publication . Article . 2019

Heparin dosing in uninterrupted anticoagulation with dabigatran vs. warfarin in atrial fibrillation ablation: RE-CIRCUIT study

Hugh Calkins; Stephan Willems; Atul Verma; Richard J. Schilling; Stefan H. Hohnloser; Ken Okumura; Matias Nordaby; Eva Kleine; Branislav Bis; Edward P. Gerstenfeld;
Open Access
  • Published: 01 Apr 2019 Journal: EP Europace, volume 21, pages 879-885 (issn: 1099-5129, eissn: 1532-2092, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Abstract Aims To describe heparin dosing requirements in patients who underwent catheter ablation of atrial fibrillation with uninterrupted anticoagulation using dabigatran etexilate (dabigatran) or warfarin to attain therapeutic activated clotting time (ACT) in the RE-CIRCUIT® study. The RE-CIRCUIT study showed significantly fewer major bleeding events in the dabigatran vs. warfarin treatment group. Unfractionated heparin was administered during the procedure to maintain ACT >300 s. Methods and results Patients were randomly assigned to dabigatran 150 mg bid or international normalized ratio-adjusted warfarin. Ablation was performed with uninterrupted ant...
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SDG: 3. Good health
free text keywords: Physiology (medical), Cardiology and Cardiovascular Medicine, Clinical Research, Ablation for Atrial Fibrillation, Atrial fibrillation, Anticoagulation, Catheter ablation, Dabigatran, Heparin dosing, Warfarin, Dabigatran, medicine.drug, medicine, Anesthesia, Heparin, Dosing, Warfarin, Atrial fibrillation, medicine.disease, business.industry, business, Activated clotting time, medicine.diagnostic_test, Ablation, medicine.medical_treatment, Catheter ablation
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EP Europace
Article . 2019
Open Access
EP Europace
Article . 2019
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