publication . Article . 2015

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

Anja Rudolph; Peter A. Fasching; Sabine Behrens; Ursula Eilber; Manjeet K. Bolla; Qin Wang; Deborah J. Thompson; Kamila Czene; Judith S. Brand; Jingmei Li; ...
Open Access English
  • Published: 16 Aug 2015 Journal: Breast Cancer Research : BCR, volume 17, issue 1 (issn: 1465-5411, eissn: 1465-542X, Copyright policy)
  • Publisher: BioMed Central
Abstract
Introduction Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants that may modify the association between MHT use and mammographic density. Methods The study comprised 6,298 postmenopausal women from the Mayo Mammography Health Study and nine studies included in the Breast Cancer Association Consortium. We selected for evaluation 1327 single nucleotide polymorphisms (SNPs) showing the lowest P-values for interaction (Pint) in a meta-analysis of genome-wide gene-environment interaction studies with MHT use o...
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Fields of Science and Technology classification: 03 medical and health sciences0302 clinical medicine0303 health sciences030220 oncology & carcinogenesis030304 developmental biology
free text keywords: Research Article, mammographic density, menopausal hormone therapy, single nucleotide polymorphism, gene - environment interaction, -, Medizinische Fakultät, Medicine(all), ddc:610, Genome-wide association study, Case-control study, Internal medicine, medicine.medical_specialty, medicine, Tamoxifen, medicine.drug, Hormone replacement therapy (menopause), medicine.medical_treatment, Mammography, medicine.diagnostic_test, Oncology, Gynecology, Breast Cancer Risk Factor, business.industry, business, Breast cancer, medicine.disease, Single-nucleotide polymorphism
Funded by
NIH| A Mayo Cohort Study of Mammographic Breast Density
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01CA097396-01A1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Identifying Genes for Mammographic Breast Density
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA128931-04
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01CA063464-05
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Breast &Prostate Cancer &Hormone-related Gene Variants
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01CA098758-01
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA177150-03
  • Funding stream: NATIONAL CANCER INSTITUTE
Supplementary Outcomes
18 research outcomes, page 1 of 2
18 research outcomes, page 1 of 2
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