project . 2011 - 2013 . Closed

DNA damage responses in mammalian cells and their contribution to human health disorders; the end-stage.

UK Research and Innovation
  • Funder: UK Research and InnovationProject code: G1000050
  • Funded under: MRC Funder Contribution: 436,582 GBP
  • Status: Closed
  • Start Date
    30 Sep 2011
    End Date
    30 Mar 2013
Description
All cells in our body carry the same genetic information encoded within the DNA sequence. The entire DNA sequence represents our genome. Our DNA is constantly damaged by exogenous and endogenously arising reactive chemicals. It is important that our genomes are stably maintained without any sequence changes. The maintenance of genomic stability is crucial for cancer avoidance and for normal growth and development. Genomic stability is maintained by DNA damage response mechanisms. Individuals impaired in such mechanisms have been described and can display elevated cancer predisposition, abnormal development and/or enhanced sensitivity to environmental agents such...
Description
All cells in our body carry the same genetic information encoded within the DNA sequence. The entire DNA sequence represents our genome. Our DNA is constantly damaged by exogenous and endogenously arising reactive chemicals. It is important that our genomes are stably maintained without any sequence changes. The maintenance of genomic stability is crucial for cancer avoidance and for normal growth and development. Genomic stability is maintained by DNA damage response mechanisms. Individuals impaired in such mechanisms have been described and can display elevated cancer predisposition, abnormal development and/or enhanced sensitivity to environmental agents such...
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