publication . Article . Other literature type . 2020

Prevalence and Predictors of Frailty in Childhood Cancer Survivors and Siblings: A Report From the Childhood Cancer Survivor Study

Samah Hayek; Todd M. Gibson; Wendy M. Leisenring; Jennifer L Guida; Maria M. Gramatges; Philip J. Lupo; Rebecca M. Howell; Kevin C. Oeffinger; Smita Bhatia; Kim Edelstein; ...
Open Access
  • Published: 20 Jan 2020 Journal: Journal of Clinical Oncology, volume 38, pages 232-247 (issn: 0732-183X, eissn: 1527-7755, Copyright policy)
  • Publisher: American Society of Clinical Oncology (ASCO)
Abstract
PURPOSETo estimate the prevalence of frailty among childhood cancer survivors and to determine the direct and indirect effects of treatment exposures, lifestyle factors, and severe, disabling, and life-threatening chronic condition on frailty.METHODSChildhood cancer survivors (≥ 5 years since diagnosis), treated between 1970 and 1999 when < 21 years old (n = 10,899; mean age, 37.6 ± 9.4 years; 48% male, 86% white) and siblings were included (n = 2,097; mean age, 42.9 ± 9.4 years). Frailty was defined as ≥ 3 of the following: low lean mass, exhaustion, low energy expenditure, walking limitations, and weakness. Generalized linear models were used to evaluate di...
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Fields of Science and Technology classification: 03 medical and health sciences0302 clinical medicine0301 basic medicine030220 oncology & carcinogenesis030304 developmental biology
Sustainable Development Goals: 3. Good health
free text keywords: Cancer Research, Oncology, ORIGINAL REPORTS, Gerontology, MEDLINE, Extramural, Childhood cancer, Childhood Cancer Survivor Study, Lifestyle factors, Medicine, business.industry, business
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