project . 2015 - 2019 . Closed

Identification and characterization of bacteriocins active against clinically important strains of Clostridium difficile

UK Research and Innovation
  • Funder: UK Research and InnovationProject code: 1644357
  • Funded under: BBSRC
  • Status: Closed
  • Start Date
    30 Sep 2015
    End Date
    03 Nov 2019
Description
The aim of this project is to identify novel bacteriocins produced by clostridia and other bacteria from environmental samples, establish their host-range by testing against a range of clinically relevant C. difficile isolates including the hypervirulent PCR-ribotype 027 strains and determine the mechanisms of bacteriocin import and activity against sensitive cells. The strategy has involved isolating spore-forming and non-spore forming bacteria form environmental samples such as sewage, soil material and animal matter. All bacterial isolates were then tested for the ability to produce active bacteriocins against strains of Clostridium difficile by a biological ...
Partners
Description
The aim of this project is to identify novel bacteriocins produced by clostridia and other bacteria from environmental samples, establish their host-range by testing against a range of clinically relevant C. difficile isolates including the hypervirulent PCR-ribotype 027 strains and determine the mechanisms of bacteriocin import and activity against sensitive cells. The strategy has involved isolating spore-forming and non-spore forming bacteria form environmental samples such as sewage, soil material and animal matter. All bacterial isolates were then tested for the ability to produce active bacteriocins against strains of Clostridium difficile by a biological ...
Partners
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