project . 2021 - 2021 . Closed

Bacterial P450 engineering for production of high value antibacterials

UK Research and Innovation
  • Funder: UK Research and InnovationProject code: NE/V010328/1
  • Funded under: NERC Funder Contribution: 5,966 GBP
  • Status: Closed
  • Start Date
    01 Jan 2021
    End Date
    31 Dec 2021
Description
BBSRC : Sian Thistlethwaite : BB/M011208/1 Many pharmaceutical drugs are synthesised by traditional organic routes, however this approach can be laborious and expensive with many difficult synthesis steps. Pharmaceutical synthesis is moving towards alternative synthetic routes such as biosynthesis in order to develop sustainable, cheaper routes of commercial production. This is crucial for antibacterial discovery, as alternative approaches are required to tackle the antibacterial resistance crisis. P450 BM3 is often utilised due to its rapid catalysis, diverse range of biotransformations and variant promiscuity yielding valuable existing and novel metabolites. W...
Description
BBSRC : Sian Thistlethwaite : BB/M011208/1 Many pharmaceutical drugs are synthesised by traditional organic routes, however this approach can be laborious and expensive with many difficult synthesis steps. Pharmaceutical synthesis is moving towards alternative synthetic routes such as biosynthesis in order to develop sustainable, cheaper routes of commercial production. This is crucial for antibacterial discovery, as alternative approaches are required to tackle the antibacterial resistance crisis. P450 BM3 is often utilised due to its rapid catalysis, diverse range of biotransformations and variant promiscuity yielding valuable existing and novel metabolites. W...
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