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Publication . Article . 2020

Assessment of biliary anatomy in potential living liver donors: Added value of gadoxetic acid-enhanced T1 MR Cholangiography (MRC) including utilization of controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique in comparison to T2W-MRC.

Luis S. Guimaraes; Ali Babaei Jandaghi; Ravi Menezes; David R. Grant; Mark S. Cattral; Kartik S. Jhaveri;
Closed Access
Published: 11 Feb 2020 Journal: Magnetic resonance imaging, volume 70 (issn: 1873-5894, Copyright policy )

Abstract Objectives To assess the added value of gadoxetic-acid–enhanced T1-weighted magnetic resonance Cholangiography (T1W-MRC) including controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)-Volumetric Interpolated Breathhold (VIBE) technique compared to T2-weighted MR Cholangiography (T2W-MRC) in depicting biliary anatomy in potential living liver donors. Methods Eighty-five potential donors including 34 men with a mean age of 35.6 years (range, 18–55 years) and 51 women with a mean age of 36.7 years (range, 23–57 years), were enrolled in this ethics-approved retrospective study. Image quality for depiction of bile ducts was evaluated by two readers in consensus in 3 separate reading sessions: 1) T2W-MRC alone, 2) T1W-MRC alone (including CAIPI-VIBE and generalized autocalibrating partially parallel acquisitions (GRAPPA)-VIBE techniques, and 3) combined T1W/T2W-MRC. Accuracy of T2W-MRC, T1W-MRC, and combined T1W/T2W-MRC for the identification/classification of the biliary variants was calculated using intraoperative cholangiogram (IOC) as the reference standard. Image quality and reader diagnostic confidence provided by CAIPI-VIBE technique was compared with GRAPPA-VIBE technique. Datasets were compared using the Wilcoxon signed-rank test. Results Image quality for depiction of the bile ducts was significantly superior in the combined T1W/T2W-MRC group, when compared to each of T2W-MRC and T1W-MRC groups independently (P value = 0.001–0.034). The combination of CAIPI-VIBE and GRAPPA-VIBE was superior compared to each of the sequences individually. The accuracy of T2W-MRC and T1W-MRC was 93% and 91%, respectively. T1W-MRC depicted four biliary variants better than T2W-MRC. Two variants not well seen in T2W-MRC were clearly shown on T1W-MRC. Conclusion Gadoxetic-acid–enhanced T1W-MRC and conventional T2W-MRC techniques are complementary for depiction of biliary variants in potential liver donors and the combination of the two improves the results. The combination of CAIPI-VIBE and GRAPPA-VIBE techniques appear to be complementary for optimal diagnostic yield of T1W-MRC.

Subjects by Vocabulary

Microsoft Academic Graph classification: Nuclear medicine business.industry business Biliary anatomy Aliasing Image quality Gadoxetic acid medicine.drug medicine Parallel imaging Magnetic resonance imaging medicine.diagnostic_test Wilcoxon signed-rank test Cholangiography


Acceleration, Adolescent, Adult, Bile Ducts, Breath Holding, Cholangiography, Contrast Media, Female, Gadolinium DTPA, Humans, Imaging, Three-Dimensional, Liver, Living Donors, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Young Adult, Radiology, Nuclear Medicine and imaging, Biomedical Engineering, Biophysics