project . 2015 - 2021 . Closed

B-CAST

Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 633784 Call for proposal: H2020-PHC-2014-two-stage
  • Funded under: H2020 | RIA Overall Budget: 6,120,860 EURFunder Contribution: 5,983,360 EUR
  • Status: Closed
  • Start Date
    01 Sep 2015
    End Date
    28 Feb 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer. The aim of B-CAST is to identify women at moderate to high risk of br...
Description
Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast cancer. Given that breast cancer is not one disease, it is now essential to better understand how risk factors act together to influence the development of pathologic-molecular subtypes of breast cancer. The aim of B-CAST is to identify women at moderate to high risk of br...
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