
  • Country: Canada
Abstract
HIV infects target cells via fusion events following surface envelope glycoprotein binding to the CD4 receptor and a chemokine co-receptor. Despite the high sequence variability of envelope across and within HIV-1 subtypes, this process requires conserved sequences and structures on gp120, which also represent good targets for HIV-1 neutralizing antibodies. Few examples of HIV-1 broadly neutralizing antibodies exist, but these antibodies may hold the key to a protective HIV-1 vaccine. One such antibody, IgG1 b12 (b12), binds the CD4 binding site on the HIV-1 envelope glycoprotein gp120. To date, no vaccine preparations have been able to elicit a b12-like respons...
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Medical Subject Headings: virus diseases
free text keywords: HIV, antibody
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