• shareshare
  • link
  • cite
  • add
auto_awesome_motion View all 2 versions
Publication . Article . 2018

Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management.

Alexander K. C. Leung; Joseph M. Lam; Kin Fon Leong;
Open Access
Published: 09 Apr 2018 Journal: Current pediatric reviews, volume 15, issue 1 (issn: 1875-6336, Copyright policy )

Background: The diagnosis of solitary cutaneous mastocytoma is mainly clinical, based on lesion morphology, the presence of a positive Darier sign, and the absence of systemic involvement. Knowledge of this condition is important so that an accurate diagnosis can be made. Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of a solitary cutaneous mastocytoma. Methods: A PubMed search was completed in Clinical Queries using the key term "solitary cutaneous mastocytoma". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. Only papers published in English language were included. The information retrieved from the above search was used in the compilation of the present article. Results: Typically, a solitary cutaneous mastocytoma presents as an indurated, erythematous, yellow- brown or reddish-brown macule, papule, plaque or nodule, usually measuring up to 5 cm in diameter. The lesion often has a peau d'orange appearance and a leathery or rubbery consistency. A solitary cutaneous mastocytoma may urticate spontaneously or when stroked or rubbed (Darier sign). Organomegaly and lymphadenopathy are characteristically absent. The majority of patients with skin lesions that erupt within the first two years of life have spontaneous resolution of the lesions before puberty. Treatment is mainly symptomatic. Reassurance and avoidance of triggering factors suffice in most cases. Conclusion: The diagnosis is mainly clinical, based on the morphology of the lesion, the presence of a positive Darier sign, and the absence of systemic involvement. A skin biopsy is usually not necessary unless the diagnosis is in doubt.

Subjects by Vocabulary

Microsoft Academic Graph classification: Randomized controlled trial law.invention law Solitary cutaneous mastocytoma Mastocytoma medicine.disease medicine Nodule (medicine) medicine.symptom Lesion Clinical trial business.industry business Papule Skin biopsy medicine.diagnostic_test Dermatology medicine.medical_specialty


Child, Diagnosis, Differential, Humans, Mastocytoma, Skin, Skin, Skin Neoplasms, Article, Indurated, hyperpigmented, macule, papule, plaque, nodule, Darier sign, Pediatrics, Perinatology and Child Health

33 references, page 1 of 4

Leung, A.K., Barankin, B.. Urticaria pigmentosa.. Consult Pediatr. 2016; 15: 311-313

Hartmann, K., Escribano, L., Grattan, C.. Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology.. J. Allergy Clin. Immunol.. 2016; 137 (1): 35-45 [OpenAIRE] [PubMed]

Ma, S.P., Hardy, T.G.. Solitary Mastocytoma of the eyelid in an adult patient with prolidase deficiency.. Ophthal. Plast. Reconstr. Surg.. 2017; 33 (1): e10-e13

Pandhi, D., Singal, A., Aggarwal, S.. Adult onset, hypopigmented solitary mastocytoma: Report of two cases.. Indian J. Dermatol. Venereol. Leprol.. 2008; 74 (1): 41-43 [OpenAIRE] [PubMed]

Azaña, J.M., Torrelo, A., Matito, A.. Update on mastocytosis (Part 1): pathophysiology, clinical features, and diagnosis.. Actas Dermosifiliogr.. 2016; 107 (1): 5-14 [OpenAIRE] [PubMed]

Klaiber, N., Kumar, S., Irani, A.M.. Mastocytosis in Children.. Curr. Allergy Asthma Rep.. 2017; 17 (11): 80 [OpenAIRE] [PubMed]

Auquit-Auckbur, I., Lazar, C., Deneuve, S.. Malignant transformation of mastocytoma developed on skin mastocytosis into cutaneous mast cell sarcoma.. Am. J. Surg. Pathol.. 2012; 36 (5): 779-782 [OpenAIRE] [PubMed]

Briley, L.D., Phillips, C.M.. Cutaneous mastocytosis: A review focusing on the pediatric population.. Clin. Pediatr. (Phila.). 2008; 47 (8): 757-761 [OpenAIRE] [PubMed]

Gopal, D., Puri, P., Singh, A., Ramesh, V.. Asymptomatic solitary cutaneous mastocytoma: A rare presentation.. Indian J. Dermatol.. 2014; 59 (6): 634

Krishnan, K.R., Ownby, D.R.. A solitary mastocytoma presenting with urticaria and angioedema in a 14-year-old boy.. Allergy Asthma Proc.. 2010; 31 (6): 520-523 [OpenAIRE] [PubMed]