publication . Article . 2012

A Multicenter Evaluation of Diagnostic Tools to Define Endpoints for Programs to Eliminate Bancroftian Filariasis

Katherine Gass; Madsen Beau De Rochars; Daniel A. Boakye; Mark Bradley; Peter Fischer; John O. Gyapong; Makoto Itoh; Nese Ituaso-Conway; Hayley Joseph; Dominique Kyelem; ...
Open Access
  • Published: 17 Jan 2012 Journal: PLoS Neglected Tropical Diseases, volume 6, page e1479 (eissn: 1935-2735, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in...
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Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Infectious Diseases, Public Health, Environmental and Occupational Health, Research Article, Medicine, Neglected Tropical Diseases, Parasitic Diseases, Medicine, business.industry, business, Filariasis, medicine.disease, Internal medicine, medicine.medical_specialty, Wuchereria bancrofti, medicine.disease_cause, Lymphatic filariasis, Parasitology, Mass drug administration, Test (assessment), Predictive value of tests, Immunology, Clinical trial, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, lcsh:Public aspects of medicine, lcsh:RA1-1270
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