project . 2016 - 2021 . Closed

Epigenetic mechanisms of androgen signalling: influences on RNA methylation and transcriptional regulation

UK Research and Innovation
  • Funder: UK Research and InnovationProject code: 1803097
  • Funded under: BBSRC
  • Status: Closed
  • Start Date
    30 Sep 2016
    End Date
    30 Mar 2021
Description
Androgens are essential for normal male embryonic and pubertal development and are implicated in multiple cancer types. Androgens, acting via the androgen receptor (AR), regulate transcription of target genes by recruiting multiple epigenetic coregulators which cooperate to modify chromatin and thereby regulate transcription. In addition we have exciting new evidence that androgen signaling exploits changes in RNA epigenetics to modulate gene expression.
Partners
Description
Androgens are essential for normal male embryonic and pubertal development and are implicated in multiple cancer types. Androgens, acting via the androgen receptor (AR), regulate transcription of target genes by recruiting multiple epigenetic coregulators which cooperate to modify chromatin and thereby regulate transcription. In addition we have exciting new evidence that androgen signaling exploits changes in RNA epigenetics to modulate gene expression.
Partners
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