publication . Article . 2017

Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity

Yu-Han Chang; Kuan Chung Wang; Kuan-Lun Chu; Derek L. Clouthier; Anh T. Tran; Miguel S. Torres Perez; Angela C. Zhou; Ali A. Abdul-Sater; Tania H. Watts;
Open Access
  • Published: 01 Nov 2017 Journal: Immunity, volume 47, pages 943-958,000,000,000 (issn: 1074-7613, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Summary T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4 + T cell accumulation and control of chronic lymphocytic choriomeningitis virus (LCMV). We found that type I interferon (IFN-I) induced TNFSF ligands GITRL, 4-1BBL, OX40L, and CD70 predominantly on monocyte-derived APCs and CD80 and CD86 predominantly on classical dendritic cells (cDCs). Mice with hypofunctional GITRL in Lyz2 + cells had decreased LCMV-spe...
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Fields of Science and Technology classification: 03 medical and health sciences0302 clinical medicine0301 basic medicine030215 immunology030104 developmental biology
free text keywords: Infectious Diseases, Immunology, Immunology and Allergy, Antigen-presenting cell, Interferon, medicine.drug, medicine, T cell, medicine.anatomical_structure, Chemokine receptor, IL-2 receptor, CD86, Immunology, Biology, CD80, Priming (immunology)
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  • Funder: Canadian Institutes of Health Research (CIHR)
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Supplementary Outcomes
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