project . 2015 - 2021 . Closed

SCORA

A systematic characterization of human regulatory architectures and their determinants of regulatory activity
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 638273 Call for proposal: ERC-2014-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,436,290 EURFunder Contribution: 1,436,290 EUR
  • Status: Closed
  • Start Date
    01 May 2015
    End Date
    31 Jan 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity. Genome-wide chromatin assays have provided insight into the properties and complex architectures by which enhancers regulate genes, but the understanding of their mechanisms is fragmented and their regulatory targets are mostly unknown. Several factors may confound the inference and interpretation of regulatory enhancer activity. There are like...
Description
Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity. Genome-wide chromatin assays have provided insight into the properties and complex architectures by which enhancers regulate genes, but the understanding of their mechanisms is fragmented and their regulatory targets are mostly unknown. Several factors may confound the inference and interpretation of regulatory enhancer activity. There are like...
Any information missing or wrong?Report an Issue