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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility

Authors: International IBD Genetics Consortium,; Rahmouni, Souad; Georges, Michel; LOUIS, Edouard;

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility

Abstract

Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD), however, as with all complex diseases, deriving pathogenic mechanisms from these non-coding GWAS discoveries has been challenging. To complement GWAS and better define actionable biological targets, we analysed sequenced data from more than 30,000 CD patients and 80,000 population controls. We observe rare coding variants in established CD susceptibility genes as well as ten genes where coding variation directly implicates the gene in disease risk for the first time.

Country
Belgium
Keywords

Génétique & processus génétiques, Sciences du vivant, Genetics & genetic processes, Life sciences

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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  • Funder: UK Research and Innovation (UKRI)
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NIH| 3/4 - The Autism Sequencing Consortium: Autism gene discovery in >20,000 exomes
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NIH| Host innate immune-microbial interactions and intestinal inflammation
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