project . 2010 - 2013 . Closed

Smc5/6 and replication fork stability

UK Research and Innovation
  • Funder: UK Research and InnovationProject code: G0901011
  • Funded under: MRC Funder Contribution: 504,889 GBP
  • Status: Closed
  • Start Date
    09 Jun 2010
    End Date
    08 Jun 2013
Description
The accurate inheritance of the genetic material (DNA) is key to the survival of all organisms. DNA has to be copied (replicated) before cells divide but obstacles such as damaged DNA bases and DNA-proteins complexes can lead to replication stalling and breaking down. Cells have developed a range of mechanisms to remove such obstacles and if the DNA damage cannot be removed it can be bypassed either during or immediately after DNA copying by a range of mechanisms. This is important for survival but can be at the expense of an increased error rate leading to mutations and an increase in genome rearrangements. Since such changes can lead to cancer it is vital that...
Description
The accurate inheritance of the genetic material (DNA) is key to the survival of all organisms. DNA has to be copied (replicated) before cells divide but obstacles such as damaged DNA bases and DNA-proteins complexes can lead to replication stalling and breaking down. Cells have developed a range of mechanisms to remove such obstacles and if the DNA damage cannot be removed it can be bypassed either during or immediately after DNA copying by a range of mechanisms. This is important for survival but can be at the expense of an increased error rate leading to mutations and an increase in genome rearrangements. Since such changes can lead to cancer it is vital that...
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