publication . Article . 2010

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Rachel M. Freathy; Dennis O. Mook-Kanamori; Ulla Sovio; Inga Prokopenko; Nicholas J. Timpson; Diane J. Berry; Nicole M. Warrington; E. Widen; Jouke-Jan Hottenga; Marika Kaakinen; ...
Open Access
  • Published: 01 May 2010 Journal: Nature Genetics, volume 42, pages 430-435 (issn: 1061-4036, eissn: 1546-1718, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs9883204 in ADCY5 (P = 7 × 10 15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of prog...
Subjects
free text keywords: Genetics, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, Genome-wide association, Type-2 diabetes risk, Gestational-age, Head circumference, Adenylyl-cyclase, Cohort, Gene, Metaanalysis, Expression, Isoforms, Adenylyl Cyclases, Alleles, Birth Weight, Cohort Studies, Cyclins, Diabetes Mellitus, Type 2, Ethnic Groups, Female, Genetic Predisposition to Disease, Genotype, Glucose, Humans, Isoenzymes, Male, Models, Genetic, Pregnancy, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Meta-Analyses of Glucose and Insulin-related traits Consortium, Wellcome Trust Case Control Consortium, Early Growth Genetics (EGG) Consortium, Adenylate Cyclase, Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences, /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_, Netherlands Twin Register (NTR), /dk/atira/pure/subjectarea/asjc/1300/1311, Genetics, Netherlands Twin Register (NTR), SDG 3 - Good Health and Well-being, Article, Pregnancy, medicine.disease, medicine, Type 2 diabetes, Diabetes mellitus, Internal medicine, medicine.medical_specialty, Birth weight, Genome-wide association study, Single-nucleotide polymorphism, Endocrinology, Gestational age, Fetus, Biology
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