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CD200:CD200R-Mediated Regulation of Immunity

Authors: Gorczynski, Reginald M.;

CD200:CD200R-Mediated Regulation of Immunity

Abstract

The type 1 membrane glycoprotein CD200, widely expressed on multiple cells/tissues, uses a structurally similar receptor (CD200R1), whose expression is more restricted to cells of the myeloid and lymphoid lineages, to transmit signals affecting responses in multiple physiological systems. Thus CD200 expression is reported to exert effects on cancer growth, autoimmune and allergic disorders, infection, transplantation, bone development and homeostasis, and reproductive biology. It was initially thought, based on the idea that CD200R1 was mostly expressed on cells of myeloid origin, that CD200:CD200R1 interactions were primarily dedicated to controlling myeloid cell function. However additional members of the CD200R family have now also been identified, although their function(s) remain unclear, and CD200R1 itself is now known to be expressed by subsets of T cells and other cells. Together these observations add layers of complexity to our understanding of CD200-related regulation. In common with a number of physiological systems, the mechanism(s) of CD200-induced signaling seem to fit within a similar framework of opposing actions of kinases and phosphatases. This paper highlights the advances in our knowledge of immunoregulation achieved following CD200:CD200R interaction and the potential clinical applicability of that information.

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161 references, page 1 of 17

Barclay, A. N., Ward, H. A.. Purification and chemical characterisation of membrane glycoproteins from rat thymocytes and brain, recognised by monoclonal antibody MRC OX2. European Journal of Biochemistry. 1982; 129 (2): 447-458

McMaster, W. R., Williams, A. F.. Monoclonal antibodies to Ia antigens from rat thymus: cross reactions with mouse and human and use in purification of rat Ia glycoproteins. Immunological Reviews. 1979; 47: 117-137

Dick, A. D., Broderick, C., Forrester, J. V., Wright, G. J.. Distribution of OX2 antigen and OX2 receptor within retina. Investigative Ophthalmology and Visual Science. 2001; 42 (1): 170-176

Rosenblum, M. D., Olasz, E. B., Yancey, K. B., Woodliff, J. E., Lazarova, Z., Gerber, K. A., Truitt, R. L.. Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?. Journal of Investigative Dermatology. 2004; 123 (5): 880-887 [OpenAIRE]

Clark, D. A., Keil, A., Chen, Z., Markert, U., Manuel, J., Gorczynski, R. M.. Placental trophoblast from successful human pregnancies expresses the tolerance signaling molecule, CD200 (OX-2). American Journal of Reproductive Immunology. 2003; 50 (3): 187-195

Wright, G. J., Cherwinski, H., Foster-Cuevas, M., Brooke, G., Puklavec, M. J., Bigler, M., Song, Y., Jenmalm, M., Gorman, D., McClanahan, T., Liu, M. R., Brown, M. H., Sedgwick, J. D., Phillips, J. H., Barclay, A. N.. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. The Journal of Immunology. 2003; 171 (6): 3034-3046 [OpenAIRE]

Gorczynski, R., Chen, Z. Q., Kai, Y., Lee, L., Wong, S., Marsden, P. A.. CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. The Journal of Immunology. 2004; 172 (12): 7744-7749

Hatherley, D., Cherwinski, H. M., Moshref, M., Barclay, A. N.. Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor. The Journal of Immunology. 2005; 175 (4): 2469-2474 [OpenAIRE]

Morelli, A. E., Thomson, A. W.. Tolerogenic dendritic cells and the quest for transplant tolerance. Nature Reviews Immunology. 2007; 7 (8): 610-621

Gordon, S.. Alternative activation of macrophages. Nature Reviews Immunology. 2003; 3: 23-35

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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  • Funder: Canadian Institutes of Health Research (CIHR)
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