project . 2016 - 2021 . Closed

Investigating pseudotyped lentiviral vector for gene delivery to the lung.

UK Research and Innovation
  • Funder: UK Research and InnovationProject code: 1808161
  • Funded under: MRC
  • Status: Closed
  • Start Date
    30 Sep 2016
    End Date
    21 Jan 2021
Description
Gene therapy has the potential to treat the underlying cause of many inherited or acquired diseases. Lentiviral vectors offer a way of introducing a gene (transgene) into cells such that it is integrated into the host cell genome. This integration provides the possibility of long term expression as lentiviruses are capable of transducing both dividing and non-dividing cells. In this project the aim is to assess ability of two different sets of pseudotypes to transduce the cells of the lung (F/HN from the Sendai virus and HA/NA from the Influenza virus). The project will compare the ability of these sets of molecules, when pseudotyped onto the same lentiviral vec...
Description
Gene therapy has the potential to treat the underlying cause of many inherited or acquired diseases. Lentiviral vectors offer a way of introducing a gene (transgene) into cells such that it is integrated into the host cell genome. This integration provides the possibility of long term expression as lentiviruses are capable of transducing both dividing and non-dividing cells. In this project the aim is to assess ability of two different sets of pseudotypes to transduce the cells of the lung (F/HN from the Sendai virus and HA/NA from the Influenza virus). The project will compare the ability of these sets of molecules, when pseudotyped onto the same lentiviral vec...
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