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Drug-eluting stents: Factors governing local pharmacokinetics
Copyright policy )Stent-based drug delivery system is a revolutionary approach to mitigate the negative affects of balloon angioplasty, improve immune responsiveness and prevent hyperplastic growth of smooth muscle in the restenotic state. Its success is therefore empirically associated with effective delivery of potent therapeutics to the target site at a therapeutic concentration, for a sufficient time, and in a biologically active form. However, local delivery with drug-eluting stents imparts large dynamic concentration gradients across tissues that can be difficult to identify, characterize and control. This review explores the factors such as physiological transport forces, drug physicochemical properties, local biological tissue properties and stent design that governs the local pharmacokinetics within the arterial wall by drug-eluting stent. Rational design and optimization of drug-eluting stents for local delivery thus requires a careful consideration of all these factors.
Microsoft Academic Graph classification: Angioplasty medicine.medical_treatment medicine Pharmacokinetics Stent design Pharmacology business.industry business Stent Drug delivery Drug media_common.quotation_subject media_common Drug-eluting stent Sufficient time Bioinformatics
Pharmaceutical Science, Cardiovascular Agents, Drug Delivery Systems, Humans, Models, Cardiovascular, Stents
Pharmaceutical Science, Cardiovascular Agents, Drug Delivery Systems, Humans, Models, Cardiovascular, Stents
Microsoft Academic Graph classification: Angioplasty medicine.medical_treatment medicine Pharmacokinetics Stent design Pharmacology business.industry business Stent Drug delivery Drug media_common.quotation_subject media_common Drug-eluting stent Sufficient time Bioinformatics
Stent-based drug delivery system is a revolutionary approach to mitigate the negative affects of balloon angioplasty, improve immune responsiveness and prevent hyperplastic growth of smooth muscle in the restenotic state. Its success is therefore empirically associated with effective delivery of potent therapeutics to the target site at a therapeutic concentration, for a sufficient time, and in a biologically active form. However, local delivery with drug-eluting stents imparts large dynamic concentration gradients across tissues that can be difficult to identify, characterize and control. This review explores the factors such as physiological transport forces, drug physicochemical properties, local biological tissue properties and stent design that governs the local pharmacokinetics within the arterial wall by drug-eluting stent. Rational design and optimization of drug-eluting stents for local delivery thus requires a careful consideration of all these factors.