project . 2020 - 2025 . On going

Bac2MUC

Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 852452 Call for proposal: ERC-2019-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,500,000 EURFunder Contribution: 1,500,000 EUR
  • Status: On going
  • Start Date
    01 Mar 2020
    End Date
    28 Feb 2025
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The intestinal microbiota consists of beneficial commensal bacteria and pathobionts that cause inflammation. The intestinal mucus layer dictates how specific members of the microbiota affect health and disease. The mucus layer consists of soluble mucins and epithelial transmembrane (TM) mucins that regulate host responses. The molecular mechanisms as to how the intestinal microbiota affect the functions of TM mucins is largely unknown. My recent work shows that TM mucin MUC1 is a key receptor for Salmonella invasion into polarized epithelial cells. We also discovered that MUC13 is a central regulator of epithelial barrier formation. I hypothesize that bacteria-m...
Description
The intestinal microbiota consists of beneficial commensal bacteria and pathobionts that cause inflammation. The intestinal mucus layer dictates how specific members of the microbiota affect health and disease. The mucus layer consists of soluble mucins and epithelial transmembrane (TM) mucins that regulate host responses. The molecular mechanisms as to how the intestinal microbiota affect the functions of TM mucins is largely unknown. My recent work shows that TM mucin MUC1 is a key receptor for Salmonella invasion into polarized epithelial cells. We also discovered that MUC13 is a central regulator of epithelial barrier formation. I hypothesize that bacteria-m...
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