publication . Article . 2019

Comparing CST Lesion Metrics as Biomarkers for Recovery of Motor and Proprioceptive Impairments After Stroke

Sonja E. Findlater; Rachel L. Hawe; Erin L. Mazerolle; Abdulaziz S Al Sultan; Jessica M. Cassidy; Stephen Scott; G. Bruce Pike; Sean P. Dukelow;
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  • Published: 22 Aug 2019 Journal: Neurorehabilitation and Neural Repair, volume 33, pages 848-861 (issn: 1545-9683, eissn: 1552-6844, Copyright policy)
  • Publisher: SAGE Publications
Abstract
Background. Corticospinal tract (CST) damage is considered a biomarker for stroke recovery. Several methods have been used to define CST damage and examine its relationship to motor performance, but which method is most useful remains unclear. Proprioceptive impairment also affects stroke recovery and may be related to CST damage. Methods. Robotic assessment quantified upper-limb motor and proprioceptive performance at 2 weeks and 6 months poststroke (n = 149). Three previously-established CST lesion metrics were calculated using clinical neuroimaging. Diffusion magnetic resonance imaging quantified CST microstructure in a subset of participants (n = 21). Stati...
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Sustainable Development Goals: 2. Zero hunger
Fields of Science and Technology classification: 03 medical and health sciences05 social sciences0302 clinical medicine0501 psychology and cognitive sciences050105 experimental psychology030217 neurology & neurosurgery
Medical Subject Headings: human activities
free text keywords: General Medicine, Medicine, business.industry, business, Corticospinal tract, Stroke, medicine.disease, Internal capsule, Stroke recovery, medicine.medical_treatment, Fractional anisotropy, Neuroimaging, Motor skill, Physical medicine and rehabilitation, medicine.medical_specialty, Lesion, medicine.symptom
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  • Funder: Canadian Institutes of Health Research (CIHR)
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