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Publication . Article . 2021

Renal Infarcts—A Perplexing Case in the Middle of the COVID-19 Pandemic

Brett Plouffe; Tamara Van Hooren; Michelle Barton; Michelle Barton; Nancy Nashid; Erkan Demirkaya; Erkan Demirkaya; +11 Authors
Open Access
Published: 14 May 2021 Journal: Frontiers in Pediatrics, volume 9 (issn: 2296-2360, Copyright policy )
Publisher: Frontiers Media S.A.
Country: Canada

Renal infarction is a rare finding in children. Associations between SARS-CoV-2 infections and thromboembolic events including renal infarcts have been described in adults. Although a similar association in children has not yet been described with this pandemic, the pediatric literature is still evolving with the recognition of new manifestations including the post-infectious Multisystem Inflammatory Syndrome in Children (MIS-C). We report the rare event of multiple renal infarcts in a 6-year-old boy manifesting several features of MIS-C 9 weeks following a self-limiting febrile illness characteristic of COVID-19. An underlying Factor V Leiden mutation was identified in this child but felt to be insufficient on its own to explain his clinical presentation. As SARS-CoV-2 testing was delayed, the failure to identify viral RNA or antibodies may not exclude the virus' potential role in precipitating the infarct in this host. Given that renal infarcts have been described in adult patients with COVID-19, reporting this perplexing case where SARS-CoV-2 may have played a role, may help identify this potential complication.

Subjects by Vocabulary

Microsoft Academic Graph classification: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pediatrics medicine.medical_specialty medicine Complication Coronavirus disease 2019 (COVID-19) Pandemic Factor V Leiden mutation Renal infarction Renal Infarct business.industry business Viral rna


renal infarct, multisystem inflammatory syndrome in children, pediatric inflammatory multisystem syndrome, COVID-19, SARS-CoV-2, merged SPECT/CT, Pediatrics, RJ1-570, Mini Review, Pediatrics, Perinatology and Child Health, COVID-19, merged SPECT/CT, multisystem inflammatory syndrome in children, pediatric inflammatory multisystem syndrome, renal infarct, SARS-CoV-2